IS3707A7 - Fjölliða örblöðrur fylltar með gasi eða lofti, nothæfar sem sviflausnir í fljótandi burðarefnum fyrir ómskoðun - Google Patents

Fjölliða örblöðrur fylltar með gasi eða lofti, nothæfar sem sviflausnir í fljótandi burðarefnum fyrir ómskoðun

Info

Publication number
IS3707A7
IS3707A7 IS3707A IS3707A IS3707A7 IS 3707 A7 IS3707 A7 IS 3707A7 IS 3707 A IS3707 A IS 3707A IS 3707 A IS3707 A IS 3707A IS 3707 A7 IS3707 A7 IS 3707A7
Authority
IS
Iceland
Prior art keywords
air
suspensions
usable
carriers
gas
Prior art date
Application number
IS3707A
Other languages
English (en)
Other versions
IS1862B (is
Inventor
Bichon Daniel
Bussat Philippe
Schneider Michel
Original Assignee
Bracco International B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8205926&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS3707(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco International B.V. filed Critical Bracco International B.V.
Publication of IS3707A7 publication Critical patent/IS3707A7/is
Publication of IS1862B publication Critical patent/IS1862B/is

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Acoustics & Sound (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
IS3707A 1990-05-18 1991-05-15 Fjölliða örblöðrur fylltar með gasi eða lofti, nothæfar sem sviflausnir í fljótandi burðarefnum fyrir ómskoðun IS1862B (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90810367 1990-05-18

Publications (2)

Publication Number Publication Date
IS3707A7 true IS3707A7 (is) 1991-11-19
IS1862B IS1862B (is) 2003-04-15

Family

ID=8205926

Family Applications (1)

Application Number Title Priority Date Filing Date
IS3707A IS1862B (is) 1990-05-18 1991-05-15 Fjölliða örblöðrur fylltar með gasi eða lofti, nothæfar sem sviflausnir í fljótandi burðarefnum fyrir ómskoðun

Country Status (19)

Country Link
US (7) US5711933A (is)
EP (1) EP0458745B2 (is)
JP (1) JP2897190B2 (is)
KR (1) KR0142180B1 (is)
CN (1) CN1055414C (is)
AT (1) ATE112173T1 (is)
AU (1) AU636481B2 (is)
CA (1) CA2042722C (is)
DE (1) DE69104264T3 (is)
DK (1) DK0458745T4 (is)
ES (1) ES2061217T5 (is)
HU (2) HU226007B1 (is)
IE (1) IE66895B1 (is)
IL (1) IL98143A (is)
IS (1) IS1862B (is)
NZ (1) NZ238160A (is)
PL (1) PL166827B1 (is)
RU (1) RU2110991C1 (is)
ZA (1) ZA913729B (is)

