JPS5867667A - １−置換−４−フエニル−イソニコペチン酸エステル - Google Patents

１−置換−４−フエニル−イソニコペチン酸エステル

Info

Publication number: JPS5867667A
Authority: JP; Japan
Prior art keywords: substituted; phenyl; acid ester; isonicopetinic; piperidino
Prior art date: 1981-10-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP16670181A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6361940B2 (de

Inventor

Tozaburo Kurihara

栗原　藤三郎

Masahiro Nagata

永田　雅寛

Shigenori Suzuki

鈴木　稠徳

Hideo Ito

秀雄伊藤

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

KAYAKU KK

Original Assignee

KAYAKU KK

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-10-19

Filing date

1981-10-19

Publication date

1983-04-22

1981-10-19 Application filed by KAYAKU KK filed Critical KAYAKU KK

1981-10-19 Priority to JP16670181A priority Critical patent/JPS5867667A/ja

1983-04-22 Publication of JPS5867667A publication Critical patent/JPS5867667A/ja

1988-11-30 Publication of JPS6361940B2 publication Critical patent/JPS6361940B2/ja

Status Granted legal-status Critical Current

Links

150000002148 esters Chemical class 0.000 title claims description 12
239000002253 acid Substances 0.000 title description 12
125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
238000006243 chemical reaction Methods 0.000 description 5
239000000203 mixture Substances 0.000 description 5
-1 3-piperidino-2-hydroxypropyl Chemical group 0.000 description 4
230000000202 analgesic effect Effects 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
239000003814 drug Substances 0.000 description 4
229940079593 drug Drugs 0.000 description 4
125000004494 ethyl ester group Chemical group 0.000 description 4
238000000034 method Methods 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical class [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
230000003444 anaesthetic effect Effects 0.000 description 3
230000003110 anti-inflammatory effect Effects 0.000 description 3
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
229910052742 iron Inorganic materials 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
206010002091 Anaesthesia Diseases 0.000 description 2
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
230000037005 anaesthesia Effects 0.000 description 2
238000000921 elemental analysis Methods 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
238000000605 extraction Methods 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000002994 raw material Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
YWRXDGYUFPGSDH-MDZDMXLPSA-N (e)-n-methyl-n-[(1-methylindol-2-yl)methyl]-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide Chemical compound N1CCCC2=CC(/C=C/C(=O)N(CC=3N(C4=CC=CC=C4C=3)C)C)=CN=C21 YWRXDGYUFPGSDH-MDZDMXLPSA-N 0.000 description 1
OYIFRKXKKNJLNN-UHFFFAOYSA-N 1-(oxiren-2-ylmethyl)piperidine Chemical group C=1OC=1CN1CCCCC1 OYIFRKXKKNJLNN-UHFFFAOYSA-N 0.000 description 1
241000143060 Americamysis bahia Species 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
206010015946 Eye irritation Diseases 0.000 description 1
NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
241000283977 Oryctolagus Species 0.000 description 1
241000270666 Testudines Species 0.000 description 1
238000006136 alcoholysis reaction Methods 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
BULLHNJGPPOUOX-UHFFFAOYSA-N chloroacetone Chemical compound CC(=O)CCl BULLHNJGPPOUOX-UHFFFAOYSA-N 0.000 description 1
239000004020 conductor Substances 0.000 description 1
210000004087 cornea Anatomy 0.000 description 1
238000001035 drying Methods 0.000 description 1
PSLIMVZEAPALCD-UHFFFAOYSA-N ethanol;ethoxyethane Chemical compound CCO.CCOCC PSLIMVZEAPALCD-UHFFFAOYSA-N 0.000 description 1
231100000013 eye irritation Toxicity 0.000 description 1
230000000193 eyeblink Effects 0.000 description 1
239000007789 gas Substances 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229960001340 histamine Drugs 0.000 description 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
229910000041 hydrogen chloride Inorganic materials 0.000 description 1
230000008595 infiltration Effects 0.000 description 1
238000001764 infiltration Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
150000002736 metal compounds Chemical class 0.000 description 1
SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
210000001747 pupil Anatomy 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000036647 reaction Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1

Landscapes

Epoxy Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP16670181A 1981-10-19 1981-10-19 １−置換−４−フエニル−イソニコペチン酸エステル Granted JPS5867667A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP16670181A JPS5867667A (ja)	1981-10-19	1981-10-19	１−置換−４−フエニル−イソニコペチン酸エステル

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP16670181A JPS5867667A (ja)	1981-10-19	1981-10-19	１−置換−４−フエニル−イソニコペチン酸エステル

Publications (2)

Publication Number	Publication Date
JPS5867667A true JPS5867667A (ja)	1983-04-22
JPS6361940B2 JPS6361940B2 (de)	1988-11-30

Family

ID=15836142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP16670181A Granted JPS5867667A (ja)	1981-10-19	1981-10-19	１−置換−４−フエニル−イソニコペチン酸エステル

Country Status (1)

Country	Link
JP (1)	JPS5867667A (de)

1981
- 1981-10-19 JP JP16670181A patent/JPS5867667A/ja active Granted

Also Published As

Publication number	Publication date
JPS6361940B2 (de)	1988-11-30

Publication	Publication Date	Title
CA1256878A (en)	1989-07-04	Benzimidazol derivatives and their production
JPH082871B2 (ja)	1996-01-17	ピペラジニルカンファースルフォニルオキシトシン拮抗物質の置換アミン誘導体
DE2011806A1 (de)	1970-10-15	Neue trieyclisehe Verbindungen
JPH0557983B2 (de)	1993-08-25
JPH03141258A (ja)	1991-06-17	新規なピペラジン誘導体
JPH0291052A (ja)	1990-03-30	置換アミン類
JPH033669B2 (de)	1991-01-21
JPH0699307B2 (ja)	1994-12-07	抗痴呆剤
JPS60174781A (ja)	1985-09-09	強心および抗高血圧オキサジアジノン化合物
JPS58146566A (ja)	1983-09-01	ピリジン誘導体
JPS58180484A (ja)	1983-10-21	１−置換Ｎ−／８α−エルゴリニル／−Ｎ′，Ｎ′−ジエチルウレア及びその製造方法
JPS6354363A (ja)	1988-03-08	キノリン誘導体
JP2777661B2 (ja)	1998-07-23	ベンゾヘテロ環化合物
JP2640953B2 (ja)	1997-08-13	芳香族複素環化合物
ELDERFIELD et al.	1952	THE VON BRAUN CYANOGEN BROMIDE REACTION. II. APPLICATION TO N-ARYLPYRROLIDINES1, 2
CA1025865A (fr)	1978-02-07	Procedes de preparation de nouvelles amides heterocycliques
US3743646A (en)	1973-07-03	Amides of 3-(2-halophenyl-5-tetrazolyl)propionic acids
JPS6144873A (ja)	1986-03-04	ピリダジノン誘導体またはその塩類
JPS59501715A (ja)	1984-10-11	ピリジル−アセチルグアニジン
JPS5946281A (ja)	1984-03-15	１置換ピロリチジン誘導体およびその用途
JPS60226877A (ja)	1985-11-12	ピペリジン誘導体
JP3639326B2 (ja)	2005-04-20	新規なアコニチン型化合物及び鎮痛・抗炎症剤
JPS60149567A (ja)	1985-08-07	新規なイミダゾ−ル誘導体およびその製法
JPS6026797B2 (ja)	1985-06-25	新規なカルボスチリル誘導体
JPS6361940B2 (de)	1988-11-30