JPS5583761A - Novel 3-phenyl-4-quinazolone derivative - Google Patents
Novel 3-phenyl-4-quinazolone derivativeInfo
- Publication number
- JPS5583761A JPS5583761A JP15576478A JP15576478A JPS5583761A JP S5583761 A JPS5583761 A JP S5583761A JP 15576478 A JP15576478 A JP 15576478A JP 15576478 A JP15576478 A JP 15576478A JP S5583761 A JPS5583761 A JP S5583761A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- compound
- activity
- quinazolone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WAIHFZPSLVDBRV-UHFFFAOYSA-N 3-phenylquinazolin-4-one Chemical class C1=NC2=CC=CC=C2C(=O)N1C1=CC=CC=C1 WAIHFZPSLVDBRV-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 230000000694 effects Effects 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 230000000302 ischemic effect Effects 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000000479 anti-thromboxane effect Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- IXWUXVSEQHFPMI-UHFFFAOYSA-N ethyl 5,7-dimethyl-4-oxo-3-phenylquinazoline-6-carboxylate Chemical compound O=C1C2=C(C)C(C(=O)OCC)=C(C)C=C2N=CN1C1=CC=CC=C1 IXWUXVSEQHFPMI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- -1 methylenedioxy Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000004648 relaxation of smooth muscle Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15576478A JPS5583761A (en) | 1978-12-19 | 1978-12-19 | Novel 3-phenyl-4-quinazolone derivative |
| NZ192392A NZ192392A (en) | 1978-12-19 | 1979-12-13 | 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones |
| US06/103,841 US4276295A (en) | 1978-12-19 | 1979-12-14 | 3-Aromatic moiety substituted-4(3H)-quinazolinones, process for production thereof, and use thereof |
| YU03063/79A YU306379A (en) | 1978-12-19 | 1979-12-14 | Process for producing 3-aromatically substituted 4(3h)-quinazolines |
| DE19792950376 DE2950376A1 (de) | 1978-12-19 | 1979-12-14 | In 3-stellung mit aromatischer gruppe substituierte 4(3h)-chinazolinone und verfahren zu deren herstellung und deren verwendung |
| AR279316A AR225028A1 (es) | 1978-12-19 | 1979-12-17 | Un procedimiento para producir una 4(3h)-quinazolinona 3-fenil o piridil-sustituida |
| IT28062/79A IT1126577B (it) | 1978-12-19 | 1979-12-17 | 4(3h)-chinazolinoni sostituiti nella meta' 3-aromatica,procedimento per la loro produzione e loro impiego |
| SE7910376A SE7910376L (sv) | 1978-12-19 | 1979-12-17 | Kinazolinonderivat |
| AU53932/79A AU526309B2 (en) | 1978-12-19 | 1979-12-17 | Substituted quinazolinones |
| NL7909118A NL7909118A (nl) | 1978-12-19 | 1979-12-18 | Gesubstitueerde chinazolinonderivaten, alsmede farmaceutische preparaten die deze derivaten als actieve component bevatten. |
| NO794135A NO794135L (no) | 1978-12-19 | 1979-12-18 | Substituerte 4(3h)-kinazolinoner, fremgangsmaate ved fremstilling og anvendelse av disse |
| DK539979A DK539979A (da) | 1978-12-19 | 1979-12-18 | Quinazolinonderivater samt deres fremstilling og anvndelse |
| GB7943565A GB2040927B (en) | 1978-12-19 | 1979-12-18 | Pharmaceutically active 3 - aromatic moiety substituted - 4 (3h) - quinazolinone derivatives |
| HU79II311A HU182733B (en) | 1978-12-19 | 1979-12-19 | Process for producing substituted quinazoline-derivatives |
| CH1125779A CH644112A5 (de) | 1978-12-19 | 1979-12-19 | 3-aromatischsubstituierte-4(3h)chinazolinone und verfahren zu ihrer herstellung. |
| CA342,295A CA1111849A (en) | 1978-12-19 | 1979-12-19 | 3-aromatic moiety substituted-4(3h)-quinazolinones, process for production thereof, and use thereof |
| ZA00796892A ZA796892B (en) | 1978-12-19 | 1979-12-19 | 3-aromatic moiety substituted-(3h)-quinazolinones, process for production thereof, and use tereof |
| AT0801179A AT375651B (de) | 1978-12-19 | 1979-12-19 | Verfahren zur herstellung von neuen in 3-stellung aromatisch substituierten4(3h)-chinazolinonderivaten und deren saeureadditionssalzen |
| DD79217854A DD150462A5 (de) | 1978-12-19 | 1979-12-19 | Verfahren zur herstellung von in 3-stellung mit aromatischer gruppe substituierten 4(3h)-chinazolinonen |
| FR7931059A FR2444671A1 (fr) | 1978-12-19 | 1979-12-19 | Nouvelles quinazolinones, leur preparation et medicament contenant ces substances |
| BE0/198633A BE880720A (fr) | 1978-12-19 | 1979-12-19 | Nouveaux derives de 4(3h)-quinazolinone substitues en position 3 par une portion aromatique, leur preparation et leur utilisation |
| ES493758A ES8202333A1 (es) | 1978-12-19 | 1980-07-28 | Un procedimiento para producir una 4(3h)-quinazolinona sus- tituida con un resto aromatico en la posicion 3 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15576478A JPS5583761A (en) | 1978-12-19 | 1978-12-19 | Novel 3-phenyl-4-quinazolone derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5583761A true JPS5583761A (en) | 1980-06-24 |
Family
ID=15612890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15576478A Pending JPS5583761A (en) | 1978-12-19 | 1978-12-19 | Novel 3-phenyl-4-quinazolone derivative |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5583761A (de) |
| AT (1) | AT375651B (de) |
| BE (1) | BE880720A (de) |
| ZA (1) | ZA796892B (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59106195A (ja) * | 1982-12-10 | 1984-06-19 | 富士通株式会社 | 厚膜パタ−ン印刷回数表示方法 |
-
1978
- 1978-12-19 JP JP15576478A patent/JPS5583761A/ja active Pending
-
1979
- 1979-12-19 AT AT0801179A patent/AT375651B/de not_active IP Right Cessation
- 1979-12-19 BE BE0/198633A patent/BE880720A/fr not_active IP Right Cessation
- 1979-12-19 ZA ZA00796892A patent/ZA796892B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59106195A (ja) * | 1982-12-10 | 1984-06-19 | 富士通株式会社 | 厚膜パタ−ン印刷回数表示方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| BE880720A (fr) | 1980-06-19 |
| AT375651B (de) | 1984-08-27 |
| ZA796892B (en) | 1980-12-31 |
| ATA801179A (de) | 1984-01-15 |
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