Families Citing this family (291)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (is) * 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US5487390A (en) * 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5370901A (en) 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
WO1992021382A1 (en) * 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
GB9116610D0 (en) * 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
NZ244147A (en) 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
SG54121A1 (en) * 1991-09-17 1998-11-16 Sonus Pharma Inc Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
MX9205298A (es) 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200391D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
GB9204918D0 (en) 1992-03-06 1992-04-22 Nycomed As Chemical compounds
JP3650393B2 (ja) * 1992-03-06 2005-05-18 アメルシャム ヘルス アクスイェ セルスカプ 造影剤におけるまたは造影剤に関する改良
US5674468A (en) * 1992-03-06 1997-10-07 Nycomed Imaging As Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
US6383470B1 (en) 1992-09-26 2002-05-07 Thomas Fritzsch Microparticle preparations made of biodegradable copolymers
DE4232755A1 (de) * 1992-09-26 1994-03-31 Schering Ag Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
SK281535B6 (sk) * 1993-01-25 2001-04-09 Sonus Pharmaceuticals, Inc. Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
CZ350895A3 (en) * 1993-07-02 1996-10-16 Molecular Biosystems Inc In protein encapsulated micro-spheres containing insoluble gas as well as their preparation and use as ultrasonic diagnostic
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
US6068857A (en) * 1993-09-09 2000-05-30 Schering Aktiengesellchaft Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
CZ208995A3 (en) 1993-12-15 1996-01-17 Bracco Research Sa Injectable ultrasound medium, process of its preparation and use
AU2432795A (en) * 1994-05-03 1995-11-29 Molecular Biosystems, Inc. Composition for ultrasonically quantitating myocardial perfusion
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
DE4428589C2 (de) * 1994-08-12 1996-11-07 Byk Gulden Lomberg Chem Fab Orales Echokontrastmittel
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
US5540909A (en) 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
GB9423419D0 (en) 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
DE19510690A1 (de) 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5759539A (en) * 1995-06-06 1998-06-02 Georgia Research Foundation, Inc. Method for rapid enzymatic alcohol removal
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
WO1996040277A2 (en) * 1995-06-07 1996-12-19 Brown University Research Foundation Spray dried polymeric microparticles containing imaging agents
US5820850A (en) * 1995-06-07 1998-10-13 Molecular Biosystems, Inc. Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
AU1354497A (en) * 1995-12-21 1997-07-14 Drexel University Hollow polymer microcapsules and method of producing
DK0904113T3 (da) * 1996-03-05 2004-08-30 Acusphere Inc Mikroindkapslede fluorerede gasser til anvendelse som billeddannende midler
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
DE19611769A1 (de) * 1996-03-14 1997-09-18 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie deren Verwendung in der Ultraschall Diagnostik
EP0935415B1 (en) 1996-05-01 2006-11-22 Imarx Pharmaceutical Corp. In vitro methods for delivering nucleic acids into a cell
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5976501A (en) * 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
DE69737915T2 (de) 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6193951B1 (en) * 1997-04-30 2001-02-27 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents
US20050019266A1 (en) * 1997-05-06 2005-01-27 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6610764B1 (en) * 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6867248B1 (en) 1997-05-12 2005-03-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
EP1007181A1 (en) 1997-07-04 2000-06-14 Nycomed Imaging As Process for the selection of particles of a preselected size from a particulate pharmaceutical product
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
EP0968000B1 (en) * 1997-08-12 2003-10-29 Bracco Research S.A. Administrable compositions and methods for magnetic resonance imaging
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US7637948B2 (en) 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
