JPS6058920B2 - セフアロスポリン類縁体 - Google Patents

セフアロスポリン類縁体

Info

Publication number
JPS6058920B2
JPS6058920B2 JP53162008A JP16200878A JPS6058920B2 JP S6058920 B2 JPS6058920 B2 JP S6058920B2 JP 53162008 A JP53162008 A JP 53162008A JP 16200878 A JP16200878 A JP 16200878A JP S6058920 B2 JPS6058920 B2 JP S6058920B2
Authority
JP
Japan
Prior art keywords
compound
group
reaction
cis
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP53162008A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5587791A (en
Inventor
正 平田
征夫 松隈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP53162008A priority Critical patent/JPS6058920B2/ja
Priority to NO794177A priority patent/NO794177L/no
Priority to CH1134579A priority patent/CH642968A5/de
Priority to FR7931527A priority patent/FR2445327A1/fr
Priority to DK549479A priority patent/DK549479A/da
Priority to CA000342597A priority patent/CA1136138A/en
Priority to GB7944080A priority patent/GB2041923B/en
Priority to IT69476/79A priority patent/IT1192795B/it
Priority to DE2952413A priority patent/DE2952413C2/de
Publication of JPS5587791A publication Critical patent/JPS5587791A/ja
Publication of JPS6058920B2 publication Critical patent/JPS6058920B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP53162008A 1978-12-26 1978-12-26 セフアロスポリン類縁体 Expired JPS6058920B2 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP53162008A JPS6058920B2 (ja) 1978-12-26 1978-12-26 セフアロスポリン類縁体
NO794177A NO794177L (no) 1978-12-26 1979-12-19 Cefalosporin-analoger og fremgangsmaate til deres fremstilling
CH1134579A CH642968A5 (de) 1978-12-26 1979-12-20 Cephalosporin-analoge und verfahren zu deren herstellung.
FR7931527A FR2445327A1 (fr) 1978-12-26 1979-12-21 Composes analogues de la cephalosporine et leurs procedes de preparation
DK549479A DK549479A (da) 1978-12-26 1979-12-21 Cephalosporin-analoge forbindelser
CA000342597A CA1136138A (en) 1978-12-26 1979-12-21 Cephalosporin analogs and methods for production thereof
GB7944080A GB2041923B (en) 1978-12-26 1979-12-21 Cephalosporin analogues and methods for production thereof
IT69476/79A IT1192795B (it) 1978-12-26 1979-12-24 Analoghi di cefalosporina e procedimento per la loro preparazione
DE2952413A DE2952413C2 (de) 1978-12-26 1979-12-27 3-Halogencarbacephem-Verbindungen und Verfahren zu ihrer Herstellung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53162008A JPS6058920B2 (ja) 1978-12-26 1978-12-26 セフアロスポリン類縁体

Publications (2)

Publication Number Publication Date
JPS5587791A JPS5587791A (en) 1980-07-02
JPS6058920B2 true JPS6058920B2 (ja) 1985-12-23

Family

ID=15746283

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53162008A Expired JPS6058920B2 (ja) 1978-12-26 1978-12-26 セフアロスポリン類縁体

Country Status (9)

Country Link
JP (1) JPS6058920B2 (de)
CA (1) CA1136138A (de)
CH (1) CH642968A5 (de)
DE (1) DE2952413C2 (de)
DK (1) DK549479A (de)
FR (1) FR2445327A1 (de)
GB (1) GB2041923B (de)
IT (1) IT1192795B (de)
NO (1) NO794177L (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63184229U (de) * 1987-05-19 1988-11-28

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0653739B2 (ja) * 1984-11-15 1994-07-20 協和醗酵工業株式会社 ３位置換カルバセフエム化合物
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof
US4885291A (en) * 1988-01-14 1989-12-05 Eli Lilly And Company 1-carba(dethia)-3-cephem derivatives
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
ZA923182B (en) * 1991-05-10 1993-11-01 Eli Liily And Company Process for preparing double blocked 1-carba (1-dethia)-3-cephem-4-carboxylic acids
DE4331391A1 (de) * 1993-09-15 1995-03-16 Josef Dr Kemmer Halbleiter(detektor)struktur
US20030236243A1 (en) * 2002-05-14 2003-12-25 Shoichet Brian K. Sterically-awkward beta-lactamase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63184229U (de) * 1987-05-19 1988-11-28

Also Published As

Publication number Publication date
GB2041923A (en) 1980-09-17
JPS5587791A (en) 1980-07-02
CH642968A5 (de) 1984-05-15
DK549479A (da) 1980-06-27
IT1192795B (it) 1988-05-04
FR2445327A1 (fr) 1980-07-25
DE2952413C2 (de) 1986-12-11
FR2445327B1 (de) 1983-05-06
IT7969476A0 (it) 1979-12-24
DE2952413A1 (de) 1980-07-17
CA1136138A (en) 1982-11-23
NO794177L (no) 1980-06-27
GB2041923B (en) 1983-07-20

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