|
US4450150A
(en)
|
1973-05-17 |
1984-05-22 |
Arthur D. Little, Inc. |
Biodegradable, implantable drug delivery depots, and method for preparing and using the same
|
|
US4232027A
(en)
|
1979-01-29 |
1980-11-04 |
E. R. Squibb & Sons, Inc. |
1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives
|
|
GB2116183B
(en)
|
1982-03-03 |
1985-06-05 |
Genentech Inc |
Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it
|
|
EP0272253A4
(fr)
|
1986-03-07 |
1990-02-05 |
Massachusetts Inst Technology |
Procede pour ameliorer la stabilite des glycoproteines.
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
AU612370B2
(en)
|
1987-05-21 |
1991-07-11 |
Micromet Ag |
Targeted multifunctional proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
|
JP2762522B2
(ja)
|
1989-03-06 |
1998-06-04 |
藤沢薬品工業株式会社 |
血管新生阻害剤
|
|
GB8912336D0
(en)
|
1989-05-30 |
1989-07-12 |
Smithkline Beckman Intercredit |
Compounds
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
ES2087997T3
(es)
|
1990-01-12 |
1996-08-01 |
Cell Genesys Inc |
Generacion de anticuerpos xenogenicos.
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US6770274B1
(en)
|
1990-09-14 |
2004-08-03 |
The General Hospital Corporation |
Viral mutant HSV mediated destruction of neoplastic cells
|
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
|
US5892112A
(en)
|
1990-11-21 |
1999-04-06 |
Glycomed Incorporated |
Process for preparing synthetic matrix metalloprotease inhibitors
|
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
|
US5780279A
(en)
|
1990-12-03 |
1998-07-14 |
Genentech, Inc. |
Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
|
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
|
CA2066898A1
(fr)
|
1991-04-29 |
1992-10-30 |
Chuan Shih |
Composes pharmaceutiques
|
|
JP3266311B2
(ja)
|
1991-05-02 |
2002-03-18 |
生化学工業株式会社 |
新規ポリペプチドおよびこれを用いる抗ｈｉｖ剤
|
|
AU658646B2
(en)
|
1991-05-10 |
1995-04-27 |
Rhone-Poulenc Rorer International (Holdings) Inc. |
Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
US6225447B1
(en)
|
1991-05-15 |
2001-05-01 |
Cambridge Antibody Technology Ltd. |
Methods for producing members of specific binding pairs
|
|
US5858657A
(en)
|
1992-05-15 |
1999-01-12 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5871907A
(en)
|
1991-05-15 |
1999-02-16 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
|
GB9125660D0
(en)
|
1991-12-03 |
1992-01-29 |
Smithkline Beecham Plc |
Novel compound
|
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
|
US7381803B1
(en)
|
1992-03-27 |
2008-06-03 |
Pdl Biopharma, Inc. |
Humanized antibodies against CD3
|
|
US5521184A
(en)
|
1992-04-03 |
1996-05-28 |
Ciba-Geigy Corporation |
Pyrimidine derivatives and processes for the preparation thereof
|
|
DE4221054A1
(de)
|
1992-06-30 |
1994-01-05 |
Herbst Bremer Goldschlaegerei |
Präparat zur prophylaktischen und therapeutischen Behandlung von Karies sowie Verfahren zum Herstellen desselben
|
|
ZA935112B
(en)
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
ZA935111B
(en)
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
|
US5256790A
(en)
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
|
EP0669929B1
(fr)
|
1992-11-13 |
2007-01-03 |
Immunex Corporation |
Ligand d'elk, une cytokine
|
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
|
US5855885A
(en)
|
1993-01-22 |
1999-01-05 |
Smith; Rodger |
Isolation and production of catalytic antibodies using phage technology
|
|
US5629327A
(en)
|
1993-03-01 |
1997-05-13 |
Childrens Hospital Medical Center Corp. |