GB9727102D0 (en) * 1997-12-22 1998-02-25 Andaris Ltd Microparticles and their therapeutic use
ATE345359T1 (de) 1997-12-22 2006-12-15 Metabolix Inc Polyhydroxyalkanoatzusammensetzungen mit kontrollierten abbaugeschwindigkeiten
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
IT1298269B1 (it) * 1998-02-18 1999-12-20 Promefarm S R L Uso di un polietilenglicole come mezzo di contrasto in ecografia
US6347241B2 (en) 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it
US6238677B1 (en) * 1998-08-18 2001-05-29 The United States Of America As Represented By The Secretary Of Agriculture Starch microcapsules for delivery of active agents
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US20090216118A1 (en) 2007-07-26 2009-08-27 Senorx, Inc. Polysaccharide markers
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
EP1159015A1 (en) 1999-03-04 2001-12-05 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
PT1163019E (pt) * 1999-03-25 2007-12-06 Metabolix Inc Dispositivos médicos e aplicações de polímeros de poli-hidroxialcanoato
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
WO2001012071A1 (en) 1999-08-13 2001-02-22 Point Biomedical Corporation Microparticles useful as ultrasonic contrast agents and for lymphatic system
EP1202670A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp HOLLOW MICROSPHERES WITH CONTROLLED FRAGILITY FOR MEDICAL USE
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US6368275B1 (en) 1999-10-07 2002-04-09 Acuson Corporation Method and apparatus for diagnostic medical information gathering, hyperthermia treatment, or directed gene therapy
US20030144570A1 (en) * 1999-11-12 2003-07-31 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
DE10013850A1 (de) * 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
EP1780283A1 (en) 2000-04-21 2007-05-02 Martek Biosciences Corporation Trophic conversion of obligate photographic algae through metabolic engineering
EP2279757A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
DE10027393B4 (de) * 2000-06-02 2007-05-16 Wella Ag Poly- und Oligoester kationischer Hydroxysäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
AU2002239290A1 (en) 2000-11-20 2002-06-03 Senorx, Inc. Tissue site markers for in vivo imaging
AU2002230993B2 (en) 2000-12-29 2006-02-02 Alkermes, Inc. Particles for inhalation having sustained release properties
US7897141B2 (en) * 2002-04-01 2011-03-01 Drexel University Echogenic polymer microcapsules and nanocapsules and methods for production and use thereof
DE60222888T3 (de) * 2001-03-30 2012-08-23 Drexel University Echogene polymermikrokapseln und nanokapseln und verfahren zu ihrer herstellung und verwendung
JP3819845B2 (ja) * 2001-04-06 2006-09-13 ブラッコ・リサーチ・ソシエテ・アノニム 流体で充填された空洞内の局所物理パラメータの改善された測定方法
DE10119522A1 (de) * 2001-04-20 2002-12-05 Innovacell Biotechnologie Gmbh Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel
KR100924990B1 (ko) * 2001-06-20 2009-11-04 니폰 가야꾸 가부시끼가이샤 불순물 함량을 감소시킨 블록 공중합체, 고분자 담체 및고분자 의약제제 및 그 제조 방법
WO2003043585A2 (en) 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US6890592B2 (en) 2002-03-13 2005-05-10 Appleton Papers Inc. Uniform microcapsules
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US20060036158A1 (en) 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
DK1590006T3 (da) * 2003-02-04 2010-12-20 Bracco Suisse Sa Ultralydskontrastmidler og fremgangsmåde til frembringelse deraf
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
EP1592456A1 (en) 2003-02-13 2005-11-09 BRACCO IMAGING S.p.A. Contrast enhanced x-ray phase imaging
US20050214859A1 (en) 2003-03-03 2005-09-29 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
ITFI20030077A1 (it) * 2003-03-26 2004-09-27 Actis Active Sensors S R L Metodo per l'indagine ecografica tramite mezzi di contrasto
PT1638615E (pt) * 2003-05-08 2015-02-04 Tepha Inc Fibras e tecidos médicos de polihidroxialcanoato
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
JP4706003B2 (ja) 2003-06-12 2011-06-22 ブラッコ・シュイス・ソシエテ・アノニム 超音波造影画像において補充曲線フィッティングを用いる血流評価法
US8021303B2 (en) 2003-06-12 2011-09-20 Bracco Research Sa System for extracting morphological information through a perfusion assessment process
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
CA2531833C (en) * 2003-07-08 2009-10-20 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
