LU88746I2 - Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique - Google Patents

Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique

Info

Publication number: LU88746I2
Authority: LU; Luxembourg
Prior art keywords: valaciclovir; optionally; pharmaceutically acceptable; hydrochloric acid; acceptable salt
Prior art date: 1987-08-15

Application number

LU88746C

Other languages

English (en)

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-15

Filing date

1988-08-12

Publication date

1996-10-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26292613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU88746(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-08-15 Priority claimed from GB878719367A external-priority patent/GB8719367D0/en

1987-11-05 Priority claimed from GB878725939A external-priority patent/GB8725939D0/en

1988-08-12 Application filed by Wellcome Found filed Critical Wellcome Found

1996-10-04 Publication of LU88746I2 publication Critical patent/LU88746I2/fr

Links

VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 2
150000003839 salts Chemical class 0.000 title 2
HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 title 1
229940093257 valacyclovir Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)

LU88746C 1987-08-15 1988-08-12 Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique LU88746I2 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB878719367A GB8719367D0 (en)	1987-08-15	1987-08-15	Therapeutic compounds
GB878725939A GB8725939D0 (en)	1987-11-05	1987-11-05	Therapeutic compounds

Publications (1)

Publication Number	Publication Date
LU88746I2 true LU88746I2 (fr)	1996-10-04

Family

ID=26292613

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU88746C LU88746I2 (fr)	1987-08-15	1988-08-12	Valaciclovir facultativement sous la forme d'un sel pharmaceutiquement acceptable y compris le sel d'addition de l'acide chlorhydrique

Country Status (30)

