JO2259B1 - Method for the manufacture of diazapine derivatives - Google Patents

Method for the manufacture of diazapine derivatives

Info

Publication number: JO2259B1
Authority: JO; Jordan
Prior art keywords: diazepine derivatives; manufacturing; lower alkyl; imidazo; hydrogen
Prior art date: 1999-05-12

Application number

JO200069A

Other languages

Arabic (ar)

English (en)

Inventor

هوفمان - ايميري فابين

Original Assignee

اف. هوفمان- لاروش أيه جي‏

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-12

Filing date

2000-05-04

Publication date

2004-10-07

2000-05-04 Application filed by اف. هوفمان- لاروش أيه جي‏ filed Critical اف. هوفمان- لاروش أيه جي‏

2004-10-07 Application granted granted Critical

2004-10-07 Publication of JO2259B1 publication Critical patent/JO2259B1/en

Links

125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
IMXWNWBXKWASOM-UHFFFAOYSA-N 3h-imidazo[1,5-a][1,4]diazepine Chemical class N1=CC=CN2CN=CC2=C1 IMXWNWBXKWASOM-UHFFFAOYSA-N 0.000 abstract 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
JCYLWUVDHLVGER-UHFFFAOYSA-N evt-201 Chemical compound O1C(CN(C)C)=NC(C2=C3N(C4=CC=CC(Cl)=C4C(=O)N(C)C3)C=N2)=N1 JCYLWUVDHLVGER-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
230000001003 psychopharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

JO200069A 1999-05-12 2000-05-04 Method for the manufacture of diazapine derivatives JO2259B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99109514		1999-05-12

Publications (1)

Publication Number	Publication Date
JO2259B1 true JO2259B1 (en)	2004-10-07

Family

ID=8238166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JO200069A JO2259B1 (en)	1999-05-12	2000-05-04	Method for the manufacture of diazapine derivatives

Country Status (14)

Country	Link
US (1)	US6281353B1 (da)
EP (1)	EP1202977B1 (da)
JP (1)	JP3590590B2 (da)
KR (1)	KR100469813B1 (da)
CN (1)	CN101426771B (da)
AT (1)	ATE256669T1 (da)
AU (1)	AU4755500A (da)
CA (1)	CA2373506C (da)
DE (1)	DE60007324T2 (da)
DK (1)	DK1202977T3 (da)
ES (1)	ES2209880T3 (da)
JO (1)	JO2259B1 (da)
MX (1)	MXPA01011445A (da)
WO (1)	WO2000069835A2 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
WO2009024325A2 (en) *	2007-08-20	2009-02-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
CN109134471B (zh) *	2017-06-27	2020-05-15	浙江京新药业股份有限公司	一种苯并二氮杂*化合物的固态形式及其制备方法和应用
CN111620834B (zh) *	2019-10-15	2022-05-24	浙江京新药业股份有限公司	一种苯并二氮杂䓬化合物的制备方法和中间体
CN113045574B (zh) *	2019-12-26	2024-06-07	浙江京新药业股份有限公司	二氮杂䓬衍生物的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1184175A (en)	1981-02-27	1985-03-19	Walter Hunkeler	Imidazodiazepines
US4352817A (en) *	1981-02-27	1982-10-05	Hoffmann-La Roche Inc.	Imidazo-diazepines and their use
CA1174673A (en) *	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
CA1185602A (en) *	1981-02-27	1985-04-16	Emilio Kyburz	Imidazodiazepines

