MA49846B1 - Anticorps liant egfr et cmet - Google Patents

Anticorps liant egfr et cmet

Info

Publication number
MA49846B1
MA49846B1 MA49846A MA49846A MA49846B1 MA 49846 B1 MA49846 B1 MA 49846B1 MA 49846 A MA49846 A MA 49846A MA 49846 A MA49846 A MA 49846A MA 49846 B1 MA49846 B1 MA 49846B1
Authority
MA
Morocco
Prior art keywords
antibody
cmet
bind
variable domain
egfr
Prior art date
Application number
MA49846A
Other languages
English (en)
Other versions
MA49846A (fr
Inventor
Mark Throsby
Ton Logtenberg
Cecilia Anna Wilhelmina Geuijen
Robertus Cornelis ROOVERS
Cornelis Adriaan De Kruif
Original Assignee
Merus N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merus N.V. filed Critical Merus N.V.
Publication of MA49846A publication Critical patent/MA49846A/fr
Publication of MA49846B1 publication Critical patent/MA49846B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des anticorps bispécifiques qui comprennent un premier domaine variable qui peut se lier à une partie extracellulaire du récepteur du facteur de croissance épidermique (EGFR) et un second domaine variable qui peut se lier à une partie extracellulaire du proto-oncogène MET, la tyrosine kinase réceptrice (cMET). L'anticorps peut comprendre une chaîne légère commune, peut être un anticorps humain, ou un anticorps pleine longueur. Dans certains modes de réalisation, l'anticorps bispécifique est un anticorps au format IgGl ayant une stœchiométrie anti-EGFR, anti-cMET de 1:1, dans d'autres, l'anticorps a un domaine variable qui peut se lier à l'EGFR et un domaine variable qui peut se lier à cMET.
MA49846A 2017-08-09 2018-08-09 Anticorps liant egfr et cmet MA49846B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17185572 2017-08-09
EP18766377.8A EP3665198B9 (fr) 2017-08-09 2018-08-09 Anticorps liant egfr et cmet
PCT/NL2018/050537 WO2019031965A1 (fr) 2017-08-09 2018-08-09 Anticorps qui se lient à l'egfr et à cmet

Publications (2)

Publication Number Publication Date
MA49846A MA49846A (fr) 2020-06-17
MA49846B1 true MA49846B1 (fr) 2025-05-30

Family

ID=59579503

Family Applications (2)

Application Number Title Priority Date Filing Date
MA49846A MA49846B1 (fr) 2017-08-09 2018-08-09 Anticorps liant egfr et cmet
MA71419A MA71419A (fr) 2017-08-09 2018-08-09 Anticorps se liant à egfr et cmet

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA71419A MA71419A (fr) 2017-08-09 2018-08-09 Anticorps se liant à egfr et cmet

Country Status (27)

Country Link
US (2) US11773170B2 (fr)
EP (2) EP4553088A3 (fr)
JP (3) JP2020530028A (fr)
KR (2) KR20200042485A (fr)
CN (4) CN118562014A (fr)
AU (2) AU2018312816B2 (fr)
BR (1) BR112020002695A2 (fr)
CA (1) CA3072404A1 (fr)
DK (1) DK3665198T3 (fr)
EA (1) EA202090215A1 (fr)
ES (1) ES3025738T3 (fr)
FI (1) FI3665198T3 (fr)
HR (1) HRP20250474T2 (fr)
HU (1) HUE071182T2 (fr)
IL (1) IL272461A (fr)
LT (1) LT3665198T (fr)
MA (2) MA49846B1 (fr)
MD (1) MD3665198T3 (fr)
MX (2) MX2020001432A (fr)
PH (1) PH12020550055A1 (fr)
PL (1) PL3665198T3 (fr)
PT (1) PT3665198T (fr)
RS (1) RS66708B9 (fr)
SG (1) SG11202001050PA (fr)
SI (1) SI3665198T1 (fr)
TW (1) TWI874301B (fr)
WO (1) WO2019031965A1 (fr)

