JP2014507455A5 - - Google Patents

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Publication number: JP2014507455A5
Authority: JP; Japan
Prior art keywords: alkyl; group; dementia; alkyloxy; cyano
Prior art date: 2012-03-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2013557074A

Other languages

English (en)

Japanese (ja)

Other versions

JP5853035B2 (ja

JP2014507455A (ja

Filing date

2012-03-07

Publication date

2015-04-23

2012-03-07 Application filed filed Critical

2012-03-07 Priority claimed from PCT/EP2012/053863 external-priority patent/WO2012120023A1/en

2014-03-27 Publication of JP2014507455A publication Critical patent/JP2014507455A/ja

2015-04-23 Publication of JP2014507455A5 publication Critical patent/JP2014507455A5/ja

2016-02-09 Application granted granted Critical

2016-02-09 Publication of JP5853035B2 publication Critical patent/JP5853035B2/ja

Status Expired - Fee Related legal-status Critical Current

2032-03-07 Anticipated expiration legal-status Critical

Links

125000000217 alkyl group Chemical group 0.000 claims 13
206010012289 Dementia Diseases 0.000 claims 8
150000001875 compounds Chemical class 0.000 claims 8
229910052739 hydrogen Inorganic materials 0.000 claims 8
239000001257 hydrogen Substances 0.000 claims 8
125000003545 alkoxy group Chemical group 0.000 claims 7
125000005843 halogen group Chemical group 0.000 claims 7
125000001072 heteroaryl group Chemical group 0.000 claims 7
-1 chloro, fluoro, cyano, methyl Chemical group 0.000 claims 6
125000004093 cyano group Chemical group *C#N 0.000 claims 6
125000001424 substituent group Chemical group 0.000 claims 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
150000002431 hydrogen Chemical class 0.000 claims 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
150000003839 salts Chemical class 0.000 claims 4
239000012453 solvate Substances 0.000 claims 4
125000000753 cycloalkyl group Chemical group 0.000 claims 3
239000008194 pharmaceutical composition Substances 0.000 claims 3
125000004076 pyridyl group Chemical group 0.000 claims 3
125000000714 pyrimidinyl group Chemical group 0.000 claims 3
208000024827 Alzheimer disease Diseases 0.000 claims 2
201000010374 Down Syndrome Diseases 0.000 claims 2
208000009829 Lewy Body Disease Diseases 0.000 claims 2
201000002832 Lewy body dementia Diseases 0.000 claims 2
208000018737 Parkinson disease Diseases 0.000 claims 2
206010044688 Trisomy 21 Diseases 0.000 claims 2
230000032683 aging Effects 0.000 claims 2
208000010877 cognitive disease Diseases 0.000 claims 2
239000003937 drug carrier Substances 0.000 claims 2
208000027061 mild cognitive impairment Diseases 0.000 claims 2
125000003373 pyrazinyl group Chemical group 0.000 claims 2
102000013455 Amyloid beta-Peptides Human genes 0.000 claims 1
108010090849 Amyloid beta-Peptides Proteins 0.000 claims 1
208000006011 Stroke Diseases 0.000 claims 1
239000004480 active ingredient Substances 0.000 claims 1
229910052799 carbon Inorganic materials 0.000 claims 1
125000004432 carbon atom Chemical group C* 0.000 claims 1
125000001309 chloro group Chemical group Cl* 0.000 claims 1
125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
208000035475 disorder Diseases 0.000 claims 1
125000001153 fluoro group Chemical group F* 0.000 claims 1
125000002541 furyl group Chemical group 0.000 claims 1
125000002883 imidazolyl group Chemical group 0.000 claims 1
238000000034 method Methods 0.000 claims 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
125000001715 oxadiazolyl group Chemical group 0.000 claims 1
125000002971 oxazolyl group Chemical group 0.000 claims 1
230000002265 prevention Effects 0.000 claims 1
125000003226 pyrazolyl group Chemical group 0.000 claims 1
125000005495 pyridazyl group Chemical group 0.000 claims 1
125000000168 pyrrolyl group Chemical group 0.000 claims 1
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
125000001113 thiadiazolyl group Chemical group 0.000 claims 1
125000000335 thiazolyl group Chemical group 0.000 claims 1
125000001544 thienyl group Chemical group 0.000 claims 1
125000001425 triazolyl group Chemical group 0.000 claims 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1

