MA26981A1 - Indanylamines acylees et leur utilisation en tant que produit pharmaceutique. - Google Patents

Indanylamines acylees et leur utilisation en tant que produit pharmaceutique.

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Publication number
MA26981A1
MA26981A1 MA27234A MA27234A MA26981A1 MA 26981 A1 MA26981 A1 MA 26981A1 MA 27234 A MA27234 A MA 27234A MA 27234 A MA27234 A MA 27234A MA 26981 A1 MA26981 A1 MA 26981A1
Authority
MA
Morocco
Prior art keywords
indanylamines
acylated
pharmaceutical product
alkyl
description
Prior art date
Application number
MA27234A
Other languages
English (en)
Inventor
Hartmut Strobel
Paulus Wohlfart
Alena Safarova
Armin Walser
Teri Suzuki
Ramalinga M Dharanipragada
Karl Schoenafinger
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of MA26981A1 publication Critical patent/MA26981A1/fr

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

INDANYLAMINES ACYLEES ET LEUR UTILISATION EN TANT QUE PRODUIT PHARMACEUTIQUE La présente invention concerne des indanylamines acylées de formule générale (I) R1-R4 possèdent les significations données dans la ; description, A est CH2, CHOH ou CH-alkyle en C1-3, B est CH2 ou CH-alkyle en C1-3, R5 est un groupe aryle ou hétéroaryle, substitué par des substituants donnés dans la description. Ces composés sont utiles dans la régulation à la hausse de la eNOS et, par conséquent, pour la fabrication d'un médicament pour le traitement, entre autres, de maladies cardio-vasculaires, d'affections rénales, de diabète, de cirrhose du foie, d„ostéoporose, d'hypertension de différents types, de rétinopathie, de problèmes de performances réduites de mémoire et d'apprentissage, de différents dysfonctionnements endothéliaux, pour diminuer le risque cardio-vasculaire de femmes ménopausées ou après prise de contraceptifs.
MA27234A 2001-02-13 2003-07-11 Indanylamines acylees et leur utilisation en tant que produit pharmaceutique. MA26981A1 (fr)

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Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
PE20020870A1 (es) * 2001-02-13 2002-11-18 Aventis Pharma Gmbh 6,7,8,9-tetrahidro-5h-benzocicloheptenil aminas aciladas
TWI241190B (en) * 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7338956B2 (en) 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
US7105513B2 (en) * 2002-08-07 2006-09-12 Sanofi-Avertis Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
EP1388342A1 (fr) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Dérivés de cycloalkenylamine condensé avec un hététoaryle et acylé et leur utilisation comme produits pharmaceutiques
US7186735B2 (en) 2002-08-07 2007-03-06 Sanofi-Aventis Deutschland Gmbh Acylated arylcycloalkylamines and their use as pharmaceuticals
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
EP1613298A4 (fr) * 2003-04-11 2007-10-03 Univ Tennessee Res Foundation Analogues d'acides lysophosphatidiques et inhibition de formation de neointima
US7132536B2 (en) * 2003-04-24 2006-11-07 Sanofi-Aventis Deutschland Gmbh Triaza- and tetraaza-anthracenedione derivatives, their preparation and their use as pharmaceuticals
GB0318464D0 (en) * 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
US8309608B2 (en) * 2003-11-06 2012-11-13 Sanofi-Aventis Deutschland Gmbh Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases
EP1529525A1 (fr) * 2003-11-06 2005-05-11 Aventis Pharma Deutschland GmbH Stimulateurs de la Transcription de l' eNOS dans le traitement cellulaire des ischemies cardiaques
