JP2664698B2 - Ｉｌ‐６の製造および用途 - Google Patents

Ｉｌ‐６の製造および用途

Info

Publication number
JP2664698B2
JP2664698B2 JP62504291A JP50429187A JP2664698B2 JP 2664698 B2 JP2664698 B2 JP 2664698B2 JP 62504291 A JP62504291 A JP 62504291A JP 50429187 A JP50429187 A JP 50429187A JP 2664698 B2 JP2664698 B2 JP 2664698B2
Authority
JP
Japan
Prior art keywords
sequence
protein
pharmaceutical composition
cells
culture medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP62504291A
Other languages
English (en)
Japanese (ja)
Other versions
JPH01503354A (ja
Inventor
クラーク、スティーブン・シー
ウォン、ゴードン・ジー
シェンデル、ポール
マッコイ、ジョン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2664698(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of JPH01503354A publication Critical patent/JPH01503354A/ja
Application granted granted Critical
Publication of JP2664698B2 publication Critical patent/JP2664698B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
JP62504291A 1986-07-08 1987-07-07 Ｉｌ‐６の製造および用途 Expired - Fee Related JP2664698B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88320786A 1986-07-08 1986-07-08
US883,207 1986-07-08
US88590586A 1986-07-15 1986-07-15
US885,905 1986-07-15
US4795787A 1987-05-08 1987-05-08
US047,957 1987-05-08

Publications (2)

Publication Number Publication Date
JPH01503354A JPH01503354A (ja) 1989-11-16
JP2664698B2 true JP2664698B2 (ja) 1997-10-15

Family

ID=27367237

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62504291A Expired - Fee Related JP2664698B2 (ja) 1986-07-08 1987-07-07 Ｉｌ‐６の製造および用途

Country Status (18)

