JPS6233572B2 - - Google Patents
Info
- Publication number
- JPS6233572B2 JPS6233572B2 JP6017982A JP6017982A JPS6233572B2 JP S6233572 B2 JPS6233572 B2 JP S6233572B2 JP 6017982 A JP6017982 A JP 6017982A JP 6017982 A JP6017982 A JP 6017982A JP S6233572 B2 JPS6233572 B2 JP S6233572B2
- Authority
- JP
- Japan
- Prior art keywords
- contact lens
- acid
- monomer
- sugar alcohol
- ketalized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 97
- 239000000178 monomer Substances 0.000 claims description 79
- 239000000463 material Substances 0.000 claims description 40
- 150000005846 sugar alcohols Chemical class 0.000 claims description 37
- 229920001577 copolymer Polymers 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 23
- -1 ester compound Chemical class 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 23
- 238000010306 acid treatment Methods 0.000 claims description 21
- 230000002209 hydrophobic effect Effects 0.000 claims description 14
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 11
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 11
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 9
- 239000002504 physiological saline solution Substances 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 229920001567 vinyl ester resin Polymers 0.000 claims description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 125000005907 alkyl ester group Chemical group 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 5
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 4
- 238000000465 moulding Methods 0.000 claims description 4
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 3
- VHSHLMUCYSAUQU-UHFFFAOYSA-N 2-hydroxypropyl methacrylate Chemical compound CC(O)COC(=O)C(C)=C VHSHLMUCYSAUQU-UHFFFAOYSA-N 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- CWWYEELVMRNKHZ-UHFFFAOYSA-N 2,3-dimethylbut-2-enamide Chemical compound CC(C)=C(C)C(N)=O CWWYEELVMRNKHZ-UHFFFAOYSA-N 0.000 claims description 2
- GWZMWHWAWHPNHN-UHFFFAOYSA-N 2-hydroxypropyl prop-2-enoate Chemical compound CC(O)COC(=O)C=C GWZMWHWAWHPNHN-UHFFFAOYSA-N 0.000 claims description 2
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical class C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims description 2
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims description 2
- FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 claims description 2
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 25
- 239000001301 oxygen Substances 0.000 description 25
- 229910052760 oxygen Inorganic materials 0.000 description 25
- 239000007864 aqueous solution Substances 0.000 description 23
- 230000035699 permeability Effects 0.000 description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- 238000006116 polymerization reaction Methods 0.000 description 19
- QRIMLDXJAPZHJE-UHFFFAOYSA-N 2,3-dihydroxypropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(O)CO QRIMLDXJAPZHJE-UHFFFAOYSA-N 0.000 description 16
- 238000006243 chemical reaction Methods 0.000 description 16
- 238000002834 transmittance Methods 0.000 description 16
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 15
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 11
- 239000000243 solution Substances 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 239000006227 byproduct Substances 0.000 description 10
- 238000007334 copolymerization reaction Methods 0.000 description 10
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 10
- 238000005498 polishing Methods 0.000 description 10
- 239000002861 polymer material Substances 0.000 description 10
- 239000000080 wetting agent Substances 0.000 description 10
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 9
- 238000007796 conventional method Methods 0.000 description 9
- 238000005520 cutting process Methods 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 8
- 238000006567 deketalization reaction Methods 0.000 description 7
- 238000006386 neutralization reaction Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
- 210000004087 cornea Anatomy 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 235000019253 formic acid Nutrition 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000003505 polymerization initiator Substances 0.000 description 6
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 5
- 238000009835 boiling Methods 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- AGJBKFAPBKOEGA-UHFFFAOYSA-M 2-methoxyethylmercury(1+);acetate Chemical compound COCC[Hg]OC(C)=O AGJBKFAPBKOEGA-UHFFFAOYSA-M 0.000 description 4
- 101100190537 Homo sapiens PNN gene Proteins 0.000 description 4
- 102100038374 Pinin Human genes 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 4
- FFHWGQQFANVOHV-UHFFFAOYSA-N dimethyldioxirane Chemical compound CC1(C)OO1 FFHWGQQFANVOHV-UHFFFAOYSA-N 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- UJKWLAZYSLJTKA-UHFFFAOYSA-N edma Chemical compound O1CCOC2=CC(CC(C)NC)=CC=C21 UJKWLAZYSLJTKA-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- XFKFBBVGUXNVOU-UHFFFAOYSA-N (4,5-dihydroxy-2-methylpent-2-en-3-yl) 2-methylprop-2-enoate Chemical compound OCC(O)C(=C(C)C)OC(=O)C(C)=C XFKFBBVGUXNVOU-UHFFFAOYSA-N 0.000 description 2
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- 150000000093 1,3-dioxanes Chemical class 0.000 description 2
- LEJBBGNFPAFPKQ-UHFFFAOYSA-N 2-(2-prop-2-enoyloxyethoxy)ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOC(=O)C=C LEJBBGNFPAFPKQ-UHFFFAOYSA-N 0.000 description 2
- XFCMNSHQOZQILR-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOC(=O)C(C)=C XFCMNSHQOZQILR-UHFFFAOYSA-N 0.000 description 2
- INQDDHNZXOAFFD-UHFFFAOYSA-N 2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOCCOC(=O)C=C INQDDHNZXOAFFD-UHFFFAOYSA-N 0.000 description 2
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical compound C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 2
- MQQXUGFEQSCYIA-OAWHIZORSA-M aluminum;(z)-4-ethoxy-4-oxobut-2-en-2-olate;propan-2-olate Chemical compound [Al+3].CC(C)[O-].CC(C)[O-].CCOC(=O)\C=C(\C)[O-] MQQXUGFEQSCYIA-OAWHIZORSA-M 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000005907 ketalization reaction Methods 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000007870 radical polymerization initiator Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- CGFYHILWFSGVJS-UHFFFAOYSA-N silicic acid;trioxotungsten Chemical compound O[Si](O)(O)O.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 CGFYHILWFSGVJS-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000011272 standard treatment Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- LDPROHWDXHWONG-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxan-5-yl) 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1COC(C)(C)OC1 LDPROHWDXHWONG-UHFFFAOYSA-N 0.000 description 1
- XUSCPDAWOTWGBD-UHFFFAOYSA-N (2-ethyl-2-methyl-1,3-dioxolan-4-yl)methyl 2-methylprop-2-enoate Chemical compound CCC1(C)OCC(COC(=O)C(C)=C)O1 XUSCPDAWOTWGBD-UHFFFAOYSA-N 0.000 description 1
- OHKXIZLLEFPHDF-UHFFFAOYSA-N (2-methyl-2-phenyl-1,3-dioxolan-4-yl)methyl 2-methylprop-2-enoate Chemical compound O1C(COC(=O)C(=C)C)COC1(C)C1=CC=CC=C1 OHKXIZLLEFPHDF-UHFFFAOYSA-N 0.000 description 1
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical group C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical group C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 description 1
- ATVJXMYDOSMEPO-UHFFFAOYSA-N 3-prop-2-enoxyprop-1-ene Chemical compound C=CCOCC=C ATVJXMYDOSMEPO-UHFFFAOYSA-N 0.000 description 1
- NEAHVGRDHLQWPP-UHFFFAOYSA-N 3-propoxycarbonylbut-3-enoic acid Chemical compound CCCOC(=O)C(=C)CC(O)=O NEAHVGRDHLQWPP-UHFFFAOYSA-N 0.000 description 1
- OZAIFHULBGXAKX-VAWYXSNFSA-N AIBN Substances N#CC(C)(C)\N=N\C(C)(C)C#N OZAIFHULBGXAKX-VAWYXSNFSA-N 0.000 description 1
- OSDWBNJEKMUWAV-UHFFFAOYSA-N Allyl chloride Chemical compound ClCC=C OSDWBNJEKMUWAV-UHFFFAOYSA-N 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- APLOSQYEODQCSX-UHFFFAOYSA-N CC(=C)C(=O)OCC(CO)OC(=O)C(C)=CCC(O)CO Chemical compound CC(=C)C(=O)OCC(CO)OC(=O)C(C)=CCC(O)CO APLOSQYEODQCSX-UHFFFAOYSA-N 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 239000004641 Diallyl-phthalate Substances 0.000 description 1
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical compound CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- KPPNYLNUTNTHER-UHFFFAOYSA-N [2-methyl-2-(2-methylpropyl)-1,3-dioxolan-4-yl]methyl 2-methylprop-2-enoate Chemical compound CC(C)CC1(C)OCC(COC(=O)C(C)=C)O1 KPPNYLNUTNTHER-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000003377 acid catalyst Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
- 229910001863 barium hydroxide Inorganic materials 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- QUDWYFHPNIMBFC-UHFFFAOYSA-N bis(prop-2-enyl) benzene-1,2-dicarboxylate Chemical compound C=CCOC(=O)C1=CC=CC=C1C(=O)OCC=C QUDWYFHPNIMBFC-UHFFFAOYSA-N 0.000 description 1
- 238000012662 bulk polymerization Methods 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- OIWOHHBRDFKZNC-UHFFFAOYSA-N cyclohexyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC1CCCCC1 OIWOHHBRDFKZNC-UHFFFAOYSA-N 0.000 description 1
- KBLWLMPSVYBVDK-UHFFFAOYSA-N cyclohexyl prop-2-enoate Chemical compound C=CC(=O)OC1CCCCC1 KBLWLMPSVYBVDK-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- GTBGXKPAKVYEKJ-UHFFFAOYSA-N decyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCOC(=O)C(C)=C GTBGXKPAKVYEKJ-UHFFFAOYSA-N 0.000 description 1
- FWLDHHJLVGRRHD-UHFFFAOYSA-N decyl prop-2-enoate Chemical compound CCCCCCCCCCOC(=O)C=C FWLDHHJLVGRRHD-UHFFFAOYSA-N 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 1
- 125000004990 dihydroxyalkyl group Chemical group 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- FFYWKOUKJFCBAM-UHFFFAOYSA-N ethenyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC=C FFYWKOUKJFCBAM-UHFFFAOYSA-N 0.000 description 1
- BLCTWBJQROOONQ-UHFFFAOYSA-N ethenyl prop-2-enoate Chemical compound C=COC(=O)C=C BLCTWBJQROOONQ-UHFFFAOYSA-N 0.000 description 1
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N glyceric acid Chemical compound OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
