JPS5817463B2 - ニコチン酸アミド誘導体 - Google Patents

ニコチン酸アミド誘導体

Info

Publication number
JPS5817463B2
JPS5817463B2 JP51036101A JP3610176A JPS5817463B2 JP S5817463 B2 JPS5817463 B2 JP S5817463B2 JP 51036101 A JP51036101 A JP 51036101A JP 3610176 A JP3610176 A JP 3610176A JP S5817463 B2 JPS5817463 B2 JP S5817463B2
Authority
JP
Japan
Prior art keywords
nicotinic acid
nitrate
acid amide
amide derivatives
nicotinamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP51036101A
Other languages
English (en)
Japanese (ja)
Other versions
JPS52122373A (en
Inventor
永野洋幸
鯨井辰男
高久栄
小笠原利近
松永功
新藤実
森陸司
菅野茂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP51036101A priority Critical patent/JPS5817463B2/ja
Priority to AU23532/77A priority patent/AU509591B2/en
Priority to DK128277A priority patent/DK145608C/da
Priority to GB1254177A priority patent/GB1562962A/en
Priority to CA274,696A priority patent/CA1088944A/en
Priority to MX775593U priority patent/MX5534E/es
Priority to MX1052777U priority patent/MX7103E/es
Priority to ES457421A priority patent/ES457421A1/es
Priority to ZA00771976A priority patent/ZA771976B/xx
Priority to CS772189A priority patent/CS228104B2/cs
Priority to SE7703868A priority patent/SE436029B/xx
Priority to BE2055790A priority patent/BE853144A/fr
Priority to SU772467501A priority patent/SU999965A3/ru
Priority to CH415377A priority patent/CH633535A5/de
Priority to FI771024A priority patent/FI66598C/fi
Priority to AR267099A priority patent/AR217423A1/es
Priority to DE2714713A priority patent/DE2714713C3/de
Priority to FR7710119A priority patent/FR2346334A1/fr
Priority to NLAANVRAGE7703624,A priority patent/NL176674C/xx
Priority to AT235077A priority patent/AT360532B/de
Priority to HU77CU155A priority patent/HU174118B/hu
Publication of JPS52122373A publication Critical patent/JPS52122373A/ja
Priority to AR271162A priority patent/AR220907A1/es
Priority to ES468462A priority patent/ES468462A1/es
Priority to SU782640400A priority patent/SU942593A3/ru
Priority to US05/940,194 priority patent/US4200640A/en
Priority to CS787549A priority patent/CS228111B2/cs
Priority to AT286979A priority patent/AT360536B/de
Publication of JPS5817463B2 publication Critical patent/JPS5817463B2/ja
Priority to NL930042C priority patent/NL930042I2/nl
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP51036101A 1976-04-02 1976-04-02 ニコチン酸アミド誘導体 Expired JPS5817463B2 (ja)

Priority Applications (28)

