LT4029B - Alpha-amidating enzyme compositions and process for their production - Google Patents

Alpha-amidating enzyme compositions and process for their production Download PDF

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Publication number
LT4029B
LT4029B LTIP1656A LTIP1656A LT4029B LT 4029 B LT4029 B LT 4029B LT IP1656 A LTIP1656 A LT IP1656A LT IP1656 A LTIP1656 A LT IP1656A LT 4029 B LT4029 B LT 4029B
Authority
LT
Lithuania
Prior art keywords
enzyme
alpha
amidating
activity
oligonucleotide probe
Prior art date
Application number
LTIP1656A
Other languages
English (en)
Lithuanian (lt)
Inventor
James P Gilligan
Barry N Jones
Arthur H Bertelsen
Nozer M Mehta
Original Assignee
Unigene Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22196693&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4029(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Unigene Lab Inc filed Critical Unigene Lab Inc
Publication of LTIP1656A publication Critical patent/LTIP1656A/xx
Publication of LT4029B publication Critical patent/LT4029B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/17—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
    • C12Y114/17003—Peptidylglycine monooxygenase (1.14.17.3)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
LTIP1656A 1987-08-14 1993-12-21 Alpha-amidating enzyme compositions and process for their production LT4029B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/086,161 US6319685B1 (en) 1984-09-27 1987-08-14 Alpha-amidating enzyme compositions and processes for their production and use

Publications (2)

Publication Number Publication Date
LTIP1656A LTIP1656A (en) 1995-07-25
LT4029B true LT4029B (en) 1996-08-26

Family

ID=22196693

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1656A LT4029B (en) 1987-08-14 1993-12-21 Alpha-amidating enzyme compositions and process for their production

Country Status (13)

Country Link
US (1) US6319685B1 (de)
EP (2) EP0529742B1 (de)
JP (1) JP2979172B2 (de)
KR (1) KR0136611B1 (de)
AT (1) ATE198355T1 (de)
CA (1) CA1341454C (de)
DE (1) DE3856446T2 (de)
DK (1) DK175538B1 (de)
FI (1) FI883722A7 (de)
HU (3) HU213227B (de)
LT (1) LT4029B (de)
NO (1) NO883592L (de)
RU (2) RU2252961C2 (de)