- PBOSTUDLECTMNL-UHFFFAOYSA-N lauryl acrylate Chemical compound CCCCCCCCCCCCOC(=O)C=C PBOSTUDLECTMNL-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- NZIDBRBFGPQCRY-UHFFFAOYSA-N octyl 2-methylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C(C)=C NZIDBRBFGPQCRY-UHFFFAOYSA-N 0.000 description 1
- 229940065472 octyl acrylate Drugs 0.000 description 1
- ANISOHQJBAQUQP-UHFFFAOYSA-N octyl prop-2-enoate Chemical compound CCCCCCCCOC(=O)C=C ANISOHQJBAQUQP-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- GYDSPAVLTMAXHT-UHFFFAOYSA-N pentyl 2-methylprop-2-enoate Chemical compound CCCCCOC(=O)C(C)=C GYDSPAVLTMAXHT-UHFFFAOYSA-N 0.000 description 1
- ULDDEWDFUNBUCM-UHFFFAOYSA-N pentyl prop-2-enoate Chemical compound CCCCCOC(=O)C=C ULDDEWDFUNBUCM-UHFFFAOYSA-N 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pentâ4âenâ2âone Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- QTECDUFMBMSHKR-UHFFFAOYSA-N prop-2-enyl prop-2-enoate Chemical compound C=CCOC(=O)C=C QTECDUFMBMSHKR-UHFFFAOYSA-N 0.000 description 1
- ZHDCHCTZRODSEN-HWKANZROSA-N propyl (e)-but-2-enoate Chemical compound CCCOC(=O)\C=C\C ZHDCHCTZRODSEN-HWKANZROSA-N 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 201000003826 superficial keratitis Diseases 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
- KRLHYNPADOCLAJ-UHFFFAOYSA-N undecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCOC(=O)C(C)=C KRLHYNPADOCLAJ-UHFFFAOYSA-N 0.000 description 1
- RRLMGCBZYFFRED-UHFFFAOYSA-N undecyl prop-2-enoate Chemical compound CCCCCCCCCCCOC(=O)C=C RRLMGCBZYFFRED-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Description
æ¬çºæã¯æ°èŠãªå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããã³
ãã®è£œé æ³ã«é¢ããã åŸæ¥ããçš®ã ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãç¥ã
ããŠããããªãã§ãïŒâããããã·ãšãã«ã¡ã¿ã¯
ãªã¬ãŒããäž»åæãšããå«æ°Žç30ã40ïŒ ïŒéé
ïŒ ã以äžåæ§ïŒã®ãã®ããã€ãšãåºãæ®åããŠã
ãã ããããªããããã®çš®ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºã¯ç®ã®è§èã®ççäžå¿ èŠãšãããé žçŽ éã«å¯Ÿã
ãŠã¯å åãªééæ§ãæããŠããªããããïŒæ¥ãã
ãçŽ16æéã®è£ çšãé床ãšãããŠããããã®é床
ãè¶ ããè£ çšã¯è§èã®çµç¹é害ãæ¹èµ·ããèŠå ãš
ãªãå±éºã§ããã ãã®ãããå«æ°Žçãé«ããã³ã³ã¿ã¯ãã¬ã³ãºæ
質äžã«å«æµžãããå€éã®æ°Žåãä»ããŠè§èã®çç
äžå¿ èŠãªé žçŽ éã倧æ°äžããè§èã«äŸçµŠãããç®
çã§ãçš®ã ã®é«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã®ç 究ã
掻çºã«è¡ãªãããŠãããé«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºçšçŽ æãšããŠãã€ãšãäžè¬çãªãã®ã¯ãâã
ãã«ãããªãã³ãäž»æåãšãããããšã¡ã¿ã¯ãªã¬
ãŒãååç©ãããšãã°ã¡ãã«ã¡ã¿ã¯ãªã¬ãŒããªã©
ã®ã¢ã«ãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâããããã·ãšã
ã«ã¡ã¿ã¯ãªã¬ãŒããªã©ãå ±éåãããŠããããå ±
éåäœã§ããããããã®å ±éåäœã¯éåžžçŽ50ã80
ïŒ ã®å«æ°ŽèœåãæããŠããããããã€ãŠãããã
ã®é«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã®å€ãã¯è§èã®å¿ èŠ
ãšããé žçŽ éã倧æ°äžããã¬ã³ãºæ質äžã«å«æµžã
ããæ°ŽåãéããŠè§èã«äŸçµŠããããšãå¯èœã§ã
ãã ããããé«å«æ°Žçã®ããããããã®ã³ã³ã¿ã¯ã
ã¬ã³ãºã¯æ質匷床ã®äœäžãã¬ã³ãºã®èŠæ Œåœ¢ç¶ã®äž
å®å®æ§ãªã©ã®æ¬ ç¹ãæããŠãããå åã«æ®åãã
ã«ã¯è³ã€ãŠããªãããŸãããããâããã«ãã
ãªãã³ãäž»åæãšããé«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãº
ãç®ã«è£ çšããã°ãããã³ãŸãæ§ã®è¡šå±€è§èçã
å€çºããåŸåãããããã®äºå®ãé«å«æ°Žæ§ã³ã³ã¿
ã¯ãã¬ã³ãºã®æ®åãé»ã倧ããªåå ãšãªã€ãŠã
ãã ãã®ããã«ãã³ã³ã¿ã¯ãã¬ã³ãºæ質ã®é žçŽ éé
æ§ã¯ãé·æéã®é£ç¶è£ çšãå¯èœãªå«æ°Žã³ã³ã¿ã¯ã
ã¬ã³ãºãæäŸããããã§å¿ èŠæ¡ä»¶ããããŠãå å
æ¡ä»¶ããããªãã®ã§ããã é·æéã®é£ç¶è£ çšãå¯èœãªå«æ°Žæ§ã³ã³ã¿ã¯ãã¬
ã³ãºãæäŸããããã§ãã¬ã³ãºçŽ æã®é žçŽ ééæ§
ã«å ããŠãã¬ã³ãºçŽ æã®çŒçµç¹ããšãã«è§èçµç¹
ã«å¯Ÿãã芪åæ§ã倧ããªèŠçŽ ãšãªãããšãç¥ãã
ãŠãããããããªãããã¬ã³ãºçŽ æã®çŒçµç¹ã«å¯Ÿ
ãã芪åæ§ã確èªããæ¹æ³ãšããŠäžå®ã®åºæºãã
ãããã§ã¯ãªãããã®ããšãããé«ãå«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºã®éçºãäžå±€å°é£ã«ããŠããã æ¬çºæè ãã¯çŒçµç¹ã«å¯Ÿãã芪åæ§ã«ãããã
é·æéã®é£ç¶è£ çšãå¯èœãªå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºãéçºãã¹ãçš®ã ç 究ãéããçµæãã±ã¿ãŒã«
åãããç³ã¢ã«ã³ãŒã«ãæããåéäœã芪氎æ§å
éäœãçæ°Žæ§åéäœãªã©ã®ä»ã®å ±éåæ§åéäœãš
å ±éåãããã€ãã§ã±ã¿ãŒã«åºãæ°Žé žåºã«å€æã
ã¹ããããããå ±éåäœãé žåŠçãããã®ã¯å«æ°Ž
æ§ã³ã³ã¿ã¯ãã¬ã³ãºã®æ質ãšããŠããããç¹æ§ã
æããããšãèŠãã ããæ¬çºæãå®æããã«ãã
ã€ãã ããªãã¡ãæ¬çºæã¯ã±ã¿ãŒã«åãããç³ã¢ã«ã³
ãŒã«ãæããåéäœã芪氎æ§åéäœããã³ïŒãŸã
ã¯ïŒçæ°Žæ§åéäœãäž»æåãšããå ±éåäœãé žåŠ
çããŠãããããã®ãæ質ãšããå«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºããã³(A)åèšå ±éåäœãæ質ãšããã³ã³
ã¿ã¯ãã¬ã³ãºãæ圢ããã€ãã§ãããé žåŠçãã
(B)ããããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºå ã«å«æµžããŠ
ããåèšé žãæ°ŽãŸãã¯ççé£å¡©æ°Žã§çœ®æããããš
ãç¹åŸŽãšããåèšå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã®è£œé
æ³ãæäŸãããã®ã§ããã å è¡æè¡ã¯ãžããããã·ã¢ã«ãã«ïŒã¡ã¿ïŒã¢ã¯
ãªã¬ãŒãããšãããã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ïŒïŒïŒïŒâãžããããã·ãããã«ã¡ã¿ã¯ãªã¬ãŒ
ãïŒãçš®ã ã®å ±éåæ§åéäœãšå ±éåãããŠå«æ°Ž
æ§ã³ã³ã¿ã¯ãã¬ã³ãºçšçŽ æãããããšãæããŠã
ãã ããªãã¡ãç±³åœç¹èš±ç¬¬3957362å·æ现æžã¯äžèš
ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããšã¡ãã«ã¡ã¿ã¯ãªã¬
ãŒããªã©ã®ã¢ã«ãã«ã¡ã¿ã¯ãªã¬ãŒããšã®å ±éåäœ
ã«ã€ããŠé瀺ããç±³åœç¹èš±ç¬¬4056496å·æ现æžã¯
äžèšã®çµæã«ããã«å°éã®æ°Žäžæº¶æ§ãšããã·åã¢
ã«ãã«ã¡ã¿ã¯ãªã¬ãŒããå ããçµæãããªãå ±é
åäœã«ã€ããŠé瀺ãããŸãç±³åœç¹èš±ç¬¬4267295å·
æ现æžã¯ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããã¢ã«ãã«
ã¡ã¿ã¯ãªã¬ãŒãããã³ïŒâããããã·ãšãã«ã¢ã¯
ãªã¬ãŒããªã©ã®èŠªæ°Žæ§åéäœãäž»æåãšããå ±é
åäœã«ã€ããŠé瀺ããŠããã ããããªããããããã®å è¡ç¹èš±æç®ã«é瀺ã
ããå ±éåäœã¯å«æ°Žçã«ãããŠãåŸæ¥ã®ïŒâãã
ããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããäž»æåãšããå ±é
åäœã®å«æ°ŽççŽ30ã40ïŒ ã«æ¯ã¹ãŠåçãããã¯ã
ãé«ãçšåºŠã§ããããã®çšåºŠã®å«æ°Žçã§ã¯è§èã®
æ°é³ä»£è¬ã«å¿ èŠãªé žçŽ éã倧æ°äžããã¬ã³ãºæ質
äžã«å«æµžãããæ°Žåãä»ããŠè§èã«äŸçµŠããããš
ã¯äžå¯èœã§ããã ããªãã¡ãåèšã®å è¡æè¡ã«ãããŠã¯äž»æåã§
ããã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒãã®åææ¹æ³ãšã
ãŠãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãã®å æ°Žå解ãšã€ãœ
ããããªãã³ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒãã®å æ°Ž
å解ãšãé瀺ãããŠãããããã®ãã¡åè ã®æ¹æ³
ã«ãã€ãã°ããã¯åæã§ããã°ãªã·ãžã«ã¡ã¿ã¯ãª
ã¬ãŒããç®ççæç©ã§ããã°ãªã»ããŒã«ã¡ã¿ã¯ãª
ã¬ãŒãäžã«äžå¯é¿çã«åŸ®éæ®åãããããå ±éå
åå¿ã«éãæ¶æ©æ©èœãæããã»ããã°ãªã»ããŒã«
ã¡ã¿ã¯ãªã¬ãŒãã®åŽéã®æ°Žé žåºéã§ãšãŒãã«çµå
ã圢æãããããããããããå ±éåäœã®æ¶æ©å¯
床ãé«ããªããçµæçã«å«æ°Žçã®åäžãæå¶ãã
ãããšã«ãªãããŸããåŸè ã®æ¹æ³ã«ãã€ãŠã°ãªã»
ããŒã«ã¡ã¿ã¯ãªã¬ãŒããããã°ããã«ãããŠãã
äžèšãšãŒãã«çµåã®åœ¢æã«ãã€ãŠåæ§ã«å«æ°Žçã®
åäžãæå¶ãããããšã«ãªããçµå±ãããã®å è¡
æè¡ã«ãããŠã¯ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããäž»
æåãšããã³ã³ã¿ã¯ãã¬ã³ãºçšå ±éåäœã«ãã
ãŠãé·æéã®é£ç¶è£ çšãå¯èœãšããã«å åãªé žçŽ
ééæ§ãæããã³ã³ã¿ã¯ãã¬ã³ãºçšå ±éåäœãã
ãããšã¯å°é£ã§ãã€ãã æ¬çºæã®æ¹æ³ã«ãããŠã¯ãåèšã®ãšããã°ãªã»
ããŒã«ã¡ã¿ã¯ãªã¬ãŒãçç³ã¢ã«ã³ãŒã«ãæããå
éäœã®æ°Žé žåºããããããã±ã¿ãŒã«åããããšã«
ããä¿è·ããŠããããã®ããã§è©²åéäœãä»ã®å ±
éåæ§åéäœãšå ±éåãããŠããããå ±éåäœã
ããææã®åœ¢ç¶ãæããã³ã³ã¿ã¯ãã¬ã³ãºãæ圢
ããããããã³ã³ã¿ã¯ãã¬ã³ãºãé žåŠçããŠè±ã±
ã¿ãŒã«ååå¿ãçèµ·ããããããšã«ããè©²å ±éå
äœäžã®ã±ã¿ãŒã«åºãæ°Žé žåºã«å€æããããšããæ¹
æ³ã«ãã€ãŠç³ã¢ã«ã³ãŒã«ãæããåéäœãå¿ é æ§
ææåãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã補é ãã
ãã®ã§ãããããåèšã®å è¡æè¡ã«ã¿ããããã
ãªå ±éåäœåå¿æã«ããããšãŒãã«çµåã®åœ¢æç
ã«ããæ¶æ©å¯åºŠã®å¢å ãé²æ¢ããããšãã§ããã
ã®çµæãé«å«æ°Žçã§ãããã³ã³ã¿ã¯ãã¬ã³ãºçšæ
質ãšããŠæãŸããç¹æ§ãæããå ±éåäœã容æã«
ããããšãã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšãããã±ã¿ãŒã«åãã
ãç³ã¢ã«ã³ãŒã«ãæããåéäœãšããŠã¯ããŸãã±
ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãšã¢ã¯ãªã«é žãã¡ã¿
ã¯ãªã«é žã®ãããªéåæ§ã«ã«ãã³é žãŸãã¯ã¢ãªã«
ã¢ã«ã³ãŒã«ã®ãããªéåæ§ã¢ã«ã³ãŒã«ãšã®ãšã¹ã
ã«ååç©ãŸãã¯ãšãŒãã«ååç©ãããããããã
ã®ãããªååç©ã®å ·äœäŸããããã°ããšãã°ã€ã
ã®ãããªãã®ã§ããã ïŒïŒïŒââã€ãœããããªãã³ã°ãªã»ããŒã«ã¡
ã¿ã¯ãªã¬ãŒãïŒIPGMAïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâãšãã«âïŒâã¡ã¿ã¯ãªã«ãªãã·
ã¡ãã«âïŒïŒïŒâãžãªããœã©ã³ïŒMEMAïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâã€ãœããã«âïŒâã¡ã¿ã¯ãªã«ãª
ãã·ã¡ãã«âïŒïŒïŒâãžãªããœã©ã³ïŒMBMAïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâããšãã«âïŒâã¡ã¿ã¯ãªã«ãªã
ã·ã¡ãã«âïŒïŒïŒâãžãªããœã©ã³ïŒMPMAïŒ ïŒâã¡ã¿ã¯ãªã«ãªãã·ã¡ãã«âã¹ãããïŒïŒïŒã
âïŒïŒïŒâãžãªããµãã«ã³ïŒïŒâMSDDïŒ ïŒæ§é åŒïŒ ïŒïŒïŒïŒïŒïŒïŒâãžâïŒïŒ¯âã€ãœããããªãã³ïŒ
ãã·ãªããŒã«âïŒâã¡ã¿ã¯ãªã¬ãŒãïŒïŒâ
MDIXïŒ ïŒæ§é åŒïŒ ãããã®ååç©ã¯ãããšãã°äžè¬åŒïŒïŒ©ïŒïŒ ïŒåŒäžãïœã¯ïŒãïŒã®æŽæ°ãè¡šããïŒã§è¡šãã
ããç³ã¢ã«ã³ãŒã«ãã¢ã»ãã³ãã¡ãã«ãšãã«ã±ã
ã³ãã·ã¯ããããµãã³ãã¢ã»ãããšãã³ãã¡ãã«
ã€ãœããã«ã±ãã³ãªã©ã®ã±ãã³ååç©ã§ã±ã¿ãŒã«
åããããããã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«
ããã¡ã¿ã¯ãªã«é žãã©ã€ããŸãã¯ã¢ã¯ãªã«é žãã©
ã€ããšåå¿ãããæ®ãã®æ°Žé žåºã«éåæ§åºãå°å ¥
ããããšã«ããããããããã®éããšãã«åèšã®
äžè¬åŒïŒïŒäžã®ïœãïŒãŸãã¯ïŒã®ç³ã¢ã«ã³ãŒã«
ãçšããã°åå¿ã容æã«é²è¡ãããããšãã§ã
ãããŸããã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒããçŽæ¥ãå
èšããã¢ã»ãã³ãã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ã
ã³ååç©ãšåå¿ãããããšã«ããIPGMAïŒ
MEMAãïŒâMSDDãªã©ã®ã±ã¿ãŒã«åã°ãªã»ã
ãŒã«ã®ã¡ã¿ã¯ãªã¬ãŒããåæããããšãå¯èœã§ã
ãããã®æ¹æ³ã«ã€ããŠã¯æ¬çºæè ããç¹é¡æ56â
106117å·æ现æžã«è©³èª¬ãããšããã§ããã ããã«æ¬çºæã®æ¹æ³ã«ãããŠã¯ãã€ãã®ã±ã¿ãŒ
ã«åãããã°ãªã»ããŒã«ãšãŒãã«ãã±ã¿ãŒã«åã
ããç³ã¢ã«ã³ãŒã«ãæããåéäœã®ïŒã€ãšããŠæ
å¹ã«çšããããšãã§ããã ã¢ãªã«ã€ãœããããªãã³ã°ãªã»ããŒã«ãšãŒãã«
ïŒALIPGïŒ ïŒæ§é åŒïŒ ïŒâã¢ãªã«ãªãã·âïŒâã¡ãã«âïŒâãšãã«â
ïŒïŒïŒâãžãªããœã©ã³ïŒALMEïŒ ïŒæ§é åŒïŒ ïŒâã¢ãªã«ãªãã·ã¡ãã¬ã³âã¹ãããïŒïŒïŒãâ
ïŒïŒïŒâãžãªããµãã«ã³ïŒALCHïŒ ïŒæ§é åŒïŒ ãããã®ãšãŒãã«ååç©ã¯ã°ãªã»ãªã³ãªã©ã®å
èšäžè¬åŒïŒïŒã§è¡šããããç³ã¢ã«ã³ãŒã«ãçš®ã
ã®ã±ãã³ã«ãã€ãŠã±ã¿ãŒã«åããã®ã¡ãã¢ãªã«ã¯
ãã©ã€ããšåå¿ãããå ¬ç¥ã®åææ¹æ³ã«ãã€ãŠã
ãããšãã§ããã»ããããšãã°ã¢ãªã«ã°ãªã·ãžã«
ãšãŒãã«ãšåçš®ã±ãã³ååç©ãšãé žè§Šåªã®ååšäž
ã§åå¿ãããããšã«ããçŽæ¥çã«åæããããšã
å¯èœã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšããããã±ã¿ãŒã«åã
ããç³ã¢ã«ã³ãŒã«ãæããåéäœã®ã»ãã®äŸãšã
ãŠã¯ãããšãã°ã€ãã®ïœâãžãªããµã³èªå°äœåã®
ã¡ã¿ã¯ãªã¬ãŒããŸãã¯ã¢ã¯ãªã¬ãŒããªã©ãããã
ããšãã§ããã ïŒïŒïŒâãžã¡ãã«âïŒâã¡ã¿ã¯ãªãã€ã«ãªãã·
âïŒïŒïŒâãžãªããµã³ïŒDMDOïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâãšãã«âïŒâã¡ã¿ã¯ãªãã€ã«â
ïœâãžãªããµã³ïŒMEDOïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâã€ãœããã«âïŒâã¡ã¿ã¯ãªãã€
ã«âïœâãžãªããµã³ïŒMBDOïŒ ïŒæ§é åŒïŒ ïŒâã¡ã¿ã¯ãªãã€ã«ãªãã·âã¹ãããïŒïŒïŒãâ
ïŒïŒïŒâãžãªããµãŠã³ãã«ã³ïŒMSDOïŒ ïŒæ§é åŒïŒ ãããã®ååç©ã¯ãã¹ãŠæ°èŠãªååç©ã§ããã
éåžžåèšã®ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãããçš®ã ã®
ã±ã¿ãŒã«åã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããåæã
ãéçšã«ãããŠå¯çæç©ãšããŠããããšãã§ã
ãã ãªããåèšããçš®ã ã®ã±ã¿ãŒã«åãããç³ã¢ã«
ã³ãŒã«ãæããåéäœã«ãããŠãšã¹ãã«ååç©ã«
ã€ããŠã¯ããã¹ãŠã¡ã¿ã¯ãªã¬ãŒãååç©ãäŸç€ºã
ããããããã«å¯Ÿå¿ããã¢ã¯ãªã¬ãŒãååç©ãæ¬
çºæã®æ¹æ³ã«ãããŠçšããããšãã§ããã ãããåçš®ã®ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ã
