MA31872B1 - Inhibiteurs de kinésine en tant que produits thérapeutiques anti-cancers - Google Patents
Inhibiteurs de kinésine en tant que produits thérapeutiques anti-cancersInfo
- Publication number
- MA31872B1 MA31872B1 MA32879A MA32879A MA31872B1 MA 31872 B1 MA31872 B1 MA 31872B1 MA 32879 A MA32879 A MA 32879A MA 32879 A MA32879 A MA 32879A MA 31872 B1 MA31872 B1 MA 31872B1
- Authority
- MA
- Morocco
- Prior art keywords
- compounds
- cancers
- ksp
- novel
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 102000010638 Kinesin Human genes 0.000 title abstract 2
- 108010063296 Kinesin Proteins 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention porte sur de nouveaux composés imidazoles qui inhibent l'activité de protéine du fuseau kinésine (ksp, également appelée eg5). Des inhibiteurs de ksp peuvent réduire une prolifération cellulaire non souhaitée et fournir d'autres effets thérapeutiques. L'invention porte également sur des compositions pharmaceutiques contenant ces nouveaux composés, et sur des procédés d'utilisation des nouveaux inhibiteurs de ksp et de leurs compositions pharmaceutiques pour traiter divers types de cancers. Les composés, compositions et procédés de l'invention sont particulièrement utiles pour traiter certaines classes de cancers qui sont résistants à des traitements par les médicaments classiques, en raison du fait qu'il a été démontré que de tels cancers restent sensibles aux composés de l'invention.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1396607P | 2007-12-14 | 2007-12-14 | |
| PCT/EP2008/067412 WO2009077448A1 (fr) | 2007-12-14 | 2008-12-12 | Inhibiteurs de kinésine en tant que produits thérapeutiques anti-cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA31872B1 true MA31872B1 (fr) | 2010-11-01 |
Family
ID=40328566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA32879A MA31872B1 (fr) | 2007-12-14 | 2010-05-31 | Inhibiteurs de kinésine en tant que produits thérapeutiques anti-cancers |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US8252832B2 (fr) |
| EP (1) | EP2229170B1 (fr) |
| JP (1) | JP5501976B2 (fr) |
| KR (1) | KR20100098394A (fr) |
| CN (1) | CN101939005B (fr) |
| AR (1) | AR069676A1 (fr) |
| AU (1) | AU2008337570B2 (fr) |
| BR (1) | BRPI0821248A2 (fr) |
| CA (1) | CA2708822A1 (fr) |
| CL (1) | CL2008003707A1 (fr) |
| CO (1) | CO6290651A2 (fr) |
| CR (1) | CR11412A (fr) |
| DO (1) | DOP2010000175A (fr) |
| EA (1) | EA018014B1 (fr) |
| EC (1) | ECSP10010248A (fr) |
| ES (1) | ES2459442T3 (fr) |
| GE (1) | GEP20125647B (fr) |
| GT (1) | GT201000172A (fr) |
| IL (1) | IL205831A0 (fr) |
| MA (1) | MA31872B1 (fr) |
| MY (1) | MY150214A (fr) |
| NI (1) | NI201000091A (fr) |
| NZ (1) | NZ585142A (fr) |
| PA (1) | PA8807801A1 (fr) |
| PE (1) | PE20091451A1 (fr) |
| SM (1) | SMP201000095B (fr) |
| TN (1) | TN2010000204A1 (fr) |
| TW (1) | TW200930704A (fr) |
| UY (1) | UY31532A1 (fr) |
| WO (1) | WO2009077448A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8765817B1 (en) | 2008-12-03 | 2014-07-01 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| US8349899B1 (en) | 2008-12-03 | 2013-01-08 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| WO2011128388A2 (fr) * | 2010-04-15 | 2011-10-20 | Novartis Ag | Composés d'oxazole et de thiazole comme inhibiteurs de ksp |
| US9498540B2 (en) | 2013-03-15 | 2016-11-22 | Novartis Ag | Cell proliferation inhibitors and conjugates thereof |
| EP2968591A1 (fr) * | 2013-03-15 | 2016-01-20 | Novartis AG | Inhibiteurs de la prolifération cellulaire et leurs conjugués |
| WO2016020791A1 (fr) | 2014-08-05 | 2016-02-11 | Novartis Ag | Conjugués anticorps ckit-médicament |