Country	Link
EP (2)	EP0308065B1 (fr)
JP (2)	JPH0662623B2 (fr)
KR (2)	KR960002849B1 (fr)
CN (1)	CN1033701C (fr)
AP (2)	AP55A (fr)
AT (1)	ATE138660T1 (fr)
AU (1)	AU612393C (fr)
CS (1)	CS276903B6 (fr)
CY (1)	CY1833A (fr)
DE (1)	DE3855333T2 (fr)
DK (2)	DK170045B1 (fr)
ES (1)	ES2087639T3 (fr)
FI (1)	FI89713C (fr)
GR (1)	GR3020372T3 (fr)
HU (1)	HU201071B (fr)
IE (1)	IE65551B1 (fr)
IL (1)	IL87434A (fr)
LU (1)	LU88746I2 (fr)
LV (1)	LV5264A3 (fr)
MC (1)	MC1968A1 (fr)
MX (1)	MX9203418A (fr)
MY (1)	MY103760A (fr)
NL (1)	NL960001I2 (fr)
NO (2)	NO167805C (fr)
NZ (1)	NZ225809A (fr)
PL (1)	PL158285B1 (fr)
PT (1)	PT88261B (fr)
SA (1)	SA95160244B1 (fr)
SG (1)	SG26346G (fr)
SU (1)	SU1634138A3 (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP55A (en) *	1987-08-15	1989-09-26	The Wellcome Foundation Ltd	Therapeutic Acyclic Nucleosides
GB8816760D0 (en) *	1988-07-14	1988-08-17	Wellcome Found	Therapeutic compounds
CA2005815C (fr) *	1988-12-19	1999-08-03	Wellcome Foundation Limited (The)	Derives antiviraux de nucleoside acyclique
GB8829571D0 (en) *	1988-12-19	1989-02-08	Wellcome Found	Antiviral compounds
DE4008858A1 (de) *	1990-03-20	1991-09-26	Hoechst Ag	Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
ATE250060T1 (de) *	1993-06-08	2003-10-15	Cancer Rec Tech Ltd	O6-substituierte guaninederivate, verfahren zu ihre herstellung und ihre anwendung für behandlung von tumorzellen
ES2157259T3 (es) *	1993-06-10	2001-08-16	Rolabo Sl	Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos.
GB9317146D0 (en) *	1993-08-18	1993-10-06	Wellcome Found	Therapeutic combinations
GB9320316D0 (en) *	1993-10-01	1993-11-17	Smithkline Beecham Plc	Pharmaceuticals
TW282470B (fr) *	1993-11-18	1996-08-01	Ajinomoto Kk
EP0665229B1 (fr) *	1994-02-01	1999-11-17	Ajinomoto Co., Inc.	Procédé pour la production de dérivés d'une base d'acide nucléique
US5840891A (en) *	1994-07-28	1998-11-24	Syntex (U.S.A.) Inc.	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
PE32296A1 (es) *	1994-07-28	1996-08-07	Hoffmann La Roche	Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) *	1994-07-28	1996-08-06	Syntex (Usa) Inc.	Achiral amino acid acyl esters of ganciclovir and its derivatives
GB9501178D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Guanine derivative
GB9501127D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Tablet
GB9501142D0 (en) *	1995-01-20	1995-03-08	Wellcome Found	Compounds for use in medicine
DE19536164A1 (de) *	1995-09-28	1997-04-03	Boehringer Ingelheim Kg	Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
ATE254463T1 (de) *	1996-01-19	2003-12-15	Glaxo Group Ltd	Verwendung von valaciclovir zur herstellung eines arzneimittels zur behandlung von genitalherpes durch einmal tägliche verabreichung
KR100491941B1 (ko) *	1996-01-26	2005-08-05	에프. 호프만-라 로슈 아게	푸린유도체의제조방법
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en)	1996-01-26	2000-03-21	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
IT1283447B1 (it) *	1996-07-18	1998-04-21	Ind Chimica Srl	Processo di preparazione del valaciclovir e relativi intermedi
EP0976750A4 (fr) *	1997-01-17	2001-05-30	Ajinomoto Kk	Nouveaux cristaux de z-valacyclovir
WO1999059574A1 (fr) *	1998-05-21	1999-11-25	Magainin Pharmaceuticals, Inc.	Procede de stimulation de la production de defensine par exposition a de l'isoleucine
EP1436295A4 (fr) *	2001-09-07	2007-07-11	Teva Pharma	Formes cristallines de chlorhydrate de valacyclovir
US20060147519A1 (en)	2002-06-24	2006-07-06	Ashish Gogia	Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050043329A1 (en) *	2002-09-06	2005-02-24	Shlomit Wizel	Crystalline forms of valacyclovir hydrochloride
CN1309732C (zh) *	2002-10-28	2007-04-11	南京长澳医药科技有限公司	6－烷氧基－2’，3’－双脱氧鸟嘌呤核苷的制备方法
EP1638972A2 (fr) *	2003-06-02	2006-03-29	Teva Pharmaceutical Industries Limited	Nouvelles formes cristallines de chlorhydrate de valacyclovir
CN1331471C (zh) *	2003-09-22	2007-08-15	陈云芳	盐酸万乃洛韦软胶囊组合物
MXPA06008197A (es) *	2004-01-21	2007-04-02	Teva Pharma	Proceso para la preparacion de clorhidrato de valaciclovir.
GB2413017A (en) *	2004-04-06	2005-10-12	Ford Global Tech Llc	An electrical connector for a vehicle
WO2006035452A1 (fr) *	2004-09-27	2006-04-06	Matrix Laboratories Ltd	Nouveau pseudomorphe d'hydrochlorure de valaciclovir
ES2379804T3 (es)	2005-05-25	2012-05-03	Eli Lilly And Company	Ésteres de ciclopropanocarboxilato de aciclovir
EP1746098A1 (fr)	2005-07-21	2007-01-24	SOLMAG S.p.A.	Des polymorphes de valacyclovir et procédé pour leur fabrication
CN101456859B (zh) *	2009-01-06	2011-07-20	华南理工大学	抗病毒药物缬昔洛韦的制备方法
WO2011158252A1 (fr)	2010-06-15	2011-12-22	Matrix Laboratories Ltd	Méthode de préparation de la forme polymorphe ii du chlorhydrate de valacyclovir
CN102850354B (zh) *	2012-10-10	2014-07-23	山东金城医药化工股份有限公司	高纯度cbz-万乃洛韦的制备方法
CN106632335A (zh) *	2016-12-27	2017-05-10	河南康达制药有限公司	一种盐酸伐昔洛韦的制备方法
RU2750867C1 (ru) *	2020-05-18	2021-07-05	Александр Сергеевич Самойлов	Производные гуанина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3627024A1 (de) *	1985-09-24	1987-04-02	Hoechst Ag	In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3534774A1 (de) *	1985-09-30	1987-04-02	Robugen Gmbh	Nucleosid-analoge verbindungen mit antiviraler aktivitaet, verfahren zu deren herstellung sowie arzneimittel mit antiviraler wirkung
AP55A (en) *	1987-08-15	1989-09-26	The Wellcome Foundation Ltd	Therapeutic Acyclic Nucleosides