JP2013557074A 2011-03-09 2012-03-07 β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な３，４−ジヒドロ−ピロロ［１，２−ａ］ピラジン−１−イルアミン誘導体 Expired - Fee Related JP5853035B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP11157418.2		2011-03-09
EP11157418		2011-03-09
PCT/EP2012/053863 WO2012120023A1 (en)	2011-03-09	2012-03-07	3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)

Publications (3)

Publication Number	Publication Date
JP2014507455A JP2014507455A (ja)	2014-03-27
JP2014507455A5 true JP2014507455A5 (2)	2015-04-23
JP5853035B2 JP5853035B2 (ja)	2016-02-09

Family

ID=43833325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2013557074A Expired - Fee Related JP5853035B2 (ja)	2011-03-09	2012-03-07	β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な３，４−ジヒドロ−ピロロ［１，２−ａ］ピラジン−１−イルアミン誘導体

Country Status (20)

Country	Link
US (1)	US9845326B2 (2)
EP (1)	EP2683721B1 (2)
JP (1)	JP5853035B2 (2)
KR (1)	KR102012675B1 (2)
CN (1)	CN103415521B (2)
AU (1)	AU2012224632B2 (2)
BR (1)	BR112013022917A2 (2)
CA (1)	CA2825620C (2)
CL (1)	CL2013002511A1 (2)
CO (1)	CO6751283A2 (2)
EA (1)	EA023824B1 (2)
ES (1)	ES2534973T3 (2)
IL (1)	IL228239A (2)
MX (1)	MX340031B (2)
MY (1)	MY163346A (2)
PH (1)	PH12013501805A1 (2)
SG (1)	SG193342A1 (2)
UA (1)	UA109687C2 (2)
WO (1)	WO2012120023A1 (2)
ZA (1)	ZA201306719B (2)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2416603C9 (ru)	2005-10-25	2012-06-20	Сионоги Энд Ко., Лтд.	Производные аминодигидротиазина
EP2147914B1 (en)	2007-04-24	2014-06-04	Shionogi&Co., Ltd.	Aminodihydrothiazine derivatives substituted with cyclic groups
EP2151435A4 (en)	2007-04-24	2011-09-14	Shionogi & Co	PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
WO2009151098A1 (ja)	2008-06-13	2009-12-17	塩野義製薬株式会社	βセクレターゼ阻害作用を有する含硫黄複素環誘導体
CN102186841A (zh)	2008-10-22	2011-09-14	盐野义制药株式会社	具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物
TWI488852B (zh)	2009-12-11	2015-06-21	Shionogi & Co	衍生物
KR101730937B1 (ko)	2010-06-09	2017-04-27	얀센 파마슈티카 엔.브이.	베타-세크레타아제(ｂａｃｅ) 저해제로 유용한 5,6-디하이드로-2ｈ-[1,4]옥사진-3-일-아민 유도체
JP5766198B2 (ja)	2010-10-29	2015-08-19	塩野義製薬株式会社	縮合アミノジヒドロピリミジン誘導体
JP5816630B2 (ja)	2010-10-29	2015-11-18	塩野義製薬株式会社	ナフチリジン誘導体
SG191097A1 (en)	2010-12-22	2013-08-30	Janssen Pharmaceutica Nv	5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
JP5853033B2 (ja)	2011-03-01	2016-02-09	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎＰｈａｒｍａｃｅｕｔｉｃａＮａａｍｌｏｚｅＶｅｎｎｏｏｔｓｃｈａｐ	β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な６，７−ジヒドロ−ピラゾロ［１，５−ａ］ピラジン−４−イルアミン誘導体
EP2683721B1 (en)	2011-03-09	2015-01-28	Janssen Pharmaceutica N.V.	3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
TW201247635A (en)	2011-04-26	2012-12-01	Shionogi & Co	Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
EP2912035A4 (en)	2012-10-24	2016-06-15	Shionogi & Co	DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY
KR102243134B1 (ko) *	2013-06-12	2021-04-22	얀센 파마슈티카 엔.브이.	베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진 유도체
CA2912156C (en) *	2013-06-12	2021-07-20	Janssen Pharmaceutica Nv	4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace)
WO2014198854A1 (en) *	2013-06-12	2014-12-18	Janssen Pharmaceutica Nv	4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace)
RU2572076C2 (ru) *	2014-03-26	2015-12-27	Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова"	1-арилпирроло[1,2-a]пиразин-3-карбоксамиды с нейропсихотропной активностью
MX2017008083A (es)	2014-12-18	2017-10-31	Janssen Pharmaceutica Nv	Compuestos 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2h-pirrol-5-amina inhibidores de beta-secretasa.
WO2018165520A1 (en)	2017-03-10	2018-09-13	Vps-3, Inc.	Metalloenzyme inhibitor compounds
AU2020321955A1 (en)	2019-07-30	2022-03-17	Eikonizo Therapapeutics, Inc.	HDAC6 inhibitors and uses thereof
IL316201A (en)	2022-04-08	2024-12-01	Eikonizo Therapeutics Inc	Oxadiazole HDAC6 inhibitors and their uses
CN117471007B (zh) *	2023-10-31	2024-08-09	广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院）	一种血浆β-淀粉样蛋白检测方法

