JPS5936684A - １−オキサセフアム化合物の製造方法 - Google Patents

１−オキサセフアム化合物の製造方法

Info

Publication number
JPS5936684A
JPS5936684A JP57147268A JP14726882A JPS5936684A JP S5936684 A JPS5936684 A JP S5936684A JP 57147268 A JP57147268 A JP 57147268A JP 14726882 A JP14726882 A JP 14726882A JP S5936684 A JPS5936684 A JP S5936684A
Authority
JP
Japan
Prior art keywords
formula
compound
group
mmol
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57147268A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0355475B2 (2
Inventor
Sadao Yamamoto
山本　貞雄
Hikari Itani
光 井谷
Hiromi Takahashi
高橋　広海
Shoji Tsuji
辻　照二
Wataru Nagata
永田　亘
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP57147268A priority Critical patent/JPS5936684A/ja
Priority to GR72205A priority patent/GR78932B/el
Priority to US06/523,414 priority patent/US4539148A/en
Priority to GB08322116A priority patent/GB2126223B/en
Priority to IE1936/83A priority patent/IE55873B1/en
Priority to DE8383401689T priority patent/DE3377276D1/de
Priority to EP83401689A priority patent/EP0102893B1/en
Priority to DK385983A priority patent/DK385983A/da
Priority to HU832963A priority patent/HU191875B/hu
Priority to IL69546A priority patent/IL69546A/xx
Priority to KR1019830003960A priority patent/KR900004149B1/ko
Priority to CA000435289A priority patent/CA1227482A/en
Publication of JPS5936684A publication Critical patent/JPS5936684A/ja
Publication of JPH0355475B2 publication Critical patent/JPH0355475B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/21—Saturated compounds having only one carboxyl group and containing keto groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0892—Compounds with a Si-O-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP57147268A 1982-08-24 1982-08-24 １−オキサセフアム化合物の製造方法 Granted JPS5936684A (ja)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP57147268A JPS5936684A (ja) 1982-08-24 1982-08-24 １−オキサセフアム化合物の製造方法
GR72205A GR78932B (2) 1982-08-24 1983-08-12
US06/523,414 US4539148A (en) 1982-08-24 1983-08-16 Production of 1-oxacephams and intermediates
GB08322116A GB2126223B (en) 1982-08-24 1983-08-17 4-substituted butyric acid derivatives
IE1936/83A IE55873B1 (en) 1982-08-24 1983-08-18 4-substituted butyric acid derivatives
DE8383401689T DE3377276D1 (en) 1982-08-24 1983-08-19 A novel production of 1-oxacephams
EP83401689A EP0102893B1 (en) 1982-08-24 1983-08-19 A novel production of 1-oxacephams
DK385983A DK385983A (da) 1982-08-24 1983-08-23 Fremgangsmaade til fremstilling af 1-oxacephamer
HU832963A HU191875B (en) 1982-08-24 1983-08-23 Process for producing 7-alpha-/acyl-amino/-3-/exomethylene or oxo/-1-dethia-1-oxacephame-4-carboxylic acid esters
IL69546A IL69546A (en) 1982-08-24 1983-08-23 3-hydroxymethyl-3-butenoic acid derivatives,processes for their preparation and process for the preparation of antibacterial 1-oxacepham derivatives using them
KR1019830003960A KR900004149B1 (ko) 1982-08-24 1983-08-24 1-옥사세팜 화합물의 제조방법
CA000435289A CA1227482A (en) 1982-08-24 1983-08-24 Production of l-oxacephams

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57147268A JPS5936684A (ja) 1982-08-24 1982-08-24 １−オキサセフアム化合物の製造方法

Publications (2)

Publication Number Publication Date
JPS5936684A true JPS5936684A (ja) 1984-02-28
JPH0355475B2 JPH0355475B2 (2) 1991-08-23

Family

ID=15426375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57147268A Granted JPS5936684A (ja) 1982-08-24 1982-08-24 １−オキサセフアム化合物の製造方法

Country Status (12)

Country Link
US (1) US4539148A (2)
EP (1) EP0102893B1 (2)
JP (1) JPS5936684A (2)
KR (1) KR900004149B1 (2)
CA (1) CA1227482A (2)
DE (1) DE3377276D1 (2)
DK (1) DK385983A (2)
GB (1) GB2126223B (2)
GR (1) GR78932B (2)
HU (1) HU191875B (2)
IE (1) IE55873B1 (2)
IL (1) IL69546A (2)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0115770B2 (en) * 1983-01-07 1996-06-19 Takeda Chemical Industries, Ltd. Thiazole Derivatives
JPH0830051B2 (ja) * 1986-05-21 1996-03-27 武田薬品工業株式会社 ４−ハロゲノ−２−置換オキシイミノ−３−オキソ酪酸のエステルまたはアミドの製造法
US4775745A (en) * 1986-12-08 1988-10-04 National Distillers And Chemical Corporation Diazonium compounds useful as components for nucleic acid probes
GB8707515D0 (en) * 1987-03-30 1987-05-07 Fujisawa Pharmaceutical Co Amino acid derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345081A (en) * 1973-09-14 1974-01-30 Lonza Ag Process for the preparation of ypsilon-alkoxy-acetoacetic esters
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents
GB1533049A (en) * 1976-04-15 1978-11-22 Bristol Myers Canada Ltd O-2-isocephem compounds and their preparation
JPS604811B2 (ja) * 1976-07-28 1985-02-06 塩野義製薬株式会社 メチルケトンのハロゲン化
JPS5398951A (en) * 1977-02-08 1978-08-29 Shionogi & Co Ltd Azetidinone derivatives and process for their preparation
CH649984A5 (de) * 1981-06-17 1985-06-28 Lonza Ag 4-hydroxyacetessigsaeureethylester.
JPS58103391A (ja) * 1981-12-11 1983-06-20 Meiji Seika Kaisha Ltd １−オキサデチア−セフエム誘導体の製造法

Also Published As

Publication number Publication date
IL69546A (en) 1988-03-31
IL69546A0 (en) 1983-11-30
CA1227482A (en) 1987-09-29
GR78932B (2) 1984-10-02
GB2126223A (en) 1984-03-21
EP0102893A1 (en) 1984-03-14
KR840005815A (ko) 1984-11-19
KR900004149B1 (ko) 1990-06-16
IE55873B1 (en) 1991-02-14
DK385983D0 (da) 1983-08-23
GB2126223B (en) 1986-06-04
DK385983A (da) 1984-02-25
IE831936L (en) 1984-02-24
US4539148A (en) 1985-09-03
JPH0355475B2 (2) 1991-08-23
DE3377276D1 (en) 1988-08-11
HU191875B (en) 1987-04-28
GB8322116D0 (en) 1983-09-21
EP0102893B1 (en) 1988-07-06

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