JPS6185307A - 美白化粧料 - Google Patents

美白化粧料

Info

Publication number: JPS6185307A
Authority: JP; Japan
Prior art keywords: azelaic acid; acid; cosmetic; urea; added
Prior art date: 1984-10-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP20687084A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6241685B2 (th

Inventor

Yasushi Nishijima

西島　靖

Tatsuro Shinomiya

四宮　達郎

Keiichi Honda

計一本田

Tadashi Matsui

正松井

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kanebo Ltd

Original Assignee

Kanebo Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-01

Filing date

1984-10-01

Publication date

1986-04-30

1984-10-01 Application filed by Kanebo Ltd filed Critical Kanebo Ltd

1984-10-01 Priority to JP20687084A priority Critical patent/JPS6185307A/ja

1986-04-30 Publication of JPS6185307A publication Critical patent/JPS6185307A/ja

1987-09-04 Publication of JPS6241685B2 publication Critical patent/JPS6241685B2/ja

Status Granted legal-status Critical Current

Links

239000002537 cosmetic Substances 0.000 title claims abstract description 19
BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims abstract description 43
239000004202 carbamide Substances 0.000 claims abstract description 18
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 16
230000002087 whitening effect Effects 0.000 claims description 20
150000001875 compounds Chemical class 0.000 claims description 18
239000004615 ingredient Substances 0.000 claims description 9
230000000694 effects Effects 0.000 abstract description 17
206010014970 Ephelides Diseases 0.000 abstract description 10
208000003351 Melanosis Diseases 0.000 abstract description 10
239000000839 emulsion Substances 0.000 abstract description 8
239000002253 acid Substances 0.000 abstract description 5
230000005764 inhibitory process Effects 0.000 abstract description 3
239000000049 pigment Substances 0.000 abstract description 2
230000002411 adverse Effects 0.000 abstract 1
230000003405 preventing effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 description 19
QAWLWCKCAGRDSK-UHFFFAOYSA-N NC(=O)N.C(CCCCCCCC(=O)O)(=O)O Chemical compound NC(=O)N.C(CCCCCCCC(=O)O)(=O)O QAWLWCKCAGRDSK-UHFFFAOYSA-N 0.000 description 14
238000009472 formulation Methods 0.000 description 14
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
102000003425 Tyrosinase Human genes 0.000 description 9
108060008724 Tyrosinase Proteins 0.000 description 9
210000003491 skin Anatomy 0.000 description 9
-1 aliphatic dicarboxylic acids Chemical class 0.000 description 7
239000000243 solution Substances 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
230000000052 comparative effect Effects 0.000 description 5
230000007423 decrease Effects 0.000 description 5
239000012071 phase Substances 0.000 description 5
238000002835 absorbance Methods 0.000 description 4
238000000034 method Methods 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
239000003205 fragrance Substances 0.000 description 3
230000002401 inhibitory effect Effects 0.000 description 3
239000006210 lotion Substances 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
239000000047 product Substances 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
206010042496 Sunburn Diseases 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
150000005690 diesters Chemical class 0.000 description 2
230000001530 keratinolytic effect Effects 0.000 description 2
239000007788 liquid Substances 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
239000003921 oil Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000008213 purified water Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
241000938001 Ameiurus catus Species 0.000 description 1
239000005973 Carvone Substances 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
108090000371 Esterases Proteins 0.000 description 1
WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
208000012641 Pigmentation disease Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
241000121220 Tricholoma matsutake Species 0.000 description 1
239000006096 absorbing agent Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
239000011651 chromium Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
150000001991 dicarboxylic acids Chemical class 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
230000035876 healing Effects 0.000 description 1
239000003906 humectant Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
230000007774 longterm Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
238000010422 painting Methods 0.000 description 1
230000035699 permeability Effects 0.000 description 1
239000012466 permeate Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
238000005375 photometry Methods 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
230000019612 pigmentation Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
239000011764 pyridoxine hydrochloride Substances 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
239000000126 substance Substances 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
229940099259 vaseline Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Cosmetics (AREA)