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4188389A (en)	1978-11-03	1980-02-12	Ayerst Mckenna & Harrison, Inc.	1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines
TW224974B (2)	1991-07-02	1994-06-11	Hoffmann La Roche
WO1998057641A1 (en)	1997-06-18	1998-12-23	Merck & Co., Inc.	ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS
CA2482991A1 (en)	2002-04-19	2003-10-30	Cellular Genomics, Inc.	Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof
TW200413378A (en)	2002-09-23	2004-08-01	Schering Corp	Novel imidazopyrazines as cyclin dependent kinase inhibitors
CN1747949A (zh)	2002-12-20	2006-03-15	法马西亚公司	无环吡唑化合物
AU2004282201A1 (en)	2003-10-15	2005-04-28	Targacept, Inc.	Azabicycyclic compounds for relieving pain and treating central nervous system disorders
WO2005108358A2 (en)	2004-04-22	2005-11-17	Eli Lilly And Company	Pyrrolidine derivatives useful as bace inhibitors
BRPI0512213A (pt)	2004-06-16	2008-02-19	Wyeth Corp	método para tratamento, prevenção ou melhora de uma doença ou distúrbio; composição farmacêutica; processo para a preparação de um composto; e uso de um composto
TW200624426A (en)	2004-09-21	2006-07-16	Lilly Co Eli	BACE inhibitors
CA2593515A1 (en) *	2005-01-14	2006-07-20	Wyeth	Amino-imidazolones for the inhibition of beta-secretase
CN2781924Y (zh)	2005-01-21	2006-05-24	厦门革新塑胶制品有限公司	折叠床中部支脚
US20070005404A1 (en)	2005-06-09	2007-01-04	Drive Diagnostics Ltd.	System and method for providing driving insurance
RU2008100164A (ru)	2005-06-14	2009-07-20	Шеринг Корпорейшн (US)	Получение и применение соединений в качестве ингибиторов протеаз
WO2007005404A1 (en)	2005-06-30	2007-01-11	Wyeth	AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION
RU2416603C9 (ru)	2005-10-25	2012-06-20	Сионоги Энд Ко., Лтд.	Производные аминодигидротиазина
TW200804290A (en)	2005-11-15	2008-01-16	Astrazeneca Ab	Compounds and uses thereof
US20090099217A1 (en)	2006-04-05	2009-04-16	Astex Therapeutics Ltd.	2-Aminopyrimidin-4-Ones And Their Use For Treating Or Preventing Alpha Beta-Related Pathologies
GB2443654A (en)	2006-05-30	2008-05-14	Matthew Emmerson Allen	System for detecting and testing drivers who show abnormal driving behaviour.
US20080051420A1 (en)	2006-06-14	2008-02-28	Astrazeneca Ab	New Compounds 317
EP2147914B1 (en)	2007-04-24	2014-06-04	Shionogi&Co., Ltd.	Aminodihydrothiazine derivatives substituted with cyclic groups
TW200902499A (en) *	2007-05-15	2009-01-16	Astrazeneca Ab	New compounds