Methods and compositions for inhibition of angiogenesis
|
|
US5516658A
(en)
|
1993-08-20 |
1996-05-14 |
Immunex Corporation |
DNA encoding cytokines that bind the cell surface receptor hek
|
|
EP0672035A1
(fr)
|
1993-10-01 |
1995-09-20 |
Novartis AG |
Derives pyrimidineamine et leurs procedes de preparation
|
|
US5656643A
(en)
|
1993-11-08 |
1997-08-12 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
|
EP0729471A1
(fr)
|
1993-11-19 |
1996-09-04 |
Abbott Laboratories |
Analogues semi-synthetiques de rapamycine (macrolides) utilises comme immunomodulateurs
|
|
NZ277498A
(en)
|
1993-12-17 |
1998-03-25 |
Novartis Ag |
Rapamycin derivatives
|
|
US5700823A
(en)
|
1994-01-07 |
1997-12-23 |
Sugen, Inc. |
Treatment of platelet derived growth factor related disorders such as cancers
|
|
IL112249A
(en)
|
1994-01-25 |
2001-11-25 |
Warner Lambert Co |
Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
|
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
|
AU2096895A
(en)
|
1994-03-07 |
1995-09-25 |
Sugen, Incorporated |
Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
|
|
WO1995028484A1
(fr)
|
1994-04-15 |
1995-10-26 |
Amgen Inc. |
Nouvelles proteines tyrosine kinases receptrices analogues a l'eph, du type hek5, hek7, hek8, hek11
|
|
EP0682027B1
(fr)
|
1994-05-03 |
1997-10-15 |
Novartis AG |
Dérivés de la pyrrolopyrimidine avec une activité anti-proliférative
|
|
US6699468B1
(en)
|
1994-06-23 |
2004-03-02 |
Georgetown University |
Replication-competent herpes simplex virus mediates destruction of neoplastic cells
|
|
US5728379A
(en)
|
1994-06-23 |
1998-03-17 |
Georgetown University |
Tumor- or cell-specific herpes simplex virus replication
|
|
US5585096A
(en)
|
1994-06-23 |
1996-12-17 |
Georgetown University |
Replication-competent herpes simplex virus mediates destruction of neoplastic cells
|
|
US6303769B1
(en)
|
1994-07-08 |
2001-10-16 |
Immunex Corporation |
Lerk-5 dna
|
|
US5919905A
(en)
|
1994-10-05 |
1999-07-06 |
Immunex Corporation |
Cytokine designated LERK-6
|
|
US6057124A
(en)
|
1995-01-27 |
2000-05-02 |
Amgen Inc. |
Nucleic acids encoding ligands for HEK4 receptors
|
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
DE69522717T2
(de)
|
1995-03-30 |
2002-02-14 |
Pfizer Inc., New York |
Chinazolinderivate
|
|
AU711592B2
(en)
|
1995-04-03 |
1999-10-14 |
Novartis Ag |
Pyrazole derivatives and processes for the preparation thereof
|
|
DK0821671T3
(da)
|
1995-04-20 |
2001-04-23 |
Pfizer |
Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
US5702892A
(en)
|
1995-05-09 |
1997-12-30 |
The United States Of America As Represented By The Department Of Health And Human Services |
Phage-display of immunoglobulin heavy chain libraries
|
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
|
US5650415A
(en)
|
1995-06-07 |
1997-07-22 |
Sugen, Inc. |
Quinoline compounds
|
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
|
US6265150B1
(en)
|
1995-06-07 |
2001-07-24 |
Becton Dickinson & Company |
Phage antibodies
|
|
KR100400620B1
(ko)
|
1995-06-09 |
2004-02-18 |
노파르티스 아게 |
라파마이신유도체
|
|
ATE212993T1
(de)
|
1995-07-06 |
2002-02-15 |
Novartis Erfind Verwalt Gmbh |
Pyrolopyrimidine und verfahren zu ihrer herstellung
|
|
DE19534177A1
(de)
|
1995-09-15 |
1997-03-20 |
Merck Patent Gmbh |
Cyclische Adhäsionsinhibitoren
|
|
AR004010A1
(es)
|
1995-10-11 |
1998-09-30 |
Glaxo Group Ltd |
Compuestos heterociclicos
|
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
ES2183905T3
(es)
|
1995-12-20 |
2003-04-01 |
Hoffmann La Roche |
Inhibidores de metaloproteasa de matriz.
