ES2157277T3 - Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica. - Google Patents
Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica.Info
- Publication number
- ES2157277T3 ES2157277T3 ES95113868T ES95113868T ES2157277T3 ES 2157277 T3 ES2157277 T3 ES 2157277T3 ES 95113868 T ES95113868 T ES 95113868T ES 95113868 T ES95113868 T ES 95113868T ES 2157277 T3 ES2157277 T3 ES 2157277T3
- Authority
- ES
- Spain
- Prior art keywords
- peritoneal
- retal
- sulodexide
- low molecular
- glucosaminoglucans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000020832 chronic kidney disease Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- GRYSXUXXBDSYRT-WOUKDFQISA-N (2r,3r,4r,5r)-2-(hydroxymethyl)-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-3-ol Chemical compound C1=NC=2C(NC)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1OC GRYSXUXXBDSYRT-WOUKDFQISA-N 0.000 abstract 2
- 229920000439 Sulodexide Polymers 0.000 abstract 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 abstract 2
- 229960003491 sulodexide Drugs 0.000 abstract 2
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 229940109239 creatinine Drugs 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Zoology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
EL OBJETO DE LA PRESENTE INVENCION ES EL USO DE ALGUNOS GLICOSAMINOGLICANOS COMO SULODEXIDO, HEPARINA DE BAJO PESO MOLECULAR Y SULFATO DE DERMATANO DE BAJO PESO MOLECULAR Y DE LAS MEDICINAS MEDIANTE USO PARENTERAL QUE LOS CONTIENEN EN EL TRATAMIENTO DE PACIENTES QUE SUFREN DE INSUFICIENCIA RENAL CRONICA SOMETIDOS A DIALISIS PERITONEAL. LA EFECTIVIDAD DE ESTE USO SE HA DEMOSTRADO TANTO POR ESTUDIOS FARMACOLOGICOS REALIZADOS EN RATAS NEFRECTOMIZADAS A LAS QUE SE LES HA PRODUCIDO LESION PERITONEAL COMO POR ESTUDIOS CLINICOS LLEVADOS A CABO EN PACIENTES QUE SUFREN DE INSUFICIENCIA RENAL CRONICA SOMETIDOS A CAPD Y TRATADOS MEDIANTE RUTA INTRAPERITONEAL (I.P.) CON VIALES DE 2 ML DE VESSEL DUE CONTENIENDO 50 MG DE SULODEXIDO. SE HA OBSERVADO UN SIGNIFICATIVO AUMENTO DE LOS TRANSPORTES PERITONEALES DE UREA Y DE CREATININA UNIDOS A UNA SIGNIFICATIVA REDUCCION DE PERDIDA DE PROTEINA EN EL EFLUENTE PERITONEAL. NO SE HAN OBSERVADO DURANTE EL ESTUDIO CAMBIOS SIGNIFICATIVOS DE LA CAPACIDAD DE ULTRAFILTRACION Y DE COMPLICACIONES HEMORRAGICOCOAGULANTES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITBO940436A IT1274351B (it) | 1994-10-06 | 1994-10-06 | Uso di alcuni glicosaminoglicani nella dialisi peritoneale. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2157277T3 true ES2157277T3 (es) | 2001-08-16 |
Family
ID=11340040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95113868T Expired - Lifetime ES2157277T3 (es) | 1994-10-06 | 1995-09-04 | Uso de glucosaminoglucanos para la fabricacion de un medicamento para el tratamiento de insuficiencia renal cronica. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5686432A (es) |
| EP (1) | EP0710483B1 (es) |
| AT (1) | ATE202282T1 (es) |
| DE (1) | DE69521388T2 (es) |
| DK (1) | DK0710483T3 (es) |
| ES (1) | ES2157277T3 (es) |
| GR (1) | GR3036158T3 (es) |
| IT (1) | IT1274351B (es) |
| PT (1) | PT710483E (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL127896A0 (en) * | 1998-12-31 | 1999-10-28 | Gail Laster | A novel treatment for preeclampsia and related diseases |
