JP2017113028A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017113028A5 JP2017113028A5 JP2017040585A JP2017040585A JP2017113028A5 JP 2017113028 A5 JP2017113028 A5 JP 2017113028A5 JP 2017040585 A JP2017040585 A JP 2017040585A JP 2017040585 A JP2017040585 A JP 2017040585A JP 2017113028 A5 JP2017113028 A5 JP 2017113028A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- seq
- antibody
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019098449A JP7450344B2 (ja) | 2014-03-07 | 2019-05-27 | 向上した薬物動態を有する抗c5抗体 |
| JP2024011008A JP2024038502A (ja) | 2014-03-07 | 2024-01-29 | 向上した薬物動態を有する抗c5抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461949932P | 2014-03-07 | 2014-03-07 | |
| US61/949,932 | 2014-03-07 | ||
| JP2016555463A JP6112469B1 (ja) | 2014-03-07 | 2015-03-06 | 向上した薬物動態を有する抗c5抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555463A Division JP6112469B1 (ja) | 2014-03-07 | 2015-03-06 | 向上した薬物動態を有する抗c5抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019098449A Division JP7450344B2 (ja) | 2014-03-07 | 2019-05-27 | 向上した薬物動態を有する抗c5抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017113028A JP2017113028A (ja) | 2017-06-29 |
| JP2017113028A5 true JP2017113028A5 (2) | 2018-03-29 |
| JP6894265B2 JP6894265B2 (ja) | 2021-06-30 |
Family
ID=52684742
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555463A Active JP6112469B1 (ja) | 2014-03-07 | 2015-03-06 | 向上した薬物動態を有する抗c5抗体 |
| JP2017040585A Active JP6894265B2 (ja) | 2014-03-07 | 2017-03-03 | 向上した薬物動態を有する抗c5抗体 |
| JP2019098449A Active JP7450344B2 (ja) | 2014-03-07 | 2019-05-27 | 向上した薬物動態を有する抗c5抗体 |
| JP2020173023A Pending JP2021036870A (ja) | 2014-03-07 | 2020-10-14 | 向上した薬物動態を有する抗c5抗体 |
| JP2024011008A Pending JP2024038502A (ja) | 2014-03-07 | 2024-01-29 | 向上した薬物動態を有する抗c5抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555463A Active JP6112469B1 (ja) | 2014-03-07 | 2015-03-06 | 向上した薬物動態を有する抗c5抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019098449A Active JP7450344B2 (ja) | 2014-03-07 | 2019-05-27 | 向上した薬物動態を有する抗c5抗体 |
| JP2020173023A Pending JP2021036870A (ja) | 2014-03-07 | 2020-10-14 | 向上した薬物動態を有する抗c5抗体 |
| JP2024011008A Pending JP2024038502A (ja) | 2014-03-07 | 2024-01-29 | 向上した薬物動態を有する抗c5抗体 |
Country Status (28)
| Country | Link |
|---|---|
| US (11) | US9079949B1 (2) |
| EP (3) | EP3594235A1 (2) |
| JP (5) | JP6112469B1 (2) |
| KR (4) | KR20230082690A (2) |
| CN (2) | CN113416254B (2) |
| AR (1) | AR099698A1 (2) |
| AU (4) | AU2015226977B2 (2) |
| BR (1) | BR112016020454B1 (2) |
| CA (2) | CA2942165C (2) |
| CY (1) | CY1118018T1 (2) |
| DK (2) | DK2970455T3 (2) |
| EA (2) | EA202090275A3 (2) |
| ES (2) | ES2749978T3 (2) |
| HR (1) | HRP20161146T1 (2) |
| HU (2) | HUE030944T2 (2) |
| IL (4) | IL296502B1 (2) |
| LT (1) | LT2970455T (2) |
| MA (2) | MA38859B1 (2) |
| ME (1) | ME02629B (2) |
| MX (2) | MX368909B (2) |
| NZ (2) | NZ631007A (2) |
| PL (2) | PL2970455T3 (2) |
| PT (2) | PT2970455T (2) |
| RS (1) | RS55386B1 (2) |
| SI (2) | SI2970455T1 (2) |
| SM (1) | SMT201600366B (2) |
| TW (4) | TW202446794A (2) |
| WO (1) | WO2015134894A1 (2) |
Families Citing this family (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2892925T3 (es) | 2006-03-31 | 2022-02-07 | Chugai Pharmaceutical Co Ltd | Métodos para controlar la farmacocinética en sangre de anticuerpos |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
| CN109517059B (zh) | 2011-06-30 | 2023-03-28 | 中外制药株式会社 | 异源二聚化多肽 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| TW201817744A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
| JP6124800B2 (ja) | 2011-11-30 | 2017-05-10 | 中外製薬株式会社 | 免疫複合体を形成する細胞内への運搬体(キャリア)を含む医薬 |
| JP6226752B2 (ja) | 2012-02-09 | 2017-11-08 | 中外製薬株式会社 | 抗体のFc領域改変体 |
| WO2013126006A1 (en) | 2012-02-20 | 2013-08-29 | Swedish Orphan Biovitrum Ab (Publ) | Polypeptides binding to human complement c5 |
| CN103382223B (zh) * | 2012-04-01 | 2015-06-10 | 上海益杰生物技术有限公司 | 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽 |
| TW202237660A (zh) | 2012-08-24 | 2022-10-01 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| MX2017004742A (es) * | 2014-10-20 | 2017-07-20 | Nestec Sa | Métodos para la predicción de niveles de farmacos anti-tnf alfa y formación de autoanticuerpos. |
| US20160168237A1 (en) | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | Method for treating a complement mediated disorder caused by an infectious agent in a patient |
| CN107207607B (zh) * | 2014-12-19 | 2021-05-04 | 中外制药株式会社 | 抗-c5抗体及使用方法 |