|
|
US6140317A
(en)
|
1996-01-23 |
2000-10-31 |
Novartis Ag |
Pyrrolopyrimidines and processes for their preparation
|
|
JP3406763B2
(ja)
|
1996-01-30 |
2003-05-12 |
東レ・ダウコーニング・シリコーン株式会社 |
シリコーンゴム組成物
|
|
GB9603097D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
|
DE19608588A1
(de)
|
1996-03-06 |
1997-09-11 |
Thomae Gmbh Dr K |
Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
DE19629652A1
(de)
|
1996-03-06 |
1998-01-29 |
Thomae Gmbh Dr K |
4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
|
AU716383B2
(en)
|
1996-03-15 |
2000-02-24 |
Novartis Ag |
Novel N-7-heterocyclyl pyrrolo(2,3-d)pyrimidines and the use thereof
|
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
|
HU228446B1
(en)
|
1996-04-12 |
2013-03-28 |
Warner Lambert Co |
Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof
|
|
GB9607729D0
(en)
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
|
DE69734513T2
(de)
|
1996-06-24 |
2006-07-27 |
Pfizer Inc. |
Phenylamino-substituierte tricyclische derivate zur behandlung hyperproliferativer krankheiten
|
|
EP0818442A3
(fr)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Dérivés cycliques de sulfones comme inhibiteurs de métalloprotéinase et de la production du facteur de nécrose des tumeurs
|
|
US6258823B1
(en)
|
1996-07-12 |
2001-07-10 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
|
ES2191187T3
(es)
|
1996-07-13 |
2003-09-01 |
Glaxo Group Ltd |
Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
|
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
|
JP4386967B2
(ja)
|
1996-07-13 |
2009-12-16 |
グラクソ、グループ、リミテッド |
プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物
|
|
HUP9903014A3
(en)
|
1996-07-18 |
2000-08-28 |
Pfizer |
Phosphinate derivatives having matrix metalloprotease inhibitor effect and medicaments containing the same
|
|
US5824318A
(en)
|
1996-07-24 |
1998-10-20 |
American Cyanamid Company |
Avirulent herpetic viruses useful as tumoricidal agents and vaccines
|
|
WO1998006842A1
(fr)
|
1996-08-16 |
1998-02-19 |
Schering Corporation |
Antigenes de surface de cellules mammaliennes et reactifs qui y sont lies
|
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
DE69738468T2
(de)
|
1996-08-23 |
2009-01-08 |
Novartis Ag |
Substituierte pyrrolopyrimidine und verfahren zu ihrer herstellung
|
|
US6153609A
(en)
|
1996-08-23 |
2000-11-28 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
|
WO1998014450A1
(fr)
|
1996-10-02 |
1998-04-09 |
Novartis Ag |
Derives de pyrimidine et procedes de preparation de ces derniers
|
|
WO1998014449A1
(fr)
|
1996-10-02 |
1998-04-09 |
Novartis Ag |
Derives de pyrazole condenses et procedes pour leur preparation
|
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
|
EP0837063A1
(fr)
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
Dérivés de 4-aminoquinazoline
|
|
GB9621757D0
(en)
|
1996-10-18 |
1996-12-11 |
Ciba Geigy Ag |
Phenyl-substituted bicyclic heterocyclyl derivatives and their use
|
|
EP2305027B1
(fr)
|
1996-12-03 |
2014-07-02 |
Amgen Fremont Inc. |
Mammifères trangèniques obtenus par génie génétique contenant des loci des immunoglobulines humaines qui comprennent plusieurs régions de VH et de Vkappa, et anticorps aussi obtenus.
|
|
AU5131998A
(en)
|
1997-01-06 |
1998-08-03 |
Pfizer Inc. |
Cyclic sulfone derivatives
|
|
ES2202796T3
(es)
|
1997-02-03 |
2004-04-01 |
Pfizer Products Inc. |
Derivados de acidos arilsulfonilaminohidroxamicos.
|
|
DE69839338T2
(de)
|
1997-02-05 |
2008-07-10 |
Warner-Lambert Company Llc |
Pyrido (2,3-d) pyrimidine und 4-amino-pyrimidine als inhibitoren der zellulären proliferation
|
|
JP2000507975A
(ja)
|
1997-02-07 |
2000-06-27 |
ファイザー・インク |
Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
|
|
BR9807678A
(pt)
|
1997-02-11 |
2000-02-15 |
Pfizer |
Derivados de ácidos arilsulfonil-hidroxâmicos
|
|
CO4950519A1
(es)
|
1997-02-13 |
2000-09-01 |
Novartis Ag |
Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
|
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
|
US6150395A
(en)
|
1997-05-30 |
2000-11-21 |
The Regents Of The University Of California |
Indole-3-carbinol (I3C) derivatives and methods
|
|
WO1999007701A1
(fr)
|
1997-08-05 |
1999-02-18 |
Sugen, Inc. |
Derives de quinoxaline tricyclique utiles en tant qu'inhibiteurs de proteine tyrosine kinase
|
|
ID23668A
(id)
|
1997-08-08 |
2000-05-11 |
Pfizer Prod Inc |
Turunan asam ariloksiarilsulfonilamino hidroksamat
|
|
US6379674B1
(en)
|
1997-08-12 |
2002-04-30 |
Georgetown University |
Use of herpes vectors for tumor therapy
|
|
WO1999020758A1
(fr)
|
1997-10-21 |
1999-04-29 |
Human Genome Sciences, Inc. |
Proteines tr11, tr11sv1 et tr11sv2 de type recepteur du facteur de necrose tumorale humain
|
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
|
GB9800569D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
|
GB9801690D0
(en)
|
1998-01-27 |
1998-03-25 |
Pfizer Ltd |
Therapeutic agents
|
|
CA2319236A1
(fr)
|
1998-02-09 |
1999-08-12 |
Genentech, Inc. |
Nouveaux homologues recepteurs du facteur necrosant des tumeurs et acides nucleiques codant ceux-ci
|
|
CA2320193A1
(fr)
|
1998-02-10 |
1999-08-19 |
Welfide Corporation |
Preparations a liberation controlee
|
|
JP2002505330A
(ja)
|
1998-03-04 |
2002-02-19 |
ブリストル−マイヤーズ スクイブ カンパニー |
ヘテロシクロ−置換イミダゾピラジン・たんぱくチロシンキナーゼ抑制剤
|
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
|
DK1071752T3
(da)
|
1998-04-21 |
2003-10-20 |
Micromet Ag |
CD19xCD3-specifikke polypeptider og anvendelsen deraf
|
|
IL139934A
(en)
|
1998-05-29 |
2007-10-31 |
Sugen Inc |
History 2 - Indulinone converted to pyrrole and pharmaceutical preparations containing them
|
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
|
WO2000002871A1
(fr)
|
1998-07-10 |
2000-01-20 |
Merck & Co., Inc. |
Nouveaux inhibiteurs de l'angiogenese
|
|
GB9815909D0
(en)
|
1998-07-21 |
1998-09-16 |
Btg Int Ltd |
Antibody preparation
|
|
CA2341409A1
(fr)
|
1998-08-31 |
2000-03-09 |
Merck And Co., Inc. |
Nouveaux inhibiteurs d'angiogenese
|
|
ES2213985T3
(es)
|
1998-11-05 |
2004-09-01 |
Pfizer Products Inc. |
Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico.