EP1713775A4 (fr) * 2004-01-30 2009-08-12 Smithkline Beecham Corp Composes chimiques
EP1568698A1 (fr) 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Dérivés de pyrrole en tant qu'inhibiteurs du facteur xa
WO2005115384A2 (fr) * 2004-05-25 2005-12-08 Metabolex, Inc. Triazoles substitués bicyliques comme modulateurs de ppar et méthodes de préparation
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101891680B (zh) 2004-06-24 2014-10-29 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
JP2007277096A (ja) * 2004-07-15 2007-10-25 Astellas Pharma Inc フェネチルニコチンアミド誘導体含有医薬
WO2006006741A1 (fr) 2004-07-15 2006-01-19 Japan Tobacco Inc. Composé benzamide fusionné et inhibiteur d'activité récepteur vanilloïde 1 (vr1)
WO2006040645A1 (fr) * 2004-10-11 2006-04-20 Ranbaxy Laboratories Limited Derives de benzamide n-(3,5-dichloropyridine-4-yle)-2,4,5-alcoxy et 2,3,4 alcoxy en tant qu'inhibiteurs de pde-iv (phosphodiesterase de type iv) pour traiter des maladies inflammatoires telles que l'asthme
KR101300046B1 (ko) * 2004-10-14 2013-08-30 애보트 게엠베하 운트 콤파니 카게 도파민 ｄ3 수용체 조절에 반응하는 질환 치료용으로 적합한 6-아미노(아자)인단 화합물
WO2006133459A1 (fr) * 2005-06-09 2006-12-14 Vertex Pharmaceuticals Incorporated Derives d'indane comme modulateurs de canaux ioniques
EP1741709A1 (fr) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Amides heterocycliques substitués contenant un linker saturé, et leur utilisation comme agent pharmaceutique
EP1741708A1 (fr) 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Amides heterocycliques substitués contenant un linker cyclique ou insaturé, et leur utilisation comme agent pharmaceutique
NZ564608A (en) 2005-07-09 2009-09-25 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
CN101374849A (zh) * 2005-12-24 2009-02-25 沃泰克斯药物股份有限公司 作为abc转运蛋白调控剂的喹啉-4-酮衍生物
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
US7906508B2 (en) 2005-12-28 2011-03-15 Japan Tobacco Inc. 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity
SI1999114T1 (sl) 2006-03-22 2015-10-30 F. Hoffmann-La Roche Ag Pirazoli kot 11-beta-hsd-1
RU2009110254A (ru) 2006-08-24 2010-09-27 Новартис АГ (CH) Производные 2-(пиразин-2-ил)тиазола и 2-(1н-пиразол-3-ил)тиразола и связанные с ним соединения в качестве ингибиторов стеароил-соа десатуразы для лечения метаболических, сердечно-сосудистых и других нарушений
CN101516877B (zh) 2006-09-22 2013-09-11 诺瓦提斯公司 杂环有机化合物
EP1905764A1 (fr) 2006-09-30 2008-04-02 Sanofi-Aventis 2-Phenylbenzimidazoles et leur utilisation comme composés pharmaceutiques
EP1923062A1 (fr) 2006-11-16 2008-05-21 sanofi-aventis Imidazo[2,1-b]thiazoles et leur utilisation comme agent pharmaceutique
EP1939180A1 (fr) 2006-12-20 2008-07-02 sanofi-aventis Hétéroarylacrylamides et leur utilisation en tant que médicament pour la stimulation de l'expression de la synthase NO endotheliale
EP2121671A1 (fr) 2006-12-20 2009-11-25 Novartis AG Hétérocycles à 5 chaînons substitués en position 2 comme inhibiteurs de scd
EP1942104A1 (fr) 2006-12-20 2008-07-09 sanofi-aventis Hétéroarylcyclopropanecarboxamide et leur utilisation pharmaceutique
EP1939181A1 (fr) 2006-12-27 2008-07-02 sanofi-aventis Carboxamides hétérocycliques et leur utilisation pour la stimulation de l'expression de la NO synthase
EP1964840A1 (fr) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]pyridines et leur utilisation en tant que produits pharmaceutiques
EP1964841A1 (fr) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]azine et son utilisation en tant que produit pharmaceutique
