LU85616A1 - Nouvelle forme cristalline delta;anhydre et stable,du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci - Google Patents

Nouvelle forme cristalline delta;anhydre et stable,du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci Download PDF

Info

Publication number: LU85616A1
Authority: LU; Luxembourg
Prior art keywords: prazosin hydrochloride; anhydrous; crystalline form; stable; chosen
Prior art date: 1984-06-25

Application number

LU85616A

Other languages

English (en)

French (fr)

Inventor

Stig Olof Engelbert Lindholm

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-06-25

Filing date

1984-10-29

Publication date

1985-06-04

1984-10-29 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1985-06-04 Publication of LU85616A1 publication Critical patent/LU85616A1/fr

Links

229960002386 prazosin hydrochloride Drugs 0.000 title claims description 28
WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 title claims description 28
238000004519 manufacturing process Methods 0.000 title claims description 6
238000000034 method Methods 0.000 claims description 16
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 12
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 12
239000003960 organic solvent Substances 0.000 claims description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 8
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 8
238000002329 infrared spectrum Methods 0.000 claims description 8
238000009835 boiling Methods 0.000 claims description 7
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 6
238000010533 azeotropic distillation Methods 0.000 claims description 5
XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims description 4
WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 3
230000001154 acute effect Effects 0.000 claims description 3
UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 claims description 2
238000010521 absorption reaction Methods 0.000 claims description 2
150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
238000002425 crystallisation Methods 0.000 claims description 2
230000008025 crystallization Effects 0.000 claims description 2
150000008282 halocarbons Chemical class 0.000 claims description 2
239000008096 xylene Substances 0.000 claims description 2
150000003738 xylenes Chemical class 0.000 claims description 2
IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims 2
150000001924 cycloalkanes Chemical class 0.000 claims 1
239000000047 product Substances 0.000 description 8
238000010992 reflux Methods 0.000 description 7
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
239000000203 mixture Substances 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
150000004683 dihydrates Chemical class 0.000 description 2
SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
OSOPPDNMJBFEOP-UHFFFAOYSA-N 6,7-dimethoxyquinazolin-4-amine hydrochloride Chemical compound Cl.C1=NC(N)=C2C=C(OC)C(OC)=CC2=N1 OSOPPDNMJBFEOP-UHFFFAOYSA-N 0.000 description 1
241000255628 Tabanidae Species 0.000 description 1
150000001335 aliphatic alkanes Chemical class 0.000 description 1
239000002220 antihypertensive agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
229960001289 prazosin Drugs 0.000 description 1
IENZQIKPVFGBNW-UHFFFAOYSA-N prazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 IENZQIKPVFGBNW-UHFFFAOYSA-N 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000029305 taxis Effects 0.000 description 1
230000000007 visual effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

LU85616A 1984-06-25 1984-10-29 Nouvelle forme cristalline delta;anhydre et stable,du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci LU85616A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI842544		1984-06-25
FI842544A FI79107C (fi)	1984-06-25	1984-06-25	Foerfarande foer framstaellning av stabil -form av prazosinhydroklorid.

Publications (1)

Publication Number	Publication Date
LU85616A1 true LU85616A1 (fr)	1985-06-04

Family

ID=8519293

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU85616A LU85616A1 (fr)	1984-06-25	1984-10-29	Nouvelle forme cristalline delta;anhydre et stable,du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci

Country Status (17)

Country	Link
US (2)	US4739055A (ja)
JP (1)	JPS6115881A (ja)
AT (1)	AT389117B (ja)
AU (1)	AU566814B2 (ja)
BE (1)	BE900925A (ja)
CH (1)	CH661045A5 (ja)
DE (1)	DE3429415A1 (ja)
FI (1)	FI79107C (ja)
FR (1)	FR2567124B1 (ja)
GB (1)	GB2160861B (ja)
IL (1)	IL73267A (ja)
IT (1)	IT1224142B (ja)
LU (1)	LU85616A1 (ja)
NL (1)	NL8403250A (ja)
NZ (1)	NZ209962A (ja)
PT (1)	PT79411B (ja)
ZA (1)	ZA85910B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0237608A1 (de) *	1986-03-21	1987-09-23	HEUMANN PHARMA GMBH & CO	Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung

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JP2756846B2 (ja) *	1989-12-28	1998-05-25	住化ファインケム株式会社	無水のε型結晶体２―〔４―（２―フロイル）ピペラジン―１―イル〕―４―アミノ―６，７―ジメトキシキナゾリン塩酸塩及びその製造方法
JPH07206857A (ja) *	1993-12-28	1995-08-08	Synthelabo Sa	アルフゾシン塩酸塩の二水和物
EA007485B1 (ru) *	2001-02-24	2006-10-27	Берингер Ингельхайм Фарма Гмбх Унд Ко. Кг	Производные ксантина, способ их получения, фармацевтическая композиция на их основе и способ ее получения
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US7501426B2 (en) *	2004-02-18	2009-03-10	Boehringer Ingelheim International Gmbh	8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
DE102004054054A1 (de)	2004-11-05	2006-05-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DE102005035891A1 (de) *	2005-07-30	2007-02-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
PE20110235A1 (es)	2006-05-04	2011-04-14	Boehringer Ingelheim Int	Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
EP1852108A1 (en) *	2006-05-04	2007-11-07	Boehringer Ingelheim Pharma GmbH & Co.KG	DPP IV inhibitor formulations
MX2008014024A (es)	2006-05-04	2008-11-14	Boehringer Ingelheim Int	Formas poliformas.
EP3542801A1 (en) *	2007-08-17	2019-09-25	Boehringer Ingelheim International GmbH	Purin derivatives for use in the treatment of fap-related diseases
PE20140960A1 (es) *	2008-04-03	2014-08-15	Boehringer Ingelheim Int	Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) *	2008-06-03	2010-02-23	Boehringer Ingelheim Int	Tratamiento de nafld
KR20200118243A (ko)	2008-08-06	2020-10-14	베링거 인겔하임 인터내셔날 게엠베하	메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
UY32030A (es)	2008-08-06	2010-03-26	Boehringer Ingelheim Int	"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
CN103816158A (zh) *	2008-08-15	2014-05-28	勃林格殷格翰国际有限公司	用于治疗fab-相关疾病的嘌呤衍生物
CN102149407A (zh)	2008-09-10	2011-08-10	贝林格尔.英格海姆国际有限公司	治疗糖尿病和相关病症的组合疗法
US20200155558A1 (en)	2018-11-20	2020-05-21	Boehringer Ingelheim International Gmbh	Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CN107011345A (zh)	2008-12-23	2017-08-04	勃林格殷格翰国际有限公司	有机化合物的盐形式
TW201036975A (en)	2009-01-07	2010-10-16	Boehringer Ingelheim Int	Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
EP2504002B1 (en)	2009-11-27	2019-10-09	Boehringer Ingelheim International GmbH	Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
KR101927068B1 (ko)	2010-05-05	2018-12-10	베링거 인겔하임 인터내셔날 게엠베하	체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
KR20200028498A (ko)	2010-06-24	2020-03-16	베링거 인겔하임 인터내셔날 게엠베하	당뇨병 요법
AR083878A1 (es)	2010-11-15	2013-03-27	Boehringer Ingelheim Int	Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
HUE061596T2 (hu)	2011-07-15	2023-07-28	Boehringer Ingelheim Int	Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
US9555001B2 (en)	2012-03-07	2017-01-31	Boehringer Ingelheim International Gmbh	Pharmaceutical composition and uses thereof
US20130303462A1 (en)	2012-05-14	2013-11-14	Boehringer Ingelheim International Gmbh	Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
ES2929025T3 (es)	2012-05-14	2022-11-24	Boehringer Ingelheim Int	Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
WO2013174767A1 (en)	2012-05-24	2013-11-28	Boehringer Ingelheim International Gmbh	A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
EP3110449B1 (en)	2014-02-28	2023-06-28	Boehringer Ingelheim International GmbH	Medical use of a dpp-4 inhibitor
BR112018072401A2 (pt)	2016-06-10	2019-02-19	Boehringer Ingelheim International Gmbh	combinações de linagliptina e metformina