|
|
GB2344287A
(en)
|
1998-12-03 |
2000-06-07 |
Ferring Bv |
Controlled release pharmaceutical formulation
|
|
EP1141338A4
(fr)
|
1998-12-31 |
2002-09-25 |
Arch Dev Corp |
Virus de l'herpes simplex recombinant utile dans le traitement des maladies neoplasiques
|
|
ATE538794T1
(de)
|
1999-01-13 |
2012-01-15 |
Bayer Healthcare Llc |
Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
|
|
WO2000054795A1
(fr)
|
1999-03-15 |
2000-09-21 |
The Trustees Of The University Of Pennsylvania |
Therapie combinee consistant a administrer un agent chimiotherapeutique et un virus oncolytique pour tuer des cellules cancereuses chez un sujet
|
|
PT1165085E
(pt)
|
1999-03-30 |
2006-10-31 |
Novartis Ag |
Derivados de ftalazina para tratar doencas inflamatorias
|
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
|
JP4587626B2
(ja)
|
1999-06-07 |
2010-11-24 |
イミュネックス・コーポレーション |
Ｔｅｋアンタゴニスト
|
|
US6521424B2
(en)
|
1999-06-07 |
2003-02-18 |
Immunex Corporation |
Recombinant expression of Tek antagonists
|
|
US6764675B1
(en)
|
1999-06-08 |
2004-07-20 |
The Uab Research Foundation |
Herpes simplex virus expressing foreign genes and method for treating cancers therewith
|
|
US6833268B1
(en)
|
1999-06-10 |
2004-12-21 |
Abgenix, Inc. |
Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
|
|
CA2378179A1
(fr)
|
1999-07-12 |
2001-01-18 |
Genentech, Inc. |
Stimulation ou inhibition de l'angiogenese et de la cardiovascularisation avec des homologues de ligands et de recepteurs du facteur de necrose tumorale
|
|
ES2219388T3
(es)
|
1999-08-24 |
2004-12-01 |
Ariad Gene Therapeutics, Inc. |
28-epi-rapalogos.
|
|
PL203782B1
(pl)
|
1999-11-05 |
2009-11-30 |
Astrazeneca Ab |
Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania
|
|
PT1233943E
(pt)
|
1999-11-24 |
2011-09-01 |
Sugen Inc |
Formulações para agentes farmacêuticos ionizáveis como ácidos livres ou bases livres
|
|
US6515004B1
(en)
|
1999-12-15 |
2003-02-04 |
Bristol-Myers Squibb Company |
N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
|
|
US6727225B2
(en)
|
1999-12-20 |
2004-04-27 |
Immunex Corporation |
TWEAK receptor
|
|
PT1252322E
(pt)
|
2000-01-21 |
2005-03-31 |
Biovex Ltd |
Estirpes de virus de herpes para terapia genica
|
|
US20020197266A1
(en)
|
2000-02-08 |
2002-12-26 |
Waldemar Debinski |
Immunotherapy using interleukin 13 receptor subunit alpha 2
|
|
AU4721901A
(en)
|
2000-02-25 |
2001-09-03 |
Immunex Corp |
Integrin antagonists
|
|
CA2416685C
(fr)
|
2000-07-19 |
2008-10-07 |
Warner-Lambert Company |
Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques
|
|
US6630500B2
(en)
|
2000-08-25 |
2003-10-07 |
Cephalon, Inc. |
Selected fused pyrrolocarbazoles
|
|
ATE430742T1
(de)
|
2000-12-21 |
2009-05-15 |
Smithkline Beecham Corp |
Pyrimidinamine als angiogenesemodulatoren
|
|
US20020147198A1
(en)
|
2001-01-12 |
2002-10-10 |
Guoqing Chen |
Substituted arylamine derivatives and methods of use
|
|
US7102009B2
(en)
|
2001-01-12 |
2006-09-05 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
US7105682B2
(en)
|
2001-01-12 |
2006-09-12 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
ATE508635T1
(de)
|
2001-03-27 |
2011-05-15 |
Catherex Inc |
Virusvektoren und ihre verwendung bei therapeutischen methoden
|
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
