JP2656211B2 - ピラゾロ〔４，３−ｃ〕ピリジン類、その製造方法およびそれを含有するセロトニン再摂取阻害剤 - Google Patents

ピラゾロ〔４，３−ｃ〕ピリジン類、その製造方法およびそれを含有するセロトニン再摂取阻害剤

Info

Publication number
JP2656211B2
JP2656211B2 JP5265158A JP26515893A JP2656211B2 JP 2656211 B2 JP2656211 B2 JP 2656211B2 JP 5265158 A JP5265158 A JP 5265158A JP 26515893 A JP26515893 A JP 26515893A JP 2656211 B2 JP2656211 B2 JP 2656211B2
Authority
JP
Japan
Prior art keywords
compound
formula
hydrogen
pyrazolo
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP5265158A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06192257A (ja
Inventor
グレゴリー・マイクル・シヤツツケ
ケビン・ジエイムズ・カツプルズ
ジヨン・デイツク・トウマー・ザフオース
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEKISUTO MARION RUSERU Inc
Original Assignee
HEKISUTO MARION RUSERU Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HEKISUTO MARION RUSERU Inc filed Critical HEKISUTO MARION RUSERU Inc
Publication of JPH06192257A publication Critical patent/JPH06192257A/ja
Application granted granted Critical
Publication of JP2656211B2 publication Critical patent/JP2656211B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
JP5265158A 1992-10-22 1993-10-22 ピラゾロ〔４，３−ｃ〕ピリジン類、その製造方法およびそれを含有するセロトニン再摂取阻害剤 Expired - Fee Related JP2656211B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US964690 1992-10-22
US07/964,690 US5264576A (en) 1992-10-22 1992-10-22 Pyrazolo[4,3-c]pyridines which are intermediates

Publications (2)

Publication Number Publication Date
JPH06192257A JPH06192257A (ja) 1994-07-12
JP2656211B2 true JP2656211B2 (ja) 1997-09-24

Family

ID=25508857

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5265158A Expired - Fee Related JP2656211B2 (ja) 1992-10-22 1993-10-22 ピラゾロ〔４，３−ｃ〕ピリジン類、その製造方法およびそれを含有するセロトニン再摂取阻害剤

Country Status (18)

Country Link
US (4) US5264576A (2)
EP (1) EP0594001B1 (2)
JP (1) JP2656211B2 (2)
KR (1) KR100295026B1 (2)
CN (1) CN1049658C (2)
AT (1) ATE195522T1 (2)
AU (1) AU671305B2 (2)
CA (1) CA2108941A1 (2)
DE (1) DE69329231T2 (2)
DK (1) DK0594001T3 (2)
ES (1) ES2152237T3 (2)
FI (1) FI103890B1 (2)
GR (1) GR3034819T3 (2)
MX (1) MX9306552A (2)
NO (1) NO300374B1 (2)
NZ (1) NZ250003A (2)
PT (1) PT594001E (2)
TW (1) TW252114B (2)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300498A (en) * 1993-06-04 1994-04-05 Hoechst-Roussel Pharmaceuticals Incorporated 6-piperazinyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acids, esters, amides and related compounds
US5618824A (en) * 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
US5565413A (en) * 1994-12-06 1996-10-15 Zeneca Limited Substituted pyridyl phenyl ketone herbicides
US20050101587A9 (en) * 2000-08-14 2005-05-12 Butler Christopher R. Method for treating allergies using substituted pyrazoles
RU2317988C2 (ru) 2000-08-14 2008-02-27 Орто-Макнейл Фармасьютикал, Инк. Замещенные пиразолы, фармацевтическая композиция на их основе, применение фармацевтической композиции и способ ингибирования активности катепсина s
AU2001281255B2 (en) 2000-08-14 2006-07-20 Ortho-Mcneil Pharmaceutical, Inc. Substituted pyrazoles
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
US20070117785A1 (en) * 2000-08-14 2007-05-24 Butler Christopher R Substituted pyrazoles and methods of treatment with substituted pyrazoles
PT1309592E (pt) * 2000-08-14 2006-07-31 Ortho Mcneil Pharm Inc Pirazoles substituidos
CN1642973A (zh) 2000-09-06 2005-07-20 奥索-麦克尼尔药品公司 治疗变态反应的方法
KR20050004214A (ko) * 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
EP2328895B1 (en) * 2008-09-16 2013-03-27 Proximagen Limited Pyrazolo[4,3-c]pyridine compounds and their use as inhibitors of SSAO
CN102558174B (zh) * 2011-08-23 2014-03-19 天津市斯芬克司药物研发有限公司 一种全新吡唑并[4,3-c]吡啶化合物的发明及其合成方法
CA2871388A1 (en) 2012-06-27 2014-01-03 F. Hoffmann-La Roche Ag 5-azaindazole compounds and methods of use

