MA49705A - Intermédiaires utiles pour la synthèse d'un inhibiteur sélectif vis-à-vis de la protéine kinase et leurs procédés de préparation - Google Patents

Intermédiaires utiles pour la synthèse d'un inhibiteur sélectif vis-à-vis de la protéine kinase et leurs procédés de préparation

Info

Publication number
MA49705A
MA49705A MA049705A MA49705A MA49705A MA 49705 A MA49705 A MA 49705A MA 049705 A MA049705 A MA 049705A MA 49705 A MA49705 A MA 49705A MA 49705 A MA49705 A MA 49705A
Authority
MA
Morocco
Prior art keywords
synthesis
protein kinase
kinase inhibitor
preparation processes
selective protein
Prior art date
Application number
MA049705A
Other languages
English (en)
Inventor
Sang-Seol Jeon
Hyun Ju
Ja-Heouk Khoo
Doo-Byung Lee
Jun-Sup Lee
Jung-Ae Lee
Jong-Chul Lim
Sang-Ho Oh
Woo-Seob Shin
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65040643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA49705(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of MA49705A publication Critical patent/MA49705A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
MA049705A 2017-07-28 2018-07-25 Intermédiaires utiles pour la synthèse d'un inhibiteur sélectif vis-à-vis de la protéine kinase et leurs procédés de préparation MA49705A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20170096226 2017-07-28

Publications (1)

Publication Number Publication Date
MA49705A true MA49705A (fr) 2021-03-31

Family

ID=65040643

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049705A MA49705A (fr) 2017-07-28 2018-07-25 Intermédiaires utiles pour la synthèse d'un inhibiteur sélectif vis-à-vis de la protéine kinase et leurs procédés de préparation

Country Status (30)

Country Link
US (1) US11198684B2 (fr)
EP (1) EP3658547B1 (fr)
JP (1) JP7189932B2 (fr)
KR (2) KR102671396B1 (fr)
CN (1) CN111295381A (fr)
AU (1) AU2018308164B2 (fr)
CA (1) CA3070070A1 (fr)
CO (1) CO2020000371A2 (fr)
DK (1) DK3658547T3 (fr)
EA (1) EA038078B1 (fr)
ES (1) ES2959967T3 (fr)
FI (1) FI3658547T3 (fr)
HR (1) HRP20231020T1 (fr)
HU (1) HUE063043T2 (fr)
IL (1) IL271975B (fr)
LT (1) LT3658547T (fr)
MA (1) MA49705A (fr)
MX (1) MX393368B (fr)
MY (1) MY201038A (fr)
NZ (1) NZ761158A (fr)
PH (1) PH12020500093A1 (fr)
PL (1) PL3658547T3 (fr)
PT (1) PT3658547T (fr)
RS (1) RS64545B1 (fr)
SA (1) SA520411115B1 (fr)
SG (1) SG11201913556SA (fr)
SI (1) SI3658547T1 (fr)
SM (1) SMT202300297T1 (fr)
UA (1) UA125595C2 (fr)
WO (1) WO2019022487A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019022486A1 (fr) * 2017-07-28 2019-01-31 Yuhan Corporation Nouveaux intermédiaires utiles pour la synthèse de dérivés d'aminopyrimidine, leur procédé de préparation et procédé de préparation de dérivés d'aminopyrimidine à l'aide de ceux-ci
SG11201913517UA (en) 2017-07-28 2020-02-27 Yuhan Corp Improved process for preparing aminopyrimidine derivatives
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
US11879013B2 (en) 2019-05-14 2024-01-23 Janssen Biotech, Inc. Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors
JP7783182B2 (ja) 2020-02-12 2025-12-09 ヤンセン バイオテツク,インコーポレーテツド c-METエクソン14スキッピング変異を有する患者の治療
US12138351B2 (en) 2020-04-14 2024-11-12 Janssen Biotech, Inc. Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or pharmaceutically acceptable salt, hydrate, or solvate thereof
CA3228195A1 (en) 2023-05-23 2025-06-30 Janssen Biotech, Inc. Methods for treatment of non-small cell lung cancer (nsclc)
AU2024337472A1 (en) 2023-09-05 2026-04-16 Janssen Biotech, Inc. Methods of treating non-small cell lung cancer
WO2026042017A1 (fr) 2024-08-19 2026-02-26 Janssen Biotech, Inc. Amivantamab en association avec le lazertinib pour le traitement du cancer du poumon non à petites cellules (cpnpc)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ603525A (en) * 2008-06-27 2015-02-27 Celgene Avilomics Res Inc Pyrimidine based compound and uses thereof
EA024729B1 (ru) * 2009-11-13 2016-10-31 Джиноско Киназные ингибиторы
EP4119551A1 (fr) * 2011-07-27 2023-01-18 Astrazeneca AB Composés de 2-(anilino 2,4,5-substitué)pyrimidine
TW201332989A (zh) * 2011-12-23 2013-08-16 Millennium Pharm Inc 雜芳基化合物及其用途
US8871778B2 (en) * 2012-01-20 2014-10-28 Genosco Substituted pyrimidine compounds and their use as SYK inhibitors
EP3144292B1 (fr) * 2014-04-14 2020-08-26 Shanghai Haiyan Pharmaceutical Technology Co., Ltd Dérivés de benzène-1,5-diamine 2,3,4,6-tétra-substitués, procédé de préparation associé et utilisation médicinale de ceux-ci
CN105461695B (zh) * 2014-09-29 2018-03-27 齐鲁制药有限公司 嘧啶或三嗪衍生物及其制备方法和用途
CN105524068B (zh) * 2014-09-30 2017-11-24 上海海雁医药科技有限公司 氮杂双环衍生物、其制法与医药上的用途
HUE054848T2 (hu) 2014-10-13 2021-09-28 Yuhan Corp Vegyületek és készítmények EGFR mutáns kináz aktivitás módosítására
CN105859721B (zh) * 2015-01-22 2018-04-17 浙江京新药业股份有限公司 一种伊布鲁替尼的制备方法
CN104788427B (zh) 2015-02-05 2017-05-31 上海泓博智源医药股份有限公司 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用
TWI726968B (zh) * 2016-01-07 2021-05-11 開曼群島商Cs醫藥技術公司 Egfr酪胺酸激酶之臨床重要突變體之選擇性抑制劑
CN106083736A (zh) * 2016-06-21 2016-11-09 郑州泰基鸿诺医药股份有限公司 一种嘧啶类化合物、egfr抑制剂及其应用