CA2702320A1 (en)	2007-10-30	2009-05-07	Arena Pharmaceuticals, Inc.	Biphenyl derivatives as modulators of the histamine-h3 receptor useful for the treatment of disorders related thereto
US8076358B2 (en)	2008-01-28	2011-12-13	Janssen Pharmaceutica Nv	6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
JP5496915B2 (ja)	2008-02-13	2014-05-21	シージーアイファーマシューティカルズ，インコーポレーテッド	６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法
TWI431004B (zh)	2008-05-02	2014-03-21	Lilly Co Eli	Ｂａｃｅ抑制劑
WO2011002409A1 (en)	2009-07-02	2011-01-06	Astrazeneca Ab	5h-pyrrolo[3,4-£>]pyrazin-7-amine derivatives inhibitors of beta-secretase
AR077277A1 (es)	2009-07-09	2011-08-17	Lilly Co Eli	Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer
UY32799A (es)	2009-07-24	2011-02-28	Novartis Ag	Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos
US8188079B2 (en)	2009-08-19	2012-05-29	Hoffman-La Roche Inc.	3-amino-5-phenyl-5,6-dihydro-2H-[1,4]oxazines
EP2500344A4 (en)	2009-11-13	2013-05-01	Shionogi & Co	AMINOTHIAZIN OR AMINOOXAZINE DERIVATIVES WITH AN AMINO TERMINATION
UA103272C2 (uk)	2009-12-11	2013-09-25	Ф. Хоффманн-Ля Рош Аг	2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2
TWI488852B (zh)	2009-12-11	2015-06-21	Shionogi & Co	衍生物
US20120258961A1 (en)	2009-12-24	2012-10-11	Shionogi & Co., Ltd.	4-amino-1,3-thiazine or oxazine derivative
WO2011080176A1 (en)	2009-12-31	2011-07-07	Novartis Ag	Pyrazine derivatives and their use in the treatment of neurological disorders
EA201291366A1 (ru)	2010-06-09	2013-04-30	Янссен Фармацевтика Нв	Производные 5-амино-3,6-дигидро-1h-пиразин-2-она в качестве ингибиторов бета-секретазы (bace)
KR101730937B1 (ko)	2010-06-09	2017-04-27	얀센 파마슈티카 엔.브이.	베타-세크레타아제(ｂａｃｅ) 저해제로 유용한 5,6-디하이드로-2ｈ-[1,4]옥사진-3-일-아민 유도체
CN102985412A (zh)	2010-06-28	2013-03-20	詹森药业有限公司	可用于治疗阿尔茨海默病及其它形式的痴呆的3-氨基-5,6-二氢-1h-吡嗪-2-酮衍生物
US8609660B2 (en)	2010-09-22	2013-12-17	Janssen Pharmaceutica Nv	4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-ylamine derivatives useful as inhibitors of beta-secretase (BACE)
JP5766198B2 (ja)	2010-10-29	2015-08-19	塩野義製薬株式会社	縮合アミノジヒドロピリミジン誘導体
SG191097A1 (en)	2010-12-22	2013-08-30	Janssen Pharmaceutica Nv	5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
CN103429589A (zh)	2011-01-12	2013-12-04	诺瓦提斯公司	噁嗪衍生物及其在治疗神经障碍中的用途
JP2012147763A (ja)	2011-01-17	2012-08-09	Toshitaka Kobayashi	乾物穿孔具
US9242943B2 (en)	2011-01-18	2016-01-26	Siena Biotech S.P.A.	1,4 oxazines as BACE1 and/or BACE2 inhibitors