| KR101860280B1 (ko) | 2014-12-19 | 2018-05-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| CN107428823B (zh) * | 2015-01-22 | 2021-10-26 | 中外制药株式会社 | 两种以上抗-c5抗体的组合与使用方法 |
| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用 |
| JP6130983B2 (ja) | 2015-02-27 | 2017-05-17 | 中外製薬株式会社 | Il−6関連疾患治療用組成物 |
| US20180072769A1 (en) * | 2015-03-23 | 2018-03-15 | Alexion Pharmaceuticals, Inc. | Virus filtration |
| US20190135903A1 (en) | 2015-03-31 | 2019-05-09 | Alexion Pharmaceuticals, Inc. | Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients |
| US20180311299A1 (en) | 2015-05-01 | 2018-11-01 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| US11207465B2 (en) | 2015-06-04 | 2021-12-28 | West Pharma. Services Il. Ltd. | Cartridge insertion for drug delivery device |
| WO2017044811A1 (en) | 2015-09-11 | 2017-03-16 | Bruce Andrien | Recombinant glycosylated eculizumab and eculizumab variants |
| CA2997745A1 (en) | 2015-09-14 | 2017-03-23 | Children's Hospital Medical Center | Methods and compositions for treatment of gaucher disease via modulation of c5a receptor |
| JP2018530574A (ja) | 2015-10-07 | 2018-10-18 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 患者の加齢黄斑変性を治療する方法 |
| EP3359555B1 (en) | 2015-10-07 | 2023-12-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| US20180311345A1 (en) * | 2015-10-30 | 2018-11-01 | Alexion Pharmaceuticals, Inc. | A method of inhibiting exacerbations of t cell-mediated allograft vasculopathy |
| IL259256B2 (en) * | 2015-12-18 | 2023-02-01 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
| US20200270363A1 (en) | 2015-12-25 | 2020-08-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| EP3402816A1 (en) * | 2016-01-11 | 2018-11-21 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment |
| EP3408291A1 (en) * | 2016-01-25 | 2018-12-05 | Shire Human Genetic Therapies, Inc. | Anti-c5 antibodies with enhanced ph switch |
| PL234632B1 (pl) * | 2016-03-02 | 2020-03-31 | Inst Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk | Przeciwciała oddziałujące z komórkami psich chłoniaków typu B i ich zastosowania |
| MA44780A (fr) | 2016-04-28 | 2019-03-06 | Chugai Pharmaceutical Co Ltd | Préparation contenant un anticorps |
| JP2019517473A (ja) * | 2016-05-27 | 2019-06-24 | アレクシオン ファーマシューティカルズ インコーポレイテッドAlexion Pharmaceuticals, Inc. | 難治性全身型重症筋無力症の処置のための方法 |
| CN109310760A (zh) | 2016-06-07 | 2019-02-05 | 诺华股份有限公司 | 抗c5抗体给药方案 |
| ES2984352T3 (es) | 2016-06-14 | 2024-10-29 | Regeneron Pharma | Anticuerpos anti-C5 y usos de los mismos |
| NZ789212A (en) * | 2016-06-17 | 2026-02-27 | Chugai Pharmaceutical Co Ltd | Anti-c5 antibodies and methods of use |
| KR102591955B1 (ko) | 2016-07-29 | 2023-10-19 | 추가이 세이야쿠 가부시키가이샤 | 증강된 fviii 보인자 기능 대체 활성을 갖는 이중특이성 항체 |
| TWI693940B (zh) | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
| EP3526250A1 (en) | 2016-10-12 | 2019-08-21 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| JP7096240B2 (ja) | 2016-10-19 | 2022-07-05 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 試料中の非結合c5の定量化方法 |
| US20200057046A1 (en) | 2016-10-27 | 2020-02-20 | Alexion Pharmaceuticals, Inc. | Assay for c5b-9 deposition in complement-associated disorders |
| EP3554543A4 (en) * | 2016-12-16 | 2020-09-02 | Samsung Bioepis Co., Ltd. | STABLE Aqueous ANTI-C5 ANTIBODY COMPOSITION |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
| IL307593A (en) * | 2017-01-31 | 2023-12-01 | Chugai Pharmaceutical Co Ltd | A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease |
| US11578137B2 (en) * | 2017-03-06 | 2023-02-14 | The Trustees Of The University Of Pennsylvania | Anti-C5 antibodies and uses thereof |
| CN110461358A (zh) | 2017-03-31 | 2019-11-15 | 公立大学法人奈良县立医科大学 | 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物 |
| ES2999550T3 (en) * | 2017-03-31 | 2025-02-26 | Alexion Pharma Inc | Method for simultaneous quantification of alxn1210 and eculizumab in human serum or urine |
| JP2020516607A (ja) | 2017-04-07 | 2020-06-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドApellis Pharmaceuticals,Inc. | 投与レジメンならびに関連組成物および方法 |
| US20200123238A1 (en) | 2017-04-19 | 2020-04-23 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| US11643473B2 (en) | 2017-04-24 | 2023-05-09 | Alexion Pharmaceuticals, Inc. | Antibody immune cell inhibitor fusion proteins |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| NZ758605A (en) * | 2017-05-30 | 2022-07-29 | Chong Kun Dang Pharmaceutical Corp | A novel anti-c-met antibody and use thereof |