Country Link
EP (2) EP0316319B1 (pl)
JP (1) JP2664698B2 (pl)
KR (1) KR960013601B1 (pl)
AT (2) ATE124959T1 (pl)
AU (1) AU615630B2 (pl)
CA (1) CA1341355C (pl)
DE (2) DE3751406T2 (pl)
DK (1) DK173279B1 (pl)
ES (1) ES2006776A6 (pl)
GR (1) GR871027B (pl)
IE (1) IE67035B1 (pl)
IL (1) IL83137A (pl)
MY (1) MY102865A (pl)
NO (1) NO176665C (pl)
PL (1) PL159182B1 (pl)
PT (1) PT85285B (pl)
SK (1) SK279144B6 (pl)
WO (1) WO1988000206A1 (pl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
EP0220574B2 (en) * 1985-10-14 2000-04-12 Yeda Research And Development Company Limited Human interferon beta2A, vectors containing genes coding for said interferon, cell lines producing same
JP2648860B2 (ja) * 1986-05-08 1997-09-03 イエダ リサーチ アンド デベロップメント コンパニー リミテッド ヒトインターフエロン−β２Ａ及びヒトインターフエロン−β２Ｂ、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途
JP2676336B2 (ja) * 1986-08-06 1997-11-12 忠三 岸本 ヒトｂ細胞分化因子の遺伝子
EP0585957A1 (en) * 1986-08-06 1994-03-09 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor
JPS6356291A (ja) * 1986-08-27 1988-03-10 Chuzo Kishimoto リコンビナントｂｃｄｆ
NZ226799A (en) * 1987-11-06 1991-08-27 Oncogen Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
CA1341588C (en) * 1988-01-26 2009-01-06 Michel Revel Human ifn-beta2/i1-6, its purification and use
IL85204A0 (en) * 1988-01-26 1988-07-31 Yeda Res & Dev Recombinant human interferon beta2,its preparation and pharmaceutical compositions comprising it
HUT52962A (en) * 1988-03-04 1990-09-28 Sandoz Ag Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
JPH022353A (ja) * 1988-03-10 1990-01-08 Tosoh Corp ヒトｂ細胞分化因子の製造法
JPH022354A (ja) * 1988-03-31 1990-01-08 Tosoh Corp ヒトｂ細胞分化因子の製造法
GB2217327B (en) * 1988-04-12 1992-01-29 British Bio Technology Synthetic interleukin-6 gene
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
US5646015A (en) * 1988-08-31 1997-07-08 Astra Ab Excretion of heterologous proteins from E. coli
US5271931A (en) * 1988-09-14 1993-12-21 The Scripps Research Institute Methods for increasing C1 inhibitor concentrations using interferon-gamma and/or interleukin-6
JPH0372429A (ja) * 1988-10-07 1991-03-27 Chugai Pharmaceut Co Ltd 血小板減少症の治療剤
US5811523A (en) 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
JP2805224B2 (ja) * 1989-01-13 1998-09-30 味の素株式会社 血小板減少症治療剤
JPH0331215A (ja) * 1989-06-27 1991-02-12 Ajinomoto Co Inc 制癌療法支持剤
DE3939706C1 (pl) * 1989-12-01 1991-03-21 Centre Regional De Transfusion Sanguine, Besancon, Fr
JPH04218000A (ja) * 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
DK0547223T3 (da) * 1990-08-31 1997-02-10 Santen Pharmaceutical Co Ltd Middel mod hornhindelidelser
AU1554592A (en) * 1991-04-18 1992-11-17 Toray Industries, Inc. Interleukin 6 composition and production thereof
US5641868A (en) * 1991-04-18 1997-06-24 Toray Industries, Inc. Interlekin-6 compositions, and a production process thereof
ZA924674B (en) * 1991-07-02 1993-04-28 Imclone Systems Inc Cysteine depleted il-6 mutein
US5338833A (en) * 1992-07-23 1994-08-16 The University Of North Carolina At Chapel Hill Carboxy terminal IL-6 muteins
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
WO1994028919A1 (fr) * 1993-06-08 1994-12-22 Ajinomoto Co., Inc. Accelerateur de la proliferation des cellules hematopietiques
US5599536A (en) * 1993-12-13 1997-02-04 Sandoz Ltd. Method for suppressing the acute phase response in a patient receiving IL-6 therapy
US5578301A (en) * 1993-12-14 1996-11-26 Sandoz Ltd. Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy
US5641657A (en) * 1994-05-19 1997-06-24 Human Genome Sciences, Inc. DNA encoding an interleukin-6 splice variant
EP0721780A3 (en) * 1994-12-16 1997-12-17 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Agent for promoting platelet and/or leukocyte production
EP0912742A1 (en) * 1996-07-19 1999-05-06 Dade Behring Marburg GmbH Viral interleukin-6
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
US7479540B1 (en) 2003-12-22 2009-01-20 Chandan Prasad Adipomodulin and related molecules and methods
JP2008532490A (ja) * 2005-02-15 2008-08-21 アポロ ライフ サイエンシズ リミテッド 分子およびそのキメラ分子
ES2302402B1 (es) * 2005-06-16 2009-05-08 Proyecto De Biomedicina Cima, S.L. Uso de una citoquina de la familia de interleuquina-6 en la preparacion de una composicion para administracion combinada con interferon-alfa.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4675285A (en) * 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
EP0220574B2 (en) * 1985-10-14 2000-04-12 Yeda Research And Development Company Limited Human interferon beta2A, vectors containing genes coding for said interferon, cell lines producing same
EP0585957A1 (en) * 1986-08-06 1994-03-09 Ajinomoto Co., Inc. Recombinant B-cell differentiation factor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PROC.NATL.ACAD.SCI.U.S.A=1980 *

Also Published As

Publication number Publication date
NO176665B (no) 1995-01-30
NO880929D0 (no) 1988-03-02
DK173279B1 (da) 2000-06-05
DE3751922D1 (de) 1996-11-14
ATE143811T1 (de) 1996-10-15
DE3751406D1 (de) 1995-08-17
NO176665C (no) 1995-05-10
EP0316319A1 (en) 1989-05-24
DK121788A (da) 1988-03-07
NO880929L (no) 1988-03-02
DE3751406T2 (de) 1995-12-21
ES2006776A6 (es) 1989-05-16
KR880701736A (ko) 1988-11-04
EP0574955A1 (en) 1993-12-22
CA1341355C (en) 2002-04-09
MY102865A (en) 1993-03-31
PT85285B (pt) 1990-03-30
IE67035B1 (en) 1996-02-21
PL266680A1 (en) 1988-07-07
PL159182B1 (pl) 1992-11-30
PT85285A (en) 1987-08-01
WO1988000206A1 (en) 1988-01-14
EP0316319B1 (en) 1995-07-12
SK515087A3 (en) 1998-07-08
AU615630B2 (en) 1991-10-10
KR960013601B1 (ko) 1996-10-09
ATE124959T1 (de) 1995-07-15
AU7696287A (en) 1988-01-29
GR871027B (en) 1987-11-02
DK121788D0 (da) 1988-03-07
IL83137A (en) 1995-05-26
EP0574955B1 (en) 1996-10-09
JPH01503354A (ja) 1989-11-16
SK279144B6 (sk) 1998-07-08
IE871726L (en) 1988-01-08
DE3751922T2 (de) 1997-04-03
EP0316319A4 (en) 1989-08-09

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