US7771951B2
(en)
|
2001-12-03 |
2010-08-10 |
Amgen Fremont Inc. |
Antibody categorization based on binding characteristics
|
|
JP2002233610A
(ja)
|
2002-02-18 |
2002-08-20 |
Olympia:Kk |
スロットマシン
|
|
US7307088B2
(en)
|
2002-07-09 |
2007-12-11 |
Amgen Inc. |
Substituted anthranilic amide derivatives and methods of use
|
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
|
WO2004033036A2
(fr)
|
2002-10-04 |
2004-04-22 |
Microchips, Inc. |
Appareil medical pour administration controlee de medicament et surveillance et/ou stimulation cardiaques
|
|
CN1513993A
(zh)
|
2002-12-31 |
2004-07-21 |
北京博泰迪生物工程科技开发有限公司 |
中国人基因组cDNA文库白细胞介素21的编码基因序列及其蛋白质的氨基酸序列
|
|
WO2004063195A1
(fr)
|
2003-01-03 |
2004-07-29 |
Sloan-Kettering Institute For Cancer Research |
Inhibiteurs de kinases a base de pyridopyrimidine
|
|
RU2369636C2
(ru)
|
2003-05-23 |
2009-10-10 |
Уайт |
Лиганд gitr и связанные с лигандом gitr молекулы и антитела и варианты их применения
|
|
JP2008501621A
(ja)
|
2003-05-31 |
2008-01-24 |
マイクロメット アクツィエン ゲゼルシャフト |
Ｂ細胞関連疾患を処置するための二重特異性抗ｃｄ３、抗ｃｄ１９抗体構築物を含む薬学的組成物
|
|
CA2531454C
(fr)
|
2003-07-08 |
2011-10-25 |
Novartis Ag |
Utilisation de rapamycine et de derives de rapamycine pour traiter les pertes de masse osseuse
|
|
EP1648900A4
(fr)
|
2003-07-11 |
2010-02-10 |
Ariad Pharma Inc |
Macrocycles contenant du phosphore
|
|
US20050048054A1
(en)
|
2003-07-11 |
2005-03-03 |
Shino Hanabuchi |
Lymphocytes; methods
|
|
TW200523262A
(en)
|
2003-07-29 |
2005-07-16 |
Smithkline Beecham Corp |
Inhibitors of AKT activity
|
|
WO2005021546A1
(fr)
|
2003-08-22 |
2005-03-10 |
Avanir Pharmaceuticals |
Derives de naphtyridine substitues servant d'inhibiteurs de facteur d'inhibition de la migration des macrophages et leur utilisation pour traiter des maladies humaines
|
|
JP4948174B2
(ja)
|
2003-10-16 |
2012-06-06 |
マイクロメット アクツィエン ゲゼルシャフト |
多重特異的脱免疫ｃｄ３−結合物質
|
|
JP2007518399A
(ja)
|
2003-12-02 |
2007-07-12 |
ジェンザイム コーポレイション |
肺癌を診断および治療する組成物並びに方法
|
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
|
CA2569509C
(fr)
|
2004-06-03 |
2014-08-12 |
Novimmune S.A. |
Anticorps anti-cd3 et leurs methodes d'utilisation
|
|
EP1765402A2
(fr)
|
2004-06-04 |
2007-03-28 |
Duke University |
Methodes et compositions ameliorant l'immunite par depletion in vivo de l'activite cellulaire immunosuppressive
|
|
WO2006002394A2
(fr)
|
2004-06-24 |
2006-01-05 |
New York University |
Souches de virus d'herpes simplex oncolytique non virulent modifiees pour bloquer la reponse hote innee
|
|
BRPI0513915A
(pt)
|
2004-08-26 |
2008-05-20 |
Pfizer |
compostos aminoeteroarila enantiomericamente puros como inibidores de proteìna quinase
|
|
TW200626610A
(en)
|
2004-10-13 |
2006-08-01 |
Wyeth Corp |
Analogs of 17-hydroxywortmannin as PI3K inhibitors
|
|
EP1809282B1
(fr)
|
2004-10-18 |
2013-01-09 |
Amgen, Inc |
Composes de thiadiazole et leurs procedes d'utilisation
|
|
US7994325B2
(en)
|
2005-03-14 |
2011-08-09 |
Merck Sharp & Dohme Corp. |
CGRP receptor antagonists
|
|
WO2006105021A2
(fr)
|
2005-03-25 |
2006-10-05 |
Tolerrx, Inc. |
Molecules de liaison gitr et leurs utilisations
|
|
ES2720160T3
(es)
|
2005-05-09 |
2019-07-18 |
Ono Pharmaceutical Co |
Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
AU2006293620A1
