ITPD910077A1 - Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. - Google Patents

Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.

Info

Publication number
ITPD910077A1
ITPD910077A1 IT000077A ITPD910077A ITPD910077A1 IT PD910077 A1 ITPD910077 A1 IT PD910077A1 IT 000077 A IT000077 A IT 000077A IT PD910077 A ITPD910077 A IT PD910077A IT PD910077 A1 ITPD910077 A1 IT PD910077A1
Authority
IT
Italy
Prior art keywords
hyaluronic acid
fraction
purification
procedure
ophthalmic use
Prior art date
Application number
IT000077A
Other languages
English (en)
Inventor
Silvana Lorenzi
Aurelio Romeo
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11389548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ITPD910077(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fidia Spa filed Critical Fidia Spa
Priority to ITPD910077A priority Critical patent/IT1247175B/it
Publication of ITPD910077A0 publication Critical patent/ITPD910077A0/it
Priority to HU9204012A priority patent/HU215193B/hu
Priority to SG1996005472A priority patent/SG46515A1/en
Priority to DK92908628T priority patent/DK0535200T3/da
Priority to AU15766/92A priority patent/AU653022B2/en
Priority to SK3771-92A priority patent/SK280191B6/sk
Priority to JP4507997A priority patent/JP2580458B2/ja
Priority to RU92016520A priority patent/RU2128666C1/ru
Priority to PL92297297A priority patent/PL168477B1/pl
Priority to DE69230242T priority patent/DE69230242T2/de
Priority to KR1019920703262A priority patent/KR0178544B1/ko
Priority to CA002084875A priority patent/CA2084875C/en
Priority to BR9205240A priority patent/BR9205240A/pt
Priority to CS923771A priority patent/CZ282248B6/cs
Priority to PCT/EP1992/000861 priority patent/WO1992018543A1/en
Priority to ES92908628T priority patent/ES2092971T3/es
Priority to AT92908628T priority patent/ATE186307T1/de
Priority to IL10161192A priority patent/IL101611A/en
Priority to EP92908628A priority patent/EP0535200B1/en
Publication of ITPD910077A1 publication Critical patent/ITPD910077A1/it
Priority to NO924873A priority patent/NO305520B1/no
Priority to FI925756A priority patent/FI104973B/fi
Priority to UA93002144A priority patent/UA27229C2/uk
Publication of IT1247175B publication Critical patent/IT1247175B/it
Application granted granted Critical
Priority to IL11345395A priority patent/IL113453A0/xx
Priority to US08/439,437 priority patent/US5559104A/en
Priority to GR20000400131T priority patent/GR3032434T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ITPD910077A 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico. IT1247175B (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
ITPD910077A IT1247175B (it) 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
EP92908628A EP0535200B1 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
CA002084875A CA2084875C (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
PCT/EP1992/000861 WO1992018543A1 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
DK92908628T DK0535200T3 (da) 1991-04-19 1992-04-16 Fremgangsmåde til oprensning af hyaluronsyre og fraktion af ren hyaluronsyre til oftalmiskanvendelse
AU15766/92A AU653022B2 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
SK3771-92A SK280191B6 (sk) 1991-04-19 1992-04-16 Frakcia kyseliny hyalurónovej, spôsob výroby frakc
JP4507997A JP2580458B2 (ja) 1991-04-19 1992-04-16 ヒアルロン酸の精製方法および眼科用の純粋なヒアルロン酸の分画
RU92016520A RU2128666C1 (ru) 1991-04-19 1992-04-16 Фракция гиалуроновой кислоты или ее соли, способ очистки этой фракции, способы получения этой фракции, фармацевтический препарат и средства, используемые в офтальмологии
PL92297297A PL168477B1 (pl) 1991-04-19 1992-04-16 Sposób otrzymywania frakcji kwasu hialuronowego, sposób otrzymywania frakcji hialuronianu sodu oraz sposób oczyszczania kwasu hialuronowego lub jego soli PL PL PL PL PL PL
DE69230242T DE69230242T2 (de) 1991-04-19 1992-04-16 Verfahren zur Reinigung von Hyaluronsäure und Fraktion von reiner Hyaluronsäurezur ophthalmischen Verwendung.
KR1019920703262A KR0178544B1 (ko) 1991-04-19 1992-04-16 안과용 순수 히알우론산 분류물 및 그의 정제방법
HU9204012A HU215193B (hu) 1991-04-19 1992-04-16 Eljárás szemészeti célra alkalmazható nagy tisztaságú hialuronsav-frakció és az ezt tartalmazó gyógyszerkészítmények előállítására
BR9205240A BR9205240A (pt) 1991-04-19 1992-04-16 Procedimento para a purificacao de acido hialuronico e fracao de acido hialuronico puro para uso oftalmico
CS923771A CZ282248B6 (cs) 1991-04-19 1992-04-16 Způsob čištění kyseliny hyaluronové a frakce čisté kyseliny hyaluronové pro oftalmologické použití
SG1996005472A SG46515A1 (en) 1991-04-19 1992-04-16 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
ES92908628T ES2092971T3 (es) 1991-04-19 1992-04-16 Procedimiento para la purificacion de acido hialuronico y fraccion de acido hialuronico puro para utilizacion oftalmologica.
AT92908628T ATE186307T1 (de) 1991-04-19 1992-04-16 Verfahren zur reinigung von hyaluronsäure und fraktion von reiner hyaluronsäurezur ophthalmischen verwendung.
IL10161192A IL101611A (en) 1991-04-19 1992-04-16 Process for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
NO924873A NO305520B1 (no) 1991-04-19 1992-12-16 FremgangsmÕte til rensing av hyaluronsyre og fraksjon av ren hyaluronsyre til oftalmologisk anvendelse
FI925756A FI104973B (fi) 1991-04-19 1992-12-18 Menetelmä hyaluronihapon puhdistamiseksi
UA93002144A UA27229C2 (uk) 1991-04-19 1993-06-16 Фракція гіалуронової кислоти або її солі для застосування в офтальмології, спосіб одержання фракції натрієвої солі гіалуронової кислоти та фармацевтичний препарат для використання в офтальмології
IL11345395A IL113453A0 (en) 1991-04-19 1995-04-20 Procedure for the purification of hydraluronic acid and fraction of pure hyaluronic acid for ophthalmic use
US08/439,437 US5559104A (en) 1991-04-19 1995-05-11 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use
GR20000400131T GR3032434T3 (en) 1991-04-19 2000-01-19 Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD910077A IT1247175B (it) 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.