æããåéäœã¯åç¬ã§ããŸãã¯ïŒçš®ä»¥äžãæ··åã
ãŠçšããããããåèšã®ALIPGïŒALMEïŒ
ALCHãªã©ã®ã±ã¿ãŒã«åãããã°ãªã»ããŒã«ã®ã¢
ãªã«ãšãŒãã«ã«ã€ããŠã¯ãè±ã±ã¿ãŒã«åãããã®
ã¡ã®å«æ°Žèœåãæ¯èŒçäœãããä»ã®è©²ç³ã¢ã«ã³ãŒ
ã«ãæããåéäœãšäœµçšããããšãæãŸããããŸ
ããåèšã®DMDOïŒMEDOïŒMBDOïŒMSDOãª
ã©ã®ïœâãžãªããµã³èªå°äœåã®ã¡ã¿ã¯ãªã¬ãŒããŸ
ãã¯ã¢ã¯ãªã¬ãŒãã«ã€ããŠã¯ãããããã°ãªã·ãž
ã«ã¡ã¿ã¯ãªã¬ãŒãããIPGMAïŒMEMAïŒ
MBMAãïŒâMSDDãçŽæ¥çã«åæããéã«å¯
çæç©ãšããŠçæãããã®ã§ããããããã®çŽåºŠ
ãé«ããããã«ã¯èžçãç¹°ãè¿ããã°ãªãããå
éãæžå°ããå·¥æ¥çã«äžå©ã§ããã®ã§ããããã«
ã€ããŠã¯ãããã察å¿ããäž»çæç©ã§ãã該ç³ã¢
ã«ã³ãŒã«ãæããåéäœãšã®æ··åç©ã®ç¶æ ã§çšã
ãããšãçŸå®çã§ããã ããã«ãæ¬çºæã®æ¹æ³ã§çšããã±ã¿ãŒã«åãã
ãç³ã¢ã«ã³ãŒã«ãæããåéäœã®äžéšããããšã
ã°ïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããªãã³â
ïŒââã¡ã¿ã¯ãªãã€ã«ââã°ã«ã³ãã©ãã·ã
ïŒå¥åïŒïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããª
ãã³âïŒââã¡ã¿ã¯ãªãã€ã«ââã°ã«ã³ãŒ
ã¹ïŒãïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããªã
ã³âïŒââã¡ã¿ã¯ãªãã€ã«ââã¬ã©ã¯ããã©
ãã·ãïŒå¥åïŒïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœã
ãããªãã³âïŒââã¡ã¿ã¯ãªãã€ã«ââã¬ã©
ã¯ããŒã¹ïŒãïŒââã¡ã¿ã¯ãªãã€ã«âïŒïŒïŒïŒ
ïŒïŒïŒâãžââã€ãœããããªãã³ââãã³ã
ãã©ãã·ãïŒå¥åïŒïŒââã¡ã¿ã¯ãªãã€ã«â
ïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããªãã³â
âãã³ããŒã¹ïŒã®ãããªç¹é¡æ56â3681å·æ现æž
äžã«é瀺ãããŠããåçš®ã®ã±ã¿ãŒã«åç³ã®ã¡ã¿ã¯
ãªã¬ãŒããŸãã¯ã¢ã¯ãªã¬ãŒãã§çœ®ãæããŠãåç
ã®å¹æãéæããããšãã§ããã 以äžæ¬çºæã®æ¹æ³ã§çšããã±ã¿ãŒã«åãããç³
ã¢ã«ã³ãŒã«ãæããåéäœã«ã€ããŠè©³çŽ°ã«èª¬æã
ããã該åéäœã¯ä»ã®çš®ã ã®åéäœãšå ±éåãå¯
èœã§ãããããã以äžã«è©³èª¬ãã芪氎æ§åéäœã
ãã³çæ°Žæ§åéäœã®å°ãªããšãïŒçš®ãšå ±éåãã
ãããšã«ãããæ¬çºæã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãº
çšã®çŽ æã調補ããããšãã§ããã 芪氎æ§åéäœã®æãŸãããã®ãšããŠã¯ãããšã
ã°ïŒâããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâã
ãããã·ãšãã«ã¢ã¯ãªã¬ãŒããïŒâããããã·ã
ããã«ã¡ã¿ã¯ãªã¬ãŒããïŒâããããã·ãããã«
ã¢ã¯ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã¿
ã¯ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¢ã¯ãª
ã¬ãŒããã¡ã¿ã¯ãªã«ã¢ãããã¢ã¯ãªã«ã¢ããããž
ã¡ãã«ã¡ã¿ã¯ãªã«ã¢ããããžã¡ãã«ã¢ã¯ãªã«ã¢ã
ããã¡ã¿ã¯ãªã«é žãã¢ã¯ãªã«é žãâããã«ãã
ãªãã³ãªã©ãããããããããã®ãã¡ããïŒçš®ãŸ
ãã¯ïŒçš®ä»¥äžãéžæããŠäœ¿çšããã ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåéäœ
ããããã®èŠªæ°Žæ§åéäœãšå ±éåããããããšã«
ãã€ãŠãããããå ±éåäœããæ圢ãããã³ã³ã¿
ã¯ãã¬ã³ãºãé žæ°Žæº¶æ¶²äžã«ãŠè±ã±ã¿ãŒã«åããŠã±
ã¿ãŒã«åºãæ°Žé žåºã«å€æããã«éããé žæº¶æ¶²ãã¬
ã³ãºçŽ æå ã«åäžãã€æå¹ã«æµžéããããææã®
è±ã±ã¿ãŒã«ååå¿ãå¹çããçèµ·ããããããšã
ã§ããããŸããããšãã°ïŒâããããã·ãšãã«ã¡
ã¿ã¯ãªã¬ãŒããïŒâããããã·ãããã«ã¡ã¿ã¯ãª
ã¬ãŒããªã©ãã®åç¬éåäœã®å«æ°Žèœåãæ¯èŒçäœ
ã芪氎æ§åéäœã®ã°ãããã±ã¿ãŒã«åãããç³ã¢
ã«ã³ãŒã«ãæããåéäœããããã®èŠªæ°Žæ§åéäœ
ãšå ±éåããããšã«ããããããæçµå«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºã®å«æ°ŽçãããçšåºŠå¶åŸ¡ããããšã
å¯èœã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšããããçæ°Žæ§åéäœ
ã®æãŸãããã®ãšããŠã¯ãããšãã°ã¡ãã«ã¡ã¿ã¯
ãªã¬ãŒããã¡ãã«ã¢ã¯ãªã¬ãŒãããšãã«ã¡ã¿ã¯ãª
ã¬ãŒãããšãã«ã¢ã¯ãªã¬ãŒããããã«ã¡ã¿ã¯ãªã¬
ãŒããããã«ã¢ã¯ãªã¬ãŒããã¢ãã«ã¡ã¿ã¯ãªã¬ãŒ
ããã¢ãã«ã¢ã¯ãªã¬ãŒããã·ã¯ãããã·ã«ã¡ã¿ã¯
ãªã¬ãŒããã·ã¯ãããã·ã«ã¢ã¯ãªã¬ãŒãããªã¯ã
ã«ã¡ã¿ã¯ãªã¬ãŒãããªã¯ãã«ã¢ã¯ãªã¬ãŒãããã·
ã«ã¡ã¿ã¯ãªã¬ãŒãããã·ã«ã¢ã¯ãªã¬ãŒãããŠã³ã
ã·ã«ã¡ã¿ã¯ãªã¬ãŒãããŠã³ãã·ã«ã¢ã¯ãªã¬ãŒãã
ã©ãŠãªã«ã¡ã¿ã¯ãªã¬ãŒããã©ãŠãªã«ã¢ã¯ãªã¬ãŒã
ãªã©ã®ã¡ã¿ã¯ãªã«é žãŸãã¯ã¢ã¯ãªã«é žã®ã¢ã«ãã«
ãšã¹ãã«ïŒãã ããã¢ã«ãã«åºã®ççŽ æ°ïŒã15
åïŒãã¡ã¿ã¯ãªã«é žãŸãã¯ã¢ã¯ãªã«é žã®ããã«ãš
ã¹ãã«ãã¡ã¿ã¯ãªã«é žãŸãã¯ã¢ã¯ãªã«é žã®ã¢ãªã«
ãšã¹ãã«ãã€ã¿ã³ã³é žãããã«ãã¯ããã³é žãã
ãã«ãªã©ã®ã€ã¿ã³ã³é žãŸãã¯ã¯ããã³é žã®ã¢ã«ã
ã«ãšã¹ãã«ãé ¢é žããã«ãããããªã³é žããã«ãª
ã©ã®èèªæã«ã«ãã³é žã®ããã«ãšã¹ãã«ãã¹ãã¬
ã³ãã¢ã¯ãªããããªã«ãªã©ãããããããããã®
ãã¡ããïŒçš®ãŸãã¯ïŒçš®ä»¥äžãéžæããŠäœ¿çšã
ããçæ°Žæ§åéäœã®äœ¿çšã¯ãããããå«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºçšæ質ã®å«æ°Žçãå¶åŸ¡ãã匷床ãé«
ãã補åã®èä¹ æ§ãåäžãããç®çã«æå¹ã§ã
ãã åèšã®çæ°Žæ§åéäœã®ãã¡ã¡ã¿ã¯ãªã«é žã®ã¢ã«
ãã«ãšã¹ãã«ãããã«ãšã¹ãã«ãã¢ãªã«ãšã¹ãã«
ãªã©ã¡ã¿ã¯ãªã«é žã®åçš®ãšã¹ãã«é¡ãäžè¿°ã®ç®ç
ã«å¯ŸããŠãšãã«æå¹ã§ããã æ¬çºæã®æ¹æ³ã«ãããã±ã¿ãŒã«åãããç³ã¢ã«
ã³ãŒã«ãæããåéäœã®äœ¿çšéã¯ã該ç³ã¢ã«ã³ãŒ
ã«ãæããåéäœãšåèšèŠªæ°Žæ§åéäœããã³ïŒãŸ
ãã¯ïŒåèšçæ°Žæ§åéäœã®äœ¿çšéã®åèš100éš
ïŒéééšã以äžåæ§ïŒäžïŒã97éšã奜ãŸããã¯20
ã85éšãããã«å¥œãŸããã¯40ã80éšã®ç¯å²ãšãã
ã®ãæãŸããã該ç³ã¢ã«ã³ãŒã«ãæããåéäœã¯
芪氎æ§åéäœããã³çæ°Žæ§åéäœã®å°ãªããšãïŒ
çš®ãšå ±éåããããã芪氎æ§åéäœã䜿çšããã°
ããããã®äœ¿çšéã¯ãåèšåéäœã®äœ¿çšéã®åèš
100éšäžïŒã95éšã奜ãŸããã¯15ã80éšãããã«
奜ãŸããã¯20ã60éšã®ç¯å²ã§ããããŸãçæ°Žæ§å
éäœã䜿çšããã°ããããã®äœ¿çšéã¯ïŒã40éšã
奜ãŸããã¯ïŒã20éšãããã«å¥œãŸããã¯ïŒã12éš
ã®ç¯å²ãšããã®ãé©åœã§ããã該ç³ã¢ã«ã³ãŒã«ã
æããåéäœã®äœ¿çšéã97éšããå€ãã°ããã¯ã
ããããã³ã³ã¿ã¯ãã¬ã³ãºã®åŒ·åºŠã匱ããªãããŸ
ãïŒéšããå°ãªãã°ããã¯ããã®äœ¿çšå¹æã®çºçŸ
ã«ä¹ãããããã®ã°ããã奜ãŸãããªãããŸãã
芪氎æ§åéäœã®äœ¿çšéã95éšããå€ãã°ããã¯ã
該ç³ã¢ã«ã³ãŒã«ãæããåéäœã®äœ¿çšå¹æã®çºçŸ
ã«ä¹ãããªããçæ°Žæ§åéäœã®äœ¿çšéã40éšãã
å€ãã°ããã¯ãé žåŠçã«ããè±ã±ã¿ãŒã«ååå¿ã
åæ»ã«é²è¡ãã«ãããªãã ãªããåèšããçæ°Žæ§åéäœã®ãã¡ã¡ã¿ã¯ãªã«
é žãŸãã¯ã¢ã¯ãªã«é žã®ããã«ãšã¹ãã«ãã¢ãªã«ãš
ã¹ãã«ã«ã€ããŠã¯ãåŸèšããæ¶æ©æ§åéäœãšããŠ
ã®æ©èœãåããŠããããããã®äœ¿çšéã¯ïŒéšä»¥äž
ãšããããšãæãŸããã äžèšïŒçš®ã®åéäœã¯ããããã®åéäœã®ãã¡äœ¿
çšããåéäœã®åèšéã100éšãšãªãããã«ãã
ããã®åéäœã«å¯Ÿããäžèšç¯å²ããé©å®éžæããŠ
䜿çšãããã ããã«æ¬çºæã®æ¹æ³ã«ãããŠã¯ãããããã³ã³
ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ãå®å®ããè溶åªæ§ãåäžã
ãããªã©ã®èŠ³ç¹ãããå¿ èŠã«å¿ããŠéåå¯èœãªå®
èœåºãïŒå以äžæããæ¶æ©æ§åéäœã䜿çšããŠã
ããããããæ¶æ©æ§åéäœãšããŠã¯ãããšãã°ãš
ãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒãããšãã¬ã³ã°
ãªã³ãŒã«ãžã¢ã¯ãªã¬ãŒãããžãšãã¬ã³ã°ãªã³ãŒã«
ãžã¡ã¿ã¯ãªã¬ãŒãããžãšãã¬ã³ã°ãªã³ãŒã«ãžã¢ã¯
ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬
ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¢ã¯ãªã¬ãŒãã
ããã«ã¡ã¿ã¯ãªã¬ãŒããããã«ã¢ã¯ãªã¬ãŒããã¢
ãªã«ã¡ã¿ã¯ãªã¬ãŒããã¢ãªã«ã¢ã¯ãªã¬ãŒãããžã
ãã«ãã³ãŒã³ããžã¢ãªã«ãã¿ã¬ãŒããããªã¡ãã
ãŒã«ãããã³ããªã¡ã¿ã¯ãªã¬ãŒããªã©ãããã
ãããããã®ãã¡ããïŒçš®ãŸãã¯ïŒçš®ä»¥äžãéžæ
ããŠäœ¿çšããããã®äœ¿çšéã¯äœ¿çšããåèšåéäœ
ã®åèšé100éšã«å¯ŸããŠ0.01ãïŒéšã®ç¯å²ã奜é©
ã§ããã åèšåéäœæ··åç©ã®éåã«éããŠã¯éåžžã®äžé£œ
åçåæ°ŽçŽ ååç©ã®éåã«äœ¿çšãããã©ãžã«ã«é
åéå§å€ã䜿çšã§ããããããã©ãžã«ã«éåéå§
å€ãšããŠã¯ãããšãã°ãã³ãŸã€ã«ããŒãªããµã€
ããã¢ãŸãã¹ã€ãœããããããªã«ãã¢ãŸãã¹ãžã¡
ãã«ãã¬ããããªã«ãªã©ãããããããããã®ã
ã¡ããïŒçš®ãŸãã¯ïŒçš®ä»¥äžãéžæããŠäœ¿çšããã
ãããéåéå§å€ã®äœ¿çšéã¯ãå ±éåãããã¹ã
å šåéäœæ··åç©100éšã«å¯ŸããŠçŽ0.01ãïŒéšã®ç¯
å²ã奜ãŸããã å ±éåã«éããæ°ŽãŸãã¯ãšãã¬ã³ã°ãªã³ãŒã«ã
ãããã¬ã³ã°ãªã³ãŒã«ãããã¬ã³ã°ãªã³ãŒã«ãã
ãªãšãã¬ã³ã°ãªã³ãŒã«ãããªãããã¬ã³ã°ãªã³ãŒ
ã«ãã°ãªã»ãªã³ãªã©ã®æ°Žæº¶æ§ã§éååå¿ã«å¯ŸããŠ
äžæŽ»æ§ãªç©è³ªã湿最å€ãšããŠåéäœæ··åç©äžã«çŽ
ïŒã45ïŒ ã®éã§ååšãããŠãããŠããããããã
湿最å€ã®äœ¿çšã¯å¿ é ã§ã¯ãªãããå ±éååå¿ãå¡
ç¶éåæ³ã«ãã湿最å€ã®ååšäžã§è¡ãªããšãã¯ã
湿最å€ãããããå ±éåäœäžã«å«æããããã
ããè±ã±ã¿ãŒã«åã®ããã®å ±éåäœã®é žåŠçã«ã
ãããŠæå¹ã§ãããããªãã¡ã湿最å€ã䜿çšãã
ããšã«ããã芪氎æ§åéäœã®äœ¿çšå²åãå°ããã°
ããããŸã€ãã䜿çšããªãã°ããã«ãããŠããã
ãããå ±éåäœããæ圢ãããã³ã³ã¿ã¯ãã¬ã³ãº
ãé žåŠçããå·¥çšã«ãããŠãã¬ã³ãºæ質äžã«å«æµž
ããã湿最å€ãä»ããŠé žæº¶æ¶²ãæå¹ã«æµžéããã
ãããšãã§ãããããè±ã±ã¿ãŒã«ååå¿ãå¹çã
ãè¡ãªããããããŸãããããã®æ¹¿æœ€å€ã䜿çšã
ãããšã«ãããããããå ±éåäœã«ç²ããäžãã
ååå å·¥çã«ãããæ©æ¢°å å·¥æ§ãåäžãããããš
ãã§ããã äžèšæ¹¿æœ€å€ã¯ãããšãã°é žåŠçåŸå«æ°Žæ§ã³ã³ã¿
ã¯ãã¬ã³ãºãã¢ã«ã«ãªæº¶æ¶²äžã§äžååŠçããã€ã
ã§æ°ŽãŸãã¯ççé£å¡©æ°Žã«æµžæŒ¬ããããã«ææã«ã
ãç ®æ²žåŠçããããšã«ãã容æã«ãããã®æ°ŽãŸã
ã¯ççé£å¡©æ°Žãšçœ®æããããšãã§ããã湿最å€ã®
䜿çšéã45ïŒ ãããå€ããããšãé žåŠçåŸã®ã¬ã³
ãºæ質ãçœæ¿ããŠå åŠæ§ãäœäžãããªã©ã®äžéœå
ãçãããããã奜ãŸãããªãã éåããã³ã³ã³ã¿ã¯ãã¬ã³ãºåœ¢ç¶ãžã®æ圢ã¯é
åžžã®éåæè¡ãæ圢æè¡ã§è¡ãªãããšãã§ããã
ããšãã°ãéåãã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«å¯Ÿå¿
ããåã®äžã§è¡ãªã€ãŠçŽæ¥ã³ã³ã¿ã¯ãã¬ã³ãºåœ¢ç¶
ã«æ圢ããããã«å¿ èŠã«å¿ããŠãããæ©æ¢°çã«ä»
äžãå å·¥ããããšãã§ããããŸãéåãé©åœãªå
ãŸãã¯å®¹åšäžã§è¡ãªã€ãŠãããã¯ç¶ãæ¿ç¶ãŸãã¯
äžžæ£ç¶ã®çŽ æãããã€ãã§ååãç 磚ãªã©ã®éåžž
ã®æ©æ¢°çå å·¥ã«ãã€ãŠææã®åœ¢ç¶ã®ã³ã³ã¿ã¯ãã¬
ã³ãºã«æ圢ããããšãã§ããã éåžžãé«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããæ©æ¢°
çå å·¥ã«ãã€ãŠæ圢ããã°ããããã®åŒ·ãåžæ°Žç¹
æ§ã®ããå å·¥ç°å¢ããšãã«æ¹¿åºŠã®å¶åŸ¡ã«å€å€§ãªæ³š
æãæããªããã°ãªããªãããšããããæ¬çºæã®
æ¹æ³ã«ãããšãã¯ãåèšã®ãšããçŽ æäžã®è©²ç³ã¢
ã«ã³ãŒã«ãæããåéäœã®æ°Žé žåºãã±ã¿ãŒã«åã«
ãã€ãŠãã¹ã¯ãããŠãããããçŽ æã®åžæ°Žç¹æ§ã¯
çžå¯Ÿçã«åŒ±ãããã®ããäžèšéåžžã®é«å«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºã®ã°ããã«ããããããšãå³æ Œãªæ¹¿
床å¶åŸ¡ã¯äžèŠã§ããããŸãã該ç³ã¢ã«ã³ãŒã«ãæ
ããåéäœãå ±éåæåãšããŠå«ãå ±éåäœãé ž
åŠçããããã«äžååŠçããã®ã¡åžæ°Žãããèšæœ€
ãããã°ããã®ç·èšæœ€çã¯éåžžã®å«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºçšçŽ æãåžæ°Žãããèšæœ€ãããã°ããã®
ç·èšæœ€çã«æ¯èŒããŠèããå°ããããã®äºå®ã¯ç®
çãšããèŠæ Œã圢ç¶ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã
éèšæœ€ç¶æ ã®çŽ æãã補é ããããã§ãã®ç確ç
ãé«ãããšãã芳ç¹ããããããŠæãŸããããšã§
ããã ããããŠæ圢ããã³ã³ã¿ã¯ãã¬ã³ãºãçš®ã ã®æ
æ©é žãŸãã¯ç¡æ©é žã§é žåŠçããããšã«ãããå ±é
åäœäžã®ã±ã¿ãŒã«åºãæ°Žé žåºã«å€æãããããšã
ã°ã€ãã®åå¿åŒã«ç€ºãããããã«ãã€ãœããããª
ãã³åºãå æ°Žå解ã«ãã€ãŠé€å»ããå ±éåäœã®èŠª
æ°Žåãè¡ãªãããã äžèšé žåŠçã«äœ¿çšãããé žãšããŠã¯ãããšãã°
å¡©é žãç¡«é žããªã³é žãé ¢é žãè»é žãããªãã«ãªã
é ¢é žãªã©ããããããã䜿çšããé žã®æ¿åºŠãé«ã
ã°ããã«ã¯ã¬ã³ãºæ質ã®å£åãæãããã¯ã©ãã¯
ãçãããããå±éºæ§ããããããé žåŠçã¯åŸã
ã«ãŸãã¯æ®µéçã«åŠç液ã®æ¿åºŠãé«ããŠè¡ãªãã®
ã奜ãŸãããé©åœãªé žæ¿åºŠããã³æµžæŒ¬æéã¯è¢«åŠ
çã¬ã³ãºã®æ質ã䜿çšããé žã®çš®é¡ã«ãã€ãŠç°ãª
ããäžæŠã«ã¯ãããªãããããšãã°å¡©é žã®ã°ãã
ã¯çŽïŒã20ïŒ æ¿åºŠã«ãããŠå®€æž©äžçŽïŒãïŒæéã
è»é žãŸãã¯é ¢é žã®ã°ããã¯çŽ30ã90ïŒ ã®æ¿åºŠã«ã
ããŠå®€æž©äžçŽïŒæéã20æ¥éãããªãã«ãªãé ¢é ž
ã®ã°ããã¯çŽ80ã90ïŒ ã®æ¿åºŠã«ãããŠå®€æž©äžçŽïŒ
ãïŒæéã®åŠçã奜é©ã§ããã被åŠçã¬ã³ãºã®æ
質äžã«èŠªæ°Žæ§åéäœãå ±éåãããŠããããã€æ¹¿
最å€ãå«æµžãããŠããªãã°ãããæ¥æ¿ãªè±ã±ã¿ãŒ
ã«ååå¿ã®å±èµ·ã¯ã³ã³ã¿ã¯ãã¬ã³ãºã«ã¯ã©ãã¯ã
çããããããããšãã«é žåŠçãåŸã ã«ãŸãã¯æ®µ
éçã«åŠç液ã®é žæ¿åºŠãé«ããŠè¡ãªãã®ã奜ãŸã
ãããã®ã°ãããããšãã°æåçŽïŒïŒ çšåºŠã®äœæ¿
床ã®é žæ°Žæº¶æ¶²äžã«æ°æéãæ°æ¥éã³ã³ã¿ã¯ãã¬ã³
ãºã浞挬ããã€ãã§é«æ¿åºŠé žæ°Žæº¶æ¶²äžã«ç§»ããã
ãŠé žåŠçãè¡ãªãããã äžèšé žåŠçã«ããåå¿ã¯æšæºåŠçæ¹æ³ããã³æš
æºåŠçæéã«å³å¯ã«èŠå¶ãããããšãªããäžå®ã®
蚱容ç¯å²å ã§åçŸæ§ããè¡ãªãããšãã§ããã
ããå·¥æ¥çå®æœã«éããŠã¯ãšãã«æå©ã§ããã ããããŠé žåŠçãããã³ã³ã¿ã¯ãã¬ã³ãºã¯ãç
é žãããªãŠã ãªã©ã®ã¢ã«ã«ãªæ§æ°Žæº¶æ¶²ã«æµžæŒ¬ããŠ
äžååŠçããŠãããããããã¯æ°ŽãŸãã¯ççé£å¡©
æ°Žäžã§æµžæŒ¬ãŸãã¯ç ®æ²žåŠçããªããããã æ¬çºæã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯é«ãå«æ°Žçãæã
é žçŽ ééæ§ã«ãããããããæè»æ§ããã³å¯ææ§
ã«å ããŠçŒçµç¹ã«å¯Ÿãããããã芪åæ§ãæãã
ãããé·æéé£ç¶è£ çšããããšãå¯èœã§ãããã
ãã«æ¬çºæã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å åŠæ§ã«ãã
ãããŸãã³ã³ã¿ã¯ãã¬ã³ãºã®ããããç¹æ§ãæãª
ãããšãªãæ°Žäžã§ã®ç ®æ²žæ®ºèåŠçãå¯èœã§ããã ã€ãã«å®æœäŸããããŠæ¬çºæã®ã³ã³ã¿ã¯ãã¬ã³
ãºããã³ãã®è£œé æ³ã詳现ã«èª¬æããããŸã代衚
çãªã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåé
äœã§ããIPGMAã®è£œé æ³ã®äžäŸãåèäŸã«ãŠèª¬
æããã åèäŸ ïŒã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãããã®IPGMAã®å
æïŒ ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã15ïœïŒ0.11ã¢ã«ïŒã