| JP2003504428A (ja) * | 1999-06-30 | 2003-02-04 | ハミルトン シビック ホスピタルズ リサーチ ディベロップメント インコーポレイテッド | クロット関連凝固因子を阻害するヘパリン組成物 |
| ITMI991503A1 (it) * | 1999-07-08 | 2001-01-08 | Bidifarm S R L | Uso di metaboliti oligosaccaridici di proteoglicani come maker in fluidi biologici di diagnosi del biabete e delle complicanze patologiche c |
| US7259152B2 (en) * | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
| AU2001291549A1 (en) * | 2000-09-08 | 2002-03-22 | Hamilton Civic Hospitals Research Development Inc. | Antithrombotic compositions |
| US20030008844A1 (en) * | 2001-05-17 | 2003-01-09 | Keryx Biopharmaceuticals, Inc. | Use of sulodexide for the treatment of inflammatory bowel disease |
| US20030013680A1 (en) * | 2001-06-12 | 2003-01-16 | Keryx | Methods using glycosaminoglycans for the treatment of nephropathy |
| PE20030263A1 (es) * | 2001-07-31 | 2003-04-17 | Novartis Ag | Composicion farmaceutica oftalmica |
| EP1890686B1 (en) | 2005-05-30 | 2017-10-04 | Fresenius Medical Care Deutschland GmbH | Peritoneal dialysis fluid |
| MX2008008213A (es) | 2005-12-22 | 2008-09-03 | Neurochem Int Ltd | Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias. |
| US20070155672A1 (en) * | 2006-01-05 | 2007-07-05 | Markus Voges | Sterilized peritoneal dialysis solutions containing heparin |
| WO2009044765A1 (ja) * | 2007-10-01 | 2009-04-09 | Seikagaku Corporation | 新規な低分子化コンドロイチン硫酸およびその用途 |
| CN101632686A (zh) * | 2008-04-04 | 2010-01-27 | 马斯特里赫特大学 | 糖胺聚糖用于修复糖萼的用途 |
| IT1401253B1 (it) | 2010-04-23 | 2013-07-18 | Uni Degli Studi Carlo Bo Urbino | Uso del sulodexide per la riduzione delle metalloproteinasi di matrice. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1245907B (it) * | 1991-05-17 | 1994-10-25 | Alfa Wassermann Spa | Uso dei glicosaminoglicani nel trattamento della nefropatia diabetica e della neuropatia diabetica. |
| IT1270846B (it) * | 1993-05-10 | 1997-05-13 | Alfa Wassermann Spa | Uso di sulodexide e delle specialita' medicinali che lo contengono nel trattamento della nefropatia diabetica. |
| DE69429576T2 (de) * | 1993-09-30 | 2002-08-22 | Seikagaku Kogyo K.K., Tokio/Tokyo | Dermatansulfatezusammensetzung als antithromotisches mittel |
-
1994
- 1994-10-06 IT ITBO940436A patent/IT1274351B/it active IP Right Grant
-
1995
- 1995-09-04 DK DK95113868T patent/DK0710483T3/da active
- 1995-09-04 AT AT95113868T patent/ATE202282T1/de active
- 1995-09-04 PT PT95113868T patent/PT710483E/pt unknown
- 1995-09-04 EP EP95113868A patent/EP0710483B1/en not_active Expired - Lifetime
- 1995-09-04 ES ES95113868T patent/ES2157277T3/es not_active Expired - Lifetime
- 1995-09-04 DE DE69521388T patent/DE69521388T2/de not_active Expired - Lifetime
- 1995-09-19 US US08/530,597 patent/US5686432A/en not_active Expired - Lifetime
-
2001
- 2001-06-29 GR GR20010401009T patent/GR3036158T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT710483E (pt) | 2001-09-28 |
| ITBO940436A1 (it) | 1996-04-06 |
| ITBO940436A0 (it) | 1994-10-06 |
| EP0710483B1 (en) | 2001-06-20 |
| US5686432A (en) | 1997-11-11 |
| DK0710483T3 (da) | 2001-09-03 |
| ATE202282T1 (de) | 2001-07-15 |
| IT1274351B (it) | 1997-07-17 |
| DE69521388D1 (de) | 2001-07-26 |
| DE69521388T2 (de) | 2001-10-11 |
| EP0710483A1 (en) | 1996-05-08 |
| GR3036158T3 (en) | 2001-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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