| BR112019028269A2 (pt) * | 2017-07-11 | 2020-07-14 | Alexion Pharmaceuticals, Inc. | polipeptídeos que se ligam ao componente c5 do complemento ou à albumina sérica e suas proteínas de fusão |
| SI3658184T1 (sl) * | 2017-07-27 | 2024-01-31 | Alexion Pharmaceuticals, Inc., | Formulacije z visoko koncentracijo protiteles proti-C5 |
| AR113142A1 (es) | 2017-09-29 | 2020-01-29 | Chugai Pharmaceutical Co Ltd | Moléculas de unión al antígeno multiespecíficas que tienen actividad de sustitución de la función de cofactor del factor viii de coagulación de sangre (fviii), y formulaciones farmacéuticas que contienen dicha molécula como ingrediente activo |
| WO2019070714A1 (en) * | 2017-10-04 | 2019-04-11 | Alexion Pharmaceuticals, Inc. | ASSAY AND ADMINISTRATION OF ANTI-C5 ANTIBODIES FOR THE TREATMENT OF PATIENTS WITH MEMBRANOPROLIFERATIVE GLOMERULONEPHRIPT |
| CA3080187A1 (en) | 2017-10-26 | 2019-05-02 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) and atypical hemolytic uremic syndrome (ahus) |
| AU2018361430B2 (en) | 2017-11-01 | 2025-08-14 | Chugai Seiyaku Kabushiki Kaisha | Antibody variant and isoform with lowered biological activity |
| EP3710589A4 (en) | 2017-11-14 | 2021-11-10 | Chugai Seiyaku Kabushiki Kaisha | ANTI-C1S ANTIBODIES AND METHOD OF USING |
| BR112020010916A2 (pt) * | 2017-12-04 | 2020-11-17 | Ra Pharmaceuticals, Inc | moduladores da atividade do complemento |
| MA51147A (fr) | 2017-12-13 | 2021-03-24 | Regeneron Pharma | Associations d'anticorps anti-c5 et utilisations associées |
| AU2018386304B2 (en) | 2017-12-15 | 2023-12-07 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| JP7402799B2 (ja) | 2017-12-22 | 2023-12-21 | ウェスト ファーマ サービシーズ イスラエル リミテッド | サイズの異なるカートリッジを利用可能な注射器 |
| WO2019143761A1 (en) * | 2018-01-17 | 2019-07-25 | Children's Hospital Medical Center | Compositions and methods for treatment of hunter's syndrome |
| US20190247560A1 (en) | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| US12404320B2 (en) * | 2018-05-31 | 2025-09-02 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) in pediatric patients |
| JP7577542B2 (ja) | 2018-06-04 | 2024-11-05 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 小児患者における非典型溶血性尿毒症症候群(aHUS)の治療のための抗C5抗体の用量および投与 |
| CN112654394B (zh) * | 2018-06-19 | 2025-07-11 | 阿塔盖有限责任公司 | 针对补体成分5的抗体分子和其用途 |
| WO2020006266A1 (en) | 2018-06-28 | 2020-01-02 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-c5 antibodies |
| EP3835321A4 (en) | 2018-08-10 | 2022-11-02 | Chugai Seiyaku Kabushiki Kaisha | ANTI-CD137 ANTIGEN-BINDING MOLECULE AND USE THEREOF |
| WO2020041301A1 (en) | 2018-08-20 | 2020-02-27 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement factor d medical disorders |
| CA3111396A1 (en) * | 2018-09-06 | 2020-03-12 | The Trustees Of The University Of Pennsylvania | Humanized anti-c5 antibodies and uses thereof |
| WO2020051532A2 (en) | 2018-09-06 | 2020-03-12 | Achillion Pharmaceuticals, Inc. | Macrocyclic compounds for the treatment of medical disorders |
| EP3852874A1 (en) | 2018-09-17 | 2021-07-28 | Kyoto University | Administration of an anti-c5 agent for treatment of hepatic injury or failure |
| US20200095307A1 (en) | 2018-09-21 | 2020-03-26 | Alexion Pharmaceuticals, Inc. | Compositions and methods for the treatment of neuromyelitis optica |
| US20200115443A1 (en) * | 2018-10-12 | 2020-04-16 | Trican Biotechnology Co., Ltd | Bi-functional fusion proteins and uses thereof |
| US20210388070A1 (en) * | 2018-10-30 | 2021-12-16 | Alexion Pharmaceuticals, Inc. | Co-administration of a hyaluronidase and anti-c5 antibody for treatment of complement-associated conditions |
| CN112996561A (zh) * | 2018-10-30 | 2021-06-18 | 亚力兄制药公司 | 用于治疗阵发性睡眠性血红蛋白尿症(pnh)的抗c5抗体的皮下剂量和施用 |
| US20220002393A1 (en) | 2018-11-20 | 2022-01-06 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis in pediatric patients |
| CA3127797A1 (en) | 2019-01-25 | 2020-07-30 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus) |
| US11642470B2 (en) * | 2019-02-11 | 2023-05-09 | West Pharma. Services IL, Ltd. | Anti-C5 antibody dispensing injector and method of injection |
| MX2021009789A (es) * | 2019-02-14 | 2021-11-17 | Alexion Pharma Inc | Dosificacion y administracion de anticuerpos anti-c5 para el tratamiento de miastenia gravis generalizada. |
| JP7654564B2 (ja) * | 2019-04-24 | 2025-04-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 二機能性ヒト化抗c5抗体ならびにそのh因子融合タンパク質およびその使用 |
