JP2004509122A - 抗菌剤としての、３−（ヘテロアリールアセトアミド）−２−オキソ−アゼチジン−１−スルホン酸誘導体 - Google Patents

抗菌剤としての、３−（ヘテロアリールアセトアミド）−２−オキソ−アゼチジン−１−スルホン酸誘導体 Download PDF

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Publication number
JP2004509122A
JP2004509122A JP2002526866A JP2002526866A JP2004509122A JP 2004509122 A JP2004509122 A JP 2004509122A JP 2002526866 A JP2002526866 A JP 2002526866A JP 2002526866 A JP2002526866 A JP 2002526866A JP 2004509122 A JP2004509122 A JP 2004509122A
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JP
Japan
Prior art keywords
compound
formula
sulfonic acid
hydrogen
pharmaceutically acceptable
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JP2002526866A
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English (en)
Japanese (ja)
Inventor
ロナルド・ジョージ・マイスティッチ
サマレンドラ・ナス・マイチ
シャルル・フィアクピュイ
ジョージ・トーマス
アンディ・ブイ・ナレンダー・レディー
サミー・エム・サラマ
ラジェシュワー・シン
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パンセリックス・リミテッド
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Publication of JP2004509122A publication Critical patent/JP2004509122A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2002526866A 2000-09-14 2001-09-14 抗菌剤としての、３−（ヘテロアリールアセトアミド）−２−オキソ−アゼチジン−１−スルホン酸誘導体 Pending JP2004509122A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23261700P 2000-09-14 2000-09-14
PCT/IB2001/002115 WO2002022613A1 (en) 2000-09-14 2001-09-14 3-(heteroaryl acetamido)-2-oxo-azetidine-1-sulfonic acids derivatives as antibacterial agents

Publications (1)

Publication Number Publication Date
JP2004509122A true JP2004509122A (ja) 2004-03-25

Family

ID=22873854

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002526866A Pending JP2004509122A (ja) 2000-09-14 2001-09-14 抗菌剤としての、３−（ヘテロアリールアセトアミド）−２−オキソ−アゼチジン−１−スルホン酸誘導体

Country Status (22)

Country Link
US (1) US6916803B2 (cs)
EP (1) EP1322648B1 (cs)
JP (1) JP2004509122A (cs)
KR (1) KR100854810B1 (cs)
CN (1) CN1189469C (cs)
AT (1) ATE298750T1 (cs)
AU (2) AU1261402A (cs)
BR (1) BR0113861A (cs)
CA (1) CA2422375C (cs)
CZ (1) CZ304586B6 (cs)
DE (1) DE60111757T2 (cs)
DK (1) DK1322648T3 (cs)
ES (1) ES2244666T3 (cs)
HU (1) HUP0301025A3 (cs)
IL (2) IL154593A0 (cs)
NO (1) NO324946B1 (cs)
NZ (1) NZ524292A (cs)
PL (1) PL218196B1 (cs)
PT (1) PT1322648E (cs)
SK (1) SK2462003A3 (cs)
WO (1) WO2002022613A1 (cs)
ZA (1) ZA200302085B (cs)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010521517A (ja) * 2007-03-23 2010-06-24 バジリア ファルマスーチカ アーゲー 細菌感染症を処置するための組合せ薬
JP2015504907A (ja) * 2012-01-24 2015-02-16 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト アミジン置換β−ラクタム化合物類、それらの調製及び抗菌剤
JP2019521173A (ja) * 2016-07-21 2019-07-25 シャンハイ インスティチュート オブ マテリア メディカ，チャイニーズ アカデミー オブ サイエンシーズ 単環式β−ラクタム−親鉄剤抱合体並びにその製造方法及び使用