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DE156532C (ja) *
US2969375A (en) *		1961-01-24		Certification of correction
BE427505A (ja) *	1937-05-25
GB1156973A (en) *	1965-07-06	1969-07-02		Quinazoline Derivatives
US3433788A (en) *	1966-04-27	1969-03-18	Union Carbide Corp	Process for recovery of amines from aqueous solutions by solvent treatment and distillation
US3421983A (en) *	1967-03-07	1969-01-14	Lummus Co	Azeotropic distillation of aqueous toluene diamine
US3511836A (en) *	1967-12-13	1970-05-12	Pfizer & Co C	2,4,6,7-tetra substituted quinazolines
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GB1308718A (en) *	1970-07-01	1973-03-07	Sir Soc Italiana Resine Spa	Method of separating vinyl acetate from liquid mixtures
IT956765B (it) *	1972-06-22	1973-10-10	Montedison Spa	Procedimento per la purificazione di 1 3 diossolano
US3935213A (en) *	1973-12-05	1976-01-27	Pfizer Inc.	Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4026894A (en) *	1975-10-14	1977-05-31	Abbott Laboratories	Antihypertensive agents
US4001237A (en) *	1976-02-18	1977-01-04	Bristol-Myers Company	Oxazole, isoxazole, thiazole and isothiazole amides
US4092315A (en) *	1976-03-01	1978-05-30	Pfizer Inc.	Novel crystalline forms of prazosin hydrochloride
FI67699C (fi) *	1979-01-31	1985-05-10	Orion Yhtymae Oy	Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
FI64367C (fi) *	1980-02-26	1986-08-05	Orion Yhtymae Oy	Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid

1984
- 1984-06-25 FI FI842544A patent/FI79107C/fi not_active IP Right Cessation
- 1984-08-09 DE DE19843429415 patent/DE3429415A1/de active Granted
- 1984-10-03 GB GB08424999A patent/GB2160861B/en not_active Expired
- 1984-10-15 US US06/660,871 patent/US4739055A/en not_active Expired - Lifetime
- 1984-10-19 IL IL73267A patent/IL73267A/xx not_active IP Right Cessation
- 1984-10-19 AU AU34510/84A patent/AU566814B2/en not_active Ceased
- 1984-10-23 NZ NZ209962A patent/NZ209962A/en unknown
- 1984-10-24 IT IT23292/84A patent/IT1224142B/it active
- 1984-10-25 NL NL8403250A patent/NL8403250A/nl not_active Application Discontinuation
- 1984-10-26 PT PT79411A patent/PT79411B/pt not_active IP Right Cessation
- 1984-10-26 CH CH5142/84A patent/CH661045A5/de not_active IP Right Cessation
- 1984-10-26 FR FR8416401A patent/FR2567124B1/fr not_active Expired - Lifetime
- 1984-10-29 LU LU85616A patent/LU85616A1/fr unknown
- 1984-10-29 JP JP59227640A patent/JPS6115881A/ja active Granted
- 1984-10-29 BE BE0/213911A patent/BE900925A/fr not_active IP Right Cessation
- 1984-10-30 AT AT0344184A patent/AT389117B/de not_active IP Right Cessation
1985
- 1985-02-06 ZA ZA85910A patent/ZA85910B/xx unknown
1988
- 1988-02-08 US US07/153,780 patent/US4873330A/en not_active Expired - Fee Related

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0237608A1 (de) *	1986-03-21	1987-09-23	HEUMANN PHARMA GMBH & CO	Kristalline, wasserfreie Sigma -Form von 2-[4-(2-Furoyl-(2-piperazin)-1-yl]-4-amino-6,7-dimethoxychinazolinhydrochlorid und Verfahren zu ihrer Herstellung

Also Published As

Publication number	Publication date
FI842544A0 (fi)	1984-06-25
FI79107C (fi)	1989-11-10
IT8423292A0 (it)	1984-10-24
IL73267A (en)	1988-06-30
FI842544L (fi)	1985-12-26
IT1224142B (it)	1990-09-26
DE3429415A1 (de)	1986-01-02
AU566814B2 (en)	1987-10-29
US4739055A (en)	1988-04-19
BE900925A (fr)	1985-02-15
JPH0481993B2 (ja)	1992-12-25
AU3451084A (en)	1986-01-02
US4873330A (en)	1989-10-10
GB8424999D0 (en)	1984-11-07
FR2567124B1 (fr)	1990-09-21
PT79411B (en)	1986-09-15
PT79411A (en)	1984-11-01
IL73267A0 (en)	1985-01-31
CH661045A5 (de)	1987-06-30
NZ209962A (en)	1987-06-30
AT389117B (de)	1989-10-25
FR2567124A1 (fr)	1986-01-10
GB2160861A (en)	1986-01-02
JPS6115881A (ja)	1986-01-23
ZA85910B (en)	1985-09-25
GB2160861B (en)	1987-11-18
FI79107B (fi)	1989-07-31
NL8403250A (nl)	1986-01-16
ATA344184A (de)	1989-03-15
DE3429415C2 (ja)	1990-05-03