WO2005020825A1 (en) * 2003-08-22 2005-03-10 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
SE0302794D0 (sv) * 2003-10-24 2003-10-24 Per Hansson Novel microparticles for ultrasound contrast imaging and drug delivery
JP2007509989A (ja) 2003-10-31 2007-04-19 ポイント バイオメディカル コーポレイション 超音波造影剤として有用な再構成可能なミクロスフィア組成物
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US20050273002A1 (en) 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
EP1696965B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
WO2005063305A1 (en) * 2003-12-22 2005-07-14 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
ATE466596T1 (de) 2004-01-20 2010-05-15 Sunnybrook & Womens College Hochfrequenz-ultraschall-darstellung mit kontrastmitteln
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
PT1778305E (pt) * 2004-08-03 2010-07-27 Tepha Inc Suturas de poli-hidroxialcanoato que n†o se enrolam
GB2417080B (en) 2004-08-13 2008-05-21 Stichting Tech Wetenschapp Intravascular ultrasound techniques
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
DK1792927T3 (da) * 2004-09-22 2013-06-10 Nippon Kayaku Kk Ny blokcopolymer, micelletilberedning og anticancermiddel indeholdende samme som aktiv ingrediens
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
EP1833373B1 (en) 2004-12-23 2015-12-16 Bracco Suisse SA A perfusion assessment method and system based on bolus administration
US20080045919A1 (en) * 2004-12-23 2008-02-21 Bracco Research S.A. Liquid Transfer Device for Medical Dispensing Containers
JP2008528204A (ja) * 2005-01-28 2008-07-31 テファ, インコーポレイテッド ポリ−4−ヒドロキシブチレート粒子を使用した塞栓形成
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
WO2006094951A1 (en) 2005-03-03 2006-09-14 Bracco Research Sa Medical imaging system based on a targeted contrast agent
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
US10357328B2 (en) 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
CA2562580C (en) 2005-10-07 2014-04-29 Inrad, Inc. Drug-eluting tissue marker
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US9198639B2 (en) 2005-11-10 2015-12-01 Bracco Suisse S.A. Detection of immobilized contrast agent in medical imaging applications based on flow dynamics analysis
US8634608B2 (en) 2005-11-10 2014-01-21 Bracco Suisse S.A. Instantaneous visualization of contrast agent concentration in imaging applications
KR101414467B1 (ko) * 2005-11-10 2014-07-18 옴니 테크놀로지스 코포레이션 탄성중합체 함유 플럭스의 연속길이층을 갖는 납땜재료
EP1797919A1 (en) * 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
JP2007196223A (ja) * 2005-12-28 2007-08-09 National Institute Of Advanced Industrial & Technology 中空マイクロカプセルの製造方法
JP5154554B2 (ja) 2006-08-01 2013-02-27 ボストン サイエンティフィック サイムド,インコーポレイテッド 非線形イメージングのためのパルスインバージョンシーケンス
WO2008051749A2 (en) 2006-10-23 2008-05-02 C. R. Bard, Inc. Breast marker
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US9579077B2 (en) 2006-12-12 2017-02-28 C.R. Bard, Inc. Multiple imaging mode tissue marker
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
WO2008075192A2 (en) * 2006-12-19 2008-06-26 Bracco International Bv Targeting and therapeutic compounds and gas-filled microvesicles comprising said com ounds
CA2670932C (en) 2006-12-21 2016-03-22 Bracco International Bv Detection of the detachment of immobilized contrast agent in medical imaging applications
JP4967101B2 (ja) * 2006-12-28 2012-07-04 独立行政法人産業技術総合研究所 中空マイクロカプセルの製造方法
EP2476703A1 (en) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
EP2200652B1 (en) * 2007-09-27 2018-03-21 Children's Medical Center Corporation Microbubbles and methods for oxygen delivery
US10130342B2 (en) 2007-12-28 2018-11-20 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
WO2011110552A1 (en) 2010-03-09 2011-09-15 Bracco Suisse Sa Initialization of fitting parameters for perfusion assessment based on bolus administration
CN101917908B (zh) 2007-12-28 2012-10-03 博莱科瑞士股份有限公司 医学成像应用中对固定造影剂的量化分析
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
EP2090322A1 (en) 2008-02-18 2009-08-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of fsh receptor ligands for diagnosis and therapy of cancer
EP2103313A1 (en) * 2008-03-19 2009-09-23 Koninklijke Philips Electronics N.V. Method for the synthesis of hollow spheres
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
WO2010040772A2 (en) * 2008-10-07 2010-04-15 Bracco Research Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
