MA31036B1 - Inhibiteurs non nucleosidiques de la transcriptase inverse - Google Patents

Inhibiteurs non nucleosidiques de la transcriptase inverse

Info

Publication number
MA31036B1
MA31036B1 MA32059A MA32059A MA31036B1 MA 31036 B1 MA31036 B1 MA 31036B1 MA 32059 A MA32059 A MA 32059A MA 32059 A MA32059 A MA 32059A MA 31036 B1 MA31036 B1 MA 31036B1
Authority
MA
Morocco
Prior art keywords
compounds
reverse transcriptase
hiv
prophylaxis
formula
Prior art date
Application number
MA32059A
Other languages
English (en)
Inventor
Neville J Anthony
Robert Gomez
Samson M Jolly
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA31036B1 publication Critical patent/MA31036B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSÉS DE FORMULE I: (I), QUI CONSISTENT EN DES INHIBITEURS DE LA TRANSCRIPTASE INVERSE DU VIH, Q, R2, R3, R6, T1, T2, ET T3 ÉTANT DÉFINIS DANS LE PRÉSENT DOCUMENT. LES COMPOSÉS DE FORMULE I, ET LES SELS ET PROMÉDICAMENTS DE CEUX-CI ACCEPTABLES SUR LE PLAN PHARMACEUTIQUE, SONT UTILES DANS L'INHIBITION DE LA TRANSCRIPTASE INVERSE DU VIH, DANS LA PROPHYLAXIE ET LE TRAITEMENT D'INFECTION PAR LE VIH ET DANS LA PROPHYLAXIE, LE RETARDEMENT DE L'APPARITION OU DE LA PROGRESSION, ET LE TRAITEMENT DU SIDA. LES COMPOSÉS ET LEURS SELS PEUVENT ÊTRE UTILISÉS COMME INGRÉDIENTS DANS DES COMPOSITIONS PHARMACEUTIQUES, FACULTATIVEMENT COMBINÉS À D'AUTRES ANTIVIRAUX, IMMUNOMODULATEURS, ANTIBIOTIQUES OU VACCINS.
MA32059A 2006-12-13 2009-06-30 Inhibiteurs non nucleosidiques de la transcriptase inverse MA31036B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87462906P 2006-12-13 2006-12-13

Publications (1)

Publication Number Publication Date
MA31036B1 true MA31036B1 (fr) 2009-12-01

Family

ID=39277099

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32059A MA31036B1 (fr) 2006-12-13 2009-06-30 Inhibiteurs non nucleosidiques de la transcriptase inverse

Country Status (29)

Country Link
US (2) US7781454B2 (fr)
EP (1) EP2121638B1 (fr)
JP (1) JP5123949B2 (fr)
KR (1) KR20090087481A (fr)
CN (1) CN101558050A (fr)
AR (1) AR064199A1 (fr)
AU (1) AU2007334598B2 (fr)
BR (1) BRPI0720196A2 (fr)
CA (1) CA2673093A1 (fr)
CL (1) CL2007003594A1 (fr)
CR (1) CR10843A (fr)
DO (1) DOP2009000138A (fr)
EA (1) EA200970572A1 (fr)
EC (1) ECSP099373A (fr)
GE (1) GEP20115320B (fr)
GT (1) GT200900158A (fr)
HN (1) HN2009001160A (fr)
IL (1) IL199103A0 (fr)
MA (1) MA31036B1 (fr)
MX (1) MX2009006285A (fr)
NI (1) NI200900103A (fr)
NO (1) NO20092636L (fr)
NZ (1) NZ577637A (fr)
PE (1) PE20081448A1 (fr)
SV (1) SV2009003294A (fr)
TN (1) TN2009000243A1 (fr)
TW (1) TW200831085A (fr)
WO (2) WO2008076223A1 (fr)
ZA (1) ZA200903395B (fr)

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Also Published As

Publication number Publication date
TN2009000243A1 (en) 2010-10-18
JP5123949B2 (ja) 2013-01-23
AR064199A1 (es) 2009-03-18
ZA200903395B (en) 2010-05-26
WO2008076225A3 (fr) 2008-08-07
GT200900158A (es) 2009-10-14
NI200900103A (es) 2010-01-26
EP2121638A2 (fr) 2009-11-25
TW200831085A (en) 2008-08-01
MX2009006285A (es) 2009-06-23
CN101558050A (zh) 2009-10-14
HN2009001160A (es) 2011-10-11
NZ577637A (en) 2011-05-27
EP2121638B1 (fr) 2016-05-25
NO20092636L (no) 2009-09-08
CL2007003594A1 (es) 2008-05-30
IL199103A0 (en) 2010-03-28
CR10843A (es) 2009-08-12
US7781454B2 (en) 2010-08-24
AU2007334598A1 (en) 2008-06-26
KR20090087481A (ko) 2009-08-17
AU2007334598B2 (en) 2013-01-17
ECSP099373A (es) 2009-07-31
WO2008076223A1 (fr) 2008-06-26
BRPI0720196A2 (pt) 2013-12-31
GEP20115320B (en) 2011-10-25
PE20081448A1 (es) 2008-10-19
JP2010510989A (ja) 2010-04-08
DOP2009000138A (es) 2009-11-15
SV2009003294A (es) 2009-11-09
EA200970572A1 (ru) 2009-12-30
US20100286192A1 (en) 2010-11-11
CA2673093A1 (fr) 2008-06-26
US20080275097A1 (en) 2008-11-06
WO2008076225A2 (fr) 2008-06-26

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