Publications (3)

Publication Number Publication Date
ITPD910077A0 ITPD910077A0 (it) 1991-04-19
ITPD910077A1 true ITPD910077A1 (it) 1992-10-19
IT1247175B IT1247175B (it) 1994-12-12

Family

ID=11389548

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD910077A IT1247175B (it) 1991-04-19 1991-04-19 Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.

Country Status (24)

Country Link
US (1) US5559104A (it)
EP (1) EP0535200B1 (it)
JP (1) JP2580458B2 (it)
KR (1) KR0178544B1 (it)
AT (1) ATE186307T1 (it)
AU (1) AU653022B2 (it)
BR (1) BR9205240A (it)
CA (1) CA2084875C (it)
CZ (1) CZ282248B6 (it)
DE (1) DE69230242T2 (it)
DK (1) DK0535200T3 (it)
ES (1) ES2092971T3 (it)
FI (1) FI104973B (it)
GR (1) GR3032434T3 (it)
HU (1) HU215193B (it)
IL (2) IL101611A (it)
IT (1) IT1247175B (it)
NO (1) NO305520B1 (it)
PL (1) PL168477B1 (it)
RU (1) RU2128666C1 (it)
SG (1) SG46515A1 (it)
SK (1) SK280191B6 (it)
UA (1) UA27229C2 (it)
WO (1) WO1992018543A1 (it)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274984B (it) * 1994-12-09 1997-07-29 Technopharma Sa Soluzioni viscosizzate con ialuronato di sodio per l'uso come fluido maschera nella fotocheratectomia terapeutica mediante laser a accimeri
IT1282219B1 (it) * 1995-12-20 1998-03-16 Fidia Advanced Biopolymers Srl Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
IT1287967B1 (it) 1996-10-17 1998-09-10 Fidia Spa In Amministrazione S Preparazioni farmaceutiche per uso anestetico locale
IT1291452B1 (it) 1997-04-14 1999-01-11 Fidia Advanced Biopolymers Srl Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
JP2002516306A (ja) 1998-05-29 2002-06-04 ボーン ケア インターナショナル インコーポレイテッド ヒドロキシ−２５−エン−ビタミンｄ化合物の製造方法
DK172900B1 (da) 1998-12-18 1999-09-27 Per Julius Nielsen Præparat samt kit til brug ved intraoculære operationer
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
RU2163123C2 (ru) * 1999-05-26 2001-02-20 Уфимский научно-исследовательский институт глазных болезней Глазные капли
RU2148404C1 (ru) * 1999-07-08 2000-05-10 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Фармацевтическая композиция для медикаментозного расширения зрачка в офтальмологии
RU2147876C1 (ru) * 1999-07-08 2000-04-27 Государственное учреждение Межотраслевой научно-технический комплекс "Микрохирургия глаза" Фармацевтическая композиция для обезболивания в офтальмологии
RU2186786C1 (ru) * 2001-03-26 2002-08-10 Воронежская государственная технологическая академия Способ получения гиалуроновой кислоты
KR100836733B1 (ko) * 2002-11-15 2008-06-10 코오롱생명과학 주식회사 히알우론산 나트륨의 회수방법 및 그를 위한 장치
RU2234310C1 (ru) * 2003-01-21 2004-08-20 Гусева Ольга Юрьевна Способ приготовления вискоэластичного протектора эндотелия роговицы
US20040167480A1 (en) * 2003-02-21 2004-08-26 Advanced Medical Optics, Inc. Administration of multiple viscoelastic solutions with a multi-compartment syringe
US20080063677A1 (en) * 2004-03-10 2008-03-13 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
US20040180025A1 (en) * 2003-03-12 2004-09-16 New Life Resources, Llc Therapeutic, nutraceutical and cosmetic applications for eggshell membrane and processed eggshell membrane preparations
US6946551B2 (en) * 2003-03-12 2005-09-20 New Life Resources, Llc Preparation of hyaluronic acid from eggshell membrane
RU2325902C2 (ru) * 2003-10-27 2008-06-10 Федеральное государственное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А.Илизарова Федерального агентства по высокотехнологичной медицинской помощи" (ФГУ "РНЦ "ВТО" им.акад. Г.А. Илизарова Росмедтехнологий") Способ выделения гликозаминогликанов из минерализованной соединительной ткани
US8580315B2 (en) * 2004-03-10 2013-11-12 Esm Technologies, Llc Anti-inflammatory activity of eggshell membrane and processed eggshell membrane preparations
US20050266390A1 (en) * 2004-06-01 2005-12-01 Yuichiro Ueda Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
KR100577075B1 (ko) * 2004-06-16 2006-05-08 주식회사 티앤라이프시스템 칼슘염 및 인산염, 또는 인산칼슘염을 이용한 히아루론산정제방법
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
CN101001649B (zh) * 2004-07-09 2011-08-31 弗罗桑医疗设备公司 包括透明质酸的止血组合物及其制备方法
