IT1187678B - Procedimento di preparazione di derivati eterociclici - Google Patents

Procedimento di preparazione di derivati eterociclici

Info

Publication number: IT1187678B
Authority: IT; Italy
Prior art keywords: substd; phenyl; carboxylic acid; acid ester; pyridine
Prior art date: 1985-07-05

Application number

IT21460/85A

Other languages

English (en)

Other versions

IT8521460A0 (it

Inventor

Claudio Semeraro

Dino Micheli

Daniele Pieraccioli

Giovanni Gaviraghi

Allan David Borthwick

Original Assignee

Glaxo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-05

Filing date

1985-07-05

Publication date

1987-12-23

1985-07-05 Application filed by Glaxo Spa filed Critical Glaxo Spa

1985-07-05 Publication of IT8521460A0 publication Critical patent/IT8521460A0/it

1985-07-05 Priority to IT21460/85A priority Critical patent/IT1187678B/it

1985-07-29 Priority to NZ212895A priority patent/NZ212895A/xx

1985-08-20 Priority to US06/767,593 priority patent/US4801599A/en

1985-08-20 Priority to GR852016A priority patent/GR852016B/el

1985-08-20 Priority to SE8503888A priority patent/SE459920B/sv

1985-08-20 Priority to ZW131/85A priority patent/ZW13185A1/xx

1985-08-20 Priority to DK378085A priority patent/DK165949C/da

1985-08-20 Priority to NL8502296A priority patent/NL193065C/nl

1985-08-21 Priority to LU86047A priority patent/LU86047A1/fr

1985-08-21 Priority to CY1494A priority patent/CY1494A/en

1985-08-21 Priority to CH3593/85A priority patent/CH666684A5/de

1985-08-21 Priority to ES546324A priority patent/ES8703839A1/es

1985-08-21 Priority to IE205485A priority patent/IE58486B1/en

1985-08-21 Priority to NO853293A priority patent/NO167142C/no

1985-08-21 Priority to LU88267C priority patent/LU88267I2/xx

1985-08-21 Priority to GB08520924A priority patent/GB2164336B/en

1985-08-21 Priority to FI853206A priority patent/FI81568C/fi

1985-08-21 Priority to JP60181934A priority patent/JPS6193162A/ja

1985-08-21 Priority to MX206376A priority patent/MX159974A/es

1985-08-22 Priority to DE3529997A priority patent/DE3529997C2/de

1985-08-22 Priority to BE0/215493A priority patent/BE903103A/fr

1985-08-22 Priority to HU853202A priority patent/HU196754B/hu

1985-08-22 Priority to FR8512631A priority patent/FR2569402B1/fr

1985-08-22 Priority to AU46576/85A priority patent/AU578724B2/en

1985-08-22 Priority to PT81000A priority patent/PT81000B/pt

1985-08-22 Priority to KR1019850006044A priority patent/KR920004482B1/ko

1985-08-22 Priority to AT0245485A priority patent/AT394042B/de

1985-08-22 Priority to PH32680A priority patent/PH22014A/en

1985-08-22 Priority to CA000489261A priority patent/CA1268180A/en

1985-09-23 Priority to CN 85107087 priority patent/CN1017893B/zh

1986-02-14 Priority to ES552050A priority patent/ES8707930A1/es

1986-02-14 Priority to ES552048A priority patent/ES8707931A1/es

1986-02-14 Priority to ES552051A priority patent/ES8707932A1/es

1986-02-14 Priority to ES552049A priority patent/ES8802497A1/es

1987-12-23 Application granted granted Critical

1987-12-23 Publication of IT1187678B publication Critical patent/IT1187678B/it

1988-07-27 Priority to JP63185661A priority patent/JPH0686430B2/ja

1989-01-23 Priority to US07/300,022 priority patent/US5011848A/en

1989-07-06 Priority to SG40889A priority patent/SG40889G/en

1990-07-12 Priority to HK529/90A priority patent/HK52990A/xx

1991-12-16 Priority to SA91120277A priority patent/SA91120277B1/ar

1991-12-23 Priority to SK4030-91A priority patent/SK278327B6/sk

1991-12-23 Priority to CS914030A priority patent/CS403091A3/cs

1993-08-20 Priority to BG098061A priority patent/BG60409B2/bg

1995-10-18 Priority to LV950318A priority patent/LV5729B4/xx

1998-11-27 Priority to NL980037C priority patent/NL980037I2/nl

1999-04-23 Priority to NO1999007C priority patent/NO1999007I1/no

Links

125000000217 alkyl group Chemical group 0.000 abstract 3
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
WLCQAKQGEJMWSR-UHFFFAOYSA-N 4-phenyl-1,4-dihydropyridine-2-carboxylic acid Chemical compound C1(=CC=CC=C1)C1C=C(NC=C1)C(=O)O WLCQAKQGEJMWSR-UHFFFAOYSA-N 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
GKQPCPXONLDCMU-UHFFFAOYSA-N lacidipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C1=CC=CC=C1C=CC(=O)OC(C)(C)C GKQPCPXONLDCMU-UHFFFAOYSA-N 0.000 abstract 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)

IT21460/85A 1984-08-22 1985-07-05 Procedimento di preparazione di derivati eterociclici IT1187678B (it)

Priority Applications (45)