EA011238B1 (ru) * 2007-04-03 2009-02-27 Марвел Лайфсайнсез Лтд. Средство, обладающее противогипоксическим, противоинсультным, улучшающим память действием
CA2697382A1 (fr) * 2007-08-27 2009-03-05 Abbott Gmbh & Co. Kg Composes 4-(4-pyrimidyl)-benzamides et utilisation de ceux-ci comme modulateurs de l'activite de kinases rho (rock)
TW200922558A (en) * 2007-09-28 2009-06-01 Mitsubishi Tanabe Pharma Corp Indazole acrylic and amide compound
US20100041891A1 (en) * 2008-08-12 2010-02-18 Takeda Pharmaceutical Company Limited Amide compound
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
CN101759683B (zh) * 2008-12-25 2011-12-28 哈尔滨誉衡药业股份有限公司 二氢化茚酰胺化合物制备方法、包含其的药物组合物、及其作为蛋白激酶抑制剂的应用
KR101727762B1 (ko) 2009-03-20 2017-04-17 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
US20130178475A1 (en) 2010-03-17 2013-07-11 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
US20130137728A1 (en) * 2010-03-24 2013-05-30 MUSC Foundation for Research and Development Compositions and Methods for the Treatment of Degenerative Diseases
WO2012003405A1 (fr) 2010-06-30 2012-01-05 Ironwood Pharmaceuticals, Inc. Stimulateurs de sgc
NZ609955A (en) 2010-11-09 2015-05-29 Ironwood Pharmaceuticals Inc Sgc stimulators
US20140051678A1 (en) * 2010-11-24 2014-02-20 Stemergie Biotechnology Sa Inhibitors of the activity of complex iii of the mitochondrial electron transport chain and use thereof for treating diseases
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN103018349B (zh) * 2011-09-22 2015-04-08 北京美迪康信医药科技有限公司 一种二氢化茚酰胺化合物的检测分析方法
US9493412B2 (en) 2011-09-27 2016-11-15 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
CN104066731B (zh) 2011-12-27 2016-06-15 铁木医药有限公司 可用作sgc刺激剂的2-苄基、3-(嘧啶-2-基)取代的吡唑类
JP2015511583A (ja) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 薬学的組成物およびその投与
US9309235B2 (en) 2012-09-18 2016-04-12 Ironwood Pharmaceuticals, Inc. SGC stimulators
US9487508B2 (en) 2012-09-19 2016-11-08 Ironwood Pharmaceuticals, Inc. SGC stimulators
SI2970243T1 (sl) 2013-03-15 2020-04-30 Cyclerion Therapeutics, Inc. SGC stimulatorji
WO2014170350A1 (fr) * 2013-04-17 2014-10-23 Albert Ludwigs Universität Freiburg Composés destinés à être utilisés comme inhibiteurs de bromodomaine
EP3092231B1 (fr) 2013-12-11 2018-06-27 Ironwood Pharmaceuticals, Inc. Stimulateurs de la sgc
EP3094327A1 (fr) 2014-01-13 2016-11-23 Ironwood Pharmaceuticals, Inc. Utilisation de stimulateurs de la sgc pour le traitement de troubles neuromusculaires
WO2016028971A1 (fr) * 2014-08-21 2016-02-25 Bristol-Myers Squibb Company Dérivés rattachés de benzamide utilisés comme puissants inhibiteurs de rock
CA2959757A1 (fr) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. Derives de pyrazole utilises comme stimulateurs de sgc
CA2961489A1 (fr) 2014-09-17 2016-03-24 Glen Robert RENNIE Stimulateurs de sgc
US20170298055A1 (en) 2014-09-17 2017-10-19 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶
WO2016073889A1 (fr) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Imidazo[1,5-a]pyrimidines substituées et leur utilisation dans le traitement de troubles médicaux
CN107001379B (zh) 2014-11-06 2022-11-01 Bial研发投资股份有限公司 取代的吡唑并[1,5-a]嘧啶以及它们在治疗医学障碍中的用途
AU2015342883B2 (en) 2014-11-06 2020-07-02 Bial - R&D Investments, S.A. Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders
DK3230255T3 (da) 2014-12-09 2020-06-22 Ezekiel Golan Regulatorer af uhæmmet adfærd
CN114403335A (zh) 2014-12-09 2022-04-29 以西结·戈兰 酒精饮料替代品
ITUB20153978A1 (it) * 2015-09-28 2017-03-28 Laboratorio Chimico Int S P A Procedimento per la preparazione di derivati di indanammina e di nuovi intermedi di sintesi.