EP2189112A1 (en) 2008-11-24 2010-05-26 Bracco Research S.A. Real-time perfusion imaging and quantification
WO2010069943A1 (en) 2008-12-16 2010-06-24 Bracco Research Sa Device for bolus administration of contrast agent
JP5453453B2 (ja) 2008-12-30 2014-03-26 シー・アール・バード・インコーポレーテッド 組織マーカの配置のためのマーカ伝送装置
JP5593382B2 (ja) 2009-06-08 2014-09-24 ブラッコ・シュイス・ソシエテ・アノニム パラメトリック画像の自動スケーリング
CA2769164C (en) 2009-09-01 2017-11-07 Bracco Suisse Sa Parametric images based on dynamic behavior over time
US8420259B2 (en) * 2009-10-14 2013-04-16 GM Global Technology Operations LLC Electrodes including an embedded compressible or shape changing component
CA2784287C (en) * 2009-12-22 2017-07-18 Evonik Degussa Corporation Emulsion-based process for preparing microparticles and workhead assembly for use with same
EP2345732A1 (en) 2010-01-19 2011-07-20 Universite Paris Descartes Methods for intracellular delivery of nucleic acids
US20110269657A1 (en) * 2010-04-28 2011-11-03 Jiten Odhavji Dihora Delivery particles
DK2603242T3 (en) 2010-08-09 2018-06-18 Bracco Suisse Sa TARGETED GAS FILLED MICROVESICLES
WO2012020001A1 (en) 2010-08-09 2012-02-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of an ocular disease in a subject
EP2654788B1 (en) 2010-12-24 2018-03-14 Bracco Suisse SA Gas-filled microvesicles for use as vaccine
EP2474327A1 (en) 2011-01-07 2012-07-11 RWTH Aachen Microdosing of ultrasound contrast agents
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
DE102011005444A1 (de) * 2011-03-11 2012-09-13 Innora Gmbh Festes, negatives Röntgenkontrastmittel zur Darstellung des Gastrointestinaltraktes
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
EP2545908A1 (en) 2011-07-11 2013-01-16 RWTH Aachen Medium for microbubbles or microparticles and preparation thereof
US20150037375A1 (en) * 2011-07-19 2015-02-05 Trustees Of Boston University Et Al Doping agents and polymeric compositions thereof for controlled drug delivery
WO2013151682A1 (en) 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
RU2508094C1 (ru) * 2012-08-03 2014-02-27 Андрей Юрьевич Хоменко Способы получения трансдермальных терапевтических систем на основе сополимеров молочной и гликолевой кислот (варианты)
BR112015014164B1 (pt) 2012-12-21 2021-12-07 Bracco Suisse Sa Método de segmentação de processamento de dados e sistema para aplicações de formação de imagem de diagnóstico.
EP2972387A1 (en) 2013-03-15 2016-01-20 Westfälische Wilhelms-Universität Münster Detection of acute renal allograft rejection
EP2968825A4 (en) 2013-03-15 2016-09-07 Childrens Medical Center Gas-filled stabilized particles and methods of use
CN105407968B (zh) 2013-07-03 2019-09-03 博莱科瑞士股份公司 用于对缺血性中风的超声处置的设备
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
BR112016022401B1 (pt) 2014-04-07 2023-04-04 Bracco Suisse S.A Método para uso com um scanner de ultrassom, meio de armazenamento legível por computador, e, sistema
WO2016012838A1 (en) 2014-07-23 2016-01-28 Universidad Andrés Bello Controlled release system comprising a gas or volatile encapsulated in a polymeric support and a matrix system; method of preparation said system, and their use applied to agribusiness, forestry, pharmaceuticals, cosmetics, among others
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
CN108601948B (zh) 2015-12-09 2021-04-20 皇家飞利浦有限公司 超声系统
KR102720431B1 (ko) 2015-12-10 2024-10-23 브라코 스위스 에스.에이. 동적 역치화에 의한 고정된 조영제의 검출
JP6991148B2 (ja) 2016-02-09 2022-01-12 ブラッコ・スイス・ソシエテ・アノニム セレクチン標的化のための組み換えキメラタンパク質
CN109641068B (zh) 2016-05-04 2022-09-30 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11147890B2 (en) 2017-02-28 2021-10-19 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
WO2019006029A1 (en) 2017-06-27 2019-01-03 Lawrence Livermore National Security, Llc POLYMER COMPOSITES WITH MEMORY OF ELASTOMERIC FORM
US12516216B2 (en) 2017-06-27 2026-01-06 Lawrence Livermore National Security, Llc Microballoon-facilitated tunable porosity of elastomeric shape memory polymer composites
CN115400230B (zh) * 2022-09-03 2023-12-22 福建医科大学附属协和医院 一种新型的多功能胃肠超声造影剂
WO2024133827A1 (en) 2022-12-21 2024-06-27 Bracco Suisse Sa Gas-filled microvesicles with perfluoro olefin
WO2025021942A1 (en) 2023-07-27 2025-01-30 Bracco Suisse Sa Ultrasound responsive vesicles containing lipid-polyamino acid conjugates
WO2025132906A1 (en) 2023-12-22 2025-06-26 Bracco Suisse Sa Focused ultrasound thermal ablation with thermal enhancers