ã¢ã»ãã³50mlïŒ0.68ã¢ã«ïŒããã³ãããããã³ã¢
ãã¡ãã«ãšãŒãã«100ppmããã©ã¹ã³ã«å ¥ãæ¹æ
äžãããã«ã±ã€ã¿ã³ã°ã¹ãã³é ž26æ°Žå¡©0.1ïœãå
ããŠç©ºæž©ã§28æéåå¿ãããããåå¿çµäºåŸç¡æ°Ž
çé žãããªãŠã 10ïœãå ããŠã±ã€ã¿ã³ã°ã¹ãã³é ž
ãäžåããã€ãã§ïŒæéæ¹æåŸã該åå¿æ¶²ãåžåŒ
éããŠæ²æ®¿ç©ãé€å»ããã®ã¡æžå§äžã«ã¢ã»ãã³
ãçå»ããããã«200mlã®ïœâãããµã³ãå ããŠ
åå¿äžã«çæããéåç©ãé€å»ãããããããïœ
âãããµã³æº¶æ¶²ã«ç¡æ°Žç¡«é žãããªãŠã 25ïœãå
ããããã«æŽ»æ§çïŒïœãå ããŠæ¹æåŸäžå€æŸçœ®ã
ãã該åå¿æ¶²ãåžåŒéããã®ã¡æžå§æ¿çž®ããæž
å§èžç粟補ãè¡ãªãã沞ç¹60âïŒ0.2mmïœã®ç¡
è²éæãªæ¶²äœ12.5ïœãããïŒåç59.2ïŒ ïŒããã
ãã液äœãåå®ãããšãããå±æçïœïŒïŒ ïŒ1.442
ã§ãããèµ€å€ç·åžåã¹ãã¯ãã«ããIPGMAã§ã
ãããšã確èªãããã æ¬åèäŸã«ãããŠåå¿æãåå¿éå§20åã20æ
éåŸããã³åå¿çµäºæïŒ28æéåŸïŒã®åå¿æ¶²ãã¬
ã¹ã¯ãããã°ã©ãã€ãŒã«ãã€ãŠèª¿ã¹ãçµæãåå¿
éå§20ååŸã«ã¯ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãã¯ã»ãš
ãã©æ¶è²»ãããIPGMAãšå¯çæç©ãã»ãŒåéç
æãã20æéåŸã«ã¯å¯çæç©ã¯æžå°ããIPGMA
ãå¢å ããŠããã28æéåŸã«ã¯å¯çæç©ã¯å®å šã«
æ¶å€±ããIPGMAã®ã¿ãšãªãããšãããªãã¡åå¿
éäžã§äžæçã«å¯çæç©ãçããããæçµçã«ã¯
çæç©ã¯IPGMAã®ã¿ãšãªãããšãå€æããããŸ
ããäžèšå¯çæç©ãæ žç£æ°å ±é³Žã¹ãã¯ãã«
ïŒNMRïŒçã«ãã€ãŠåæãããšããã該å¯çæç©
ãDMDOã§ããããšã確èªãããã ãªããæ¬åèäŸã§äœ¿çšããã¢ã»ãã³ã«ä»£ããŠ
çš®ã ã®ã±ãã³ãããšãã°ã¡ãã«ãšãã«ã±ãã³ãã¡
ãã«ã€ãœããã«ã±ãã³ãã·ã¯ããããµãã³ãªã©ã
ãããã䜿çšããããšã«ãããæ¬åèäŸãšåæ§ã®
æ¹æ³ã§MEMAïŒMBMAãïŒâMSDDãªã©ã®çš®ã
ã®ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåéäœ
ã調補ããããšãã§ãããŸããã®åå¿éçšã«ãã
ãŠå¯çæç©ãšããŠããããMEDOïŒMBDOïŒ
MSDOãªã©ã®ãžãªããµã³èªå°äœåã®è©²ç³ã¢ã«ã³ãŒ
ã«ãæããåéäœãåæã«ããããšãã§ããææ
ã§ããã°èžçãç¹°ãè¿ãããšã«ãããããå¯çæ
ç©ã®çŽåºŠãé«ããããšãã§ããã å®æœäŸ ïŒ IPGMA72.52ïœãâããã«ãããªãã³ïŒä»¥äž
âVPãšç¥èšïŒ13.74ïœãã¡ãã«ã¡ã¿ã¯ãªã¬ãŒã
ïŒä»¥äžMMAãšç¥èšïŒ13.74ïœããã³éåéå§å€ãš
ããŠã¢ãŸãã¹ãžã¡ãã«ãã¬ããããªã«ïŒä»¥äž
ADMVNãšç¥èšïŒ0.06ïœãæ··åãã溶解ãããŠè©Š
éšç®¡ã«å ¥ããæ枩氎槜äžã«ãããŠ40âã§24æéé
åãããããã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæ
éã60âã§ïŒæéã80âã§ïŒæéã100âã§ïŒæ
éãæåŸã«110âã§ïŒæéå ç±éåãããŠç¡è²é
æãªæ£ç¶ã®éåäœçŽ æãããããã®ãã®ãåžžæ³ã«
ããååããç 磚å å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢
ç¶ã«æ圢ããã®ã¡ã2Nå¡©é žæ°Žæº¶æ¶²äžã«24æé浞
挬ããŠé žåŠçããã€ãã§ããããå«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºãèžçæ°Žäžã«15åé浞挬ããã®ã¡ã0.5
ïŒ çé žãããªãŠã 氎溶液äžã«30åé浞挬ããŠäžå
åŠçãè¡ãªããããã«èžçæ°Žäžã«15åé浞挬ãã
ãããã®ã¡ã«0.9ïŒ ççé£å¡©æ°Žäžã§ïŒæéç ®æ²žåŠ
çããŠç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãããã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯æè»ã§å¯ææ§ãæ
ããå«æ°Žç60.2ïŒ ãé žçŽ ééä¿æ°2.46Ã10-10c.c.ã»
cmïŒcm2ã»secã»mmïœãå±æçïŒïœïŒïŒ ïŒ1.391ã§ã
å¯èŠå ç·ééçã90ïŒ ãè¶ ãããã®ã§ãã€ãã ãªããå«æ°Žçã®æž¬å®ã¯20âã0.9ïŒ ççé£å¡©æ°Ž
äžã§ã®é£œåå«æ°Žçã«ã€ããŠè¡ãªãããŸãé žçŽ éé
ä¿æ°ã®æž¬å®ã¯çå粟æ©å·¥æ¥(æ ª)補ã®è£œç§ç åŒãã€ã«
ã é žçŽ ééçèšã䜿çšãã35âã0.9ïŒ å¡©åãã
ãªãŠã 氎溶液äžã«ãŠçœéé»æ¥µæ³ã«ããè¡ãªã€ãã
å¯èŠå ç·ééçã®æž¬å®ã¯(æ ª)島接補äœæ補UVã»210
ã䜿çšããæ³¢é·780ã380nmã®é åã«ãŠç³è±æ¿ã«
æŸãã§è¡ãªã€ããå±æçã¯ãšã«ãå åŠ(æ ª)補ã®ã¢ã
ãå±æèšãçšããŠãã€ã¹ã¯åœ¢ç¶ã®è©Šéšçã«ã€ããŠ
枬å®ããã æ¯èŒäŸ ïŒ ãŸããã¢ã¡ãªã«ç¹èš±ç¬¬4267295å·æ现æžã®å®æœ
äŸïŒã®èšèŒã«æºæ ããŠãã€ãã®ãšããã°ãªã»ããŒ
ã«ã¡ã¿ã¯ãªã¬ãŒããåæããã åžè²©ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãïŒäžè±ã¬ã€ãšã³
(æ ª)補ãåååã¢ã¯ãªãšã¹ãã«ïŒ§ïŒïŒKgãèžçæ°Ž
1500mlããã³æ¿ç¡«é ž2.5mlãïŒæ¥éæ¹æãããã
ã®éãåå¿ãã©ã¹ã³ã24ã29âã®æ°ŽæµŽäžã«ä¿ã€
ãã ããããåå¿æ··åç©ã10ïŒ æ°Žé žåãããªãŠã æ°Ž
溶液ã§äžåããã€ãã§ãšãŒãã«åïŒã§ïŒåæœåº
ããæœåºåŸæ°Žå±€ã«å¡©åãããªãŠã ã飜åããã飜
åå¡©æ°Žäžã«åé¢ãã油局ãåãåºããå¡©åã¡ãã¬
ã³ã«æº¶è§£ãããããããã該溶液äžã«ç¡æ°Žç¡«é žã
ããªãŠã ãå ããŠ16æéå·ææã«æŸçœ®ããã®ã¡ã
å£éããŠç¡«é žãããªãŠã ãé€å»ããããã«å·æ°ŽæµŽ
äžã§ãšããã¬ãŒã¿ã«ããå¡©åã¡ãã¬ã³ãæžå§é€å»
ããç¡è²éæ液äœã®ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ãããã ã€ãã«ãå®æœäŸïŒã«ãããŠããå«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºã®æ§æéšåãšããŠã®ã°ãªã»ããŒã«ã¡ã¿ã¯
ãªã¬ãŒããâVPïŒMMAã®ïŒæåã®çè«äžã®ã¢
ã«æ¯ã«äžèŽããããã«ãäžèšã®ã°ãªã»ããŒã«ã¡ã¿
ã¯ãªã¬ãŒãããã³ïŒ®âVPïŒMMAã®é åéããã
ãã67.86ïœã16.07ïœã16.07ïœãšããããã«
ADMVN0.06ïœã䜿çšããŠå®æœäŸïŒãšåæ§ã®éå
æ¡ä»¶ã«ãããç¡è²éæãªæ£ç¶ã®éåäœçŽ æãã
ãããã®ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠ
ã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã€ãã§0.9ïŒ
ççé£å¡©æ°Žã«æµžæŒ¬ããæ°Žåèšæœ€ãããããããã
ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç49.5ïŒ ãé žçŽ ééä¿æ°
1.47Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±æç
ïŒïœïŒïŒ ïŒ1.412ã§ãã€ãããã ããå¯èŠå ç·ééç
ã¯90ïŒ ãè¶ ããã æ¯èŒäŸ ïŒ ãŸããã¢ã¡ãªã«ç¹èš±ç¬¬4056496å·æ现æžã®å®æœ
äŸïŒã®èšèŒã«æºæ ããŠãã€ãã®ãšããã°ãªã»ããŒ
ã«ã¡ã¿ã¯ãªã¬ãŒããåæããã ã€ãœããããªãã³ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ïŒKgãèžçæ°ŽïŒãæ¿ç¡«é žïŒïœããã³ããããã
ã³ã¢ãã¡ãã«ãšãŒãã«0.4ïœã16æé25ã30âã®
氎济äžã§æ¹æããã®ã¡ãæ°Žé žåããªãŠã ã§ç¡«é žã
äžåããã€ãã§çããç¡«é žããªãŠã ã®æ²æ®¿ãå¥
ããå£æ¶²ã«å¡©åãããªãŠã ãå ããŠé£œåããã飜
åå¡©æ°Žäžã«åé¢ãã油局ããšãŒãã«ã§æœåºããã
ãããæœåºæ¶²ã«ç¡æ°Žç¡«é žãããªãŠã ãå ããŠäžå€
å·ææã§æŸçœ®ããããã«å£éããã®ã¡å·æ°ŽæµŽäžã§
ãšããã¬ãŒã¿ãŒã«ãã溶åªãæžå§èžçããç¡è²é
æ液äœã®ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããããã ã€ãã§ãããããã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ã䜿çšãã以å€ã¯æ¯èŒäŸïŒãšãŸã€ããåæ§ã«ããŠ
å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãäœæããããã®ã³ã³ã¿
ã¯ãã¬ã³ãºã¯å«æ°Žç54.3ïŒ ãé žçŽ ééä¿æ°1.72Ã
10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±æçïŒïœïŒïŒ 
ïŒ
1.404ã§ãããå¯èŠå ç·ééçã90ïŒ ãè¶ ããã
ã®ã§ãã€ãã å®æœäŸïŒãæ¯èŒäŸïŒïŒïŒããæ¬çºæã®å«æ°Žæ§ã³
ã³ã¿ã¯ãã¬ã³ãºã®å«æ°Žçãããé«ãå€ã瀺ãããš
ããããã å®æœäŸ ïŒ IPGMA75ïœãïŒâããããã·ãšãã«ã¡ã¿ã¯ãª
ã¬ãŒãïŒä»¥äžïŒâHEMAãšç¥èšïŒ20ïœãã©ãŠãª
ã«ã¡ã¿ã¯ãªã¬ãŒãïŒä»¥äžLMAãšç¥èšïŒïŒïœãã
ã³ADMVN0.07ïœãæ··åãã溶解ãããŠè©Šéšç®¡ã«
å ¥ããæ枩氎槜äžã«ãããŠ35âã§48æééåã
ããããã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæéã
60âã§ïŒæéã80âã§ïŒæéã100âã§ïŒæéã
æåŸã«110âã§ïŒæéå ç±éåãããŠãæ£ç¶ã®é
åäœçŽ æãããããã®ãã®ãåžžæ³ã«ããååãã
ç 磚å å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ãã
ã®ã¡ã50ïŒ ã®é žæ°Žæº¶æ¶²äžã«30åéã6Nå¡©é žæ°Žæº¶
液äžã«ïŒæéïŒãŸãã¯ã3.6Nå¡©é žæ°Žæº¶æ¶²äžã§ïŒ
æéïŒæµžæŒ¬ããŠé žåŠçãè¡ãªããã€ãã§0.024ïŒ
çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠäžååŠçãã
ç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç63.1ïŒ ãé žçŽ é
éæ°2.27Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±æ
çïŒïœïŒïŒ ïŒ1.390ã§ãå¯èŠå ç·ééçã90ïŒ ãè¶
ãããã®ã§ãã€ãã å®æœäŸ ïŒãïŒ å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸïŒãšåæ§ã«ããŠå®éšãè¡ãªãå«æ°Žæ§
ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã ãªãå®æœäŸïŒã®IPGMAã®å ±éåäœã®é žåŠçå
ãšé žåŠçåŸã®èµ€å€åžåã¹ãã¯ãã«ãæ¥æ¬åå å·¥æ¥
(æ ª)補â202ã䜿çšããŠãæ³¢æ°4000ã400cm-1ã®é
åã«ãããŠæž¬å®ãããã€ãŒãã第ïŒå³ã«ãããŠã
ãããããã³ïŒ¢ã§ç€ºãã第ïŒå³ã«ãããŠ3400cm
-1ä»è¿ã«ãããOHåºã®åžåãããé žåŠçåŸã®
IPGMAã®å ±éåäœã«æ°Žé žåºã®æãããªå¢å ãã¿
ããããšåæã«280cm-1ä»è¿ã«ããããžãªããœã©
ã³ç°ã®æ¶å€±ãèªããããã
ãã®è£œé æ³ã«é¢ããã åŸæ¥ããçš®ã ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãç¥ã
ããŠããããªãã§ãïŒâããããã·ãšãã«ã¡ã¿ã¯
ãªã¬ãŒããäž»åæãšããå«æ°Žç30ã40ïŒ ïŒéé
ïŒ ã以äžåæ§ïŒã®ãã®ããã€ãšãåºãæ®åããŠã
ãã ããããªããããã®çš®ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºã¯ç®ã®è§èã®ççäžå¿ èŠãšãããé žçŽ éã«å¯Ÿã
ãŠã¯å åãªééæ§ãæããŠããªããããïŒæ¥ãã
ãçŽ16æéã®è£ çšãé床ãšãããŠããããã®é床
ãè¶ ããè£ çšã¯è§èã®çµç¹é害ãæ¹èµ·ããèŠå ãš
ãªãå±éºã§ããã ãã®ãããå«æ°Žçãé«ããã³ã³ã¿ã¯ãã¬ã³ãºæ
質äžã«å«æµžãããå€éã®æ°Žåãä»ããŠè§èã®çç
äžå¿ èŠãªé žçŽ éã倧æ°äžããè§èã«äŸçµŠãããç®
çã§ãçš®ã ã®é«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã®ç 究ã
掻çºã«è¡ãªãããŠãããé«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºçšçŽ æãšããŠãã€ãšãäžè¬çãªãã®ã¯ãâã
ãã«ãããªãã³ãäž»æåãšãããããšã¡ã¿ã¯ãªã¬
ãŒãååç©ãããšãã°ã¡ãã«ã¡ã¿ã¯ãªã¬ãŒããªã©
ã®ã¢ã«ãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâããããã·ãšã
ã«ã¡ã¿ã¯ãªã¬ãŒããªã©ãå ±éåãããŠããããå ±
éåäœã§ããããããã®å ±éåäœã¯éåžžçŽ50ã80
ïŒ ã®å«æ°ŽèœåãæããŠããããããã€ãŠãããã
ã®é«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã®å€ãã¯è§èã®å¿ èŠ
ãšããé žçŽ éã倧æ°äžããã¬ã³ãºæ質äžã«å«æµžã
ããæ°ŽåãéããŠè§èã«äŸçµŠããããšãå¯èœã§ã
ãã ããããé«å«æ°Žçã®ããããããã®ã³ã³ã¿ã¯ã
ã¬ã³ãºã¯æ質匷床ã®äœäžãã¬ã³ãºã®èŠæ Œåœ¢ç¶ã®äž
å®å®æ§ãªã©ã®æ¬ ç¹ãæããŠãããå åã«æ®åãã
ã«ã¯è³ã€ãŠããªãããŸãããããâããã«ãã
ãªãã³ãäž»åæãšããé«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãº
ãç®ã«è£ çšããã°ãããã³ãŸãæ§ã®è¡šå±€è§èçã
å€çºããåŸåãããããã®äºå®ãé«å«æ°Žæ§ã³ã³ã¿
ã¯ãã¬ã³ãºã®æ®åãé»ã倧ããªåå ãšãªã€ãŠã
ãã ãã®ããã«ãã³ã³ã¿ã¯ãã¬ã³ãºæ質ã®é žçŽ éé
æ§ã¯ãé·æéã®é£ç¶è£ çšãå¯èœãªå«æ°Žã³ã³ã¿ã¯ã
ã¬ã³ãºãæäŸããããã§å¿ èŠæ¡ä»¶ããããŠãå å
æ¡ä»¶ããããªãã®ã§ããã é·æéã®é£ç¶è£ çšãå¯èœãªå«æ°Žæ§ã³ã³ã¿ã¯ãã¬
ã³ãºãæäŸããããã§ãã¬ã³ãºçŽ æã®é žçŽ ééæ§
ã«å ããŠãã¬ã³ãºçŽ æã®çŒçµç¹ããšãã«è§èçµç¹
ã«å¯Ÿãã芪åæ§ã倧ããªèŠçŽ ãšãªãããšãç¥ãã
ãŠãããããããªãããã¬ã³ãºçŽ æã®çŒçµç¹ã«å¯Ÿ
ãã芪åæ§ã確èªããæ¹æ³ãšããŠäžå®ã®åºæºãã
ãããã§ã¯ãªãããã®ããšãããé«ãå«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºã®éçºãäžå±€å°é£ã«ããŠããã æ¬çºæè ãã¯çŒçµç¹ã«å¯Ÿãã芪åæ§ã«ãããã
é·æéã®é£ç¶è£ çšãå¯èœãªå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºãéçºãã¹ãçš®ã ç 究ãéããçµæãã±ã¿ãŒã«
åãããç³ã¢ã«ã³ãŒã«ãæããåéäœã芪氎æ§å
éäœãçæ°Žæ§åéäœãªã©ã®ä»ã®å ±éåæ§åéäœãš
å ±éåãããã€ãã§ã±ã¿ãŒã«åºãæ°Žé žåºã«å€æã
ã¹ããããããå ±éåäœãé žåŠçãããã®ã¯å«æ°Ž
æ§ã³ã³ã¿ã¯ãã¬ã³ãºã®æ質ãšããŠããããç¹æ§ã
æããããšãèŠãã ããæ¬çºæãå®æããã«ãã
ã€ãã ããªãã¡ãæ¬çºæã¯ã±ã¿ãŒã«åãããç³ã¢ã«ã³
ãŒã«ãæããåéäœã芪氎æ§åéäœããã³ïŒãŸã
ã¯ïŒçæ°Žæ§åéäœãäž»æåãšããå ±éåäœãé žåŠ
çããŠãããããã®ãæ質ãšããå«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºããã³(A)åèšå ±éåäœãæ質ãšããã³ã³
ã¿ã¯ãã¬ã³ãºãæ圢ããã€ãã§ãããé žåŠçãã
(B)ããããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºå ã«å«æµžããŠ
ããåèšé žãæ°ŽãŸãã¯ççé£å¡©æ°Žã§çœ®æããããš
ãç¹åŸŽãšããåèšå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã®è£œé
æ³ãæäŸãããã®ã§ããã å è¡æè¡ã¯ãžããããã·ã¢ã«ãã«ïŒã¡ã¿ïŒã¢ã¯
ãªã¬ãŒãããšãããã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ïŒïŒïŒïŒâãžããããã·ãããã«ã¡ã¿ã¯ãªã¬ãŒ
ãïŒãçš®ã ã®å ±éåæ§åéäœãšå ±éåãããŠå«æ°Ž
æ§ã³ã³ã¿ã¯ãã¬ã³ãºçšçŽ æãããããšãæããŠã
ãã ããªãã¡ãç±³åœç¹èš±ç¬¬3957362å·æ现æžã¯äžèš
ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããšã¡ãã«ã¡ã¿ã¯ãªã¬
ãŒããªã©ã®ã¢ã«ãã«ã¡ã¿ã¯ãªã¬ãŒããšã®å ±éåäœ
ã«ã€ããŠé瀺ããç±³åœç¹èš±ç¬¬4056496å·æ现æžã¯
äžèšã®çµæã«ããã«å°éã®æ°Žäžæº¶æ§ãšããã·åã¢
ã«ãã«ã¡ã¿ã¯ãªã¬ãŒããå ããçµæãããªãå ±é
åäœã«ã€ããŠé瀺ãããŸãç±³åœç¹èš±ç¬¬4267295å·
æ现æžã¯ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããã¢ã«ãã«
ã¡ã¿ã¯ãªã¬ãŒãããã³ïŒâããããã·ãšãã«ã¢ã¯
ãªã¬ãŒããªã©ã®èŠªæ°Žæ§åéäœãäž»æåãšããå ±é
åäœã«ã€ããŠé瀺ããŠããã ããããªããããããã®å è¡ç¹èš±æç®ã«é瀺ã
ããå ±éåäœã¯å«æ°Žçã«ãããŠãåŸæ¥ã®ïŒâãã
ããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããäž»æåãšããå ±é
åäœã®å«æ°ŽççŽ30ã40ïŒ ã«æ¯ã¹ãŠåçãããã¯ã
ãé«ãçšåºŠã§ããããã®çšåºŠã®å«æ°Žçã§ã¯è§èã®
æ°é³ä»£è¬ã«å¿ èŠãªé žçŽ éã倧æ°äžããã¬ã³ãºæ質
äžã«å«æµžãããæ°Žåãä»ããŠè§èã«äŸçµŠããããš