| MX2021013441A (es) | 2019-05-15 | 2021-12-10 | Chugai Pharmaceutical Co Ltd | Molecula de union a antigenos, composicion farmaceutica y metodo. |
| WO2020242849A1 (en) | 2019-05-24 | 2020-12-03 | Alexion Pharmaceuticals, Inc. | Methods of treating vitiligo using an anti-c5 antibody |
| CN113966224A (zh) * | 2019-06-04 | 2022-01-21 | Ra制药公司 | 采用补体抑制剂的炎性疾病治疗 |
| US20220259305A1 (en) | 2019-08-05 | 2022-08-18 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis with eculizumab |
| WO2021067526A1 (en) | 2019-10-02 | 2021-04-08 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
| EP4054634A1 (en) * | 2019-11-08 | 2022-09-14 | Alexion Pharmaceuticals, Inc. | High concentration anti-c5 antibody formulations |
| KR20220110827A (ko) * | 2019-12-09 | 2022-08-09 | 알렉시온 파마슈티칼스, 인코포레이티드 | 시신경척수염 스펙트럼 장애의 치료를 위한 항-c5 항체 |
| JP7734673B2 (ja) | 2019-12-23 | 2025-09-05 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 抗c5抗体を使用して妊娠関連非典型溶血性尿毒症症候群を治療する方法 |
| WO2021168320A1 (en) | 2020-02-20 | 2021-08-26 | Achillion Pharmaceuticals, Inc. | Heteroaryl compounds for treatment of complement factor d mediated disorders |
| JP2023522208A (ja) | 2020-04-16 | 2023-05-29 | アシスタンス ピュブリック-オピト ド パリ | ウイルスによって引き起こされる補体媒介性障害を処置する方法 |
| MX2022013606A (es) | 2020-04-30 | 2023-01-16 | Alnylam Pharmaceuticals Inc | Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas. |
| BR112022022980A2 (pt) | 2020-05-12 | 2022-12-20 | Alexion Pharma Inc | Uso de inibidores de fator d de complemento sozinhos ou em combinação com anticorpos anti-c5 para tratamento de hemoglobinúria paroxística noturna |
| WO2021231720A1 (en) | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Method of using extracellular vesicles to detect complement activation, and uses thereof to assess and/or monitor treatment of a complement-mediated disease |
| CN113754763B (zh) * | 2020-06-05 | 2024-03-08 | 天辰生物医药(苏州)有限公司 | 分离的抗原结合蛋白及其用途 |
| US20230303670A1 (en) * | 2020-06-24 | 2023-09-28 | Alexion Pharmaceuticals, Inc. | Subcutaneous (sc) administration of anti-c5 antibodies for treatment of complement-associated conditions |
| WO2021263056A1 (en) * | 2020-06-25 | 2021-12-30 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of amyotrophic lateral sclerosis |
| JP2023533030A (ja) | 2020-07-09 | 2023-08-01 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 小児患者において発作性夜間血色素尿症(pnh)を治療するための抗c5抗体の投薬量及び投与 |
| IL300115A (en) * | 2020-08-13 | 2023-03-01 | Alexion Pharma Inc | Dosage and Administration of ANTI-C5 Antibodies for Hematopoietic Stem Cell Transplantation Treatment (HSCT-TMA) |
| CN116261569A (zh) | 2020-09-21 | 2023-06-13 | 阿雷克森制药公司 | 用于治疗包括狼疮性肾炎(LN)和/或IgA肾病(IgAN)的C5介导的肾小球肾炎(GN)的抗C5抗体的剂量和施用 |
| WO2022066774A1 (en) | 2020-09-23 | 2022-03-31 | Achillion Pharmaceuticals, Inc. | Pharmaceutical compounds for the treatment of complement mediated disorders |
| CA3196434A1 (en) | 2020-10-23 | 2022-04-28 | Krista K. JOHNSON | Methods of treating patients having complement disorders using anti-c5 antibodies |
| JP2023552456A (ja) * | 2020-12-07 | 2023-12-15 | インベテックス インコーポレイテッド | 治療薬の家畜動物における半減期を増加させるための組成物及びその使用方法 |
| CN114149501B (zh) * | 2020-12-11 | 2023-05-26 | 天士力生物医药股份有限公司 | 抗c5抗体及其应用 |
| CN117042798A (zh) * | 2020-12-25 | 2023-11-10 | 宾夕法尼亚大学理事会 | 人源化抗-c5抗体和因子h融合蛋白及其用途 |
| KR20230134533A (ko) | 2021-01-22 | 2023-09-21 | 알렉시온 파마슈티칼스, 인코포레이티드 | 항-c5 항체를 이용한 보체 매개 혈전성 미세혈관병증의치료 방법 |
| CA3220629A1 (en) | 2021-05-28 | 2022-12-01 | Tobin J. CAMMETT | Methods for detecting cm-tma biomarkers |
| WO2022265915A1 (en) | 2021-06-14 | 2022-12-22 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treating dermatomyositis (dm) |
| JP2024526742A (ja) | 2021-07-14 | 2024-07-19 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 重症筋無力症の治療のための抗c5抗体の投与量及び投与 |
| WO2023023220A1 (en) | 2021-08-20 | 2023-02-23 | Alexion Pharmaceuticals, Inc. | Methods for treating sickle cell disease or beta thalassemia using a complement alternative pathway inhibitor |
| EP4402174A1 (en) | 2021-09-17 | 2024-07-24 | Novartis AG | Methods for prevention of graft rejection in xenotransplantation |
| TW202333749A (zh) | 2021-10-29 | 2023-09-01 | 美商艾拉倫製藥股份有限公司 | 補體因子b(cfb)irna組成物及其使用方法 |
| CA3237246A1 (en) * | 2021-11-01 | 2023-05-04 | Ipc Research, Llc | Administration of c5-binding proteins |
| CN120035450A (zh) | 2022-09-06 | 2025-05-23 | 阿雷克森制药公司 | 造血干细胞移植物相关血栓性微血管病(hsct-tma)患者的诊断和预后生物标志物谱 |
| TW202426048A (zh) | 2022-09-06 | 2024-07-01 | 美商阿雷希昂製藥公司 | 用於治療造血幹細胞移植相關血栓性(hsct-tma)的抗c5抗體的補充劑量和投與 |