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US3900420A (en) * 1970-05-18 1975-08-19 Felix Sebba Microgas emulsions and method of forming same
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
US4089800A (en) * 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH624011A5 (is) * 1977-08-05 1981-07-15 Battelle Memorial Institute
CH621479A5 (is) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
IL58965A (en) * 1978-12-19 1982-08-31 Mars Inc Production of microcapsules
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4316391A (en) * 1979-11-13 1982-02-23 Ultra Med, Inc. Flow rate measurement
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
FR2504408B1 (fr) * 1981-04-24 1986-02-14 Couvreur Patrick Procede de preparation de particules submicroscopiques, particules ainsi obtenues et compositions pharmaceutiques les contenant
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
US4511515A (en) * 1983-06-28 1985-04-16 Corning Glass Works Method for making a volatile cerium diketonate compound
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US5618514A (en) * 1983-12-21 1997-04-08 Nycomed Imaging As Diagnostic and contrast agent
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5283067A (en) * 1987-01-30 1994-02-01 Ciba-Geigy Corporation Parenteral suspensions
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
CH672733A5 (is) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
DE3721721C1 (de) * 1987-07-01 1988-06-09 Hoechst Ag Verfahren zur Umhuellung von Granulaten
DE3741201A1 (de) * 1987-12-02 1989-06-15 Schering Ag Ultraschallarbeitsverfahren und mittel zu dessen durchfuehrung
IE61591B1 (en) * 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
US5730954A (en) * 1988-08-23 1998-03-24 Schering Aktiengesellschaft Preparation comprising cavitate- or clathrate-forming host/guest complexes as contrast agent
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
DE3934656A1 (de) * 1989-10-13 1991-04-18 Schering Ag Verfahren zur herstellung von waessrigen dispersionen
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
DE4004430A1 (de) * 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
US5578292A (en) * 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (is) * 1990-04-02 1993-05-01 Sint Sa
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5556610A (en) * 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5487390A (en) * 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5149329A (en) * 1990-12-12 1992-09-22 Wayne State University Surgical suture carrier and method for urinary bladder neck suspension
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
CA2112905A1 (en) * 1991-07-05 1993-01-21 Michael R. Violante Ultrasmall non-aggregated porous particles entrapping gas-bubbles
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
CA2148372A1 (en) * 1992-11-02 1994-05-11 Margaret A. Wheatley Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
CZ350895A3 (en) * 1993-07-02 1996-10-16 Molecular Biosystems Inc In protein encapsulated micro-spheres containing insoluble gas as well as their preparation and use as ultrasonic diagnostic
EP1550464A1 (en) * 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US5601085A (en) * 1995-10-02 1997-02-11 Nycomed Imaging As Ultrasound imaging