ã¯äžå¯èœã§ããã ããªãã¡ãåèšã®å è¡æè¡ã«ãããŠã¯äž»æåã§
ããã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒãã®åææ¹æ³ãšã
ãŠãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãã®å æ°Žå解ãšã€ãœ
ããããªãã³ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒãã®å æ°Ž
å解ãšãé瀺ãããŠãããããã®ãã¡åè ã®æ¹æ³
ã«ãã€ãã°ããã¯åæã§ããã°ãªã·ãžã«ã¡ã¿ã¯ãª
ã¬ãŒããç®ççæç©ã§ããã°ãªã»ããŒã«ã¡ã¿ã¯ãª
ã¬ãŒãäžã«äžå¯é¿çã«åŸ®éæ®åãããããå ±éå
åå¿ã«éãæ¶æ©æ©èœãæããã»ããã°ãªã»ããŒã«
ã¡ã¿ã¯ãªã¬ãŒãã®åŽéã®æ°Žé žåºéã§ãšãŒãã«çµå
ã圢æãããããããããããå ±éåäœã®æ¶æ©å¯
床ãé«ããªããçµæçã«å«æ°Žçã®åäžãæå¶ãã
ãããšã«ãªãããŸããåŸè ã®æ¹æ³ã«ãã€ãŠã°ãªã»
ããŒã«ã¡ã¿ã¯ãªã¬ãŒããããã°ããã«ãããŠãã
äžèšãšãŒãã«çµåã®åœ¢æã«ãã€ãŠåæ§ã«å«æ°Žçã®
åäžãæå¶ãããããšã«ãªããçµå±ãããã®å è¡
æè¡ã«ãããŠã¯ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããäž»
æåãšããã³ã³ã¿ã¯ãã¬ã³ãºçšå ±éåäœã«ãã
ãŠãé·æéã®é£ç¶è£ çšãå¯èœãšããã«å åãªé žçŽ
ééæ§ãæããã³ã³ã¿ã¯ãã¬ã³ãºçšå ±éåäœãã
ãããšã¯å°é£ã§ãã€ãã æ¬çºæã®æ¹æ³ã«ãããŠã¯ãåèšã®ãšããã°ãªã»
ããŒã«ã¡ã¿ã¯ãªã¬ãŒãçç³ã¢ã«ã³ãŒã«ãæããå
éäœã®æ°Žé žåºããããããã±ã¿ãŒã«åããããšã«
ããä¿è·ããŠããããã®ããã§è©²åéäœãä»ã®å ±
éåæ§åéäœãšå ±éåãããŠããããå ±éåäœã
ããææã®åœ¢ç¶ãæããã³ã³ã¿ã¯ãã¬ã³ãºãæ圢
ããããããã³ã³ã¿ã¯ãã¬ã³ãºãé žåŠçããŠè±ã±
ã¿ãŒã«ååå¿ãçèµ·ããããããšã«ããè©²å ±éå
äœäžã®ã±ã¿ãŒã«åºãæ°Žé žåºã«å€æããããšããæ¹
æ³ã«ãã€ãŠç³ã¢ã«ã³ãŒã«ãæããåéäœãå¿ é æ§
ææåãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã補é ãã
ãã®ã§ãããããåèšã®å è¡æè¡ã«ã¿ããããã
ãªå ±éåäœåå¿æã«ããããšãŒãã«çµåã®åœ¢æç
ã«ããæ¶æ©å¯åºŠã®å¢å ãé²æ¢ããããšãã§ããã
ã®çµæãé«å«æ°Žçã§ãããã³ã³ã¿ã¯ãã¬ã³ãºçšæ
質ãšããŠæãŸããç¹æ§ãæããå ±éåäœã容æã«
ããããšãã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšãããã±ã¿ãŒã«åãã
ãç³ã¢ã«ã³ãŒã«ãæããåéäœãšããŠã¯ããŸãã±
ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãšã¢ã¯ãªã«é žãã¡ã¿
ã¯ãªã«é žã®ãããªéåæ§ã«ã«ãã³é žãŸãã¯ã¢ãªã«
ã¢ã«ã³ãŒã«ã®ãããªéåæ§ã¢ã«ã³ãŒã«ãšã®ãšã¹ã
ã«ååç©ãŸãã¯ãšãŒãã«ååç©ãããããããã
ã®ãããªååç©ã®å ·äœäŸããããã°ããšãã°ã€ã
ã®ãããªãã®ã§ããã ïŒïŒïŒââã€ãœããããªãã³ã°ãªã»ããŒã«ã¡
ã¿ã¯ãªã¬ãŒãïŒIPGMAïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâãšãã«âïŒâã¡ã¿ã¯ãªã«ãªãã·
ã¡ãã«âïŒïŒïŒâãžãªããœã©ã³ïŒMEMAïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâã€ãœããã«âïŒâã¡ã¿ã¯ãªã«ãª
ãã·ã¡ãã«âïŒïŒïŒâãžãªããœã©ã³ïŒMBMAïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâããšãã«âïŒâã¡ã¿ã¯ãªã«ãªã
ã·ã¡ãã«âïŒïŒïŒâãžãªããœã©ã³ïŒMPMAïŒ ïŒâã¡ã¿ã¯ãªã«ãªãã·ã¡ãã«âã¹ãããïŒïŒïŒã
âïŒïŒïŒâãžãªããµãã«ã³ïŒïŒâMSDDïŒ ïŒæ§é åŒïŒ ïŒïŒïŒïŒïŒïŒïŒâãžâïŒïŒ¯âã€ãœããããªãã³ïŒ
ãã·ãªããŒã«âïŒâã¡ã¿ã¯ãªã¬ãŒãïŒïŒâ
MDIXïŒ ïŒæ§é åŒïŒ ãããã®ååç©ã¯ãããšãã°äžè¬åŒïŒïŒ©ïŒïŒ ïŒåŒäžãïœã¯ïŒãïŒã®æŽæ°ãè¡šããïŒã§è¡šãã
ããç³ã¢ã«ã³ãŒã«ãã¢ã»ãã³ãã¡ãã«ãšãã«ã±ã
ã³ãã·ã¯ããããµãã³ãã¢ã»ãããšãã³ãã¡ãã«
ã€ãœããã«ã±ãã³ãªã©ã®ã±ãã³ååç©ã§ã±ã¿ãŒã«
åããããããã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«
ããã¡ã¿ã¯ãªã«é žãã©ã€ããŸãã¯ã¢ã¯ãªã«é žãã©
ã€ããšåå¿ãããæ®ãã®æ°Žé žåºã«éåæ§åºãå°å ¥
ããããšã«ããããããããã®éããšãã«åèšã®
äžè¬åŒïŒïŒäžã®ïœãïŒãŸãã¯ïŒã®ç³ã¢ã«ã³ãŒã«
ãçšããã°åå¿ã容æã«é²è¡ãããããšãã§ã
ãããŸããã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒããçŽæ¥ãå
èšããã¢ã»ãã³ãã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ã
ã³ååç©ãšåå¿ãããããšã«ããIPGMAïŒ
MEMAãïŒâMSDDãªã©ã®ã±ã¿ãŒã«åã°ãªã»ã
ãŒã«ã®ã¡ã¿ã¯ãªã¬ãŒããåæããããšãå¯èœã§ã
ãããã®æ¹æ³ã«ã€ããŠã¯æ¬çºæè ããç¹é¡æ56â
106117å·æ现æžã«è©³èª¬ãããšããã§ããã ããã«æ¬çºæã®æ¹æ³ã«ãããŠã¯ãã€ãã®ã±ã¿ãŒ
ã«åãããã°ãªã»ããŒã«ãšãŒãã«ãã±ã¿ãŒã«åã
ããç³ã¢ã«ã³ãŒã«ãæããåéäœã®ïŒã€ãšããŠæ
å¹ã«çšããããšãã§ããã ã¢ãªã«ã€ãœããããªãã³ã°ãªã»ããŒã«ãšãŒãã«
ïŒALIPGïŒ ïŒæ§é åŒïŒ ïŒâã¢ãªã«ãªãã·âïŒâã¡ãã«âïŒâãšãã«â
ïŒïŒïŒâãžãªããœã©ã³ïŒALMEïŒ ïŒæ§é åŒïŒ ïŒâã¢ãªã«ãªãã·ã¡ãã¬ã³âã¹ãããïŒïŒïŒãâ
ïŒïŒïŒâãžãªããµãã«ã³ïŒALCHïŒ ïŒæ§é åŒïŒ ãããã®ãšãŒãã«ååç©ã¯ã°ãªã»ãªã³ãªã©ã®å
èšäžè¬åŒïŒïŒã§è¡šããããç³ã¢ã«ã³ãŒã«ãçš®ã
ã®ã±ãã³ã«ãã€ãŠã±ã¿ãŒã«åããã®ã¡ãã¢ãªã«ã¯
ãã©ã€ããšåå¿ãããå ¬ç¥ã®åææ¹æ³ã«ãã€ãŠã
ãããšãã§ããã»ããããšãã°ã¢ãªã«ã°ãªã·ãžã«
ãšãŒãã«ãšåçš®ã±ãã³ååç©ãšãé žè§Šåªã®ååšäž
ã§åå¿ãããããšã«ããçŽæ¥çã«åæããããšã
å¯èœã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšããããã±ã¿ãŒã«åã
ããç³ã¢ã«ã³ãŒã«ãæããåéäœã®ã»ãã®äŸãšã
ãŠã¯ãããšãã°ã€ãã®ïœâãžãªããµã³èªå°äœåã®
ã¡ã¿ã¯ãªã¬ãŒããŸãã¯ã¢ã¯ãªã¬ãŒããªã©ãããã
ããšãã§ããã ïŒïŒïŒâãžã¡ãã«âïŒâã¡ã¿ã¯ãªãã€ã«ãªãã·
âïŒïŒïŒâãžãªããµã³ïŒDMDOïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâãšãã«âïŒâã¡ã¿ã¯ãªãã€ã«â
ïœâãžãªããµã³ïŒMEDOïŒ ïŒæ§é åŒïŒ ïŒâã¡ãã«âïŒâã€ãœããã«âïŒâã¡ã¿ã¯ãªãã€
ã«âïœâãžãªããµã³ïŒMBDOïŒ ïŒæ§é åŒïŒ ïŒâã¡ã¿ã¯ãªãã€ã«ãªãã·âã¹ãããïŒïŒïŒãâ
ïŒïŒïŒâãžãªããµãŠã³ãã«ã³ïŒMSDOïŒ ïŒæ§é åŒïŒ ãããã®ååç©ã¯ãã¹ãŠæ°èŠãªååç©ã§ããã
éåžžåèšã®ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãããçš®ã ã®
ã±ã¿ãŒã«åã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããåæã
ãéçšã«ãããŠå¯çæç©ãšããŠããããšãã§ã
ãã ãªããåèšããçš®ã ã®ã±ã¿ãŒã«åãããç³ã¢ã«
ã³ãŒã«ãæããåéäœã«ãããŠãšã¹ãã«ååç©ã«
ã€ããŠã¯ããã¹ãŠã¡ã¿ã¯ãªã¬ãŒãååç©ãäŸç€ºã
ããããããã«å¯Ÿå¿ããã¢ã¯ãªã¬ãŒãååç©ãæ¬
çºæã®æ¹æ³ã«ãããŠçšããããšãã§ããã ãããåçš®ã®ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ã
æããåéäœã¯åç¬ã§ããŸãã¯ïŒçš®ä»¥äžãæ··åã
ãŠçšããããããåèšã®ALIPGïŒALMEïŒ
ALCHãªã©ã®ã±ã¿ãŒã«åãããã°ãªã»ããŒã«ã®ã¢
ãªã«ãšãŒãã«ã«ã€ããŠã¯ãè±ã±ã¿ãŒã«åãããã®
ã¡ã®å«æ°Žèœåãæ¯èŒçäœãããä»ã®è©²ç³ã¢ã«ã³ãŒ
ã«ãæããåéäœãšäœµçšããããšãæãŸããããŸ
ããåèšã®DMDOïŒMEDOïŒMBDOïŒMSDOãª
ã©ã®ïœâãžãªããµã³èªå°äœåã®ã¡ã¿ã¯ãªã¬ãŒããŸ
ãã¯ã¢ã¯ãªã¬ãŒãã«ã€ããŠã¯ãããããã°ãªã·ãž
ã«ã¡ã¿ã¯ãªã¬ãŒãããIPGMAïŒMEMAïŒ
MBMAãïŒâMSDDãçŽæ¥çã«åæããéã«å¯
çæç©ãšããŠçæãããã®ã§ããããããã®çŽåºŠ
ãé«ããããã«ã¯èžçãç¹°ãè¿ããã°ãªãããå
éãæžå°ããå·¥æ¥çã«äžå©ã§ããã®ã§ããããã«
ã€ããŠã¯ãããã察å¿ããäž»çæç©ã§ãã該ç³ã¢
ã«ã³ãŒã«ãæããåéäœãšã®æ··åç©ã®ç¶æ ã§çšã
ãããšãçŸå®çã§ããã ããã«ãæ¬çºæã®æ¹æ³ã§çšããã±ã¿ãŒã«åãã
ãç³ã¢ã«ã³ãŒã«ãæããåéäœã®äžéšããããšã
ã°ïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããªãã³â
ïŒââã¡ã¿ã¯ãªãã€ã«ââã°ã«ã³ãã©ãã·ã
ïŒå¥åïŒïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããª
ãã³âïŒââã¡ã¿ã¯ãªãã€ã«ââã°ã«ã³ãŒ
ã¹ïŒãïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããªã
ã³âïŒââã¡ã¿ã¯ãªãã€ã«ââã¬ã©ã¯ããã©
ãã·ãïŒå¥åïŒïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœã
ãããªãã³âïŒââã¡ã¿ã¯ãªãã€ã«ââã¬ã©
ã¯ããŒã¹ïŒãïŒââã¡ã¿ã¯ãªãã€ã«âïŒïŒïŒïŒ
ïŒïŒïŒâãžââã€ãœããããªãã³ââãã³ã
ãã©ãã·ãïŒå¥åïŒïŒââã¡ã¿ã¯ãªãã€ã«â
ïŒïŒïŒïŒïŒïŒïŒâãžââã€ãœããããªãã³â
âãã³ããŒã¹ïŒã®ãããªç¹é¡æ56â3681å·æ现æž
äžã«é瀺ãããŠããåçš®ã®ã±ã¿ãŒã«åç³ã®ã¡ã¿ã¯
ãªã¬ãŒããŸãã¯ã¢ã¯ãªã¬ãŒãã§çœ®ãæããŠãåç
ã®å¹æãéæããããšãã§ããã 以äžæ¬çºæã®æ¹æ³ã§çšããã±ã¿ãŒã«åãããç³
ã¢ã«ã³ãŒã«ãæããåéäœã«ã€ããŠè©³çŽ°ã«èª¬æã
ããã該åéäœã¯ä»ã®çš®ã ã®åéäœãšå ±éåãå¯
èœã§ãããããã以äžã«è©³èª¬ãã芪氎æ§åéäœã
ãã³çæ°Žæ§åéäœã®å°ãªããšãïŒçš®ãšå ±éåãã
ãããšã«ãããæ¬çºæã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãº
çšã®çŽ æã調補ããããšãã§ããã 芪氎æ§åéäœã®æãŸãããã®ãšããŠã¯ãããšã
ã°ïŒâããããã·ãšãã«ã¡ã¿ã¯ãªã¬ãŒããïŒâã
ãããã·ãšãã«ã¢ã¯ãªã¬ãŒããïŒâããããã·ã
ããã«ã¡ã¿ã¯ãªã¬ãŒããïŒâããããã·ãããã«
ã¢ã¯ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã¿
ã¯ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¢ã¯ãª
ã¬ãŒããã¡ã¿ã¯ãªã«ã¢ãããã¢ã¯ãªã«ã¢ããããž
ã¡ãã«ã¡ã¿ã¯ãªã«ã¢ããããžã¡ãã«ã¢ã¯ãªã«ã¢ã
ããã¡ã¿ã¯ãªã«é žãã¢ã¯ãªã«é žãâããã«ãã
ãªãã³ãªã©ãããããããããã®ãã¡ããïŒçš®ãŸ
ãã¯ïŒçš®ä»¥äžãéžæããŠäœ¿çšããã ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåéäœ
ããããã®èŠªæ°Žæ§åéäœãšå ±éåããããããšã«
ãã€ãŠãããããå ±éåäœããæ圢ãããã³ã³ã¿
ã¯ãã¬ã³ãºãé žæ°Žæº¶æ¶²äžã«ãŠè±ã±ã¿ãŒã«åããŠã±
ã¿ãŒã«åºãæ°Žé žåºã«å€æããã«éããé žæº¶æ¶²ãã¬
ã³ãºçŽ æå ã«åäžãã€æå¹ã«æµžéããããææã®
è±ã±ã¿ãŒã«ååå¿ãå¹çããçèµ·ããããããšã
ã§ããããŸããããšãã°ïŒâããããã·ãšãã«ã¡
ã¿ã¯ãªã¬ãŒããïŒâããããã·ãããã«ã¡ã¿ã¯ãª
ã¬ãŒããªã©ãã®åç¬éåäœã®å«æ°Žèœåãæ¯èŒçäœ
ã芪氎æ§åéäœã®ã°ãããã±ã¿ãŒã«åãããç³ã¢
ã«ã³ãŒã«ãæããåéäœããããã®èŠªæ°Žæ§åéäœ
ãšå ±éåããããšã«ããããããæçµå«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºã®å«æ°ŽçãããçšåºŠå¶åŸ¡ããããšã
å¯èœã§ããã æ¬çºæã®æ¹æ³ã«ãããŠçšããããçæ°Žæ§åéäœ
ã®æãŸãããã®ãšããŠã¯ãããšãã°ã¡ãã«ã¡ã¿ã¯
ãªã¬ãŒããã¡ãã«ã¢ã¯ãªã¬ãŒãããšãã«ã¡ã¿ã¯ãª
ã¬ãŒãããšãã«ã¢ã¯ãªã¬ãŒããããã«ã¡ã¿ã¯ãªã¬
ãŒããããã«ã¢ã¯ãªã¬ãŒããã¢ãã«ã¡ã¿ã¯ãªã¬ãŒ
ããã¢ãã«ã¢ã¯ãªã¬ãŒããã·ã¯ãããã·ã«ã¡ã¿ã¯
ãªã¬ãŒããã·ã¯ãããã·ã«ã¢ã¯ãªã¬ãŒãããªã¯ã
ã«ã¡ã¿ã¯ãªã¬ãŒãããªã¯ãã«ã¢ã¯ãªã¬ãŒãããã·
ã«ã¡ã¿ã¯ãªã¬ãŒãããã·ã«ã¢ã¯ãªã¬ãŒãããŠã³ã
ã·ã«ã¡ã¿ã¯ãªã¬ãŒãããŠã³ãã·ã«ã¢ã¯ãªã¬ãŒãã
ã©ãŠãªã«ã¡ã¿ã¯ãªã¬ãŒããã©ãŠãªã«ã¢ã¯ãªã¬ãŒã
ãªã©ã®ã¡ã¿ã¯ãªã«é žãŸãã¯ã¢ã¯ãªã«é žã®ã¢ã«ãã«
ãšã¹ãã«ïŒãã ããã¢ã«ãã«åºã®ççŽ æ°ïŒã15
åïŒãã¡ã¿ã¯ãªã«é žãŸãã¯ã¢ã¯ãªã«é žã®ããã«ãš
ã¹ãã«ãã¡ã¿ã¯ãªã«é žãŸãã¯ã¢ã¯ãªã«é žã®ã¢ãªã«
ãšã¹ãã«ãã€ã¿ã³ã³é žãããã«ãã¯ããã³é žãã
ãã«ãªã©ã®ã€ã¿ã³ã³é žãŸãã¯ã¯ããã³é žã®ã¢ã«ã
ã«ãšã¹ãã«ãé ¢é žããã«ãããããªã³é žããã«ãª
ã©ã®èèªæã«ã«ãã³é žã®ããã«ãšã¹ãã«ãã¹ãã¬
ã³ãã¢ã¯ãªããããªã«ãªã©ãããããããããã®
ãã¡ããïŒçš®ãŸãã¯ïŒçš®ä»¥äžãéžæããŠäœ¿çšã
ããçæ°Žæ§åéäœã®äœ¿çšã¯ãããããå«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºçšæ質ã®å«æ°Žçãå¶åŸ¡ãã匷床ãé«
ãã補åã®èä¹ æ§ãåäžãããç®çã«æå¹ã§ã
ãã åèšã®çæ°Žæ§åéäœã®ãã¡ã¡ã¿ã¯ãªã«é žã®ã¢ã«
ãã«ãšã¹ãã«ãããã«ãšã¹ãã«ãã¢ãªã«ãšã¹ãã«
ãªã©ã¡ã¿ã¯ãªã«é žã®åçš®ãšã¹ãã«é¡ãäžè¿°ã®ç®ç
ã«å¯ŸããŠãšãã«æå¹ã§ããã æ¬çºæã®æ¹æ³ã«ãããã±ã¿ãŒã«åãããç³ã¢ã«
ã³ãŒã«ãæããåéäœã®äœ¿çšéã¯ã該ç³ã¢ã«ã³ãŒ
ã«ãæããåéäœãšåèšèŠªæ°Žæ§åéäœããã³ïŒãŸ
ãã¯ïŒåèšçæ°Žæ§åéäœã®äœ¿çšéã®åèš100éš
ïŒéééšã以äžåæ§ïŒäžïŒã97éšã奜ãŸããã¯20
ã85éšãããã«å¥œãŸããã¯40ã80éšã®ç¯å²ãšãã
ã®ãæãŸããã該ç³ã¢ã«ã³ãŒã«ãæããåéäœã¯
芪氎æ§åéäœããã³çæ°Žæ§åéäœã®å°ãªããšãïŒ
çš®ãšå ±éåããããã芪氎æ§åéäœã䜿çšããã°
ããããã®äœ¿çšéã¯ãåèšåéäœã®äœ¿çšéã®åèš
100éšäžïŒã95éšã奜ãŸããã¯15ã80éšãããã«
奜ãŸããã¯20ã60éšã®ç¯å²ã§ããããŸãçæ°Žæ§å
éäœã䜿çšããã°ããããã®äœ¿çšéã¯ïŒã40éšã
奜ãŸããã¯ïŒã20éšãããã«å¥œãŸããã¯ïŒã12éš
ã®ç¯å²ãšããã®ãé©åœã§ããã該ç³ã¢ã«ã³ãŒã«ã
æããåéäœã®äœ¿çšéã97éšããå€ãã°ããã¯ã
ããããã³ã³ã¿ã¯ãã¬ã³ãºã®åŒ·åºŠã匱ããªãããŸ
ãïŒéšããå°ãªãã°ããã¯ããã®äœ¿çšå¹æã®çºçŸ
ã«ä¹ãããããã®ã°ããã奜ãŸãããªãããŸãã
芪氎æ§åéäœã®äœ¿çšéã95éšããå€ãã°ããã¯ã
該ç³ã¢ã«ã³ãŒã«ãæããåéäœã®äœ¿çšå¹æã®çºçŸ
ã«ä¹ãããªããçæ°Žæ§åéäœã®äœ¿çšéã40éšãã
å€ãã°ããã¯ãé žåŠçã«ããè±ã±ã¿ãŒã«ååå¿ã
åæ»ã«é²è¡ãã«ãããªãã ãªããåèšããçæ°Žæ§åéäœã®ãã¡ã¡ã¿ã¯ãªã«
é žãŸãã¯ã¢ã¯ãªã«é žã®ããã«ãšã¹ãã«ãã¢ãªã«ãš
ã¹ãã«ã«ã€ããŠã¯ãåŸèšããæ¶æ©æ§åéäœãšããŠ
ã®æ©èœãåããŠããããããã®äœ¿çšéã¯ïŒéšä»¥äž
ãšããããšãæãŸããã äžèšïŒçš®ã®åéäœã¯ããããã®åéäœã®ãã¡äœ¿
çšããåéäœã®åèšéã100éšãšãªãããã«ãã
ããã®åéäœã«å¯Ÿããäžèšç¯å²ããé©å®éžæããŠ
䜿çšãããã ããã«æ¬çºæã®æ¹æ³ã«ãããŠã¯ãããããã³ã³
ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ãå®å®ããè溶åªæ§ãåäžã
ãããªã©ã®èŠ³ç¹ãããå¿ èŠã«å¿ããŠéåå¯èœãªå®
èœåºãïŒå以äžæããæ¶æ©æ§åéäœã䜿çšããŠã
ããããããæ¶æ©æ§åéäœãšããŠã¯ãããšãã°ãš
ãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒãããšãã¬ã³ã°
ãªã³ãŒã«ãžã¢ã¯ãªã¬ãŒãããžãšãã¬ã³ã°ãªã³ãŒã«
ãžã¡ã¿ã¯ãªã¬ãŒãããžãšãã¬ã³ã°ãªã³ãŒã«ãžã¢ã¯
ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬
ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¢ã¯ãªã¬ãŒãã
ããã«ã¡ã¿ã¯ãªã¬ãŒããããã«ã¢ã¯ãªã¬ãŒããã¢
ãªã«ã¡ã¿ã¯ãªã¬ãŒããã¢ãªã«ã¢ã¯ãªã¬ãŒãããžã
ãã«ãã³ãŒã³ããžã¢ãªã«ãã¿ã¬ãŒããããªã¡ãã
ãŒã«ãããã³ããªã¡ã¿ã¯ãªã¬ãŒããªã©ãããã