| JP6971858B2 (ja) | 2015-06-22 | 2021-11-24 | バイエル ファーマ アクチエンゲゼルシャフト | 酵素開裂性基を有する抗体薬物複合体（ａｄｃ）および抗体プロドラッグ複合体（ａｐｄｃ） |
| CN105418527A (zh) * | 2015-12-28 | 2016-03-23 | 青岛友诚高新技术有限公司 | 一种具有抗乳腺导管癌活性的化合物及其制备方法、用途 |
| CN105646361B (zh) * | 2016-02-17 | 2017-12-01 | 吉首大学 | 一种2,4,5‑三芳基咪唑型化合物及其制法和用途 |
| CN110312534B (zh) | 2016-12-21 | 2023-04-04 | 拜耳制药股份公司 | 具有酶促可裂解基团的抗体-药物-缀合物(adc) |
| CN106668863B (zh) * | 2017-02-21 | 2019-04-23 | 南方医科大学 | 靶向ktn1治疗皮肤鳞状细胞癌的药物 |
| GB201706162D0 (en) * | 2017-04-19 | 2017-05-31 | Nat Univ Singapore | Compounds |
| CN111954532A (zh) * | 2018-04-13 | 2020-11-17 | 上海交通大学医学院附属瑞金医院 | 杂芳基酰胺类化合物的抗肿瘤多药耐药性、治疗癌症的用途和蛋白质-药物分子复合物 |
| CN109646679A (zh) * | 2019-01-28 | 2019-04-19 | 中国科学院长春应用化学研究所 | 铁离子螯合剂及其可药用盐的用途 |
| CN111529526B (zh) * | 2020-04-14 | 2021-04-23 | 广州领晟医疗科技有限公司 | 一种化合物在制备治疗急性胰腺炎的药物中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0510929A (pt) * | 2004-06-18 | 2007-07-17 | Chiron Corp | derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer |
| US7271271B2 (en) | 2004-06-28 | 2007-09-18 | Amgen Sf, Llc | Imidazolo-related compounds, compositions and methods for their use |
| TW200800951A (en) | 2005-08-09 | 2008-01-01 | Novartis Ag | Substituted imidazole compounds as KSP inhibitors |
| WO2008086122A2 (fr) | 2007-01-05 | 2008-07-17 | Novartis Ag | Dérivés cyclisés en tant qu'inhibiteurs d'eg-5 |
-
2008
- 2008-11-25 US US12/313,923 patent/US8252832B2/en not_active Expired - Fee Related
- 2008-12-12 CA CA2708822A patent/CA2708822A1/fr not_active Abandoned
- 2008-12-12 NZ NZ585142A patent/NZ585142A/en not_active IP Right Cessation
- 2008-12-12 CL CL2008003707A patent/CL2008003707A1/es unknown
- 2008-12-12 AU AU2008337570A patent/AU2008337570B2/en not_active Ceased
- 2008-12-12 ES ES08863009.0T patent/ES2459442T3/es active Active
- 2008-12-12 PE PE2008002064A patent/PE20091451A1/es not_active Application Discontinuation
- 2008-12-12 MY MYPI2010002030A patent/MY150214A/en unknown
- 2008-12-12 TW TW097148535A patent/TW200930704A/zh unknown
- 2008-12-12 WO PCT/EP2008/067412 patent/WO2009077448A1/fr not_active Ceased
- 2008-12-12 PA PA20088807801A patent/PA8807801A1/es unknown
- 2008-12-12 AR ARP080105410A patent/AR069676A1/es not_active Application Discontinuation
- 2008-12-12 BR BRPI0821248-1A patent/BRPI0821248A2/pt not_active IP Right Cessation
- 2008-12-12 CN CN200880120667.8A patent/CN101939005B/zh not_active Expired - Fee Related
- 2008-12-12 JP JP2010537460A patent/JP5501976B2/ja not_active Expired - Fee Related
- 2008-12-12 KR KR1020107012912A patent/KR20100098394A/ko not_active Withdrawn
- 2008-12-12 EA EA201000900A patent/EA018014B1/ru not_active IP Right Cessation
- 2008-12-12 EP EP08863009.0A patent/EP2229170B1/fr active Active
- 2008-12-12 GE GEAP200811846A patent/GEP20125647B/en unknown
- 2008-12-15 UY UY31532A patent/UY31532A1/es not_active Application Discontinuation
-
2010
- 2010-05-05 CR CR11412A patent/CR11412A/es not_active Application Discontinuation
- 2010-05-07 TN TN2010000204A patent/TN2010000204A1/fr unknown
- 2010-05-17 IL IL205831A patent/IL205831A0/en unknown
- 2010-05-31 MA MA32879A patent/MA31872B1/fr unknown
- 2010-06-02 NI NI201000091A patent/NI201000091A/es unknown
- 2010-06-10 CO CO10070369A patent/CO6290651A2/es not_active Application Discontinuation
- 2010-06-11 DO DO2010000175A patent/DOP2010000175A/es unknown
- 2010-06-14 GT GT201000172A patent/GT201000172A/es unknown
- 2010-06-14 EC EC2010010248A patent/ECSP10010248A/es unknown
- 2010-07-13 SM SM201000095T patent/SMP201000095B/it unknown
-
2012
- 2012-07-11 US US13/546,713 patent/US8664256B2/en not_active Expired - Fee Related
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