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994890A (en) * 1974-01-31 1976-11-30 Chugai Seiyaku Kabushiki Kaisha 1-Aminoalkyl, 3-phenyl indazoles
JPS5944314B2 (ja) * 1975-01-15 1984-10-29 中外製薬株式会社 インダゾ−ル誘導体の製法
JPS5936627B2 (ja) * 1975-07-25 1984-09-05 中外製薬株式会社 インダゾ−ル誘導体の製法
DK27383A (da) * 1982-02-17 1983-08-18 Lepetit Spa Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
JPH0615542B2 (ja) * 1986-07-22 1994-03-02 吉富製薬株式会社 ピラゾロピリジン化合物
EP0338087A4 (en) * 1987-10-13 1991-07-24 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyrazole compounds, process for their preparation, and their medicinal use
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
EP0494774A1 (en) * 1991-01-11 1992-07-15 MERCK SHARP & DOHME LTD. Indazole-substituted fivemembered heteroaromatic compounds
GB9216783D0 (en) * 1992-08-07 1992-09-23 Ici Plc Heterocyclic derivatives
US5300478A (en) * 1993-01-28 1994-04-05 Zeneca Limited Substituted fused pyrazolo compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ＣＨＥＭＩＣＡＬ ＡＢＳＴＲＡＣＴＳ 第１０８巻要約番号１１１４４８（１９８８）ＢＵＬＬ．ＣＨＥＭ．ＳＯＣ．ＪＡＰ．，４４〜３！（１９７１）Ｐ．８５８−８５９

Also Published As

Publication number Publication date
EP0594001B1 (en) 2000-08-16
ES2152237T3 (es) 2001-02-01
MX9306552A (es) 1994-06-30
DE69329231T2 (de) 2001-03-29
FI103890B (fi) 1999-10-15
AU4912893A (en) 1994-05-05
US5428169A (en) 1995-06-27
CN1049658C (zh) 2000-02-23
ATE195522T1 (de) 2000-09-15
EP0594001A1 (en) 1994-04-27
KR100295026B1 (ko) 2001-09-17
US5264576A (en) 1993-11-23
NO300374B1 (no) 1997-05-20
TW252114B (2) 1995-07-21
DK0594001T3 (da) 2000-10-30
FI934621A0 (fi) 1993-10-20
GR3034819T3 (en) 2001-02-28
DE69329231D1 (de) 2000-09-21
FI934621L (fi) 1994-04-23
KR940009185A (ko) 1994-05-20
NO933784L (no) 1994-04-25
NZ250003A (en) 1996-03-26
CA2108941A1 (en) 1994-04-23
FI103890B1 (fi) 1999-10-15
US5296491A (en) 1994-03-22
US5380847A (en) 1995-01-10
CN1099033A (zh) 1995-02-22
PT594001E (pt) 2001-01-31
AU671305B2 (en) 1996-08-22
NO933784D0 (no) 1993-10-21
JPH06192257A (ja) 1994-07-12

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