Application Number	Priority Date	Filing Date	Title
IT21460/85A IT1187678B (it)	1985-07-05	1985-07-05	Procedimento di preparazione di derivati eterociclici
NZ212895A NZ212895A (en)	1984-08-22	1985-07-29	1,4-dihydropyridine derivatives and pharmaceutical compositions
US06/767,593 US4801599A (en)	1984-08-22	1985-08-20	1,4-dihydropyridines
GR852016A GR852016B (it)	1984-08-22	1985-08-20
SE8503888A SE459920B (sv)	1984-08-22	1985-08-20	Estrar av 4-(2-(2-karboxietenyl)fenyl)-dihydropyridindikarboxylsyror, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
ZW131/85A ZW13185A1 (en)	1984-08-22	1985-08-20	Heterocyclic derivatives
DK378085A DK165949C (da)	1984-08-22	1985-08-20	1,4-dihydropyridinderivater, fremgangsmaader til fremstilling deraf og farmaceutiske praeparater indeholdende forbindelserne
NL8502296A NL193065C (nl)	1984-08-22	1985-08-20	4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialkyl -3,5-pyridinedicarbonzuur diësterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat.
LU86047A LU86047A1 (fr)	1984-08-22	1985-08-21	Derives heterocycliques
CY1494A CY1494A (en)	1984-08-22	1985-08-21	4-aryl-1,-4-dihydropyridine-3,5-dicaboxylate derivatives
CH3593/85A CH666684A5 (de)	1984-08-22	1985-08-21	Derivate der 1,4-dihydropyridin-3,5-dicarbonsaeureester.
ES546324A ES8703839A1 (es)	1984-08-22	1985-08-21	Un procedimiento para la preparacion de esteres de acidos 1,4-dihidro-3,5-piridin-dicarbaxolicos.
IE205485A IE58486B1 (en)	1984-08-22	1985-08-21	4-Aryl-1, -4-dihydropyridine-3,5-dicarboxylate derivatives
NO853293A NO167142C (no)	1984-08-22	1985-08-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater.
LU88267C LU88267I2 (it)	1984-08-22	1985-08-21
GB08520924A GB2164336B (en)	1984-08-22	1985-08-21	4-aryl-1,4-dihydropyridine-3,5-dicarboxylate derivatives
FI853206A FI81568C (fi)	1984-08-22	1985-08-21	Foerfarande foer framstaellning av terapeutiskt anvaendbara 1,4-dihydropyridinderivat.
JP60181934A JPS6193162A (ja)	1984-08-22	1985-08-21	複素環式誘導体
MX206376A MX159974A (es)	1984-08-22	1985-08-21	Procedimiento para la preparacion de esteres del acido 4-(2-(2-carboxietenil)fenil)-1,4-dihidro-2,6-dialquil-3,5 piridincarboxilico
FR8512631A FR2569402B1 (fr)	1984-08-22	1985-08-22	Derives d'acide 3,5-pyridine-dicarboxylique, procede pour leur preparation et composition pharmaceutique les contenant
BE0/215493A BE903103A (fr)	1984-08-22	1985-08-22	Derives heterocycliques
HU853202A HU196754B (en)	1984-08-22	1985-08-22	Process for production of derivatives of dihydropiridin and medical compositions containing them
DE3529997A DE3529997C2 (de)	1984-08-22	1985-08-22	Substituierte 4-Phenyl-1,4-dihydropyridincarbonsäureester