Application Number Priority Date Filing Date Title
JP51036101A JPS5817463B2 (ja) 1976-04-02 1976-04-02 ニコチン酸アミド誘導体
AU23532/77A AU509591B2 (en) 1976-04-02 1977-03-23 Pyridine derivatives
DK128277A DK145608C (da) 1976-04-02 1977-03-23 Analogifremgangsmaade til fremstilling af salpetersyreesteren af n-(2-hydroxyethyl)nicotinamid
GB1254177A GB1562962A (en) 1976-04-02 1977-03-24 Nicotinamide derivatives processes for producting the same and pharmaceutical compositions containing the same
CA274,696A CA1088944A (en) 1976-04-02 1977-03-24 Nitric ester of n-(2-hydroxyethyl)nicotinamide and a process for the preparation of same
MX775593U MX5534E (es) 1976-04-02 1977-03-30 Procedimiento para la preparacion de derivados de nicotinamida
MX1052777U MX7103E (es) 1976-04-02 1977-03-30 Procedimiento para preparar derivados de nicotinamida
ES457421A ES457421A1 (es) 1976-04-02 1977-03-31 Un procedimiento para la preparacion de nuevos derivados de piridina.
ZA00771976A ZA771976B (en) 1976-04-02 1977-03-31 Novel pyridine derivative,process for preparing the same and pharmaceutical composition containing the same
AR267099A AR217423A1 (es) 1976-04-02 1977-04-01 Procedimiento de preparacion de esteres nitricos de n-(2-hidroxietil)-nicotinamida
SE7703868A SE436029B (sv) 1976-04-02 1977-04-01 Forfarande for framstellning av salpetersyraestern av n-(2-hydroxietyl)-nikotinamid
BE2055790A BE853144A (fr) 1976-04-02 1977-04-01 Derive nouveau de la pyridine, procede pour sa composition pharmaceutique contenant ce derive
SU772467501A SU999965A3 (ru) 1976-04-02 1977-04-01 Способ получени эфира азотной кислоты N-/2-оксиэтил/-никотинамида или его солей
CH415377A CH633535A5 (en) 1976-04-02 1977-04-01 Process for the preparation of pyridine derivatives.
FI771024A FI66598C (fi) 1976-04-02 1977-04-01 Foerfarande foer framstaellning av terapeutiskt anvaendbara sapetersyraestrar av n-(hydroxialkyl)pyridinkarboxamidderiv at
CS772189A CS228104B2 (en) 1976-04-02 1977-04-01 Preparation of esters of nitric acid and n-/2-hydroxyethyl/nicotinamides
DE2714713A DE2714713C3 (de) 1976-04-02 1977-04-01 Salpetersäureester von N-(2-HydroxyäthyO-nicotinamid, Verfahren zu dessen Herstellung und Arzneimittel
FR7710119A FR2346334A1 (fr) 1976-04-02 1977-04-04 Nouveaux derives de la pyridine, leur procede de preparation et leurs applications therapeutiques
NLAANVRAGE7703624,A NL176674C (nl) 1976-04-02 1977-04-04 Werkwijze ter bereiding van een geneesmiddel voor de behandeling van circulatiestoringen en werkwijze ter bereiding van de geneeskrachtige verbindingen.
AT235077A AT360532B (de) 1976-04-02 1977-04-04 Verfahren zur herstellung des neuen salpeter- saeureesters von n-(2-hydroxyaethyl)nicotinamid unter von desssen salzen
HU77CU155A HU174118B (hu) 1976-04-02 1977-09-01 Sposob poluchenija novykh slozhnykh ehfirov i solej n-/2-gidroksi-ehtil/-niamido-azotnoj kisloty
AR271162A AR220907A1 (es) 1976-04-02 1978-02-20 Procedimiento de preparacion de esteres nitricos de n-(2-hidroxietil)nicotinamida
ES468462A ES468462A1 (es) 1976-04-02 1978-03-31 Ÿun procedimiento para la preparacion de nuevos derivados depiridinaŸ
SU782640400A SU942593A3 (ru) 1976-04-02 1978-07-28 Способ получени азотнокислого эфира N-/2-оксиэтил/ никотинамида или его солей
US05/940,194 US4200640A (en) 1976-04-02 1978-09-07 Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
CS787549A CS228111B2 (cs) 1976-04-02 1978-11-20 Způsob přípravy esteru kyseliny dusičné a N-(2-hydroxyethylJ-nikotinamidu
AT286979A AT360536B (de) 1976-04-02 1979-04-17 Verfahren zur herstellung des neuen salpeter- saeureesters von n-(2-hydroxyaethyl)nicotinamid und von dessen salzen
NL930042C NL930042I2 (nl) 1976-04-02 1993-05-28 Werkwijze ter bereiding van een geneesmiddel voor de behandeling van circulatiestoringen en werkwijze ter bereiding van de geneeskrachtige verbindingen.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51036101A JPS5817463B2 (ja) 1976-04-02 1976-04-02 ニコチン酸アミド誘導体

Publications (2)

Publication Number Publication Date
JPS52122373A JPS52122373A (en) 1977-10-14
JPS5817463B2 true JPS5817463B2 (ja) 1983-04-07

Family

ID=12460366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51036101A Expired JPS5817463B2 (ja) 1976-04-02 1976-04-02 ニコチン酸アミド誘導体

Country Status (5)

Country Link
JP (1) JPS5817463B2 (cs)
BE (1) BE853144A (cs)
CS (1) CS228104B2 (cs)
SU (2) SU999965A3 (cs)
ZA (1) ZA771976B (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192562U (ja) * 1983-06-07 1984-12-20 四国化成工業株式会社 支柱

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020100598A (ja) 2018-12-25 2020-07-02 公益財団法人応用生化学研究所 レンバチニブ誘導体、並びにそれを用いた医薬研究用組成物及び腫瘍治療剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59192562U (ja) * 1983-06-07 1984-12-20 四国化成工業株式会社 支柱

Also Published As

Publication number Publication date
ZA771976B (en) 1978-03-29
SU999965A3 (ru) 1983-02-23
BE853144A (fr) 1977-08-01
SU942593A3 (ru) 1982-07-07
CS228104B2 (en) 1984-05-14
JPS52122373A (en) 1977-10-14

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Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term
R154 Certificate of patent or utility model (reissue)

Free format text: JAPANESE INTERMEDIATE CODE: R154