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AU2012233003B2 (en) * 2005-12-07 2014-12-18 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
CA2783572C (en) * 2005-12-07 2016-08-09 Basilea Pharmaceutica Ag Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
US20110046101A1 (en) * 2008-03-17 2011-02-24 Dmitrienko Gary I Bate-lactamase inhibitors
RS60310B1 (sr) 2010-08-10 2020-07-31 Rempex Pharmaceuticals Inc Ciklični derivati estra boronske kiseline, postupak za pripremu injihove terapeutske upotrebe
US9012491B2 (en) 2011-08-31 2015-04-21 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN102757405B (zh) * 2012-07-25 2014-04-16 山东理工大学 含噻二唑的香兰素衍生物、其制备方法及其用途
KR20150103269A (ko) 2013-01-04 2015-09-09 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
KR20150103270A (ko) 2013-01-04 2015-09-09 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
SI3140310T1 (sl) 2014-05-05 2020-01-31 Rempex Pharmaceuticals, Inc. Sinteza boronatnih soli in njihova uporaba
EP3139930B1 (en) 2014-05-05 2024-08-14 Melinta Therapeutics, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
WO2015179308A1 (en) 2014-05-19 2015-11-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EA201692301A1 (ru) 2014-07-01 2017-06-30 Ремпекс Фармасьютикалз, Инк. Производные бороновой кислоты и их терапевтическое применение
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
EP3233869B1 (en) 2014-12-19 2019-09-25 Rempex Pharmaceuticals, Inc. Apparatus and continuous flow process for production of boronic acid derivatives
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
AU2017339587A1 (en) 2016-12-21 2019-07-04 Aicuris Gmbh & Co. Kg Combination therapy with amidine substituted ß-lactam compounds and ß-lactamase inhibitors for infections with antibiotic resistant bacterial strains
MX2020003495A (es) 2017-10-11 2020-09-18 Qpex Biopharma Inc Derivados de acido boronico y sintesis de los mismos.
WO2019144969A1 (zh) 2018-01-29 2019-08-01 南京明德新药研发股份有限公司 用于治疗细菌感染的单环β-内酰胺化合物
US12016868B2 (en) 2018-04-20 2024-06-25 Qpex Biopharma, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2020125670A1 (zh) 2018-12-18 2020-06-25 南京明德新药研发有限公司 单环β-内酰胺化合物在制药中的应用
SI25892A (sl) * 2019-09-05 2021-03-31 Gorenje Gospodinjski Aparati, D.O.O. Pralni stroj, ki se polni s sprednje strani, z električnim svetlobnim telesom
CN114423766B (zh) * 2019-09-11 2024-05-17 丹诺医药(苏州）有限公司 用于治疗细菌感染的青霉烷衍生物
EP4046998B1 (en) 2019-11-22 2024-02-28 Suzhou Erye Pharmaceutical Co., Ltd. Sulfonylurea ring substituted monocyclic beta-lactam antibiotics
CN114828850B (zh) 2019-12-19 2024-08-13 深圳嘉科生物科技有限公司 化合物在制药中的应用
BR112022022367A2 (pt) 2020-05-05 2023-01-10 Qpex Biopharma Inc Derivados e síntese de ácido borônico, formas polimórficas e usos terapêuticos dos mesmos
CN113754651B (zh) * 2020-06-02 2023-04-18 中国医学科学院医药生物技术研究所 一种β-内酰胺化合物、其用途及其制备方法
EP4685147A3 (en) 2021-03-31 2026-04-15 Fedora Pharmaceuticals Inc. Lactivicin compounds, their preparation and use as antibacterial agents
JP2024532211A (ja) * 2021-08-20 2024-09-05 ユニバーシティ・オブ・ノートル・ダム・デュ・ラック 単環式β－ラクタムとシデロフォア模倣体との結合体
CN115304594B (zh) 2022-10-12 2023-02-14 苏州二叶制药有限公司 磺酰脲环取代的化合物的盐型及其晶型

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998047895A1 (en) * 1997-04-24 1998-10-29 Naeja Pharmaceutical Inc. 2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT β-LACTAMASE INHIBITORS

Family Cites Families (5)

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US4632985A (en) * 1985-06-03 1986-12-30 E. R. Squibb & Sons, Inc. 3-acylamino-2-oxo-1-azetidinesulfonic acids
GB8810396D0 (en) 1988-05-03 1988-06-08 Glaxo Group Ltd Chemical process
US5112968A (en) * 1989-07-28 1992-05-12 E. R. Squibb & Sons, Inc. Monobactam hydrazide derivatives
US5250691A (en) * 1991-09-09 1993-10-05 E. R. Squibb & Sons, Inc. Heteroaryl derivatives of monocyclic beta-lactam antibiotics
US5994340A (en) * 1997-08-29 1999-11-30 Synphar Laboratories, Inc. Azetidinone derivatives as β-lactamase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998047895A1 (en) * 1997-04-24 1998-10-29 Naeja Pharmaceutical Inc. 2-OXO-1-AZETIDINE SULFONIC ACID DERIVATIVES AS POTENT β-LACTAMASE INHIBITORS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010521517A (ja) * 2007-03-23 2010-06-24 バジリア ファルマスーチカ アーゲー 細菌感染症を処置するための組合せ薬
JP2015504907A (ja) * 2012-01-24 2015-02-16 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト アミジン置換β−ラクタム化合物類、それらの調製及び抗菌剤
JP2019521173A (ja) * 2016-07-21 2019-07-25 シャンハイ インスティチュート オブ マテリア メディカ，チャイニーズ アカデミー オブ サイエンシーズ 単環式β−ラクタム−親鉄剤抱合体並びにその製造方法及び使用

Also Published As

Publication number Publication date
PT1322648E (pt) 2005-11-30
US20040019203A1 (en) 2004-01-29
CN1189469C (zh) 2005-02-16
NO324946B1 (no) 2008-01-07
HUP0301025A2 (hu) 2004-04-28
KR20030039369A (ko) 2003-05-17
IL154593A0 (en) 2003-09-17
EP1322648A1 (en) 2003-07-02
CZ304586B6 (cs) 2014-07-23
KR100854810B1 (ko) 2008-08-27
CA2422375C (en) 2011-03-15
CZ2003606A3 (cs) 2003-08-13
IL154593A (en) 2008-06-05
CN1458932A (zh) 2003-11-26
EP1322648B1 (en) 2005-06-29
WO2002022613A1 (en) 2002-03-21
AU1261402A (en) 2002-03-26
CA2422375A1 (en) 2002-03-21
AU2002212614B2 (en) 2006-12-07
ZA200302085B (en) 2004-03-15
NO20031162D0 (no) 2003-03-13
PL360537A1 (en) 2004-09-06
US6916803B2 (en) 2005-07-12
NZ524292A (en) 2004-09-24
ES2244666T3 (es) 2005-12-16
HUP0301025A3 (en) 2009-03-30
ATE298750T1 (de) 2005-07-15
DE60111757T2 (de) 2006-04-27
NO20031162L (no) 2003-03-13
DK1322648T3 (da) 2005-10-31
BR0113861A (pt) 2004-01-27
SK2462003A3 (en) 2003-09-11
PL218196B1 (pl) 2014-10-31
HK1054377A1 (en) 2003-11-28
DE60111757D1 (de) 2005-08-04

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