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US4708934A (en) * 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US5789234A (en) * 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US5871995A (en) * 1989-08-15 1999-02-16 Shiseido Company, Ltd. Purified enzymes participating in C-terminal amidation
DK0465404T3 (da) * 1990-06-01 1995-12-18 Ciba Geigy Ag Peptidylhydroxylglycin-N-C-lyase og DNA, som koder derfor
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
DK67691D0 (da) * 1991-03-01 1991-04-15 Carlbiotech Ltd As Enzymatisk fremgangsmaade til c-terminal modificering af peptider og mellemprodukter til brug ved fremgangsmaaden
WO1996017941A2 (en) * 1994-12-07 1996-06-13 Bionebraska, Inc. Production of c-terminal amidated peptides from recombinant protein constructs
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
DK2088188T3 (da) 1997-04-16 2012-01-02 Unigene Lab Inc Direkte ekspression af peptider i dyrkningsmedier
JP4483579B2 (ja) 2002-07-26 2010-06-16 味の素株式会社 トリペプチド以上のペプチドの製造方法
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US7531518B2 (en) * 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7648965B2 (en) * 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US20060089723A1 (en) * 2004-10-25 2006-04-27 Murphy Kieran P Method for bone augmentation
US7445911B2 (en) * 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
US20060293667A1 (en) * 2005-05-19 2006-12-28 Agnes Vignery Bone implant device and methods of using same
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
BRPI1006943A2 (pt) 2009-01-22 2021-06-15 Unigene Laboratories Inc. peptídeo, composição farmacêutica que compreende o peptídeo e método para supressão do apetite, prevenção ou tratamento de uma condição de sobrepeso ou obesidade, ou para tratar diabetes
KR20120116942A (ko) 2009-11-23 2012-10-23 아밀린 파마슈티칼스, 인크. 폴리펩티드 접합체
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
WO2012050930A2 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc Engineered polypeptides having enhanced duration of action
CA2812951A1 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Llc Engineered polypeptides having enhanced duration of action
ES2712805T3 (es) 2011-06-15 2019-05-14 Resother Pharma Aps Næsseslottet Productos farmacéuticos antiinflamatorios
JP6040464B2 (ja) 2011-07-08 2016-12-07 アエゲリオン・ファーマシューティカルズ・インコーポレイテッドＡｅｇｅｒｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド
CN104271588B (zh) 2011-07-08 2017-10-10 安米林药品有限责任公司 具有增强的作用持续时间和降低的免疫原性的工程改造的多肽
US9533022B2 (en) 2011-11-02 2017-01-03 KeyBioscience A/S Peptide analogs for treating diseases and disorders
JP6170933B2 (ja) 2011-11-02 2017-07-26 キーバイオサイエンス・アクチエンゲゼルシャフト ペプチドの使用
RS57519B1 (sr) 2011-11-02 2018-10-31 Keybioscience Ag Mimetici kalcitonina za lečenje bolesti i poremećaja
SI3068796T1 (en) 2013-11-14 2018-05-31 Keybioscience Ag Calcitonin mimetics for the treatment of diseases and disorders
JP2016540762A (ja) 2013-12-02 2016-12-28 ステルス バイオセラピューティックス コープ 白斑の治療のための組成物及び方法
WO2015183995A2 (en) 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
WO2015183988A1 (en) 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Therapeutic compositions including therapeutic small molecules and uses thereof
US10627392B2 (en) 2014-06-17 2020-04-21 Stealth Biotherapeutics Corp Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening
GB201500263D0 (en) 2015-01-08 2015-02-25 Keybioscience Ag Calcitonin analogues for treating diseases and disorders
EP3244878B1 (de) 2015-01-12 2022-08-10 Enteris BioPharma, Inc. Feste orale darreichungsformen
GB201704429D0 (en) 2017-03-21 2017-05-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
GB201813677D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201813678D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Acylated calcitonin mimetics
GB202001024D0 (en) 2020-01-24 2020-03-11 Key Bioscience Ag Oxyntomodulin mimetics
JP2023516007A (ja) * 2020-02-26 2023-04-17 ペーアーエム セラノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 治療目的のペプチジルグリシンα－アミド化モノオキシゲナーゼ（ＰＡＭ）の使用
WO2022266467A2 (en) 2021-06-17 2022-12-22 Dana-Farber Cancer Institute, Inc. Recombinant histone polypeptide and uses thereof

Citations (1)

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B A EIPPER, R E MAINS, AND C C GLEMBOTSKI: "Identification in pituitary tissue of a peptide alpha-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper, and ascorbic acid", PROC. NATI. ACAD. SCI. USA, 1983, pages 5144 - 5148
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Also Published As

Publication number Publication date
DK448988A (da) 1989-02-15
AU2057688A (en) 1989-02-16
FI883722A7 (fi) 1989-02-15
EP0308067A3 (de) 1989-07-26
DK175538B1 (da) 2004-11-29
DE3856446D1 (de) 2001-02-01
US6319685B1 (en) 2001-11-20
KR0136611B1 (ko) 1998-04-25
HU212071A9 (en) 1996-02-28
LTIP1656A (en) 1995-07-25
EP0529742A1 (de) 1993-03-03
ATE198355T1 (de) 2001-01-15
AU629795B2 (en) 1992-10-15
RU2252961C2 (ru) 2005-05-27
KR890003947A (ko) 1989-04-19
NO883592L (no) 1989-02-15
NO883592D0 (no) 1988-08-12
CA1341454C (en) 2004-04-20
JPH02104281A (ja) 1990-04-17
DE3856446T2 (de) 2001-07-12
RU2080385C1 (ru) 1997-05-27
EP0308067A2 (de) 1989-03-22
JP2979172B2 (ja) 1999-11-15
HU00552A9 (en) 1995-10-30
HU213227B (en) 1997-07-28
FI883722A0 (fi) 1988-08-10
EP0529742B1 (de) 2000-12-27
DK448988D0 (da) 1988-08-11

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