ãããããã®ãã¡ããïŒçš®ãŸãã¯ïŒçš®ä»¥äžãéžæ
ããŠäœ¿çšããããã®äœ¿çšéã¯äœ¿çšããåèšåéäœ
ã®åèšé100éšã«å¯ŸããŠ0.01ãïŒéšã®ç¯å²ã奜é©
ã§ããã åèšåéäœæ··åç©ã®éåã«éããŠã¯éåžžã®äžé£œ
åçåæ°ŽçŽ ååç©ã®éåã«äœ¿çšãããã©ãžã«ã«é
åéå§å€ã䜿çšã§ããããããã©ãžã«ã«éåéå§
å€ãšããŠã¯ãããšãã°ãã³ãŸã€ã«ããŒãªããµã€
ããã¢ãŸãã¹ã€ãœããããããªã«ãã¢ãŸãã¹ãžã¡
ãã«ãã¬ããããªã«ãªã©ãããããããããã®ã
ã¡ããïŒçš®ãŸãã¯ïŒçš®ä»¥äžãéžæããŠäœ¿çšããã
ãããéåéå§å€ã®äœ¿çšéã¯ãå ±éåãããã¹ã
å šåéäœæ··åç©100éšã«å¯ŸããŠçŽ0.01ãïŒéšã®ç¯
å²ã奜ãŸããã å ±éåã«éããæ°ŽãŸãã¯ãšãã¬ã³ã°ãªã³ãŒã«ã
ãããã¬ã³ã°ãªã³ãŒã«ãããã¬ã³ã°ãªã³ãŒã«ãã
ãªãšãã¬ã³ã°ãªã³ãŒã«ãããªãããã¬ã³ã°ãªã³ãŒ
ã«ãã°ãªã»ãªã³ãªã©ã®æ°Žæº¶æ§ã§éååå¿ã«å¯ŸããŠ
äžæŽ»æ§ãªç©è³ªã湿最å€ãšããŠåéäœæ··åç©äžã«çŽ
ïŒã45ïŒ ã®éã§ååšãããŠãããŠããããããã
湿最å€ã®äœ¿çšã¯å¿ é ã§ã¯ãªãããå ±éååå¿ãå¡
ç¶éåæ³ã«ãã湿最å€ã®ååšäžã§è¡ãªããšãã¯ã
湿最å€ãããããå ±éåäœäžã«å«æããããã
ããè±ã±ã¿ãŒã«åã®ããã®å ±éåäœã®é žåŠçã«ã
ãããŠæå¹ã§ãããããªãã¡ã湿最å€ã䜿çšãã
ããšã«ããã芪氎æ§åéäœã®äœ¿çšå²åãå°ããã°
ããããŸã€ãã䜿çšããªãã°ããã«ãããŠããã
ãããå ±éåäœããæ圢ãããã³ã³ã¿ã¯ãã¬ã³ãº
ãé žåŠçããå·¥çšã«ãããŠãã¬ã³ãºæ質äžã«å«æµž
ããã湿最å€ãä»ããŠé žæº¶æ¶²ãæå¹ã«æµžéããã
ãããšãã§ãããããè±ã±ã¿ãŒã«ååå¿ãå¹çã
ãè¡ãªããããããŸãããããã®æ¹¿æœ€å€ã䜿çšã
ãããšã«ãããããããå ±éåäœã«ç²ããäžãã
ååå å·¥çã«ãããæ©æ¢°å å·¥æ§ãåäžãããããš
ãã§ããã äžèšæ¹¿æœ€å€ã¯ãããšãã°é žåŠçåŸå«æ°Žæ§ã³ã³ã¿
ã¯ãã¬ã³ãºãã¢ã«ã«ãªæº¶æ¶²äžã§äžååŠçããã€ã
ã§æ°ŽãŸãã¯ççé£å¡©æ°Žã«æµžæŒ¬ããããã«ææã«ã
ãç ®æ²žåŠçããããšã«ãã容æã«ãããã®æ°ŽãŸã
ã¯ççé£å¡©æ°Žãšçœ®æããããšãã§ããã湿最å€ã®
䜿çšéã45ïŒ ãããå€ããããšãé žåŠçåŸã®ã¬ã³
ãºæ質ãçœæ¿ããŠå åŠæ§ãäœäžãããªã©ã®äžéœå
ãçãããããã奜ãŸãããªãã éåããã³ã³ã³ã¿ã¯ãã¬ã³ãºåœ¢ç¶ãžã®æ圢ã¯é
åžžã®éåæè¡ãæ圢æè¡ã§è¡ãªãããšãã§ããã
ããšãã°ãéåãã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«å¯Ÿå¿
ããåã®äžã§è¡ãªã€ãŠçŽæ¥ã³ã³ã¿ã¯ãã¬ã³ãºåœ¢ç¶
ã«æ圢ããããã«å¿ èŠã«å¿ããŠãããæ©æ¢°çã«ä»
äžãå å·¥ããããšãã§ããããŸãéåãé©åœãªå
ãŸãã¯å®¹åšäžã§è¡ãªã€ãŠãããã¯ç¶ãæ¿ç¶ãŸãã¯
äžžæ£ç¶ã®çŽ æãããã€ãã§ååãç 磚ãªã©ã®éåžž
ã®æ©æ¢°çå å·¥ã«ãã€ãŠææã®åœ¢ç¶ã®ã³ã³ã¿ã¯ãã¬
ã³ãºã«æ圢ããããšãã§ããã éåžžãé«å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããæ©æ¢°
çå å·¥ã«ãã€ãŠæ圢ããã°ããããã®åŒ·ãåžæ°Žç¹
æ§ã®ããå å·¥ç°å¢ããšãã«æ¹¿åºŠã®å¶åŸ¡ã«å€å€§ãªæ³š
æãæããªããã°ãªããªãããšããããæ¬çºæã®
æ¹æ³ã«ãããšãã¯ãåèšã®ãšããçŽ æäžã®è©²ç³ã¢
ã«ã³ãŒã«ãæããåéäœã®æ°Žé žåºãã±ã¿ãŒã«åã«
ãã€ãŠãã¹ã¯ãããŠãããããçŽ æã®åžæ°Žç¹æ§ã¯
çžå¯Ÿçã«åŒ±ãããã®ããäžèšéåžžã®é«å«æ°Žæ§ã³ã³
ã¿ã¯ãã¬ã³ãºã®ã°ããã«ããããããšãå³æ Œãªæ¹¿
床å¶åŸ¡ã¯äžèŠã§ããããŸãã該ç³ã¢ã«ã³ãŒã«ãæ
ããåéäœãå ±éåæåãšããŠå«ãå ±éåäœãé ž
åŠçããããã«äžååŠçããã®ã¡åžæ°Žãããèšæœ€
ãããã°ããã®ç·èšæœ€çã¯éåžžã®å«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºçšçŽ æãåžæ°Žãããèšæœ€ãããã°ããã®
ç·èšæœ€çã«æ¯èŒããŠèããå°ããããã®äºå®ã¯ç®
çãšããèŠæ Œã圢ç¶ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã
éèšæœ€ç¶æ ã®çŽ æãã補é ããããã§ãã®ç確ç
ãé«ãããšãã芳ç¹ããããããŠæãŸããããšã§
ããã ããããŠæ圢ããã³ã³ã¿ã¯ãã¬ã³ãºãçš®ã ã®æ
æ©é žãŸãã¯ç¡æ©é žã§é žåŠçããããšã«ãããå ±é
åäœäžã®ã±ã¿ãŒã«åºãæ°Žé žåºã«å€æãããããšã
ã°ã€ãã®åå¿åŒã«ç€ºãããããã«ãã€ãœããããª
ãã³åºãå æ°Žå解ã«ãã€ãŠé€å»ããå ±éåäœã®èŠª
æ°Žåãè¡ãªãããã äžèšé žåŠçã«äœ¿çšãããé žãšããŠã¯ãããšãã°
å¡©é žãç¡«é žããªã³é žãé ¢é žãè»é žãããªãã«ãªã
é ¢é žãªã©ããããããã䜿çšããé žã®æ¿åºŠãé«ã
ã°ããã«ã¯ã¬ã³ãºæ質ã®å£åãæãããã¯ã©ãã¯
ãçãããããå±éºæ§ããããããé žåŠçã¯åŸã
ã«ãŸãã¯æ®µéçã«åŠç液ã®æ¿åºŠãé«ããŠè¡ãªãã®
ã奜ãŸãããé©åœãªé žæ¿åºŠããã³æµžæŒ¬æéã¯è¢«åŠ
çã¬ã³ãºã®æ質ã䜿çšããé žã®çš®é¡ã«ãã€ãŠç°ãª
ããäžæŠã«ã¯ãããªãããããšãã°å¡©é žã®ã°ãã
ã¯çŽïŒã20ïŒ æ¿åºŠã«ãããŠå®€æž©äžçŽïŒãïŒæéã
è»é žãŸãã¯é ¢é žã®ã°ããã¯çŽ30ã90ïŒ ã®æ¿åºŠã«ã
ããŠå®€æž©äžçŽïŒæéã20æ¥éãããªãã«ãªãé ¢é ž
ã®ã°ããã¯çŽ80ã90ïŒ ã®æ¿åºŠã«ãããŠå®€æž©äžçŽïŒ
ãïŒæéã®åŠçã奜é©ã§ããã被åŠçã¬ã³ãºã®æ
質äžã«èŠªæ°Žæ§åéäœãå ±éåãããŠããããã€æ¹¿
最å€ãå«æµžãããŠããªãã°ãããæ¥æ¿ãªè±ã±ã¿ãŒ
ã«ååå¿ã®å±èµ·ã¯ã³ã³ã¿ã¯ãã¬ã³ãºã«ã¯ã©ãã¯ã
çããããããããšãã«é žåŠçãåŸã ã«ãŸãã¯æ®µ
éçã«åŠç液ã®é žæ¿åºŠãé«ããŠè¡ãªãã®ã奜ãŸã
ãããã®ã°ãããããšãã°æåçŽïŒïŒ çšåºŠã®äœæ¿
床ã®é žæ°Žæº¶æ¶²äžã«æ°æéãæ°æ¥éã³ã³ã¿ã¯ãã¬ã³
ãºã浞挬ããã€ãã§é«æ¿åºŠé žæ°Žæº¶æ¶²äžã«ç§»ããã
ãŠé žåŠçãè¡ãªãããã äžèšé žåŠçã«ããåå¿ã¯æšæºåŠçæ¹æ³ããã³æš
æºåŠçæéã«å³å¯ã«èŠå¶ãããããšãªããäžå®ã®
蚱容ç¯å²å ã§åçŸæ§ããè¡ãªãããšãã§ããã
ããå·¥æ¥çå®æœã«éããŠã¯ãšãã«æå©ã§ããã ããããŠé žåŠçãããã³ã³ã¿ã¯ãã¬ã³ãºã¯ãç
é žãããªãŠã ãªã©ã®ã¢ã«ã«ãªæ§æ°Žæº¶æ¶²ã«æµžæŒ¬ããŠ
äžååŠçããŠãããããããã¯æ°ŽãŸãã¯ççé£å¡©
æ°Žäžã§æµžæŒ¬ãŸãã¯ç ®æ²žåŠçããªããããã æ¬çºæã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯é«ãå«æ°Žçãæã
é žçŽ ééæ§ã«ãããããããæè»æ§ããã³å¯ææ§
ã«å ããŠçŒçµç¹ã«å¯Ÿãããããã芪åæ§ãæãã
ãããé·æéé£ç¶è£ çšããããšãå¯èœã§ãããã
ãã«æ¬çºæã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å åŠæ§ã«ãã
ãããŸãã³ã³ã¿ã¯ãã¬ã³ãºã®ããããç¹æ§ãæãª
ãããšãªãæ°Žäžã§ã®ç ®æ²žæ®ºèåŠçãå¯èœã§ããã ã€ãã«å®æœäŸããããŠæ¬çºæã®ã³ã³ã¿ã¯ãã¬ã³
ãºããã³ãã®è£œé æ³ã詳现ã«èª¬æããããŸã代衚
çãªã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåé
äœã§ããIPGMAã®è£œé æ³ã®äžäŸãåèäŸã«ãŠèª¬
æããã åèäŸ ïŒã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãããã®IPGMAã®å
æïŒ ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã15ïœïŒ0.11ã¢ã«ïŒã
ã¢ã»ãã³50mlïŒ0.68ã¢ã«ïŒããã³ãããããã³ã¢
ãã¡ãã«ãšãŒãã«100ppmããã©ã¹ã³ã«å ¥ãæ¹æ
äžãããã«ã±ã€ã¿ã³ã°ã¹ãã³é ž26æ°Žå¡©0.1ïœãå
ããŠç©ºæž©ã§28æéåå¿ãããããåå¿çµäºåŸç¡æ°Ž
çé žãããªãŠã 10ïœãå ããŠã±ã€ã¿ã³ã°ã¹ãã³é ž
ãäžåããã€ãã§ïŒæéæ¹æåŸã該åå¿æ¶²ãåžåŒ
éããŠæ²æ®¿ç©ãé€å»ããã®ã¡æžå§äžã«ã¢ã»ãã³
ãçå»ããããã«200mlã®ïœâãããµã³ãå ããŠ
åå¿äžã«çæããéåç©ãé€å»ãããããããïœ
âãããµã³æº¶æ¶²ã«ç¡æ°Žç¡«é žãããªãŠã 25ïœãå
ããããã«æŽ»æ§çïŒïœãå ããŠæ¹æåŸäžå€æŸçœ®ã
ãã該åå¿æ¶²ãåžåŒéããã®ã¡æžå§æ¿çž®ããæž
å§èžç粟補ãè¡ãªãã沞ç¹60âïŒ0.2mmïœã®ç¡
è²éæãªæ¶²äœ12.5ïœãããïŒåç59.2ïŒ ïŒããã
ãã液äœãåå®ãããšãããå±æçïœïŒïŒ ïŒ1.442
ã§ãããèµ€å€ç·åžåã¹ãã¯ãã«ããIPGMAã§ã
ãããšã確èªãããã æ¬åèäŸã«ãããŠåå¿æãåå¿éå§20åã20æ
éåŸããã³åå¿çµäºæïŒ28æéåŸïŒã®åå¿æ¶²ãã¬
ã¹ã¯ãããã°ã©ãã€ãŒã«ãã€ãŠèª¿ã¹ãçµæãåå¿
éå§20ååŸã«ã¯ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãã¯ã»ãš
ãã©æ¶è²»ãããIPGMAãšå¯çæç©ãã»ãŒåéç
æãã20æéåŸã«ã¯å¯çæç©ã¯æžå°ããIPGMA
ãå¢å ããŠããã28æéåŸã«ã¯å¯çæç©ã¯å®å šã«
æ¶å€±ããIPGMAã®ã¿ãšãªãããšãããªãã¡åå¿
éäžã§äžæçã«å¯çæç©ãçããããæçµçã«ã¯
çæç©ã¯IPGMAã®ã¿ãšãªãããšãå€æããããŸ
ããäžèšå¯çæç©ãæ žç£æ°å ±é³Žã¹ãã¯ãã«
ïŒNMRïŒçã«ãã€ãŠåæãããšããã該å¯çæç©
ãDMDOã§ããããšã確èªãããã ãªããæ¬åèäŸã§äœ¿çšããã¢ã»ãã³ã«ä»£ããŠ
çš®ã ã®ã±ãã³ãããšãã°ã¡ãã«ãšãã«ã±ãã³ãã¡
ãã«ã€ãœããã«ã±ãã³ãã·ã¯ããããµãã³ãªã©ã
ãããã䜿çšããããšã«ãããæ¬åèäŸãšåæ§ã®
æ¹æ³ã§MEMAïŒMBMAãïŒâMSDDãªã©ã®çš®ã
ã®ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåéäœ
ã調補ããããšãã§ãããŸããã®åå¿éçšã«ãã
ãŠå¯çæç©ãšããŠããããMEDOïŒMBDOïŒ
MSDOãªã©ã®ãžãªããµã³èªå°äœåã®è©²ç³ã¢ã«ã³ãŒ
ã«ãæããåéäœãåæã«ããããšãã§ããææ
ã§ããã°èžçãç¹°ãè¿ãããšã«ãããããå¯çæ
ç©ã®çŽåºŠãé«ããããšãã§ããã å®æœäŸ ïŒ IPGMA72.52ïœãâããã«ãããªãã³ïŒä»¥äž
âVPãšç¥èšïŒ13.74ïœãã¡ãã«ã¡ã¿ã¯ãªã¬ãŒã
ïŒä»¥äžMMAãšç¥èšïŒ13.74ïœããã³éåéå§å€ãš
ããŠã¢ãŸãã¹ãžã¡ãã«ãã¬ããããªã«ïŒä»¥äž
ADMVNãšç¥èšïŒ0.06ïœãæ··åãã溶解ãããŠè©Š
éšç®¡ã«å ¥ããæ枩氎槜äžã«ãããŠ40âã§24æéé
åãããããã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæ
éã60âã§ïŒæéã80âã§ïŒæéã100âã§ïŒæ
éãæåŸã«110âã§ïŒæéå ç±éåãããŠç¡è²é
æãªæ£ç¶ã®éåäœçŽ æãããããã®ãã®ãåžžæ³ã«
ããååããç 磚å å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢
ç¶ã«æ圢ããã®ã¡ã2Nå¡©é žæ°Žæº¶æ¶²äžã«24æé浞
挬ããŠé žåŠçããã€ãã§ããããå«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºãèžçæ°Žäžã«15åé浞挬ããã®ã¡ã0.5
ïŒ çé žãããªãŠã 氎溶液äžã«30åé浞挬ããŠäžå
åŠçãè¡ãªããããã«èžçæ°Žäžã«15åé浞挬ãã
ãããã®ã¡ã«0.9ïŒ ççé£å¡©æ°Žäžã§ïŒæéç ®æ²žåŠ
çããŠç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãããã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯æè»ã§å¯ææ§ãæ
ããå«æ°Žç60.2ïŒ ãé žçŽ ééä¿æ°2.46Ã10-10c.c.ã»
cmïŒcm2ã»secã»mmïœãå±æçïŒïœïŒïŒ ïŒ1.391ã§ã
å¯èŠå ç·ééçã90ïŒ ãè¶ ãããã®ã§ãã€ãã ãªããå«æ°Žçã®æž¬å®ã¯20âã0.9ïŒ ççé£å¡©æ°Ž
äžã§ã®é£œåå«æ°Žçã«ã€ããŠè¡ãªãããŸãé žçŽ éé
ä¿æ°ã®æž¬å®ã¯çå粟æ©å·¥æ¥(æ ª)補ã®è£œç§ç åŒãã€ã«
ã é žçŽ ééçèšã䜿çšãã35âã0.9ïŒ å¡©åãã
ãªãŠã 氎溶液äžã«ãŠçœéé»æ¥µæ³ã«ããè¡ãªã€ãã
å¯èŠå ç·ééçã®æž¬å®ã¯(æ ª)島接補äœæ補UVã»210
ã䜿çšããæ³¢é·780ã380nmã®é åã«ãŠç³è±æ¿ã«
æŸãã§è¡ãªã€ããå±æçã¯ãšã«ãå åŠ(æ ª)補ã®ã¢ã
ãå±æèšãçšããŠãã€ã¹ã¯åœ¢ç¶ã®è©Šéšçã«ã€ããŠ
枬å®ããã æ¯èŒäŸ ïŒ ãŸããã¢ã¡ãªã«ç¹èš±ç¬¬4267295å·æ现æžã®å®æœ
äŸïŒã®èšèŒã«æºæ ããŠãã€ãã®ãšããã°ãªã»ããŒ
ã«ã¡ã¿ã¯ãªã¬ãŒããåæããã åžè²©ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãïŒäžè±ã¬ã€ãšã³
(æ ª)補ãåååã¢ã¯ãªãšã¹ãã«ïŒ§ïŒïŒKgãèžçæ°Ž
1500mlããã³æ¿ç¡«é ž2.5mlãïŒæ¥éæ¹æãããã
ã®éãåå¿ãã©ã¹ã³ã24ã29âã®æ°ŽæµŽäžã«ä¿ã€
ãã ããããåå¿æ··åç©ã10ïŒ æ°Žé žåãããªãŠã æ°Ž
溶液ã§äžåããã€ãã§ãšãŒãã«åïŒã§ïŒåæœåº
ããæœåºåŸæ°Žå±€ã«å¡©åãããªãŠã ã飜åããã飜
åå¡©æ°Žäžã«åé¢ãã油局ãåãåºããå¡©åã¡ãã¬
ã³ã«æº¶è§£ãããããããã該溶液äžã«ç¡æ°Žç¡«é žã
ããªãŠã ãå ããŠ16æéå·ææã«æŸçœ®ããã®ã¡ã
å£éããŠç¡«é žãããªãŠã ãé€å»ããããã«å·æ°ŽæµŽ
äžã§ãšããã¬ãŒã¿ã«ããå¡©åã¡ãã¬ã³ãæžå§é€å»
ããç¡è²éæ液äœã®ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ãããã ã€ãã«ãå®æœäŸïŒã«ãããŠããå«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºã®æ§æéšåãšããŠã®ã°ãªã»ããŒã«ã¡ã¿ã¯
ãªã¬ãŒããâVPïŒMMAã®ïŒæåã®çè«äžã®ã¢
ã«æ¯ã«äžèŽããããã«ãäžèšã®ã°ãªã»ããŒã«ã¡ã¿
ã¯ãªã¬ãŒãããã³ïŒ®âVPïŒMMAã®é åéããã
ãã67.86ïœã16.07ïœã16.07ïœãšããããã«
ADMVN0.06ïœã䜿çšããŠå®æœäŸïŒãšåæ§ã®éå
æ¡ä»¶ã«ãããç¡è²éæãªæ£ç¶ã®éåäœçŽ æãã
ãããã®ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠ
ã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã€ãã§0.9ïŒ
ççé£å¡©æ°Žã«æµžæŒ¬ããæ°Žåèšæœ€ãããããããã
ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç49.5ïŒ ãé žçŽ ééä¿æ°
1.47Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±æç
ïŒïœïŒïŒ ïŒ1.412ã§ãã€ãããã ããå¯èŠå ç·ééç
ã¯90ïŒ ãè¶ ããã æ¯èŒäŸ ïŒ ãŸããã¢ã¡ãªã«ç¹èš±ç¬¬4056496å·æ现æžã®å®æœ
äŸïŒã®èšèŒã«æºæ ããŠãã€ãã®ãšããã°ãªã»ããŒ
ã«ã¡ã¿ã¯ãªã¬ãŒããåæããã ã€ãœããããªãã³ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ïŒKgãèžçæ°ŽïŒãæ¿ç¡«é žïŒïœããã³ããããã
ã³ã¢ãã¡ãã«ãšãŒãã«0.4ïœã16æé25ã30âã®
氎济äžã§æ¹æããã®ã¡ãæ°Žé žåããªãŠã ã§ç¡«é žã
äžåããã€ãã§çããç¡«é žããªãŠã ã®æ²æ®¿ãå¥
ããå£æ¶²ã«å¡©åãããªãŠã ãå ããŠé£œåããã飜
åå¡©æ°Žäžã«åé¢ãã油局ããšãŒãã«ã§æœåºããã
ãããæœåºæ¶²ã«ç¡æ°Žç¡«é žãããªãŠã ãå ããŠäžå€
å·ææã§æŸçœ®ããããã«å£éããã®ã¡å·æ°ŽæµŽäžã§
ãšããã¬ãŒã¿ãŒã«ãã溶åªãæžå§èžçããç¡è²é
æ液äœã®ã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒããããã ã€ãã§ãããããã°ãªã»ããŒã«ã¡ã¿ã¯ãªã¬ãŒã
ã䜿çšãã以å€ã¯æ¯èŒäŸïŒãšãŸã€ããåæ§ã«ããŠ
å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãäœæããããã®ã³ã³ã¿
ã¯ãã¬ã³ãºã¯å«æ°Žç54.3ïŒ ãé žçŽ ééä¿æ°1.72Ã
10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±æçïŒïœïŒïŒ 
ïŒ
1.404ã§ãããå¯èŠå ç·ééçã90ïŒ ãè¶ ããã
ã®ã§ãã€ãã å®æœäŸïŒãæ¯èŒäŸïŒïŒïŒããæ¬çºæã®å«æ°Žæ§ã³
ã³ã¿ã¯ãã¬ã³ãºã®å«æ°Žçãããé«ãå€ã瀺ãããš
ããããã å®æœäŸ ïŒ IPGMA75ïœãïŒâããããã·ãšãã«ã¡ã¿ã¯ãª
ã¬ãŒãïŒä»¥äžïŒâHEMAãšç¥èšïŒ20ïœãã©ãŠãª
ã«ã¡ã¿ã¯ãªã¬ãŒãïŒä»¥äžLMAãšç¥èšïŒïŒïœãã
ã³ADMVN0.07ïœãæ··åãã溶解ãããŠè©Šéšç®¡ã«
å ¥ããæ枩氎槜äžã«ãããŠ35âã§48æééåã
ããããã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæéã
60âã§ïŒæéã80âã§ïŒæéã100âã§ïŒæéã
æåŸã«110âã§ïŒæéå ç±éåãããŠãæ£ç¶ã®é
åäœçŽ æãããããã®ãã®ãåžžæ³ã«ããååãã