Also Published As

Publication number Publication date
CO2020000371A2 (es) 2020-05-05
KR20190013555A (ko) 2019-02-11
SG11201913556SA (en) 2020-02-27
BR112020001457A2 (pt) 2020-07-28
PH12020500093A1 (en) 2020-09-14
CN111295381A (zh) 2020-06-16
SMT202300297T1 (it) 2023-11-13
EA038078B1 (ru) 2021-07-02
EP3658547A1 (fr) 2020-06-03
JP7189932B2 (ja) 2022-12-14
KR20230137282A (ko) 2023-10-04
EP3658547A4 (fr) 2021-03-31
RS64545B1 (sr) 2023-09-29
HRP20231020T1 (hr) 2023-12-08
KR102671396B1 (ko) 2024-05-31
JP2020528916A (ja) 2020-10-01
PL3658547T3 (pl) 2024-01-03
IL271975B (en) 2022-08-01
FI3658547T3 (fi) 2023-10-26
US11198684B2 (en) 2021-12-14
NZ761158A (en) 2022-08-26
US20210155607A1 (en) 2021-05-27
CA3070070A1 (fr) 2019-01-31
IL271975A (en) 2020-02-27
LT3658547T (lt) 2023-10-10
WO2019022487A1 (fr) 2019-01-31
AU2018308164B2 (en) 2021-12-09
HUE063043T2 (hu) 2023-12-28
ES2959967T3 (es) 2024-02-29
SA520411115B1 (ar) 2023-01-18
PT3658547T (pt) 2023-10-20
SI3658547T1 (sl) 2023-10-30
UA125595C2 (uk) 2022-04-27
DK3658547T3 (da) 2023-10-16
EA202090384A1 (ru) 2020-05-20
MX393368B (es) 2025-03-24
AU2018308164A1 (en) 2020-01-30
KR102746929B1 (ko) 2024-12-26
EP3658547B1 (fr) 2023-08-16
MY201038A (en) 2024-01-31

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