RU2280041C1 (ru) * 2005-04-21 2006-07-20 Общество с ограниченной ответственностью Научно-производственное предприятие "Тульская индустрия ЛТД" Способ получения водорастворимых солевых комплексов гиалуроновой кислоты (варианты)
DE102005030011A1 (de) * 2005-06-17 2006-12-21 Aesculap Ag & Co. Kg Verfahren zur Herstellung von sterilen Polysaccharidlösungen
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
ITMI20061668A1 (it) * 2006-09-01 2008-03-02 Schiena Michele Giuseppe Di Composizione a base di acido ialuronico e suoi sali per il trattamento di lesioni epiteliali
KR101509139B1 (ko) * 2006-11-23 2015-04-08 주식회사 엘지생명과학 히알루론산의 정제방법
KR100894042B1 (ko) * 2007-04-13 2009-04-20 가톨릭대학교 산학협력단 설파살라진-히알루론산 혼합물의 제조방법 및 이로부터얻어진 혼합물을 포함하는 후발성 백내장 억제용 조성물
US9089592B2 (en) 2007-04-26 2015-07-28 Seikagaku Corporation Method for micro-incision cataract surgery, a method of evaluation of a viscoelastic material, a composition for evaluation of a viscoelastic material and a method for evaluation using the composition
US8759321B2 (en) * 2007-06-13 2014-06-24 Bausch & Lomb Incorporated Ophthalmic composition with hyaluronic acid and polymeric biguanide
RU2501811C2 (ru) * 2007-11-13 2013-12-20 Био-Текнолоджи Дженерал (Изрейел) Лтд. Способ стерилизации посредством фильтрации разбавленных вязкоэластичных биополимеров (варианты)
US9096819B2 (en) 2008-01-31 2015-08-04 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer
US8119112B2 (en) * 2008-01-31 2012-02-21 Bausch & Lomb Incorporated Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid
JP5758797B2 (ja) 2008-04-04 2015-08-05 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法
US20100286010A1 (en) * 2008-09-03 2010-11-11 Erning Xia Ophthalmic Compositions with Hyaluronic Acid
US20100086512A1 (en) 2008-10-02 2010-04-08 Rolf Schaefer Mucomimetic compositions and uses therefore
US20100178317A1 (en) * 2009-01-09 2010-07-15 Burke Susan E Lens Care Solutions with Hyaluronic Acid
CN103442720A (zh) * 2011-03-02 2013-12-11 电气化学工业株式会社 含透明质酸或透明质酸盐的水溶液
CN103547273A (zh) * 2011-03-02 2014-01-29 电气化学工业株式会社 一种向具有树脂制筒部的注射器内注入含透明质酸或透明质酸盐的水溶液而成的预充式注射器
JP5957439B2 (ja) * 2011-03-02 2016-07-27 デンカ株式会社 ヒアルロン酸またはその塩を含む水溶液
CN103442721A (zh) * 2011-03-02 2013-12-11 电气化学工业株式会社 含透明质酸或透明质酸盐的水溶液
JP5957438B2 (ja) * 2011-03-02 2016-07-27 デンカ株式会社 ヒアルロン酸またはその塩を含む水溶液
CA2830933A1 (en) 2011-03-23 2012-09-27 University Of Utah Research Foundation Methods for treating or preventing urological inflammation
RU2477138C1 (ru) * 2011-11-02 2013-03-10 Общество с ограниченной ответственностью Научно-производственное предприятие "Тульская индустрия ЛТД" Способ получения заполняющего материала для пластической хирургии и инструментальной косметологии, заполняющий материал и способ введения заполняющего материала в проблемную зону
ITMI20120664A1 (it) 2012-04-20 2013-10-21 Anika Therapeutics Srl Biomateriali a base di gellano per l'uso come filler in chirurgia
US10723812B2 (en) 2014-02-06 2020-07-28 New York University Method for separating hyaluronan and quantifying its molecular mass distribution in biological samples
IT201600079633A1 (it) * 2016-07-28 2018-01-28 Fidia Farm Spa Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico
WO2018053111A1 (en) 2016-09-15 2018-03-22 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
CN111228653A (zh) 2018-11-13 2020-06-05 格莱科米拉治疗公司 用电离辐射加强癌症治疗的方法
IT201900019724A1 (it) * 2019-10-24 2021-04-24 Bmg Pharma S P A “procedimento in solvente organico per la purificazione dell’acido ialuronico sale sodico”
AU2020395914B2 (en) 2019-12-05 2026-03-26 Cis Biopharma Ag High hyaluronate multi-purpose disinfection solutions for ophthalmic applications
RU2765951C1 (ru) * 2021-05-14 2022-02-07 Общество с ограниченной ответственностью "АВЕО" Способ очистки гиалуроната от эндотоксинов
EP4395796A4 (en) 2021-09-01 2024-12-25 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
EP4457266A4 (en) 2021-12-28 2025-10-22 Shanghai Qisheng Biological Preparation Co Ltd HYALURONIC ACID-COLLAGEN COPOLYMER COMPOSITIONS AND THEIR MEDICAL APPLICATIONS