1988
- 1988-08-10 AP APAP/P/1988/000099A patent/AP55A/en active
- 1988-08-10 AP APAP/P/1991/000238A patent/AP160A/en active
- 1988-08-11 MC MC881999A patent/MC1968A1/fr unknown
- 1988-08-12 MY MYPI88000934A patent/MY103760A/en unknown
- 1988-08-12 KR KR1019880010298A patent/KR960002849B1/ko not_active Expired - Lifetime
- 1988-08-12 HU HU884332A patent/HU201071B/hu unknown
- 1988-08-12 CS CS885594A patent/CS276903B6/cs not_active IP Right Cessation
- 1988-08-12 EP EP88307512A patent/EP0308065B1/fr not_active Expired - Lifetime
- 1988-08-12 AT AT93120604T patent/ATE138660T1/de not_active IP Right Cessation
- 1988-08-12 EP EP93120604A patent/EP0596542B1/fr not_active Expired - Lifetime
- 1988-08-12 PL PL1988274215A patent/PL158285B1/pl unknown
- 1988-08-12 LU LU88746C patent/LU88746I2/fr unknown
- 1988-08-12 IE IE246388A patent/IE65551B1/en not_active IP Right Cessation
- 1988-08-12 ES ES93120604T patent/ES2087639T3/es not_active Expired - Lifetime
- 1988-08-12 DE DE3855333T patent/DE3855333T2/de not_active Expired - Lifetime
- 1988-08-12 FI FI883757A patent/FI89713C/fi not_active IP Right Cessation
- 1988-08-12 PT PT88261A patent/PT88261B/pt not_active IP Right Cessation
- 1988-08-12 NZ NZ225809A patent/NZ225809A/en unknown
- 1988-08-12 CN CN88106535A patent/CN1033701C/zh not_active Expired - Lifetime
- 1988-08-12 JP JP63200320A patent/JPH0662623B2/ja not_active Expired - Lifetime
- 1988-08-12 SU SU884356404A patent/SU1634138A3/ru active
- 1988-08-12 AU AU20978/88A patent/AU612393C/en not_active Expired
- 1988-08-12 IL IL87434A patent/IL87434A/xx not_active IP Right Cessation
- 1988-08-12 DK DK451388A patent/DK170045B1/da not_active IP Right Cessation
- 1988-08-12 NO NO883612A patent/NO167805C/no not_active IP Right Cessation
1990
- 1990-08-28 JP JP2226434A patent/JPH07113025B2/ja not_active Expired - Lifetime
1992
- 1992-06-25 MX MX9203418A patent/MX9203418A/es unknown
- 1992-12-18 LV LV920335A patent/LV5264A3/xx unknown
1994
- 1994-07-08 DK DK082694A patent/DK170803B1/da not_active IP Right Cessation
1995
- 1995-02-24 SG SG1995903373A patent/SG26346G/en unknown
- 1995-09-20 SA SA95160244A patent/SA95160244B1/ar unknown
- 1995-12-01 CY CY183395A patent/CY1833A/xx unknown
1996
- 1996-01-17 KR KR1019960000775A patent/KR960004940B1/ko not_active Expired - Lifetime
- 1996-01-18 NL NL960001C patent/NL960001I2/nl unknown
- 1996-06-27 GR GR960401743T patent/GR3020372T3/el unknown
- 1996-12-17 NO NO1996015C patent/NO1996015I1/no unknown

Also Published As

Publication number	Publication date
SU1634138A3 (ru)	1991-03-07
EP0596542B1 (fr)	1996-05-29
ATE138660T1 (de)	1996-06-15
EP0308065B1 (fr)	1995-01-04
KR960002849B1 (ko)	1996-02-27
NO883612D0 (no)	1988-08-12
DK451388A (da)	1989-02-16
EP0308065A3 (en)	1989-09-27
NO883612L (no)	1989-02-16
DK82694A (da)	1994-07-08
NZ225809A (en)	1991-07-26
FI883757L (fi)	1989-02-16
EP0308065A2 (fr)	1989-03-22
NO167805B (no)	1991-09-02
AP55A (en)	1989-09-26
FI89713C (fi)	1993-11-10
MC1968A1 (fr)	1989-09-29
LV5264A3 (lv)	1993-10-10
NO1996015I1 (no)	1996-12-17
KR960004940B1 (ko)	1996-04-18
CN1033701C (zh)	1997-01-01
CS8805594A2 (en)	1990-06-13
MX9203418A (es)	1992-07-01
JPH07113025B2 (ja)	1995-12-06
SG26346G (en)	1995-09-01
GR3020372T3 (en)	1996-09-30
KR890003761A (ko)	1989-04-17
CY1833A (en)	1995-12-01
FI883757A0 (fi)	1988-08-12
MY103760A (en)	1993-09-30
NL960001I1 (nl)	1996-03-01
CN1032538A (zh)	1989-04-26
SA95160244B1 (ar)	2006-10-02
ES2087639T3 (es)	1996-07-16
AU612393B2 (en)	1991-07-11
IE882463L (en)	1989-02-15
IL87434A (en)	1993-06-10
HU201071B (en)	1990-09-28
NO167805C (no)	1991-12-11
DK451388D0 (da)	1988-08-12
JPH0662623B2 (ja)	1994-08-17
AU612393C (en)	2006-08-17
IE65551B1 (en)	1995-11-01
DE3855333D1 (de)	1996-07-04
PL158285B1 (en)	1992-08-31
AU2097888A (en)	1989-02-16
JPS6468373A (en)	1989-03-14
FI89713B (fi)	1993-07-30
JPH03115284A (ja)	1991-05-16
AP8800099A0 (en)	1988-08-01
PT88261B (pt)	1995-03-01
DK170803B1 (da)	1996-01-22
IL87434A0 (en)	1989-01-31
NL960001I2 (nl)	1996-11-01
DE3855333T2 (de)	1996-12-05
DK170045B1 (da)	1995-05-08
PT88261A (pt)	1989-06-30
AP160A (en)	1991-11-18
CS276903B6 (en)	1992-09-16
PL274215A1 (en)	1990-02-19
HUT47935A (en)	1989-04-28
EP0596542A1 (fr)	1994-05-11