| TW202423479A (zh) | 2022-09-28 | 2024-06-16 | 美商阿雷希昂製藥公司 | 用於預防或最小化患有慢性腎病的患者中的心臟手術相關急性腎損傷(csa-aki)和/或隨後的主要不良腎事件(make)的抗c5抗體之劑量及投與 |
| WO2024238421A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of biomarkers for the identification and treatment of complement-mediated disorders |
| WO2024238422A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of a panel of lectins for detection of complement biomarkers in urine extracellular vesicles |
| CN116712390B (zh) * | 2023-08-04 | 2023-11-14 | 上海览屹医药科技有限公司 | 一种高浓度高稳定性的抗体制剂及其制备方法 |
| WO2025045250A1 (en) | 2023-09-03 | 2025-03-06 | Kira Pharmaceuticals (Us) Llc | Anti-human factor d antibody constructs and uses thereof |
| AU2025214388A1 (en) | 2024-02-02 | 2026-03-19 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treating iga nephropathy (igan) |
| WO2025199107A1 (en) | 2024-03-19 | 2025-09-25 | Alexion Pharmaceuticals, Inc. | Risk evaluation and management strategy involving patient follow-ups relating to the use or discontinuation of a complement inhibitor |
| WO2025221479A1 (en) | 2024-04-16 | 2025-10-23 | Alexion Pharmaceuticals, Inc. | Biomarkers for monitoring effective treatment of neuromyelitis optica spectrum disorder (nmosd) with complement component c5 inhibitors |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| WO1987000201A1 (en) | 1985-07-05 | 1987-01-15 | Whitehead Institute For Biomedical Research | Epithelial cells expressing foreign genetic material |
| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| EP0245993B1 (en) * | 1986-04-28 | 1993-05-26 | Cetus Oncology Corporation | Monoclonal antibodies against c5a and des-arg74-c5a, their production and use |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| EP0378576B1 (en) | 1987-09-11 | 1995-01-18 | Whitehead Institute For Biomedical Research | Transduced fibroblasts and uses therefor |
| WO1989005345A1 (en) | 1987-12-11 | 1989-06-15 | Whitehead Institute For Biomedical Research | Genetic modification of endothelial cells |
| JP2917998B2 (ja) | 1988-02-05 | 1999-07-12 | ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ | 修飾された肝細胞およびその用途 |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
| JP3249516B2 (ja) | 1990-10-31 | 2002-01-21 | ソマティクス セラピー コーポレイション | 遺伝子治療のためのレトロウイルスのベクター |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| GB9026191D0 (en) | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
| CA2110799A1 (en) | 1991-06-14 | 1992-12-23 | Arnold H. Horwitz | Microbially-produced antibody fragments and their conjugates |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| BR9306765A (pt) | 1992-07-23 | 1998-12-08 | Minnesota Mining & Mfg | Processo para a preparação de uma partícula abrasiva e artigo abrasivo |
| AU701578B2 (en) | 1992-08-21 | 1999-02-04 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
| WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| IT1265573B1 (it) | 1993-09-17 | 1996-11-22 | Zanussi Grandi Impianti Spa | Forno di cottura di alimenti con porta perfezionata |
| US5308341A (en) | 1993-09-28 | 1994-05-03 | Becton, Dickinson And Company | Method of testing the dose accuracy of a medication delivery device |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| NZ281112A (en) | 1994-03-07 | 1998-04-27 | Inhale Therapeutic Syst | Powdered insulin delivered as an aerosol |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
| US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US6001329A (en) | 1996-05-06 | 1999-12-14 | Uab Research Foundation | Radiolabeled fusion toxins for cancer therapy |
| US6146361A (en) | 1996-09-26 | 2000-11-14 | Becton Dickinson And Company | Medication delivery pen having a 31 gauge needle |
| WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
| GB9626960D0 (en) | 1996-12-27 | 1997-02-12 | Glaxo Group Ltd | Valve for aerosol container |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| WO1998047531A2 (en) | 1997-04-21 | 1998-10-29 | Arch Development Corporation | Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial tcr signal and induce clonal anergy |
| US5954047A (en) | 1997-10-17 | 1999-09-21 | Systemic Pulmonary Development, Ltd. | Methods and apparatus for delivering aerosolized medication |
| ES2292236T3 (es) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | Variantes de anticuerpos y sus fragmentos. |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6302855B1 (en) | 1998-05-20 | 2001-10-16 | Novo Nordisk A/S | Medical apparatus for use by a patient for medical self treatment of diabetes |