AU46576/85A AU578724B2 (en)	1984-08-22	1985-08-22	Dihydropyridines and their preparation and pharmaceutical formulation
PT81000A PT81000B (pt)	1984-08-22	1985-08-22	Processo para a preparacao de compostos de fenilpiridina substituidos
KR1019850006044A KR920004482B1 (ko)	1984-08-22	1985-08-22	헤테로사이클릭 유도체의 제조방법
AT0245485A AT394042B (de)	1984-08-22	1985-08-22	Verfahren zur herstellung von neuen dihydropyridincarbonsaeure-derivaten
PH32680A PH22014A (en)	1984-08-22	1985-08-22	Heterocyclic derivatives and pharmaceutical compositions containing the same
CA000489261A CA1268180A (en)	1984-08-22	1985-08-22	Derivatives of 4-phenyl-1,4-dihydropyridine-3, 5-dicarboxylic acid
CN 85107087 CN1017893B (zh)	1985-07-05	1985-09-23	二氢吡啶衍生物的制备方法
ES552048A ES8707931A1 (es)	1984-08-22	1986-02-14	Un procedimiento para la preparacion de esteres del acido 1,4, dihidro-3,5-piridincarboxilico.
ES552049A ES8802497A1 (es)	1984-08-22	1986-02-14	Un procedimiento para la preparacion de esteres del acido 1,4-dihidro -3,5-piridindi-carboxilico.
ES552050A ES8707930A1 (es)	1984-08-22	1986-02-14	Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3, 5, piridincarboxilico.
ES552051A ES8707932A1 (es)	1984-08-22	1986-02-14	Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3,5, piridincarboxilico.
JP63185661A JPH0686430B2 (ja)	1984-08-22	1988-07-27	複素環式誘導体
US07/300,022 US5011848A (en)	1984-08-22	1989-01-23	1.4-dihydro pyridines
SG40889A SG40889G (en)	1984-08-22	1989-07-06	4-aryl-1,4-dihydropyridine-3,5-dicarboxylate derivatives
HK529/90A HK52990A (en)	1984-08-22	1990-07-12	4-aryl-1, -4- dihydropyridine-3, 5- dicaboxylate derivatives
SA91120277A SA91120277B1 (ar)	1984-08-22	1991-12-16	4،1 – ثنائي بايريدينات 1,4 - dihydropyridines
SK4030-91A SK278327B6 (en)	1984-08-22	1991-12-23	4-aryl-1,4-dihydropiridine-3,5-dicarboxylates and pharmaceutical agents containing them
CS914030A CS403091A3 (en)	1984-08-22	1991-12-23	4-aryl-1,4-dihydropyridine-3,5-dicarboxylates,process of their preparation and pharmaceutical comprising them
BG098061A BG60409B2 (bg)	1984-08-22	1993-08-20	4-арил-1,4-дихидропиридин-3,5-дикарбоксилни производни
LV950318A LV5729B4 (lv)	1984-08-22	1995-10-18	1,4 dihidropiridini
NL980037C NL980037I2 (nl)	1984-08-22	1998-11-27	4-(Ortho-gesubstitueerd fenyl)-1,4-dihydro-2,6-dialyl-3,5-pyridinedicarbonzuur diesterderivaten met antihypertensieve werking en farmaceutisch preparaat dat deze bevat.
NO1999007C NO1999007I1 (no)	1984-08-22	1999-04-23	Lacidipin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT21460/85A IT1187678B (it)	1985-07-05	1985-07-05	Procedimento di preparazione di derivati eterociclici