JP20687084A 1984-10-01 1984-10-01 美白化粧料 Granted JPS6185307A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP20687084A JPS6185307A (ja)	1984-10-01	1984-10-01	美白化粧料

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP20687084A JPS6185307A (ja)	1984-10-01	1984-10-01	美白化粧料

Publications (2)

Publication Number	Publication Date
JPS6185307A true JPS6185307A (ja)	1986-04-30
JPS6241685B2 JPS6241685B2 (th)	1987-09-04

Family

ID=16530400

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP20687084A Granted JPS6185307A (ja)	1984-10-01	1984-10-01	美白化粧料

Country Status (1)

Country	Link
JP (1)	JPS6185307A (th)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6483011A (en) *	1987-09-25	1989-03-28	Sansho Seiyaku Kk	Melanization inhibitory drug for external use
JP2013170124A (ja) *	2012-02-17	2013-09-02	Rohto Pharmaceutical Co Ltd	アゼライン酸を含有する外用組成物
CN108187070A (zh) *	2018-03-15	2018-06-22	山东滨州智源生物科技有限公司	一种壬二酸羟丙基倍他环糊精包合物的制备方法

1984
- 1984-10-01 JP JP20687084A patent/JPS6185307A/ja active Granted

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6483011A (en) *	1987-09-25	1989-03-28	Sansho Seiyaku Kk	Melanization inhibitory drug for external use
US4990330A (en) *	1987-09-25	1991-02-05	Sansho Seiyaku Co., Ltd.	Compositions for topical use having melanin synthesis-inhibiting activity
JP2013170124A (ja) *	2012-02-17	2013-09-02	Rohto Pharmaceutical Co Ltd	アゼライン酸を含有する外用組成物
CN108187070A (zh) *	2018-03-15	2018-06-22	山东滨州智源生物科技有限公司	一种壬二酸羟丙基倍他环糊精包合物的制备方法

Also Published As

Publication number	Publication date
JPS6241685B2 (th)	1987-09-04

Publication	Publication Date	Title
US6391287B1 (en)	2002-05-21	Composition containing at least one bicyclic aromatic compound and at least one lipophilic sunscreen, and uses thereof
CA1295257C (en)	1992-02-04	Skin treatment composition and method
JP2565513B2 (ja)	1996-12-18	メラニン生成抑制外用薬剤
US5750563A (en)	1998-05-12	Preparation for epidermis
JPH0616531A (ja)	1994-01-25	化粧料
JPH05294821A (ja)	1993-11-09	（２，５−ジヒドロキシフェニル）カルボン酸誘導体、それらの同族体又は塩を有効成分として含有する、脱色作用のある皮膚用又は化粧料組成物
JPH06199646A (ja)	1994-07-19	美白化粧料
US20020026068A1 (en)	2002-02-28	Composition containing aminophenol derivative, use thereof, and process for dissolving aminophenol derivative
DE19720339A1 (de)	1998-11-19	Wirkstoffe und Zubereitungen für die Hautaufhellung und zur Verhinderung der Hautbräunung
JPH0859450A (ja)	1996-03-05	皮膚外用剤
JP2780803B2 (ja)	1998-07-30	皮膚外用剤
JPH0196109A (ja)	1989-04-14	美白化粧料
JP2002370962A (ja)	2002-12-24	美白用化粧料および皮膚老化防止・改善用化粧料
JPH10279419A (ja)	1998-10-20	皮膚外用剤
JPH06219958A (ja)	1994-08-09	メラニン産生抑制剤及び皮膚外用剤
JP2906269B2 (ja)	1999-06-14	皮膚外用剤
JP3270219B2 (ja)	2002-04-02	皮膚外用剤
JPS6241685B2 (th)	1987-09-04
JPH01100112A (ja)	1989-04-18	皮膚外用剤
JPS6023307A (ja)	1985-02-05	美白化粧料
JP2896816B2 (ja)	1999-05-31	化粧料
JPH02237906A (ja)	1990-09-20	皮膚外用剤
JP3382146B2 (ja)	2003-03-04	皮膚外用剤
JP3026616B2 (ja)	2000-03-27	美白化粧料
JP2000256168A (ja)	2000-09-19	皮膚外用剤