(en)
|
2005-09-20 |
2007-03-29 |
Pfizer Products Inc. |
Dosage forms and methods of treatment using a tyrosine kinase inhibitor
|
|
EP1981884B1
(fr)
|
2006-01-18 |
2012-06-13 |
Amgen, Inc |
Composés thiazoliques comme inhibiteurs de protéine kinase b
|
|
US20110212086A1
(en)
|
2006-01-19 |
2011-09-01 |
Genzyme Corporation |
GITR Antibodies For The Treatment of Cancer
|
|
TW200745163A
(en)
|
2006-02-17 |
2007-12-16 |
Syntonix Pharmaceuticals Inc |
Peptides that block the binding of IgG to FcRn
|
|
PE20081679A1
(es)
|
2006-12-07 |
2008-12-18 |
Hoffmann La Roche |
Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso
|
|
CN101230334B
(zh)
|
2007-01-22 |
2011-06-01 |
北京奥源和力生物技术有限公司 |
单纯疱疹病毒和重组病毒及宿主细胞及其药物组合物
|
|
CN101230335B
(zh)
|
2007-01-22 |
2010-08-11 |
北京奥源和力生物技术有限公司 |
单纯疱疹病毒和重组病毒及宿主细胞及其药物组合物
|
|
US7705018B2
(en)
|
2007-03-23 |
2010-04-27 |
Amgen Inc. |
Substituted quinolines and their uses in treatment of inflammatory and related conditions
|
|
AU2008231304B2
(en)
|
2007-03-23 |
2011-05-12 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
EP2132207A2
(fr)
|
2007-03-23 |
2009-12-16 |
Amgen Inc. |
Composés hétérocycliques et leurs utilisations
|
|
RU2769948C2
(ru)
|
2007-04-03 |
2022-04-11 |
Эмджен Рисерч (Мьюник) Гмбх |
CD3-Эпсилон-связывающий домен с межвидовой специфичностью
|
|
WO2008119567A2
(fr)
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Domaine de liaison spécifique d'espèces croisées
|
|
BRPI0810140A2
(pt)
|
2007-04-19 |
2014-10-29 |
Dong A Pharm Co Ltd |
Composição de microempresa biodegradável adequada para a liberação controlada de um peptídeo de controle de glicose e formulação da mesma
|
|
CA2689092C
(fr)
|
2007-06-07 |
2013-01-15 |
Amgen Inc. |
Modulators de la raf kinase et leurs methods d'utilisation
|
|
CA2693677C
(fr)
|
2007-07-12 |
2018-02-13 |
Tolerx, Inc. |
Therapies combinees utilisant des molecules de liaison au gitr
|
|
WO2009011871A2
(fr)
|
2007-07-17 |
2009-01-22 |
Amgen Inc. |
Thiadiazoles modulateurs de l'activité de pkb
|
|
WO2009011880A2
(fr)
|
2007-07-17 |
2009-01-22 |
Amgen Inc. |
Modulateurs hétérocycliques de pkb
|
|
ES2401557T3
(es)
|
2007-08-02 |
2013-04-22 |
Amgen, Inc |
Moduladores de Pl3 cinasas y métodos de uso
|
|
CA2699202C
(fr)
|
2007-09-12 |
2016-09-27 |
F. Hoffmann-La Roche Ag |
Combinaisons de composes inhibiteurs des phosphoinositide 3-kinases et agents chimiotherapeutiques, et leurs procedes d'utilisation
|
|
EP2214675B1
(fr)
|
2007-10-25 |
2013-11-20 |
Genentech, Inc. |
Procédé de préparation de composés de thiénopyrimidine
|
|
CL2008003798A1
(es)
|
2007-12-19 |
2009-10-09 |
Amgen Inc |
Compuestos derivados de heterobiciclos aromaticos sustituidos, inhibidores de pi3 quinasa; composicion farmaceutica; utiles en el tratamiento de cancer, melanomas, glioblastomas, entre otras enfermedades.
|
|
WO2009085185A1
(fr)
|
2007-12-19 |
2009-07-09 |
Amgen Inc. |
Composés condensés de pyridine, de pyrimidine et de triazine en tant qu'inhibiteurs du cycle cellulaire
|
|
EP2262837A4
(fr)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
Protéines de liaison avec pd-1
|
|
MX2010010975A
(es)
|
2008-04-07 |
2010-11-01 |
Amgen Inc |
Amino piridinas/pirimidinas gem-disustituidas y espirociclicas como inhibidores de ciclo celular.