| HU230769B1 (hu) | 1999-01-15 | 2018-03-28 | Genentech Inc. | Módosított effektor-funkciójú polipeptid-változatok |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1169053A1 (en) | 1999-04-13 | 2002-01-09 | Inhale Therapeutic Systems, Inc. | Pulmonary administration of dry powder formulations for treating infertility |
| WO2000061178A1 (en) | 1999-04-13 | 2000-10-19 | Inhale Therapeutics Systems, Inc. | Pulmonary administration of dry powder formulations for treating infertility |
| US6192891B1 (en) | 1999-04-26 | 2001-02-27 | Becton Dickinson And Company | Integrated system including medication delivery pen, blood monitoring device, and lancer |
| GB9910975D0 (en) | 1999-05-13 | 1999-07-14 | Univ Strathclyde | Rapid dehydration of proteins |
| US6277099B1 (en) | 1999-08-06 | 2001-08-21 | Becton, Dickinson And Company | Medication delivery pen |
| PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| ATE547080T1 (de) | 2000-08-30 | 2012-03-15 | Univ Johns Hopkins | Vorrichtungen zur intraokularen arzneimittelabgabe |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| BRPI0211953B8 (pt) * | 2001-08-17 | 2021-05-25 | Genentech Inc | anticorpo monoclonal ou fragmento de ligação a antígeno que se liga a c5 e c5a sem a prevenção da formação de c5b, linhagem celular, composição farmacêutica, bem como método in vitro para inibir a atividade de c5a e método de diagnóstico in vitro |
| AU2002333554C1 (en) | 2001-09-12 | 2008-12-11 | Becton, Dickinson And Company | Microneedle-based pen device for drug delivery and method for using same |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| AU2003256266A1 (en) | 2002-06-12 | 2003-12-31 | Genencor International, Inc. | Methods and compositions for milieu-dependent binding of a targeted agent to a target |
| US20050271660A1 (en) | 2002-09-06 | 2005-12-08 | Alexion Pharmaceuticals, Inc. | Nebulization of monoclonal antibodies for treating pulmonary diseases |
| US9415102B2 (en) | 2002-09-06 | 2016-08-16 | Alexion Pharmaceuticals, Inc. | High concentration formulations of anti-C5 antibodies |
| US20040102469A1 (en) | 2002-09-13 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for reducing the mortality rate |
| GB0222023D0 (en) | 2002-09-21 | 2002-10-30 | Aventis Pharma Ltd | Inhaler |
| WO2004029207A2 (en) | 2002-09-27 | 2004-04-08 | Xencor Inc. | Optimized fc variants and methods for their generation |
| FR2849436B1 (fr) | 2002-12-27 | 2007-01-05 | Patrick Frayssinet | Particules et ceramiques de phosphates de calcium pour transfection in vivo et in vitro |
| WO2004073551A2 (en) | 2003-02-18 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Transscleral drug delivery device and related methods |
| AU2004261229A1 (en) | 2003-07-29 | 2005-02-10 | Eisai, Inc. | Antibodies and methods for generating genetically altered antibodies with enhanced effector function |
| GB0324368D0 (en) | 2003-10-17 | 2003-11-19 | Univ Cambridge Tech | Polypeptides including modified constant regions |
| US20050249723A1 (en) | 2003-12-22 | 2005-11-10 | Xencor, Inc. | Fc polypeptides with novel Fc ligand binding sites |
| EP1737890A2 (en) | 2004-03-24 | 2007-01-03 | Xencor, Inc. | Immunoglobulin variants outside the fc region |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| GB0416328D0 (en) | 2004-07-21 | 2004-08-25 | Univ Cardiff | Use of dry powder compositions for pulmonary delivery |
| US20060074225A1 (en) | 2004-09-14 | 2006-04-06 | Xencor, Inc. | Monomeric immunoglobulin Fc domains |
| US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| DK1817340T3 (da) | 2004-11-12 | 2012-08-13 | Xencor Inc | Fc-varianter med ændret binding til fcrn |
| WO2006094234A1 (en) | 2005-03-03 | 2006-09-08 | Xencor, Inc. | Methods for the design of libraries of protein variants |
| CA2602663A1 (en) | 2005-03-31 | 2006-10-05 | Xencor, Inc. | Fc variants with optimized properties |
| WO2007041635A2 (en) | 2005-10-03 | 2007-04-12 | Xencor, Inc. | Fc variants with optimized fc receptor binding properties |
| BRPI0620316A2 (pt) | 2005-12-21 | 2011-11-08 | Wyeth Corp | formulações de proteìnas com viscosidades reduzida e seus usos |
| RS53864B1 (sr) | 2006-03-02 | 2015-08-31 | Alexion Pharmaceuticals, Inc. | Produžavanje preživljavanja alografta inhibiranjem aktivnosti komplementa |
| PL3167888T3 (pl) * | 2006-03-15 | 2024-08-26 | Alexion Pharmaceuticals, Inc. | Leczenie pacjentów z napadową nocną hemoglobinurią za pomocą inhibitora dopełniacza |