Publications (2)

Publication Number	Publication Date
IT8521460A0 IT8521460A0 (it)	1985-07-05
IT1187678B true IT1187678B (it)	1987-12-23

Family

ID=11182131

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT21460/85A IT1187678B (it)	1984-08-22	1985-07-05	Procedimento di preparazione di derivati eterociclici

Country Status (2)

Country	Link
CN (1)	CN1017893B (it)
IT (1)	IT1187678B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101973930B (zh) *	2010-10-14	2012-11-28	西安交通大学	一种选择性舒张脑血管的二氢吡啶衍生物及其合成方法和用途

1985
- 1985-07-05 IT IT21460/85A patent/IT1187678B/it active
- 1985-09-23 CN CN 85107087 patent/CN1017893B/zh not_active Expired

Also Published As

Publication number	Publication date
CN1017893B (zh)	1992-08-19
IT8521460A0 (it)	1985-07-05
CN85107087A (zh)	1986-12-31

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19970730

Publication	Publication Date	Title
FI101622B1 (fi)	1998-07-31	Menetelmä terapeuttisesti aktiivisten N-(4-piperidyyli)(dihydrobentsofuraani)karboksamidi- tai N-(4-piperidyyli)(dihydro-2H-bentsopyraani)karboksamidijohdannaisten valmistamiseksi ja välituote
DK558185A (da)	1986-06-04	Benzoxazol- og benzothiazolaminderivater
ATE185344T1 (de)	1999-10-15	Piperidinderivate von benzimidazole als antihistaminische und antiallergische mittel
ES2070151T3 (es)	1995-06-01	Agentes cardiotonicos.
DK26289A (da)	1989-07-22	Anvendelse af 1,4-disubstitueret piperidinyl til fremstilling af et farmaceutisk praeparat til behandling af insomnia
NO975094L (no)	1998-05-07	Vinylpyrrolidoncefalosporinderivater
DE59505373D1 (de)	1999-04-22	Verwendung von 5-Acyl-1,4-dihydropyridin zur Bekämpfung der Erkrankungen des ZNS
IL100450A (en)	1997-01-10	Pharmaceutical compositions containing fused dihydropyridines certain such novel compounds and their preparation
DE3864177D1 (de)	1991-09-19	Dihydropyridinamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
MY101864A (en)	1992-01-31	Barbituric acid derivatives
ES2081810T3 (es)	1996-03-16	Derivados de 4-fenil-4-(n-(2-fluorofenil)amido)-piperidina.
DE69201184D1 (de)	1995-02-23	5- Piperazinylalkyl-1,5-Benzothiazepinone verwendbar als Calciumantagonisten.
IT1205685B (it)	1989-03-31	Processo per la preparazione di alfa-(alchilfenil)-4-(idrossi difenilmetil)-1-piperidina butanolo
ITMI910359A1 (it)	1992-08-13	Impiego medicamentoso di derivati diidropiridinici
KR870002135A (ko)	1987-03-30	광학적 활성, 치환된 1,4-디히드로피리딘의 제조방법
PT84084B (en)	1989-01-12	Process for preparing methionine-substituted 1,4-dihydropyridines
RU93054780A (ru)	1996-10-10	Применение лацидипина для лечения артериосклероза
ES8609254A1 (es)	1986-07-16	Un procedimiento para preparar un derivado de piridinodicar-boxilato
PT73274A (en)	1981-07-01	Process for preparing new naphthimidazole and naphthoxazole derivatives and pharmaceutical compositions containing the same
FR2446830A1 (fr)	1980-08-14	Dithienylpiperidines, leur preparation et leurs utilisations therapeutiques
IT1189729B (it)	1988-02-04	Esteri alcossi-e fenossi-alchilici dell'acido 2, 6-dimetil-4-(2-difluorometossifenil)-1,4diipropiridin-3,5-dicarbonico ad attivita' farmaceutica
MY101878A (en)	1992-02-15	1,3,4-thiadiazole