2000
- 2000-05-04 JO JO200069A patent/JO2259B1/en active
- 2000-05-05 EP EP00929501A patent/EP1202977B1/en not_active Expired - Lifetime
- 2000-05-05 MX MXPA01011445A patent/MXPA01011445A/es active IP Right Grant
- 2000-05-05 DK DK00929501T patent/DK1202977T3/da active
- 2000-05-05 AT AT00929501T patent/ATE256669T1/de active
- 2000-05-05 DE DE60007324T patent/DE60007324T2/de not_active Expired - Lifetime
- 2000-05-05 ES ES00929501T patent/ES2209880T3/es not_active Expired - Lifetime
- 2000-05-05 CN CN008074224A patent/CN101426771B/zh not_active Expired - Lifetime
- 2000-05-05 KR KR10-2001-7014340A patent/KR100469813B1/ko not_active Expired - Lifetime
- 2000-05-05 CA CA002373506A patent/CA2373506C/en not_active Expired - Lifetime
- 2000-05-05 JP JP2000618252A patent/JP3590590B2/ja not_active Expired - Lifetime
- 2000-05-05 AU AU47555/00A patent/AU4755500A/en not_active Abandoned
- 2000-05-05 WO PCT/EP2000/004033 patent/WO2000069835A2/en not_active Ceased
- 2000-05-08 US US09/566,831 patent/US6281353B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60007324D1 (de)	2004-01-29
DE60007324T2 (de)	2004-10-21
KR20010112485A (ko)	2001-12-20
CA2373506A1 (en)	2000-11-23
ES2209880T3 (es)	2004-07-01
JP3590590B2 (ja)	2004-11-17
CA2373506C (en)	2007-09-11
ATE256669T1 (de)	2004-01-15
WO2000069835A3 (en)	2002-03-07
DK1202977T3 (da)	2004-04-05
KR100469813B1 (ko)	2005-02-02
US6281353B1 (en)	2001-08-28
JP2002544265A (ja)	2002-12-24
EP1202977B1 (en)	2003-12-17
MXPA01011445A (es)	2002-06-04
AU4755500A (en)	2000-12-05
CN101426771A (zh)	2009-05-06
WO2000069835A2 (en)	2000-11-23
CN101426771B (zh)	2011-11-16
EP1202977A2 (en)	2002-05-08

Similar Documents

Publication	Publication Date	Title
CA1185602A (en)	1985-04-16	Imidazodiazepines
ATE421967T1 (de)	2009-02-15	Nichtvernetzende pyrroloä2,1-cüä1, 4übenzodiazepine als potentielle antitumor- agentien und ihre herstellung
CA1067491A (en)	1979-12-04	Diazepine derivatives
MY127939A (en)	2007-01-31	Pharmaceutical agents for the treatment of parkinson's disease, adhd and microadenomas
MA29623B1 (fr)	2008-07-01	Derives de pyrazolo [3, 4-d] azepine comme antagonistes d'histamine h3
DE59203611D1 (de)	1995-10-19	Verfahren zur Herstellung von 3-Amino-9,13b-dihydro-1H-dibenz-[c,f]imidazol[1,5-a]azepin-hydrochlorid.
CA2184802A1 (en)	1997-04-11	Process for manufacture of imidazo benzodiazepine derivatives
JO2259B1 (en)	2004-10-07	Method for the manufacture of diazapine derivatives
CA2372040A1 (en)	2000-11-23	Imidazodiazepine derivative
MX2007004250A (es)	2007-06-12	Derivados de imidazo[1,5-a]triazolo[1,5-d]benzodiazepina para el tratamiento de trastornos cognitivos.
GR1002883B (el)	1998-03-24	Νεα παραγωγα της 2, 3-βενζοδιαζεπινης
MX2007004640A (es)	2007-06-08	Derivados de benzodiazepina sustituidos con halogeno.
BR0213177A (pt)	2004-09-14	Derivados de 5-metóxi-8-aril-[1,2,4]triazolo[1,5-a]piridina
FI71150C (fi)	1986-11-24	Foerfarande foer framstaellning av som neuroleptiska laekemedel anvaendbara 2,4-dihydro-1,2,3-triazolo/4,5-b/ /1,5/bensodiazepinderivat
ATE251162T1 (de)	2003-10-15	Triazolo(4,5-d)pyrimidin-verbindungen
HU9203325D0 (en)	1993-01-28	Benzo-thieno(2,3-b)pyrazine-2,3(1h,4h)-dione derivatives
DE69910574D1 (de)	2003-09-25	Pyrazolo[1,5-a]triazine als crf antagonisten
AP9801410A0 (en)	1998-12-31	Indoline derivatives useful as 5-HT-2C receptor antagonists.
AP1631A (en)	2006-07-12	Polymorphs of N-methyl-N- (3- {3- [2-thienylcarbonyl] -pyrazol- [1,5-?] -pyrimidin-7-yl} phenyl) acetamide and compositions and methods related thereto.
GB2425309A (en)	2006-10-25	C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers
ATE469904T1 (de)	2010-06-15	Pyren-gebundene pyrrolo(2,1-c)(1,4)benzodiazepin- derivate zur verwendung als antikrebsmittel
US3717653A (en)	1973-02-20	Triazolobenzodiazepines and their production
US4001261A (en)	1977-01-04	Process for the production of 1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]-benzodiazepine
Walser et al.	1987	Quinazolines and 1, 4‐benzodiazepines. XCVI. Compounds derived from benzodiazepine‐2‐acetic acid
PT80746A (en)	1985-08-01	Pyrrolo<1,2-b> <1,2,5>triazepines a process and intermediates for their preparation and their use as medicaments