| ES2892925T3 (es) | 2006-03-31 | 2022-02-07 | Chugai Pharmaceutical Co Ltd | Métodos para controlar la farmacocinética en sangre de anticuerpos |
| US8037880B2 (en) | 2006-04-07 | 2011-10-18 | The University Of Western Ontario | Dry powder inhaler |
| US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
| AU2007313300A1 (en) | 2006-10-16 | 2008-04-24 | Medimmune, Llc. | Molecules with reduced half-lives, compositions and uses thereof |
| WO2008092117A2 (en) | 2007-01-25 | 2008-07-31 | Xencor, Inc. | Immunoglobulins with modifications in the fcr binding region |
| US20090110679A1 (en) | 2007-07-13 | 2009-04-30 | Luk-Chiu Li | Methods and compositions for pulmonary administration of a TNFa inhibitor |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| RU2529951C2 (ru) | 2007-12-26 | 2014-10-10 | Ксенкор, Инк. | ВАРИАНТЫ Fc С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ C FcRn |
| KR102057826B1 (ko) | 2008-04-11 | 2019-12-20 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복 결합하는 항원 결합 분자 |
| EP3524620A1 (en) | 2008-10-14 | 2019-08-14 | Genentech, Inc. | Immunoglobulin variants and uses thereof |
| LT2894165T (lt) * | 2008-11-10 | 2023-03-10 | Alexion Pharmaceuticals, Inc. | Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui |
| EP2373689A1 (en) * | 2008-12-12 | 2011-10-12 | MedImmune, LLC | Crystals and structure of a human igg fc variant with enhanced fcrn binding |
| NZ597259A (en) * | 2009-06-23 | 2014-04-30 | Alexion Pharma Inc | Bispecific antibodies that bind to complement proteins |
| MX2012005151A (es) * | 2009-11-05 | 2012-08-23 | Federico Ii University Of Naples | Tratamiento de hemoglobinuria nocturna paroxismica, anemias hemoliticas y estados de enfermedad que involucran hemolisis intravascular y extravascular. |
| SG183867A1 (en) * | 2010-03-11 | 2012-10-30 | Rinat Neuroscience Corp | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
| TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| SG185107A1 (en) | 2010-04-30 | 2012-12-28 | Alexion Pharma Inc | Antibodies having reduced immunogenicity in a human |
| EP2824111B1 (en) * | 2010-04-30 | 2017-03-22 | Alexion Pharmaceuticals, Inc. | Anti-C5A Antibodies and Methods for Using the Antibodies |
| TWI812066B (zh) | 2010-11-30 | 2023-08-11 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| WO2012088247A2 (en) * | 2010-12-22 | 2012-06-28 | Medimmune, Llc | Anti-c5/c5a/c5adesr antibodies and fragments |
| EP2698431B1 (en) | 2011-03-30 | 2020-09-09 | Chugai Seiyaku Kabushiki Kaisha | Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| TW201817744A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
| WO2013165690A1 (en) * | 2012-04-30 | 2013-11-07 | Medimmune, Llc | Molecules with reduced effector function and extended half-lives, compositions, and uses thereof |
| NZ631007A (en) | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
| US20190135903A1 (en) | 2015-03-31 | 2019-05-09 | Alexion Pharmaceuticals, Inc. | Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients |
| US20180311299A1 (en) | 2015-05-01 | 2018-11-01 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
| US20180311345A1 (en) | 2015-10-30 | 2018-11-01 | Alexion Pharmaceuticals, Inc. | A method of inhibiting exacerbations of t cell-mediated allograft vasculopathy |
| ES2984352T3 (es) * | 2016-06-14 | 2024-10-29 | Regeneron Pharma | Anticuerpos anti-C5 y usos de los mismos |
| EP3526250A1 (en) | 2016-10-12 | 2019-08-21 | Alexion Pharmaceuticals, Inc. | Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of a kidney transplant |
-
2014
- 2014-09-11 NZ NZ631007A patent/NZ631007A/en unknown
- 2014-09-11 NZ NZ711451A patent/NZ711451A/en unknown
-
2015
- 2015-03-06 ES ES16177656T patent/ES2749978T3/es active Active
- 2015-03-06 LT LTEP15710396.1T patent/LT2970455T/lt unknown
- 2015-03-06 KR KR1020237018254A patent/KR20230082690A/ko active Pending
- 2015-03-06 TW TW113129415A patent/TW202446794A/zh unknown
- 2015-03-06 EP EP19176561.9A patent/EP3594235A1/en active Pending
- 2015-03-06 EA EA202090275A patent/EA202090275A3/ru unknown
- 2015-03-06 TW TW109133882A patent/TWI845769B/zh active
- 2015-03-06 BR BR112016020454-9A patent/BR112016020454B1/pt active IP Right Grant
- 2015-03-06 SI SI201530009A patent/SI2970455T1/sl unknown
- 2015-03-06 SI SI201530940T patent/SI3095795T1/sl unknown
- 2015-03-06 HR HRP20161146TT patent/HRP20161146T1/hr unknown
- 2015-03-06 PT PT157103961T patent/PT2970455T/pt unknown
- 2015-03-06 JP JP2016555463A patent/JP6112469B1/ja active Active