WO2017072020A1 (fr) * 2015-10-27 2017-05-04 Boehringer Ingelheim International Gmbh Utilisation de dérivés hétéroarylcarboxamides comme inhibiteurs de la kallicréine plasmatique
WO2017072021A1 (fr) * 2015-10-27 2017-05-04 Boehringer Ingelheim International Gmbh Utilisation de dérivés hétéroarylcarboxamides comme inhibiteurs de la kallicréine plasmatique
GB201601301D0 (en) * 2016-01-25 2016-03-09 Takeda Pharmaceutical Novel compounds
WO2017176962A1 (fr) 2016-04-06 2017-10-12 Lysosomal Therapeutics, Inc. Composés pyrrolo[1,2-a]pyrimidinyl carboxamide et leur utilisation dans le traitement de troubles médicaux
WO2017176960A1 (fr) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Composés de pyrazolo[1,5-a]pyrimidinyl carboxamide et leur utilisation dans le traitement de troubles médicaux
US10787454B2 (en) 2016-04-06 2020-09-29 BIAL—BioTech Investments, Inc. Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
MX389579B (es) 2016-05-05 2025-03-20 Bial R&D Invest S A IMIDAZO[1,2-b]PIRIDAZINAS SUSTITUIDAS, IMIDAZO[1,5-b]PIRIDAZINAS SUSTITUIDAS, COMPUESTOS RELACIONADOS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MÉDICOS
WO2017192931A1 (fr) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. Imidazo[1,2-a]pyridines substituées, imidazo[1,2-a]pyrazines substituées, composés apparentés et leur utilisation dans le traitement de troubles médicaux
BR112019000293A2 (pt) 2016-07-07 2019-04-16 Ironwood Pharmaceuticals, Inc. formas sólidas de um estimulador de sgc
KR102513343B1 (ko) 2016-07-07 2023-03-22 사이클리온 테라퓨틱스, 인크. sGC 자극제의 인 전구약물
GB201801355D0 (en) 2018-01-26 2018-03-14 Enterprise Therapeutics Ltd Compounds
EP3801525A4 (fr) * 2018-06-08 2022-03-23 The General Hospital Corporation Inhibiteurs de la prolyl-arnt-synthétase
US12091399B2 (en) 2018-10-10 2024-09-17 Boehringer Ingelheim International Gmbh Phenyltetrazole derivatives as plasma kallikrein inhibitors
US10807973B2 (en) * 2018-12-28 2020-10-20 Endogena Therapeutics, Inc. Compounds for use as therapeutically active substances in the treatment of retinal diseases
CN113677334B (zh) * 2019-02-01 2024-04-09 马歇尔大学科研协会 瞬时受体电位melastatin 8(trpm8)拮抗剂和相关方法
IL317949A (en) * 2019-05-03 2025-02-01 Praxis Prec Medicines Inc KCNT1 inhibitors and methods of use
TWI873290B (zh) 2020-02-13 2025-02-21 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
TW202144331A (zh) 2020-02-13 2021-12-01 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
KR20230005813A (ko) 2020-02-28 2023-01-10 프락시스 프리시젼 메디신즈, 인크. Kcnt1 억제제 및 사용 방법
US11773088B2 (en) 2020-11-02 2023-10-03 Praxis Precision Medicines, Inc. KCNT1 inhibitors and methods of use
WO2023098699A1 (fr) * 2021-12-01 2023-06-08 Nanjing Immunophage Biotech Co., Ltd Composés et leurs utilisations en tant qu'inhibiteurs de cd38
WO2023211855A1 (fr) * 2022-04-25 2023-11-02 Praxis Precision Medicines, Inc. Inhibiteurs de kcnt1 comprenant un noyau thiophène et procédés d'utilisation
WO2024123716A1 (fr) * 2022-12-05 2024-06-13 Praxis Precision Medicines, Inc. Inhibiteurs de kcnt1 comprenant un noyau cyclique de sulfonamide et procédés d'utilisation
AR131715A1 (es) * 2023-01-30 2025-04-23 Eurofarma Laboratorios S A AMIDAS BLOQUEADORAS DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y KITS
CN116574084A (zh) * 2023-04-17 2023-08-11 华南理工大学 一种噻吩衍生物及其合成方法与应用

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670282B2 (de) 1967-10-24 1977-02-24 Antidiabetisch wirksame hydrindensulfonylamino-pyrimidine sowie verfahren zu deren herstellung
US4192888A (en) 1978-04-10 1980-03-11 Smithkline Corporation Pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase
AU543804B2 (en) 1980-10-31 1985-05-02 Takeda Chemical Industries Ltd. Amides having bicyclic substituents on nitrogen
CA2015473C (fr) 1989-04-28 1998-04-14 Iwao Kinoshita Derives de triphenylmethane
AU632809B2 (en) 1989-05-25 1993-01-14 Takeda Chemical Industries Ltd. Benzocycloalkane benzopyran and benzothiopyran urea derivatives and production thereof
DE69013607T2 (de) 1989-08-02 1995-03-02 Takeda Chemical Industries Ltd Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
JPH03218371A (ja) 1989-08-02 1991-09-25 Takeda Chem Ind Ltd ピラゾール誘導体
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
AT392915B (de) 1990-03-28 1991-07-10 Chemiefaser Lenzing Ag Verfahren zum abtrennen von wasser aus einer verduennten waesserigen loesung von n-methylmorpholin-n-oxid, n-methylmorpholin und/oder morpholin
GB9010404D0 (en) * 1990-05-09 1990-06-27 Pfizer Ltd Therapeutic agents
CA2139088A1 (fr) 1993-12-28 1995-06-29 Akihiko Ishida Derives indane, procedes pour leur preparation et intermediaires synthetiques pour ceux-ci
US5583221A (en) 1994-05-04 1996-12-10 Eli Lilly And Company Substituted fused and bridged bicyclic compounds as therapeutic agents
US5459274A (en) 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
TW397812B (en) 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
JPH0971534A (ja) 1995-06-26 1997-03-18 Tanabe Seiyaku Co Ltd 医薬組成物
PT841929E (pt) 1995-08-02 2003-09-30 Darwin Discovery Ltd Quinolonas e sua utilizacao terapeutica
ES2211965T3 (es) 1995-08-02 2004-07-16 Darwin Discovery Limited Quinolonas y su utilizacion terapeutica.