ç 磚å å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ãã
ã®ã¡ã50ïŒ ã®é žæ°Žæº¶æ¶²äžã«30åéã6Nå¡©é žæ°Žæº¶
液äžã«ïŒæéïŒãŸãã¯ã3.6Nå¡©é žæ°Žæº¶æ¶²äžã§ïŒ
æéïŒæµžæŒ¬ããŠé žåŠçãè¡ãªããã€ãã§0.024ïŒ
çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠäžååŠçãã
ç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç63.1ïŒ ãé žçŽ é
éæ°2.27Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±æ
çïŒïœïŒïŒ ïŒ1.390ã§ãå¯èŠå ç·ééçã90ïŒ ãè¶
ãããã®ã§ãã€ãã å®æœäŸ ïŒãïŒ å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸïŒãšåæ§ã«ããŠå®éšãè¡ãªãå«æ°Žæ§
ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã ãªãå®æœäŸïŒã®IPGMAã®å ±éåäœã®é žåŠçå
ãšé žåŠçåŸã®èµ€å€åžåã¹ãã¯ãã«ãæ¥æ¬åå å·¥æ¥
(æ ª)補â202ã䜿çšããŠãæ³¢æ°4000ã400cm-1ã®é
åã«ãããŠæž¬å®ãããã€ãŒãã第ïŒå³ã«ãããŠã
ãããããã³ïŒ¢ã§ç€ºãã第ïŒå³ã«ãããŠ3400cm
-1ä»è¿ã«ãããOHåºã®åžåãããé žåŠçåŸã®
IPGMAã®å ±éåäœã«æ°Žé žåºã®æãããªå¢å ãã¿
ããããšåæã«280cm-1ä»è¿ã«ããããžãªããœã©
ã³ç°ã®æ¶å€±ãèªããããã
ãè¡šã
å®æœäŸ ïŒ
MEMA67ïœãïŒâHEMA25ïœLMA6ïœã
MMH2ïœããšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒ
ãïŒä»¥äžEDMAãšç¥èšïŒ0.3ïœããã³éåéå§å€
ãšããŠã¢ãŸãã¹ã€ãœããããããªã«ïŒä»¥äžAIBN
ãšç¥èšïŒ0.07ïœãæ··åã溶解ãããŠè©Šéšç®¡ã«å ¥
ããæ枩氎槜äžã«ãããŠ40âã§24æééåããã
ããã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæéã60â
ã§ïŒæéã80âã§ïŒæéã100âã§ïŒæéãæåŸ
ã«110âã§ïŒæé段éçã«å ç±éåãããŠæ£ç¶ã®
éåäœçŽ æãããã ãã®ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠã³
ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ãå®æœäŸïŒ
ãšåæ§ã®æ¡ä»¶ã§é žåŠçãšäžååŠçãè¡ãªãç®çãš
ããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããããã®ã³ã³ã¿
ã¯ãã¬ã³ãºã¯å«æ°Žç51.3ïŒ ãé žçŽ ééä¿æ°1.64Ã
10-10c.c.ã»cm2ã»secã»mmïœãå±æçïŒïœïŒïŒ ïŒ1.4
07
ã§ãå¯èŠå ç·ééçã90ïŒ ãã倧ã§ãã€ãã å®æœäŸ ïŒãïŒ å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸïŒãšåæ§ã«ããŠå®éšãè¡ãªãå«æ°Žæ§
ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã
MMH2ïœããšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒ
ãïŒä»¥äžEDMAãšç¥èšïŒ0.3ïœããã³éåéå§å€
ãšããŠã¢ãŸãã¹ã€ãœããããããªã«ïŒä»¥äžAIBN
ãšç¥èšïŒ0.07ïœãæ··åã溶解ãããŠè©Šéšç®¡ã«å ¥
ããæ枩氎槜äžã«ãããŠ40âã§24æééåããã
ããã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæéã60â
ã§ïŒæéã80âã§ïŒæéã100âã§ïŒæéãæåŸ
ã«110âã§ïŒæé段éçã«å ç±éåãããŠæ£ç¶ã®
éåäœçŽ æãããã ãã®ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠã³
ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ãå®æœäŸïŒ
ãšåæ§ã®æ¡ä»¶ã§é žåŠçãšäžååŠçãè¡ãªãç®çãš
ããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããããã®ã³ã³ã¿
ã¯ãã¬ã³ãºã¯å«æ°Žç51.3ïŒ ãé žçŽ ééä¿æ°1.64Ã
10-10c.c.ã»cm2ã»secã»mmïœãå±æçïŒïœïŒïŒ ïŒ1.4
07
ã§ãå¯èŠå ç·ééçã90ïŒ ãã倧ã§ãã€ãã å®æœäŸ ïŒãïŒ å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸïŒãšåæ§ã«ããŠå®éšãè¡ãªãå«æ°Žæ§
ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã
ãè¡šã
å®æœäŸ 10
MPMA50ïœãïŒâHEMA44ïœãLMA6ïœã
EDMA0.3ïœããã³éåéå§å€ãšããŠADMVN0.07
ïœãæ··åãã溶解ãããŠè©Šéšç®¡ã«å ¥ããæ枩氎槜
äžã«ãããŠ35âã§48æééåãããããã«ç±é¢šåŸª
ç°ä¹Ÿç¥åšã«ãŠ45âã§16æéã70âã§ïŒæéã90â
ã§ïŒæé段éçã«å ç±éåãããæ£ç¶ã®éåäœçŽ
æãããããã®ãã®ãåžžæ³ã«ããååããç 磚å
å·¥ã«ããã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®
ã¡ãå®æœäŸïŒãšåæ§ã®æ¡ä»¶ã§é žåŠçãšäžååŠçã
è¡ãªãç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãããã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç35.8ïŒ ãé žçŽ
ééä¿æ°1.22Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœã
å±æçïŒïœïŒïŒ ïŒ1.431ã§ãå¯èŠå ç·ééçã90ïŒ
ãã倧ã§ãã€ãã å®æœäŸ 11ã13 å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ10ãšåæ§ã«ããŠå®éšãè¡ãªãå«æ°Žæ§
ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã
EDMA0.3ïœããã³éåéå§å€ãšããŠADMVN0.07
ïœãæ··åãã溶解ãããŠè©Šéšç®¡ã«å ¥ããæ枩氎槜
äžã«ãããŠ35âã§48æééåãããããã«ç±é¢šåŸª
ç°ä¹Ÿç¥åšã«ãŠ45âã§16æéã70âã§ïŒæéã90â
ã§ïŒæé段éçã«å ç±éåãããæ£ç¶ã®éåäœçŽ
æãããããã®ãã®ãåžžæ³ã«ããååããç 磚å
å·¥ã«ããã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®
ã¡ãå®æœäŸïŒãšåæ§ã®æ¡ä»¶ã§é žåŠçãšäžååŠçã
è¡ãªãç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãããã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç35.8ïŒ ãé žçŽ
ééä¿æ°1.22Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœã
å±æçïŒïœïŒïŒ ïŒ1.431ã§ãå¯èŠå ç·ééçã90ïŒ
ãã倧ã§ãã€ãã å®æœäŸ 11ã13 å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ10ãšåæ§ã«ããŠå®éšãè¡ãªãå«æ°Žæ§
ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã
ãè¡šã
å®æœäŸ 14
ïŒâMDIX70ïœãïŒâHEMA25ïœãLMA4.5
ïœãAMA0.5ïœããã³éåéå§å€ãšããŠ
ADMVN0.07ïœãæ··åãã溶解ããè©Šéšç®¡ã«å ¥ã
æ枩氎槜äžã«ãããŠ40âã§24æééåããããã
ã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæéã60âã§ïŒ
æéã80âã§ïŒæéã100âã§ïŒæéã110âã§ïŒ
æé段éçã«å ç±éåãè¡ãªããæ£ç¶ã®éåäœçŽ
æãããããã®ãã®ãåžžæ³ã«ããååããç 磚å
å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã
å®æœäŸïŒãšåæ§ã®æ¡ä»¶ã§é žåŠçãšäžååŠçãè¡ãª
ãç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããã
ã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç72.0ïŒ ãé žçŽ ééä¿
æ°2.76Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœå±æç
ïŒïœïŒïŒ ïŒ1.374ã§å¯èŠå ç·ééçã90ïŒ ãã倧ã§ã
ã€ãã å®æœäŸ 15ã17 å ±å®åã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ14ãšåæ§ã«ããŠå®éšãè¡ãªãã³ã³ã¿
ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã
ïœãAMA0.5ïœããã³éåéå§å€ãšããŠ
ADMVN0.07ïœãæ··åãã溶解ããè©Šéšç®¡ã«å ¥ã
æ枩氎槜äžã«ãããŠ40âã§24æééåããããã
ã«ç±é¢šåŸªç°ä¹Ÿç¥åšäžã«ãŠ50âã§ïŒæéã60âã§ïŒ
æéã80âã§ïŒæéã100âã§ïŒæéã110âã§ïŒ
æé段éçã«å ç±éåãè¡ãªããæ£ç¶ã®éåäœçŽ
æãããããã®ãã®ãåžžæ³ã«ããååããç 磚å
å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã
å®æœäŸïŒãšåæ§ã®æ¡ä»¶ã§é žåŠçãšäžååŠçãè¡ãª
ãç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããã
ã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç72.0ïŒ ãé žçŽ ééä¿
æ°2.76Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœå±æç
ïŒïœïŒïŒ ïŒ1.374ã§å¯èŠå ç·ééçã90ïŒ ãã倧ã§ã
ã€ãã å®æœäŸ 15ã17 å ±å®åã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ14ãšåæ§ã«ããŠå®éšãè¡ãªãã³ã³ã¿
ã¯ãã¬ã³ãºããããçµæã第ïŒè¡šã«ç€ºãã
ãè¡šã
å®æœäŸ 18
IPGMA70ïœãLMA6ïœãMMA2ïœããã³
AMA0.2ïœãããªãåéäœæ··åç©ã«ã湿最å€ãšã
ãŠããªãããã¬ã³ã°ãªã³ãŒã«ïŒå¹³åååé
3.000ïŒïŒïœãéåéå§å€ãšããŠADMVN0.03ïœã
ããããå ããŠæ··åãã溶解ãããã®ã¡ãã³ã³ã¿
ã¯ãã¬ã³ãºã®åœ¢ç¶ã«å¯Ÿå¿ãã圢ç¶ã®éåãšéåã
æããæååšäžã«æ³šå ¥ãã埪ç°ä¹Ÿç¥åšäžã«ãŠ35â
ã§48æéã50âã§ïŒæéã60âã§ïŒæé段éçã«
å ç±éåæ圢ãè¡ãªã€ãã®ã¡è±åããããããã³
ã³ã¿ã¯ãã¬ã³ãºåœ¢ç¶ã®æ圢ç©ã50ïŒ ã®é žæ°Žæº¶æ¶²äž
ã«30åéã6Nå¡©é žæ°Žæº¶æ¶²äžã«ïŒæé浞挬ããã€
ãã§0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠ
ã³ã³ã¿ã¯ãã¬ã³ãºå ã®é žãäžåããããã«0.9ïŒ
ççé£å¡©æ°Žäžã«æµžæŒ¬ããŠïŒæéã®ç ®æ²žãïŒåºŠç¹°ã
è¿ããŠç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãããã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç89.6ïŒ ãé žçŽ
ééä¿æ°4.50Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœã
å±æçïŒïœïŒïŒ ïŒ1.350ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 19 IPGMA70ïœãALIPG6ïœãïŒâHEMA15ïœã
LMA6ïœãMMA2ïœãAMA0.2ïœããã³
ADMVN0.07ïœã䜿çšããå®æœäŸ14ãšåæ§ã«ããŠ
ç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç60.2ïŒ ãé žçŽ é
éä¿æ°2.46Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.391ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 20 IPGMA33.5ïœãMEMA33.5ïœãïŒâHEMA25
ïœãLMA6ïœãMMA2ïœãEDMA0.3ïœããã³
ADMVN0.2ïœã䜿çšããŠå®æœäŸ14ãšåæ§ã®éå
æ¡ä»¶ã§éåãããéæãªæ£ç¶ã®éåäœçŽ æãã
ãããã®ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠ
ã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã4Nå¡©
é žæ°Žæº¶æ¶²äžã«ïŒæé浞挬ããŠé žåŠçããã€ãã§
0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠäžå
åŠçãè¡ãªãç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã
ããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç50.0ïŒ ãé žçŽ é
éä¿æ°1.63Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.408ãå¯èŠå ç·ééçã90ïŒ ãè¶
ãããã®ã§ãã€ãã å®æœäŸ 21 MEMA25ïœãïŒâMDIX25ïœãïŒâHEMA44
ïœãLMA6ïœãEDMA0.3ïœããã³ADMVN0.2ïœ
ã䜿çšããé žåŠçæ¡ä»¶ã2Nå¡©é žæ°Žæº¶æ¶²äžã§ïŒæ
éãšããã»ãã¯å®æœäŸ20ãšåæ§ã«ããŠç®çç©ã®å«
æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç52.5ïŒ ãé žçŽ é
éä¿æ°1.69Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.403ãå¯èŠå ç·ééçã90ïŒ ãè¶
ãããã®ã§ãã€ãã å®æœäŸ 22 DMDOãšIPGMAãééæ¯ã§82ïŒ18ã§å«ãæ··å
液ïŒä»¥äžVKãšç¥èšïŒ100ïœãAMA0.5ïœã
EDMA0.2ïœããã³ADMVN0.1ïœã䜿çšããå®æœ
äŸ14ãšåæ§ã®éåæ¡ä»¶ã§éåãããéæãªæ£ç¶ã®
éåäœçŽ æãããããã®ãã®ãåžžæ³ã«ããåå
ããç 磚å å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢
ããã®ã¡ã50ïŒ ã®é žæ°Žæº¶æ¶²äžã«20åéã6Nå¡©é ž
氎溶液äžã«ïŒæé浞挬ããŠé žåŠçãè¡ãªããã€ã
ã§0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠäž
ååŠçããç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç75.7ïŒ ãé žçŽ é
éä¿æ°2.75Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.370ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 23ïŒ24 å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ22ãšåæ§ã«ããŠå®éšãè¡ãªããç®ç
ç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒ
è¡šã«ç€ºãã
AMA0.2ïœãããªãåéäœæ··åç©ã«ã湿最å€ãšã
ãŠããªãããã¬ã³ã°ãªã³ãŒã«ïŒå¹³åååé
3.000ïŒïŒïœãéåéå§å€ãšããŠADMVN0.03ïœã
ããããå ããŠæ··åãã溶解ãããã®ã¡ãã³ã³ã¿
ã¯ãã¬ã³ãºã®åœ¢ç¶ã«å¯Ÿå¿ãã圢ç¶ã®éåãšéåã
æããæååšäžã«æ³šå ¥ãã埪ç°ä¹Ÿç¥åšäžã«ãŠ35â
ã§48æéã50âã§ïŒæéã60âã§ïŒæé段éçã«
å ç±éåæ圢ãè¡ãªã€ãã®ã¡è±åããããããã³
ã³ã¿ã¯ãã¬ã³ãºåœ¢ç¶ã®æ圢ç©ã50ïŒ ã®é žæ°Žæº¶æ¶²äž
ã«30åéã6Nå¡©é žæ°Žæº¶æ¶²äžã«ïŒæé浞挬ããã€
ãã§0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠ
ã³ã³ã¿ã¯ãã¬ã³ãºå ã®é žãäžåããããã«0.9ïŒ
ççé£å¡©æ°Žäžã«æµžæŒ¬ããŠïŒæéã®ç ®æ²žãïŒåºŠç¹°ã
è¿ããŠç®çãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãããã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç89.6ïŒ ãé žçŽ
ééä¿æ°4.50Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœã
å±æçïŒïœïŒïŒ ïŒ1.350ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 19 IPGMA70ïœãALIPG6ïœãïŒâHEMA15ïœã
LMA6ïœãMMA2ïœãAMA0.2ïœããã³
ADMVN0.07ïœã䜿çšããå®æœäŸ14ãšåæ§ã«ããŠ
ç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç60.2ïŒ ãé žçŽ é
éä¿æ°2.46Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.391ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 20 IPGMA33.5ïœãMEMA33.5ïœãïŒâHEMA25
ïœãLMA6ïœãMMA2ïœãEDMA0.3ïœããã³
ADMVN0.2ïœã䜿çšããŠå®æœäŸ14ãšåæ§ã®éå
æ¡ä»¶ã§éåãããéæãªæ£ç¶ã®éåäœçŽ æãã
ãããã®ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠ
ã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã4Nå¡©
é žæ°Žæº¶æ¶²äžã«ïŒæé浞挬ããŠé žåŠçããã€ãã§
0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠäžå
åŠçãè¡ãªãç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã
ããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç50.0ïŒ ãé žçŽ é
éä¿æ°1.63Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.408ãå¯èŠå ç·ééçã90ïŒ ãè¶
ãããã®ã§ãã€ãã å®æœäŸ 21 MEMA25ïœãïŒâMDIX25ïœãïŒâHEMA44
ïœãLMA6ïœãEDMA0.3ïœããã³ADMVN0.2ïœ