- 2015-03-06 EA EA201691764A patent/EA035025B1/ru unknown
- 2015-03-06 MA MA38859A patent/MA38859B1/fr unknown
- 2015-03-06 CN CN202110517494.0A patent/CN113416254B/zh active Active
- 2015-03-06 DK DK15710396.1T patent/DK2970455T3/en active
- 2015-03-06 WO PCT/US2015/019225 patent/WO2015134894A1/en not_active Ceased
- 2015-03-06 PL PL15710396T patent/PL2970455T3/pl unknown
- 2015-03-06 CA CA2942165A patent/CA2942165C/en active Active
- 2015-03-06 ES ES15710396.1T patent/ES2589230T3/es active Active
- 2015-03-06 IL IL296502A patent/IL296502B1/en unknown
- 2015-03-06 ME MEP-2016-264A patent/ME02629B/me unknown
- 2015-03-06 EP EP16177656.2A patent/EP3095795B1/en active Active
- 2015-03-06 TW TW104107187A patent/TWI667256B/zh active
- 2015-03-06 EP EP15710396.1A patent/EP2970455B1/en active Active
- 2015-03-06 KR KR1020177032026A patent/KR102304136B1/ko active Active
- 2015-03-06 PT PT161776562T patent/PT3095795T/pt unknown
- 2015-03-06 RS RS20160996A patent/RS55386B1/sr unknown
- 2015-03-06 TW TW108122663A patent/TWI708785B/zh active
- 2015-03-06 MX MX2016011628A patent/MX368909B/es active IP Right Grant
- 2015-03-06 MA MA050373A patent/MA50373A/fr unknown
- 2015-03-06 DK DK16177656.2T patent/DK3095795T3/da active
- 2015-03-06 CN CN201580012081.XA patent/CN106459189B/zh active Active
- 2015-03-06 KR KR1020217011897A patent/KR102539636B1/ko active Active
- 2015-03-06 HU HUE15710396A patent/HUE030944T2/en unknown
- 2015-03-06 AR ARP150100697A patent/AR099698A1/es active IP Right Grant
- 2015-03-06 CA CA3166772A patent/CA3166772A1/en active Pending
- 2015-03-06 KR KR1020167027411A patent/KR101796886B1/ko active Active
- 2015-03-06 AU AU2015226977A patent/AU2015226977B2/en active Active
- 2015-03-06 US US14/641,026 patent/US9079949B1/en active Active
- 2015-03-06 HU HUE16177656A patent/HUE046091T2/hu unknown
- 2015-03-06 PL PL16177656T patent/PL3095795T3/pl unknown
- 2015-06-01 US US14/727,313 patent/US9107861B1/en active Active
- 2015-07-01 US US14/789,329 patent/US9206251B2/en active Active
- 2015-10-27 US US14/923,879 patent/US9371377B2/en active Active
-
2016
- 2016-05-20 US US15/160,364 patent/US9663574B2/en active Active
- 2016-08-17 IL IL247331A patent/IL247331B/en active IP Right Grant
- 2016-09-07 MX MX2019012455A patent/MX2019012455A/es unknown
- 2016-09-16 CY CY20161100922T patent/CY1118018T1/el unknown
- 2016-10-12 SM SM201600366T patent/SMT201600366B/it unknown
-
2017
- 2017-03-03 JP JP2017040585A patent/JP6894265B2/ja active Active
- 2017-04-20 US US15/492,622 patent/US9803007B1/en active Active
- 2017-09-19 US US15/708,658 patent/US10227400B2/en active Active
-
2019
- 2019-01-14 US US16/246,842 patent/US10584164B2/en active Active
- 2019-05-27 JP JP2019098449A patent/JP7450344B2/ja active Active
- 2019-09-24 AU AU2019236617A patent/AU2019236617B2/en active Active
-
2020
- 2020-01-23 US US16/750,173 patent/US11434280B2/en active Active
- 2020-03-17 IL IL273337A patent/IL273337B/en unknown
- 2020-10-14 JP JP2020173023A patent/JP2021036870A/ja active Pending
- 2020-11-16 AU AU2020267324A patent/AU2020267324B2/en active Active
-
2021
- 2021-11-15 IL IL288139A patent/IL288139A/en unknown
-
2023
- 2023-07-07 US US18/219,138 patent/US20240141024A1/en active Pending
-
2024
- 2024-01-29 JP JP2024011008A patent/JP2024038502A/ja active Pending
- 2024-07-16 AU AU2024204884A patent/AU2024204884A1/en active Pending
-
2025
- 2025-01-09 US US19/014,615 patent/US20250145698A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017113028A5 (2) | ||
| CN104774266B (zh) | 白介素-13结合蛋白 | |
| CN108367075B (zh) | 4-1bb结合蛋白及其用途 | |
| JP2020500538A5 (2) | ||
| JP2018521638A5 (2) | ||
| JP2021514973A5 (2) | ||
| JP2014526898A5 (2) | ||
| AU2016204274A1 (en) | Antibodies that bind to OX40 and their uses | |
| JP2017536341A5 (2) | ||
| JP2017523786A5 (2) | ||
| JP2016529229A5 (2) | ||
| TW201124427A (en) | IL-1 binding proteins | |
| AU2021221287B2 (en) | Engineered anti-IL-2 antibodies | |
| JP2017534577A5 (2) | ||
| JP2013538057A5 (2) | ||
| JP2011528901A5 (2) | ||
| JP2017530722A5 (2) | ||
| JP2012525829A5 (2) | ||
| JP2016511277A5 (2) | ||
| PE20210554A1 (es) | Anticuerpos anti-cxcr5 y composiciones y usos de los mismos | |
| AR065506A1 (es) | Anticuerpos antagonistas ox40 y su uso en el tratamiento de enfermedades | |
| JP2017500018A5 (2) | ||
| PE20221585A1 (es) | Anticuerpo anti antigeno-4 asociado al linfocito t citotoxico (ctla-4) y uso del mismo | |
| JP2012531922A5 (ja) | Toll様受容体2へのヒト化抗体またはその抗原結合部位 | |
| JP2019509054A5 (2) |