Publication	Publication Date	Title
LU90426I2 (fr)	1999-10-06	Abacavir facultativement sous la forme d'un sel pharmaceutiquement acceptable ou d'un d-rive y compris le sulfate d'abacavir
LU88809I2 (fr)	1997-01-03	Lamivudine facultativement sous la forme d'un sel pharmaceutiquement acceptable
LU90593I2 (fr)	2000-08-07	Quetiapine facutativement sous forme d'un sel pharmaceutiquement acceptabe
LU91306I2 (fr)	2007-03-19	Mitratapide, optionnellement sous forme d'un sel d'addition acide pharmaceutiquement acceptable (YARVITAN)
LU90468I2 (fr)	2000-01-03	Zanamivir facultativement sous la forme d'un sel ou d'un derive pharmaceutiquement acceptable
LU91290I2 (fr)	2007-01-22	Céfovécine, optionnellement sous la forme d'un sel, dont le sel de sodium (CONVENIAr)
LU91372I2 (fr)	2007-12-24	Retapamulin optionnellement sous forme d'un sel pharmaceutiquement acceptable (altargo)
LU88842I2 (fr)	1997-01-27	Nebivolol optionnellement sous forme d'un sel ou d'un hydrate pharmaceutiquement acceptable en particulier hydroclorure de Nebivolol
LU90097I2 (fr)	1997-07-16	Ropinirole facultativement sous forme de sels pharmaceutiquement acceptables et de préférence le sel hydrochlorique
LU91599I2 (fr)	2009-10-19	Lasofoxifene, optionnellement sous forme d'un sel d'addition acide, d'un N-oxyde, d'unester ou d'un sel d'ammonium quaternaire, non toxiques et pharmacologiquement acceptables, y compris le sel tartrate (FABLYN - lasofoxifene)
LU92407I2 (fr)	2014-05-19	Afatinib, éventuellement sous la forme d'un sel pharmaceutiquement acceptable, y compris le sel dimaléate
LU91442I2 (fr)	2008-07-21	"Varénicline, optionnellement sous forme d'un sel pharmaceutiquement acceptable, y compris le sel tartrate"
HU902444D0 (en)	1990-08-28	Moisturizing base for the local use of vitamine acid
FI895417A0 (fi)	1989-11-14	Menetelmä uusien terapeuttisesti käyttökelpoisten 2'-halometylideeninukleosidien valmistamiseksi
GB2206334B (en)	1991-10-23	Improvements in or relating to casket liners
FR2567540B1 (fr)	1988-10-14	Procede de preparation d'un interferon leucocytaire humain alpha-2
FR2609391B1 (fr)	1991-02-15	Preparations pharmaceutiques sous forme de suppositoires bioadhesifs
IL87185A (en)	1993-06-10	Preparation of quinolone- carboxylic acids
FR2604355B1 (fr)	1988-11-25	Composition pour le nettoyage de la peau sous forme d'un baton ou stick
FI900145L (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
EP0353474A3 (fr)	1991-03-27	Dérivé de glycérol et son utilisation pharmaceutique
FR2626884B1 (fr)	1991-11-08	Procede de preparation de n-phosphonomethyl-imino-diacetique et de chlorure d'acide en resultant
TR24836A (tr)	1992-05-01	PIRIDIN KARBOKSILIK ASIT TüREVLERININ HAZIRLANMASI ICIN PROSES
FR2610924B1 (fr)	1990-05-04	Procede de preparation d'hydroxybiphenyles
FR2607676B1 (fr)	1991-03-22	Procede d'obtention de compositions alimentaires sous forme de mousse