ã䜿çšããé žåŠçæ¡ä»¶ã2Nå¡©é žæ°Žæº¶æ¶²äžã§ïŒæ
éãšããã»ãã¯å®æœäŸ20ãšåæ§ã«ããŠç®çç©ã®å«
æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç52.5ïŒ ãé žçŽ é
éä¿æ°1.69Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.403ãå¯èŠå ç·ééçã90ïŒ ãè¶
ãããã®ã§ãã€ãã å®æœäŸ 22 DMDOãšIPGMAãééæ¯ã§82ïŒ18ã§å«ãæ··å
液ïŒä»¥äžVKãšç¥èšïŒ100ïœãAMA0.5ïœã
EDMA0.2ïœããã³ADMVN0.1ïœã䜿çšããå®æœ
äŸ14ãšåæ§ã®éåæ¡ä»¶ã§éåãããéæãªæ£ç¶ã®
éåäœçŽ æãããããã®ãã®ãåžžæ³ã«ããåå
ããç 磚å å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢
ããã®ã¡ã50ïŒ ã®é žæ°Žæº¶æ¶²äžã«20åéã6Nå¡©é ž
氎溶液äžã«ïŒæé浞挬ããŠé žåŠçãè¡ãªããã€ã
ã§0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠäž
ååŠçããç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãã
ãã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç75.7ïŒ ãé žçŽ é
éä¿æ°2.75Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.370ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 23ïŒ24 å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ22ãšåæ§ã«ããŠå®éšãè¡ãªããç®ç
ç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒ
è¡šã«ç€ºãã
ãè¡šã
ãè¡šã
å®æœäŸ 25
IPGMA85ïœãMMA15ïœãEDMA0.5ïœããã³
ADMVN0.2ïœã䜿çšããŠå®æœäŸ14ãšåæ§ã®éå
æ¡ä»¶ã§éåãããæ£ç¶ã®éåäœçŽ æãããããã®
ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠã³ã³ã¿ã¯
ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã40ïŒ ã®é žæ°Žæº¶æ¶²
äžã«20åéã3Nå¡©é žæ°Žæº¶æ¶²äžã«40åé浞挬ããŠ
é žåŠçãè¡ãªããã€ãã§0.024ïŒ çé žãããªãŠã
氎溶液äžã«æµžæŒ¬ããŠäžååŠçãè¡ãªããããã«
0.9ïŒ ççé£å¡©æ°Žäžã«ãŠïŒæéç ®æ²žåŠçããç®ç
ç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç55.8ïŒ ãé žçŽ é
éä¿æ°2.00Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.399ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 26 IPGMA80ïœãïŒâHEMA5ïœãMMA15ïœã
EDMA0.5ïœããã³ADMVN0.2ïœã䜿çšããå®æœ
äŸ25ãšåæ§ã«ããŠç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç53.4ïŒ ãé žçŽ é
éä¿æ°1.70Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.401ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 27 IPGMA15ïœãALIPG15ïœãïŒïŒïŒïŒïŒïŒïŒâ
ãžââã€ãœããããªãã³âïŒââã¡ã¿ã¯ãªã
ã€ã«ââã°ã«ã³ãã©ãã·ãïŒä»¥äžMDGãšç¥
èšïŒ15ïœãïŒâHEMA40ïœãMMA15ïœã
AMA0.2ïœããã³ADMVN0.2ïœã䜿çšããŠå®æœäŸ
14ãšåæ§ã®éåæ¡ä»¶ã§éåãããæ£ç¶ã®éåäœçŽ
æãããããã®ãã®ãåžžæ³ã«ããååããç 磚å
å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã
2Nå¡©é žæ°Žæº¶æ¶²äžã«ïŒæé浞挬ããŠé žåŠçããã€
ãã§0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠ
äžååŠçãè¡ãªãç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç64.1ïŒ ãé žçŽ é
éä¿æ°2.35Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.385ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 28ã31 å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ27ãšåæ§ã«ããŠå®éšãè¡ãªããç®ç
ç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒ
è¡šã«ç€ºãã
ADMVN0.2ïœã䜿çšããŠå®æœäŸ14ãšåæ§ã®éå
æ¡ä»¶ã§éåãããæ£ç¶ã®éåäœçŽ æãããããã®
ãã®ãåžžæ³ã«ããååããç 磚å å·¥ããŠã³ã³ã¿ã¯
ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã40ïŒ ã®é žæ°Žæº¶æ¶²
äžã«20åéã3Nå¡©é žæ°Žæº¶æ¶²äžã«40åé浞挬ããŠ
é žåŠçãè¡ãªããã€ãã§0.024ïŒ çé žãããªãŠã
氎溶液äžã«æµžæŒ¬ããŠäžååŠçãè¡ãªããããã«
0.9ïŒ ççé£å¡©æ°Žäžã«ãŠïŒæéç ®æ²žåŠçããç®ç
ç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç55.8ïŒ ãé žçŽ é
éä¿æ°2.00Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.399ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 26 IPGMA80ïœãïŒâHEMA5ïœãMMA15ïœã
EDMA0.5ïœããã³ADMVN0.2ïœã䜿çšããå®æœ
äŸ25ãšåæ§ã«ããŠç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç53.4ïŒ ãé žçŽ é
éä¿æ°1.70Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.401ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 27 IPGMA15ïœãALIPG15ïœãïŒïŒïŒïŒïŒïŒïŒâ
ãžââã€ãœããããªãã³âïŒââã¡ã¿ã¯ãªã
ã€ã«ââã°ã«ã³ãã©ãã·ãïŒä»¥äžMDGãšç¥
èšïŒ15ïœãïŒâHEMA40ïœãMMA15ïœã
AMA0.2ïœããã³ADMVN0.2ïœã䜿çšããŠå®æœäŸ
14ãšåæ§ã®éåæ¡ä»¶ã§éåãããæ£ç¶ã®éåäœçŽ
æãããããã®ãã®ãåžžæ³ã«ããååããç 磚å
å·¥ããŠã³ã³ã¿ã¯ãã¬ã³ãºã®åœ¢ç¶ã«æ圢ããã®ã¡ã
2Nå¡©é žæ°Žæº¶æ¶²äžã«ïŒæé浞挬ããŠé žåŠçããã€
ãã§0.024ïŒ çé žãããªãŠã 氎溶液äžã«æµžæŒ¬ããŠ
äžååŠçãè¡ãªãç®çç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºãããã ãã®ã³ã³ã¿ã¯ãã¬ã³ãºã¯å«æ°Žç64.1ïŒ ãé žçŽ é
éä¿æ°2.35Ã10-10c.c.ã»cmïŒcm2ã»secã»mmïœãå±
æçïŒïœïŒïŒ ïŒ1.385ã§ãå¯èŠå ç·ééçã90ïŒ ã
è¶ ãããã®ã§ãã€ãã å®æœäŸ 28ã31 å ±éåã«ãããåæåã第ïŒè¡šã«ç€ºãéçšãã
ã»ãã¯å®æœäŸ27ãšåæ§ã«ããŠå®éšãè¡ãªããç®ç
ç©ã®å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããããçµæã第ïŒ
è¡šã«ç€ºãã
ãè¡šã
å®æœäŸ16ã§ããããã³ã³ã¿ã¯ãã¬ã³ãºãïŒçŸœã®
çœè²å®¶å ã®å³çŒã«21æ¥éé£ç¶è£ çšããããšããã
è§èè¡šé¢ã«ãããŠäœãã®ç°åžžãèªããããããŸã
ã°ãªã³ãŒã²ã³éã®æžå°ããŸã€ãã芳å¯ããããã
ãã«çµç¹åŠçæèŠã«ãããŠãè¡ç®¡æ°çãå®è³ªçãª
æµ®è «ããã³ççæ§çŽ°è浞最ããªããå¯Ÿç §çŒã§ãã
å·ŠçŒãšã®éã«åœ¢æ çã«ææãªå€åããŸã€ããèªã
ããããããããŠè¯å¥œãªè£ çšæ§ã瀺ããã
çœè²å®¶å ã®å³çŒã«21æ¥éé£ç¶è£ çšããããšããã
è§èè¡šé¢ã«ãããŠäœãã®ç°åžžãèªããããããŸã
ã°ãªã³ãŒã²ã³éã®æžå°ããŸã€ãã芳å¯ããããã
ãã«çµç¹åŠçæèŠã«ãããŠãè¡ç®¡æ°çãå®è³ªçãª
æµ®è «ããã³ççæ§çŽ°è浞最ããªããå¯Ÿç §çŒã§ãã
å·ŠçŒãšã®éã«åœ¢æ çã«ææãªå€åããŸã€ããèªã
ããããããããŠè¯å¥œãªè£ çšæ§ã瀺ããã
第ïŒå³ã¯æ¬çºæã«ãããIPGMAã®å
±éåäœã®
芪氎æ§ååŠçåãšèŠªæ°Žæ§ååŠçåŸã®èµ€å€ç·åžåã¹
ãã¯ãã«ãã€ãŒãã§ããã
芪氎æ§ååŠçåãšèŠªæ°Žæ§ååŠçåŸã®èµ€å€ç·åžåã¹
ãã¯ãã«ãã€ãŒãã§ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåé
äœã芪氎æ§åéäœããã³ïŒãŸãã¯ïŒçæ°Žæ§åéäœ
ãäž»æåãšããå ±éåäœãé žåŠçããŠããããã
ã®ãæ質ãšããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã ïŒ (A) ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæãã
åéäœã芪氎æ§åéäœããã³ïŒãŸãã¯ïŒçæ°Žæ§
åéäœãäž»æåãšããå ±éåäœãæ質ãšããã³
ã³ã¿ã¯ãã¬ã³ãºãæ圢ããã€ãã§è©²ã³ã³ã¿ã¯ã
ã¬ã³ãºãé žåŠçãã (B) ãããã®ã¡ãããããå«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³
ãºå ã«å«æµžããŠããåèšé žãæ°ŽãŸãã¯ççé£å¡©
æ°Žã§çœ®æããããšãç¹åŸŽãšããå«æ°Žæ§ã³ã³ã¿ã¯
ãã¬ã³ãºã®è£œé æ³ã ïŒ ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåé
äœãã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãšéåæ§ã«ã«
ãã³é žãšã®ãšã¹ãã«ååç©ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®è£œé æ³ã ïŒ ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãæããåé
äœãã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãšéåæ§ã¢ã«
ã³ãŒã«ãšã®ãšãŒãã«ååç©ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®è£œé æ³ã ïŒ ã±ã¿ãŒã«åãããç³ã¢ã«ã³ãŒã«ãäžè¬åŒ
ïŒïŒïŒ ïŒåŒäžãïœã¯ïŒãïŒã®æŽæ°ãè¡šããïŒã§è¡šãã
ããç³ã¢ã«ã³ãŒã«ã®èªå°äœã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé ãŸãã¯ç¬¬ïŒé èšèŒã®è£œé æ³ã ïŒ çšãã芪氎æ§åéäœãïŒâããããã·ãšãã«
ã¡ã¿ã¯ãªã¬ãŒããïŒâããããã·ãšãã«ã¢ã¯ãªã¬
ãŒããïŒâããããã·ãããã«ã¡ã¿ã¯ãªã¬ãŒãã
ïŒâããããã·ãããã«ã¢ã¯ãªã¬ãŒããããªãšã
ã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã¿ã¯ãªã¬ãŒããããªãšãã¬
ã³ã°ãªã³ãŒã«ã¢ãã¢ã¯ãªã¬ãŒããã¡ã¿ã¯ãªã«ã¢ã
ããã¢ã¯ãªã«ã¢ããããžã¡ãã«ã¡ã¿ã¯ãªã«ã¢ã
ãããžã¡ãã«ã¢ã¯ãªã«ã¢ãããã¡ã¿ã¯ãªã«é žãã¢
ã¯ãªã«é žããã³ïŒ®âããã«ãããªãã³ãããªã矀
ããéžã°ããïŒçš®ãŸãã¯ïŒçš®ä»¥äžã§ããç¹èš±è«æ±
ã®ç¯å²ç¬¬ïŒé èšèŒã®è£œé æ³ã ïŒ çšããçæ°Žæ§åéäœãã¡ã¿ã¯ãªã«é žãŸãã¯ã¢
ã¯ãªã«é žã®ã¢ã«ãã«ãšã¹ãã«ïŒãã ããã¢ã«ãã«
åºã®ççŽ æ°ã¯ïŒã15åïŒãã¡ã¿ã¯ãªã«é žãŸãã¯ã¢
ã¯ãªã«é žã®ããã«ãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãŸãã¯
ã¢ã¯ãªã«é žã®ã¢ãªã«ãšã¹ãã«ãã€ã¿ã³ã³é žãŸãã¯
ã¯ããã³é žã®ã¢ã«ãã«ãšã¹ãã«ãèèªæã«ã«ãã³
é žã®ããã«ãšã¹ãã«ãã¹ãã¬ã³ããã³ã¢ã¯ãªãã
ããªã«ãããªã矀ããéžã°ããïŒçš®ãŸãã¯ïŒçš®ä»¥
äžã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®è£œé æ³ã
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6017982A JPS58176618A (ja) | 1982-04-10 | 1982-04-10 | å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããã³ãã®è£œé æ³ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6017982A JPS58176618A (ja) | 1982-04-10 | 1982-04-10 | å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããã³ãã®è£œé æ³ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58176618A JPS58176618A (ja) | 1983-10-17 |
| JPS6233572B2 true JPS6233572B2 (ja) | 1987-07-21 |
Family
ID=13134662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6017982A Granted JPS58176618A (ja) | 1982-04-10 | 1982-04-10 | å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºããã³ãã®è£œé æ³ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58176618A (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998033089A1 (en) * | 1997-01-23 | 1998-07-30 | Menicon Co., Ltd. | Process for producing contact lens with hydrophilic surface and contact lens obtained thereby |
| TWI291953B (ja) * | 2001-10-23 | 2008-01-01 | Mitsubishi Rayon Co | |
| TWI367214B (en) * | 2004-09-15 | 2012-07-01 | Dongjin Semichem Co Ltd New | Photoresist monomer having spiro cyclic ketal group, polymer thereof and photoresist composition including the same |
| CN1931858B (zh) * | 2004-09-15 | 2011-09-21 | æ ªåŒäŒç€Ÿäžè¿äžçŸè¯ | å å«å ·æèºç¯çŒ©é ®åºå¢çåäœçå å»è¶èåç©åå ¶ç»åç© |
| EP2472324A1 (en) * | 2010-12-31 | 2012-07-04 | Rohm and Haas Electronic Materials LLC | Monomers, polymers, photoresist compositions and methods of forming photolithographic patterns |
-
1982
- 1982-04-10 JP JP6017982A patent/JPS58176618A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58176618A (ja) | 1983-10-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4451629A (en) | Contact lens and process for preparing the same | |
| US4139692A (en) | Copolymer for contact lens, its preparation and contact lens made thereof | |
| US4139513A (en) | Copolymer for soft contact lens, its preparation and soft contact lens made thereof | |
| US4405773A (en) | Hydrophylic contact lenses and methods for making same | |
| JPS6410808B2 (ja) | ||
| JPH06340722A (ja) | éç°ç¶ã¢ãããŒãå°å ¥ãããçŒã¬ã³ãºããªã㌠| |
| CA1182614A (en) | Contact lens and process for preparing the same | |
| JP2020523120A (ja) | çŒå ã¬ã³ãºçµæç© | |
| JP4144088B2 (ja) | ã³ã³ã¿ã¯ãã¬ã³ãºçšããªããŒããã³ãããçšããã³ã³ã¿ã¯ãã¬ã³ãº | |
| JPS628769B2 (ja) | ||
| JPS6233572B2 (ja) | ||
| EP1885290A2 (en) | High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers | |
| JP2804273B2 (ja) | é«å«æ°Žæ§çŒçšã¬ã³ãºææ | |
| JPS6261927B2 (ja) | ||
| JPH06102471A (ja) | å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãº | |
| JP2746376B2 (ja) | ã³ã³ã¿ã¯ãã¬ã³ãº | |
| JPS61111308A (ja) | ããçŽ å«æããªãâããã³å»ççšé žçŽ ééäœ | |
| JPH0357454B2 (ja) | ||
| JPS60173518A (ja) | å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãºã®è£œé æ³ | |
| US20070197733A1 (en) | Star macromonomers and polymeric materials and medical devices comprising same | |
| JPH1060053A (ja) | çŒçšã¬ã³ãºããã³ãã®è£œé æ³ | |
| JPH10177152A (ja) | å«æ°Žæ§ãœããã³ã³ã¿ã¯ãã¬ã³ãº | |
| JP3088857B2 (ja) | å«æ°Žæ§ã³ã³ã¿ã¯ãã¬ã³ãº | |
| JP3396927B2 (ja) | ã³ã³ã¿ã¯ãã¬ã³ãº | |
| JPS6230613B2 (ja) |