Publication	Publication Date	Title
LU85616A1 (fr)	1985-06-04	Nouvelle forme cristalline delta;anhydre et stable,du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci
EP0210084B1 (fr)	1989-02-08	Amides, procédés pour leur préparation et médicaments les contenant
KR0173307B1 (ko)	1999-02-01	1-페닐-이미다졸린-2,5-디온 유도체의 신규 제조 방법
EP2185543B1 (fr)	2014-05-21	Procede de dedoublement optique de sels de l'omeprazole
EP1403266B1 (fr)	2014-04-09	Nouveau procédé de synthèse industriel du ranélate de strontium et de ses hydrates
FR2663934A1 (fr)	1992-01-03	Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.
EP2595976A1 (fr)	2013-05-29	Procede de preparation de derives d'amino-benzoyl-benzofurane
EP0382634A1 (fr)	1990-08-16	Nouveaux dérivés de la pyridazine, procédé de préparation et compositions pharmaceutiques en contenant
EP0309324A1 (fr)	1989-03-29	Procédé de synthèse d'alpha amino N alkyles et de leurs esters. Application à la synthèse de carboxyalkyl dipeptides
EP0612716B1 (fr)	1996-05-08	Procédé pour la préparation d'un aminoalcool optiquement pur
FR2793490A1 (fr)	2000-11-17	Procede de preparation du (1r,2s,4r)-(-)-2-[(2'-{n,n- dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[methyl]- bicyclo[2.2.1]-heptane et ses sels d'addition d'acide pharmaceutiquement acceptables
EP0708759B1 (fr)	2000-08-02	Procede pour la preparation de pyrazines substituees
FR2615188A1 (fr)	1988-11-18	Derives d'hydrazine, procede d'obtention et compositions pharmaceutiques les contenant
CH594650A5 (en)	1978-01-13	Antiinflammatory (1,2)-benzothiazine derivs. prepn.
CA1129886A (fr)	1982-08-17	Procede de preparation de n-alcoylamino benzophenones
FR2565972A1 (fr)	1985-12-20	Preparation des derives d'amines
JP4664903B2 (ja)	2011-04-06	４，１０β−ジアセトキシ−２α−ベンゾイルオキシ−５β，２０−エポキシ−１，１３α−ジヒドロキシ−９−オキソ−１９−ノルシクロプロパ［ｇ］タキサ−１１−エンの製造方法
EP1214309B8 (fr)	2004-07-14	Preparation d'amidines derivees de l'acide 6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylique
FR2633622A1 (fr)	1990-01-05	Derives de sulfonyl indolizine, leur procede de preparation et leur utilisation comme intermediaires de synthese
EP0003456A1 (fr)	1979-08-08	Dérivés d'amino-3-cardénolides, procédé pour leur préparation, et médicaments les contenant
JPH0520427B2 (ja)	1993-03-19
FR2845993A1 (fr)	2004-04-23	Composes pharmaceutiques inhibiteurs specifiques de la pde5 du muscle lisse, compositions pharmaceutiques les contenant et utilisations therapeutiques
CH624094A5 (en)	1981-07-15	Process for the preparation of 5-amino-2-propargyloxy-N-n-butylbenzamide
CZ45193A3 (en)	1994-02-16	Salts of (r)-4-nitro-alphamethyl benzene methaneamine
JPH07224033A (ja)	1995-08-22	光学活性アザスピロ化合物の製法

LU85616A1 - Nouvelle forme cristalline delta;anhydre et stable,du chlorhydrate de prazosine et nouveau procede de fabrication de celle-ci - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (2)

Publications (1)

Family

ID=8519293

Family Applications (1)

Country Status (17)

Cited By (1)

Families Citing this family (31)

Family Cites Families (16)

Cited By (1)

Also Published As

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