JP5853033B2 (ja)	2011-03-01	2016-02-09	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎＰｈａｒｍａｃｅｕｔｉｃａＮａａｍｌｏｚｅＶｅｎｎｏｏｔｓｃｈａｐ	β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な６，７−ジヒドロ−ピラゾロ［１，５−ａ］ピラジン−４−イルアミン誘導体
EP2683721B1 (en) *	2011-03-09	2015-01-28	Janssen Pharmaceutica N.V.	3,4-DIHYDRO-PYRROLO[1,2-a]PYRAZIN-1-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
TW201247635A (en)	2011-04-26	2012-12-01	Shionogi & Co	Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them
CA2851445A1 (en)	2011-10-13	2013-04-18	Novartis Ag	Novel oxazine derivatives and their use in the treatment of disease
UA111749C2 (uk)	2011-12-05	2016-06-10	Янссен Фармацевтика Нв	Похідні 6-дифторметил-5,6-дигідро-2h-[1,4]оксазин-3-аміну
ES2582473T3 (es)	2011-12-06	2016-09-13	Janssen Pharmaceutica, N.V.	Derivados de 5-(3-aminofenil)-5-alquil-5,6-dihidro-2H-[1,4]oxazin-3-amina para el tratamiento de trastornos en que está implicada la beta-secretasa
EP2934539B1 (en)	2012-12-20	2019-03-27	Merck Sharp & Dohme Corp.	C5, c6 oxacyclic-fused iminothiazine dioxide compounds as bace inhibitors
CA2912156C (en)	2013-06-12	2021-07-20	Janssen Pharmaceutica Nv	4-amino-6-phenyl-5,6-dihydroimidazo[1,5-a]pyrazin-3(2h)-one derivatives as inhibitors of beta-secretase (bace)
KR102243134B1 (ko)	2013-06-12	2021-04-22	얀센 파마슈티카 엔.브이.	베타-세크레타제(bace) 저해제로서의 4-아미노-6-페닐-5,6-디하이드로이미다조[1,5-a]피라진 유도체
WO2014198854A1 (en)	2013-06-12	2014-12-18	Janssen Pharmaceutica Nv	4-amino-6-phenyl-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazine derivatives as inhibitors of beta-secretase (bace)
MX2017008083A (es)	2014-12-18	2017-10-31	Janssen Pharmaceutica Nv	Compuestos 2,3,4,5-tetrahidropiridin-6-amina y 3,4-dihidro-2h-pirrol-5-amina inhibidores de beta-secretasa.

2012
- 2012-03-07 EP EP12707319.5A patent/EP2683721B1/en not_active Not-in-force
- 2012-03-07 CN CN201280012485.5A patent/CN103415521B/zh not_active Expired - Fee Related
- 2012-03-07 PH PH1/2013/501805A patent/PH12013501805A1/en unknown
- 2012-03-07 KR KR1020137022396A patent/KR102012675B1/ko not_active Expired - Fee Related
- 2012-03-07 CA CA2825620A patent/CA2825620C/en active Active
- 2012-03-07 WO PCT/EP2012/053863 patent/WO2012120023A1/en not_active Ceased
- 2012-03-07 BR BR112013022917A patent/BR112013022917A2/pt not_active Application Discontinuation
- 2012-03-07 SG SG2013067210A patent/SG193342A1/en unknown
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- 2012-03-07 JP JP2013557074A patent/JP5853035B2/ja not_active Expired - Fee Related
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