|
|
JP2011516603A
(ja)
|
2008-04-17 |
2011-05-26 |
アブリンクス エン．ヴェー． |
血清タンパク質と結合することが可能なペプチド、並びにこれを含む化合物、構築物及びポリペプチド
|
|
EP2307400B1
(fr)
|
2008-05-30 |
2014-04-23 |
Amgen, Inc |
Inhibiteurs de la pi3 kinase
|
|
WO2010003118A1
(fr)
|
2008-07-02 |
2010-01-07 |
Trubion Pharmaceuticals, Inc. |
Protéines de liaison multi-cibles antagonistes du tgf-b
|
|
WO2010030002A1
(fr)
|
2008-09-12 |
2010-03-18 |
国立大学法人三重大学 |
Cellule capable d'exprimer un ligand gitr exogène
|
|
EP3106468A1
(fr)
|
2008-10-01 |
2016-12-21 |
Amgen Research (Munich) GmbH |
Anticorps bispécifique à chaîne unique psmaxcd3 particulière d'une espèce à l'autre
|
|
US20110263647A1
(en)
|
2009-01-15 |
2011-10-27 |
Amgen Inc. |
Fluoroisoquinoline substituted thiazole compounds and methods of use
|
|
WO2010096314A1
(fr)
|
2009-02-18 |
2010-08-26 |
Amgen Inc. |
Composés d'indole ou benzimidazole convenant comme inhibiteurs de la kinase mtor
|
|
US20120107267A1
(en)
|
2009-03-11 |
2012-05-03 |
Novo Nordisk A/S |
Interleukin-21 variants having antagonistic binding to the il-21 receptor
|
|
JP2012521354A
(ja)
|
2009-03-20 |
2012-09-13 |
アムジエン・インコーポレーテツド |
Ｐｉ３キナーゼの阻害薬
|
|
UY32582A
(es)
|
2009-04-28 |
2010-11-30 |
Amgen Inc |
Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
|
|
WO2010132598A1
(fr)
|
2009-05-13 |
2010-11-18 |
Amgen Inc. |
Composés hétéroaryle en tant qu'inhibiteurs des pikk
|
|
UY32743A
(es)
|
2009-06-25 |
2010-12-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
|
JP2012531436A
(ja)
|
2009-06-25 |
2012-12-10 |
アムジエン・インコーポレーテツド |
複素環式化合物およびそれらのｐｉ３ｋ活性阻害剤としての使用
|
|
US8754089B2
(en)
|
2009-06-25 |
2014-06-17 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
MX2011013666A
(es)
|
2009-06-25 |
2012-03-06 |
Amgen Inc |
Compuestos heterociclicos y sus usos.
|
|
KR101747103B1
(ko)
|
2009-06-26 |
2017-06-14 |
리제너론 파마슈티칼스 인코포레이티드 |
천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체
|
|
RU2595409C2
(ru)
|
2009-09-03 |
2016-08-27 |
Мерк Шарп И Доум Корп., |
Анти-gitr-антитела
|
|
NZ598758A
(en)
|
2009-09-11 |
2013-12-20 |
Amgen Inc |
N-4 (-((3-(2-amino-4 pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer
|
|
BR112012009450A2
(pt)
|
2009-10-30 |
2017-05-23 |
Novozymes Biopharma Dk As |
variantes de albumina
|
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
|
SG181952A1
(en)
|
2009-12-29 |
2012-07-30 |
Emergent Product Dev Seattle |
Heterodimer binding proteins and uses thereof
|
|
EP2635598A1
(fr)
|
2010-11-01 |
2013-09-11 |
Novozymes Biopharma DK A/S |
Variants d'albumine
|
|
EP2686682A4
(fr)
|
2011-03-11 |
2015-03-11 |
Amgen Inc |
Procédé d'analyse mutationnelle corrélée pour améliorer des anticorps thérapeutiques
|
|
US9133164B2
(en)
|
2011-04-13 |
2015-09-15 |
Innov88 Llc |
MIF inhibitors and their uses
|
|
AU2012251583B2
(en)
|
2011-05-05 |
2017-06-08 |
Albumedix Ltd. |
Albumin variants
|
|
US20130028882A1
(en)
|
2011-07-07 |
2013-01-31 |
Humanitas Technology, LLC |
Antiviral compositions and methods of their use
|
|
LT2753355T
(lt)
|
2011-09-08 |
2019-01-25 |
New York University |
Onkolitinis herpes simplex virusas ir jo terapinis panaudojimas
|
|
WO2013039954A1
(fr)
|
2011-09-14 |
2013-03-21 |
Sanofi |
Anticorps anti-gitr
|
|
TWI679212B
(zh)
|
2011-11-15 |
2019-12-11 |
美商安進股份有限公司 |
針對ｂｃｍａ之e3以及ｃｄ３的結合分子
|
|
EP2780364A2
(fr)
|