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT252264B (de) * 1965-03-17 1967-02-10 Etapharm Chem Pharm Lab Ges M Verfahren zur Herstellung eines reinen hochviskosen Hyaluronsäurepräparates
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4766348A (en) * 1983-06-09 1988-08-23 Gte Products Corporation Single-ended metal halogen lamp and fabrication process employing ionization potential selection of additive gases
CH666897A5 (fr) * 1983-10-11 1988-08-31 Fidia Spa Fractions d'acide hyaluronique non inflammatoire, procedes et compositions pharmaceutiques.
US5093487A (en) * 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
NO161573C (no) * 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
JPS6121241A (ja) * 1984-07-10 1986-01-29 オリエンタル建設株式会社 プレストレストコンクリ−ト部材組立式ラ−メン構造体における多スパン梁の構築方法
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
AU600257B2 (en) * 1986-03-21 1990-08-09 International Pharmaceutical Products, Inc. Non-inflammatory hyaluronic acid fraction and process for preparing it
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
JPH0813847B2 (ja) * 1987-08-11 1996-02-14 日本化薬株式会社 ヒアルロン酸の分画法
JPH01210401A (ja) * 1988-02-17 1989-08-24 Mitsubishi Rayon Co Ltd 酸性多糖類の分離法
JPH0723317B2 (ja) * 1988-03-17 1995-03-15 生化学工業株式会社 角膜上皮層障害症治療剤
US4920104A (en) * 1988-05-16 1990-04-24 Medchem Products, Inc. Sodium hyaluronate composition
JP2731545B2 (ja) * 1988-10-12 1998-03-25 電気化学工業株式会社 ヒアルロン酸の精製方法