Families Citing this family (25)

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JP7296728B2 (ja) 2015-10-23 2023-06-23 メルス ナムローゼ フェンノートシャップ 癌の成長を抑制する結合分子
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法
JP7737220B2 (ja) 2017-03-31 2025-09-10 メルス ナムローゼ フェンノートシャップ ＮＲＧ１融合遺伝子を有する細胞の処置における使用のためのＥｒｂＢ－２及びＥｒｂＢ３結合二重特異性抗体
RS66708B9 (sr) * 2017-08-09 2025-08-29 Merus Nv Antitela koja se vezuju za egfr i cmet
CA3094318A1 (fr) * 2018-03-30 2019-10-03 Merus N.V. Anticorps multivalent
US11254736B2 (en) * 2019-02-15 2022-02-22 Integral Molecular, Inc. Antibodies comprising a common light chain and uses thereof
EP3966238A2 (fr) 2019-05-09 2022-03-16 Merus N.V. Domaines variants pour la multimérisation de protéines et leur séparation
CN114340684B (zh) 2019-09-16 2025-09-12 瑞泽恩制药公司 用于免疫pet成像的放射性标记的met结合蛋白
CN112898427B (zh) * 2019-12-03 2023-06-30 同济大学苏州研究院 一种抗c-Met单臂抗体及其制备方法和应用
WO2022104236A2 (fr) * 2020-11-16 2022-05-19 Ab Therapeutics, Inc. Anticorps multispécifiques et leurs utilisations
EP4372001A4 (fr) * 2021-07-14 2025-02-12 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Molécule de liaison à l'antigène se liant spécifiquement à hgfr et egfr, et utilisation pharmaceutique de celle-ci
CN119278214A (zh) 2022-03-07 2025-01-07 美勒斯公司 用结合EGFR和cMET的抗体治疗
EP4490189A1 (fr) 2022-03-07 2025-01-15 Merus N.V. Polythérapie comprenant des anticorps se liant à l'egfr et au cmet
CA3256857A1 (fr) * 2022-06-29 2024-01-04 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Anticorps anti-egfr/met et leurs utilisations
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CN121969654A (zh) * 2023-08-02 2026-05-01 百泰生物药业有限公司 EGFR/c-Met双特异性抗体及其应用
AU2024382013A1 (en) 2023-11-17 2026-06-18 Merus B.V. COMBINATION THERAPY INCLUDING ANTIBODIES THAT BIND EGFR AND cMET.
CN120271706A (zh) * 2023-12-29 2025-07-08 上海安领科生物医药有限公司 抗egfr单抗、其双特异性抗体、药物组合物和用途
WO2025148868A1 (fr) 2024-01-08 2025-07-17 泰励生物科技（上海）有限公司 Conjugué anticorps-médicament et son utilisation
TW202608927A (zh) * 2024-04-30 2026-03-01 荷蘭商美勒斯公司 多特異性抗體－藥物偶聯物
TW202608928A (zh) * 2024-04-30 2026-03-01 荷蘭商美勒斯公司 多特異性抗體藥物偶聯物
WO2025247206A1 (fr) * 2024-05-27 2025-12-04 上海迈晋生物医药科技有限公司 Molécule de liaison à l'antigène se liant de manière spécifique à egfr et cmet, conjugué de médicament associé et utilisation médicale associée
CN121045388A (zh) * 2024-05-30 2025-12-02 英百瑞(杭州)生物医药有限公司 针对人c-Met和人EGFR的双特异性抗体及其用途
WO2025247330A1 (fr) * 2024-05-31 2025-12-04 江苏先声生物制药有限公司 Conjugué anticorps-médicament bispécifique anti-egfr × cmet et son utilisation
WO2026145542A1 (fr) * 2024-12-30 2026-07-09 康源博创生物科技(北京)有限公司 Polypeptide et anticorps le contenant

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