CZ287969B6 (cs) 1995-08-10 2001-03-14 Astra Pharmaceuticals Limited Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití
JPH09255592A (ja) 1996-01-17 1997-09-30 Shionogi & Co Ltd 不斉ボラン還元による光学活性アルコールの製造法
SE9701681D0 (sv) 1997-05-05 1997-05-05 Astra Ab New compounds
WO1999026927A2 (fr) * 1997-11-21 1999-06-03 Nps Pharmaceuticals, Inc. Antagonistes des recepteurs du glutamate metabotropes, utilises pour le traitement de maladies du systeme nerveux central
US6180597B1 (en) 1998-03-19 2001-01-30 Brigham And Women's Hospital, Inc. Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors
WO2000003746A2 (fr) * 1998-07-14 2000-01-27 The Brigham And Women's Hospital, Inc. Remise a niveau de la synthase dl'oxyde nitrique des cellules endotheliales de type iii par des agents venant disloquer l'organisation cytosquelettique de l'actine
IL141396A0 (en) 1998-08-20 2002-03-10 Agouron Pharma Non-peptide gnrh agents, methods and intermediates for their preparation
US6326379B1 (en) * 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
DE19858191A1 (de) 1998-12-17 2000-06-21 Aventis Cropscience Gmbh 4-Haloalkyl-3-heterocyclylpyridine und 4-Haloalkyl-5-heterocyclyl-pyrimidine und ihre Verwendung als Repellentien
AUPP891299A0 (en) 1999-02-26 1999-03-25 Fujisawa Pharmaceutical Co., Ltd. New 6-membered cyclic compounds
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
IT1317826B1 (it) 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
DE10019758A1 (de) 2000-04-20 2001-10-25 Bayer Ag Fungizide Wirkstoffkombinationen
DE10021246A1 (de) 2000-04-25 2001-10-31 Schering Ag Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel
GB0021831D0 (en) 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
WO2002024631A1 (fr) * 2000-09-18 2002-03-28 Pharmacia & Upjohn Company Procede de fabrication de (2s)-2-(dipropylamino)-6-ethoxy-2,3-dihydro-1h-indene-5-carboxamide
ATE430745T1 (de) 2000-10-12 2009-05-15 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
PE20020856A1 (es) 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
TWI241190B (en) 2001-02-13 2005-10-11 Aventis Pharma Gmbh 4-Fluoro-N-indan-2-yl benzamide and its use as pharmaceutical
PE20020870A1 (es) 2001-02-13 2002-11-18 Aventis Pharma Gmbh 6,7,8,9-tetrahidro-5h-benzocicloheptenil aminas aciladas
WO2002083648A1 (fr) * 2001-04-16 2002-10-24 Eisai Co., Ltd. Nouveau compose a base de 1h-indazole
US7263610B2 (en) * 2002-07-30 2007-08-28 Imagictv, Inc. Secure multicast flow
US7338956B2 (en) 2002-08-07 2008-03-04 Sanofi-Aventis Deutschland Gmbh Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals
US7105513B2 (en) 2002-08-07 2006-09-12 Sanofi-Avertis Deutschland Gmbh Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
US7186735B2 (en) 2002-08-07 2007-03-06 Sanofi-Aventis Deutschland Gmbh Acylated arylcycloalkylamines and their use as pharmaceuticals
US8309608B2 (en) 2003-11-06 2012-11-13 Sanofi-Aventis Deutschland Gmbh Use of eNOS transcription enhancers in the cell therapy of ischemic heart diseases

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