Also Published As

Publication number Publication date
AU636481B2 (en) 1993-04-29
ES2061217T3 (es) 1994-12-01
ATE112173T1 (de) 1994-10-15
US6200548B1 (en) 2001-03-13
KR0142180B1 (ko) 1998-06-01
ES2061217T5 (es) 2001-12-01
IL98143A0 (en) 1992-06-21
EP0458745B2 (en) 2001-09-12
DE69104264T2 (de) 1995-02-16
DK0458745T4 (da) 2001-11-12
NZ238160A (en) 1993-12-23
US6139818A (en) 2000-10-31
HU226007B1 (en) 2008-02-28
AU7614491A (en) 1991-11-21
CN1055414C (zh) 2000-08-16
PL166827B1 (pl) 1995-06-30
CN1056634A (zh) 1991-12-04
US5840275A (en) 1998-11-24
DK0458745T3 (da) 1994-11-21
JP2897190B2 (ja) 1999-05-31
IE66895B1 (en) 1996-02-07
EP0458745A1 (en) 1991-11-27
US6123922A (en) 2000-09-26
US5711933A (en) 1998-01-27
KR910019643A (ko) 1991-12-19
US5863520A (en) 1999-01-26
CA2042722C (en) 1999-08-17
ZA913729B (en) 1992-02-26
RU2110991C1 (ru) 1998-05-20
JPH04226923A (ja) 1992-08-17
HU911646D0 (en) 1991-11-28
IS1862B (is) 2003-04-15
DE69104264D1 (de) 1994-11-03
IL98143A (en) 1995-10-31
CA2042722A1 (en) 1991-11-19
US20040126322A1 (en) 2004-07-01
DE69104264T3 (de) 2002-06-13
EP0458745B1 (en) 1994-09-28
HUT58508A (en) 1992-03-30

Similar Documents

Publication Publication Date Title
IS1862B (is) Fjölliða örblöðrur fylltar með gasi eða lofti, nothæfar sem sviflausnir í fljótandi burðarefnum fyrir ómskoðun
DE69433356D1 (de) An der oberfläche modifizierte, biocompatible membranen
DE69432370D1 (de) Proteinverkapselte, unlösliche, gasenthaltende Mikrokügelchen, deren Herstellung und Anwendung als bildgebende Mittel für Ultraschall
DK0531421T3 (da) Kontrastmedier til ultralydsimagografi
MD940199A (ro) Agenţi contrastanţi şi aplicarea acestora
BR9814393A (pt) Micropartìculas e uso terapêutico ou diagnóstico delas
DE69222764D1 (de) Poröse anorganische ultraschallkontrastmittel
ATE185982T1 (de) Wasserabsorbierende polymere mit verbesserten eigenschaften, verfahren zu deren herstellung und deren verwendung
KR930001896A (ko) 디클로페낙 나트륨 경고제
ATE225375T1 (de) Oberflächenmodifizierte endgruppen für biomedizinische polymere
RU94045927A (ru) Контрастные агенты и их применение
CA2500625A1 (en) Wick-based delivery system with wick made of different composite materials
NO953638L (no) Gass-genererende kontrastmidler
AU1774692A (en) Absorbent mat, especially for organic hydrocarbons
KR950031091A (ko) 염증성 장 질환 치료용 약제학적 조성물
ES2193310T3 (es) Composicion antibacteriana de agua y metodo de fabricacion.
AU3092889A (en) Composition enabling at least two incompatible thermoplastic polymers to be made compatible, its use for the production of thermoplastic alloys and thermoplastic alloys obtained
CA2392080A1 (en) Blood-compatible polymer surfaces
DE59610768D1 (de) Mittel mit retardwirkung
ES2182913T3 (es) Uso de una alcanolamida alcoxilada junto con un tensioactivo ionico en calidad de agente reductor del rozamiento.
KR950008383A (ko) 미생물 부착을 촉진시키는 입자의 제조방법
KR870008941A (ko) 고흡수성수지조성물
TH21069A (th) โครงสร้างดูดซับที่ปรับปรุงลักษณะซึมแทรกของของเหลว
ES2013393A6 (es) Un metodo para aumentar la resistencia a la adsorcion de un polimero que tiene grupos carboxilo o hidroxilo superficiales.