Also Published As

Publication number Publication date
IL113453A (en) 1995-07-31
HU215193B (hu) 1998-10-28
NO305520B1 (no) 1999-06-14
RU2128666C1 (ru) 1999-04-10
ES2092971T1 (es) 1996-12-16
AU653022B2 (en) 1994-09-15
US5559104A (en) 1996-09-24
WO1992018543A1 (en) 1992-10-29
EP0535200A1 (en) 1993-04-07
DK0535200T3 (da) 2000-05-08
GR3032434T3 (en) 2000-05-31
IL101611A (en) 1996-06-18
JP2580458B2 (ja) 1997-02-12
DE69230242T2 (de) 2000-06-21
FI104973B (fi) 2000-05-15
CA2084875C (en) 1998-01-06
ES2092971T3 (es) 2000-01-01
PL297297A1 (en) 1993-09-06
CZ377192A3 (en) 1993-05-12
JPH05508183A (ja) 1993-11-18
DE69230242D1 (de) 1999-12-09
HU9204012D0 (en) 1993-03-29
KR930700557A (ko) 1993-03-15
ATE186307T1 (de) 1999-11-15
CA2084875A1 (en) 1992-10-20
IT1247175B (it) 1994-12-12
IL113453A0 (en) 1995-07-31
SK280191B6 (sk) 1999-09-10
SG46515A1 (en) 1998-02-20
ITPD910077A0 (it) 1991-04-19
NO924873L (no) 1993-02-19
FI925756L (fi) 1992-12-18
KR0178544B1 (ko) 1999-04-01
FI925756A0 (fi) 1992-12-18
NO924873D0 (no) 1992-12-16
AU1576692A (en) 1992-11-17
SK377192A3 (en) 1995-06-07
CZ282248B6 (cs) 1997-06-11
UA27229C2 (uk) 2000-08-15
BR9205240A (pt) 1993-08-31
HUT63186A (en) 1993-07-28
PL168477B1 (pl) 1996-02-29
EP0535200B1 (en) 1999-11-03

Similar Documents

Publication Publication Date Title
BR9205240A (pt) Procedimento para a purificacao de acido hialuronico e fracao de acido hialuronico puro para uso oftalmico
RU92016520A (ru) Фракция гиалуроновой кислоты или ее соли для применения в офтальмологии, способ получения гиалуроновой кислоты и ее соли, фармацевтический препарат
EP1224935A3 (en) Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
MY131501A (en) Process for the prepration of clavulanic acid
AU1331588A (en) Method for treatment of alcohol abuse
AU617044B2 (en) Herbicidal 1,3,5-triazin-2-ylaminocarbonylamino- sulfonylbenzoic esters, the preparation and use thereof
AU2829395A (en) Method for reducing intraocular pressure in the mammalian eye by administration of calcium chelators
NO840526L (no) Derivater av n-iminopyridiniumbetainer, fremgangsmaate til deres fremstilling og deres anvendelse i medikamenter
EP0331078A3 (en) Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof
AU639746B2 (en) Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses
EP0345028A3 (en) Treatment of glaucoma using phosphodiesterase inhibitor
ES8507123A1 (es) Procedimiento para la preparacion de un derivado de 4-alquil-2-hidroxi-3-metil-2-fenil-morfolina
ITRM920039A0 (it) Uso dell'acido ialuronico lubrificante di protesi oculari.
NO924806L (no) Etanoladdukter av 6-sulfonylsubstituerte 3-hydroksykromaner og deres anvendelse som inhalasjonsmiddel ved sykdommer
AU646844B2 (en) Method for preparing N-protected (2S,3S)-3-ethylaspartic acid dialkyl esters
AU5932394A (en) New compound, leustroducsin H, its preparation and its therapeutic use
AU625096C (en) Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
PT91498A (pt) Processo para preparacao de acidos e esteres quinolonocarboxilicos azabiciclicos em ponte amino-substituidos
MX9605668A (es) Sal de estilbazolio, su preparacion y uso.
HUT52625A (en) Optical means, particularly therapeutic aid, in first of all for correcting deficiencies of eye
RU93049583A (ru) Искусственный хрусталик глаза
RU1805934C (ru) Эксплантат дл склеропластических операций
AU690609B2 (en) Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
DK0456988T3 (da) Anvendelse af naproxen som pulpudvidende middel
AU1263797A (en) Method for reducing intraocular pressure in the mammalian eye by administration of gamma aminobutyric acid (GABA) agonists

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990210