2011-11-18 |
2014-09-24 |
Eleven Biotherapeutics, Inc. |
Protéines ayant une demi-vie et d'autres propriétés améliorées
|
|
WO2013109904A1
(fr)
|
2012-01-19 |
2013-07-25 |
University Of Miami |
Compositions, procédés et série de traitements contre le cancer et des maladies auto-immunes
|
|
ES2664328T3
(es)
|
2012-03-16 |
2018-04-19 |
Albumedix A/S |
Variantes de albúmina
|
|
CN104379563B
(zh)
|
2012-04-10 |
2018-12-21 |
加利福尼亚大学董事会 |
用于治疗癌症的组合物和方法
|
|
EP2847219A1
(fr)
|
2012-05-07 |
2015-03-18 |
Amgen Inc. |
Anticorps anti-érythropoïétine
|
|
WO2013169693A1
(fr)
|
2012-05-09 |
2013-11-14 |
Bristol-Myers Squibb Company |
Méthodes destinées à traiter le cancer à l'aide d'un polypeptide il-21 et d'un anticorps anti-pd-1
|
|
EP2882746B1
(fr)
|
2012-08-07 |
2016-12-07 |
Merck Patent GmbH |
Dérivés de pyridopyrimidine en tant qu'inhibiteurs de protéine kinase
|
|
CA2890766A1
(fr)
|
2012-11-08 |
2014-05-15 |
Novozymes Biopharma Dk A/S |
Variants d'albumine
|
|
EP2970121B1
(fr)
|
2013-03-15 |
2017-12-13 |
Araxes Pharma LLC |
Inhibiteurs covalents de k-ras g12c
|
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
|
WO2014143659A1
(fr)
|
2013-03-15 |
2014-09-18 |
Araxes Pharma Llc |
Inhibiteurs covalents irréversibles de la gtpase k-ras g12c
|
|
WO2015000585A1
(fr)
|
2013-07-02 |
2015-01-08 |
Walter Sebald |
Mutéines de cytokines de la famille des récepteurs de la chaîne gamma conjuguées à un groupe non protéine
|
|
GB201312059D0
(en)
|
2013-07-05 |
2013-08-21 |
Univ Leuven Kath |
Novel GAK modulators
|
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
AR098003A1
(es)
*
|
2013-10-10 |
2016-04-27 |
Araxes Pharma Llc |
Inhibidores de kras g12c
|
|
EP3636639A1
(fr)
*
|
2013-10-10 |
2020-04-15 |
Araxes Pharma LLC |
Inhibiteurs de kras g12c
|
|
GB201320729D0
(en)
*
|
2013-11-25 |
2014-01-08 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
|
US9828363B2
(en)
|
2014-01-20 |
2017-11-28 |
Cleave Biosciences, Inc. |
Fused pyrimidines as inhibitors of P97 complex
|
|
KR102738546B1
(ko)
|
2014-02-19 |
2024-12-04 |
메르크 파텐트 게엠베하 |
암-표적화된 ｉｌ-12 면역요법
|
|
WO2016035008A1
(fr)
|
2014-09-04 |
2016-03-10 |
Lupin Limited |
Dérivés de pyridopyrimidine utilisés comme inhibiteurs de mek
|
|
JO3556B1
(ar)
*
|
2014-09-18 |
2020-07-05 |
Araxes Pharma Llc |
علاجات مدمجة لمعالجة السرطان
|
|
WO2016049565A1
(fr)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Compositions et procédés pour inhiber la ras
|
|
WO2016049568A1
(fr)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Méthodes et compositions permettant l'inhibition de la ras
|
|
JP2017528498A
(ja)
|
2014-09-25 |
2017-09-28 |
アラクセス ファーマ エルエルシー |
Ｋｒａｓ ｇ１２ｃ変異体タンパク質のインヒビター
|
|
ES2898765T3
(es)
|
2015-04-10 |
2022-03-08 |
Araxes Pharma Llc |
Compuestos de quinazolina sustituidos y métodos de uso de los mismos
|
|
ES2856880T3
(es)
*
|
2015-04-15 |
2021-09-28 |
Araxes Pharma Llc |
Inhibidores tricíclicos condensados de KRAS y métodos de uso de los mismos
|
|
CA2993013A1
(fr)
|
2015-07-22 |
2017-01-26 |
Araxes Pharma Llc |
Composes de quinazoline substitues et leur utilisation en tant qu'inhibiteurs de proteines kras, hras et/ou nras mutantes g12c
|
|
TWI744242B
(zh)
|
2015-07-31 |
2021-11-01 |
德商安美基研究（慕尼黑）公司 |
Egfrviii及cd3抗體構築體
|
|
TW202346349A
(zh)
|
2015-07-31 |
2023-12-01 |
德商安美基研究（慕尼黑）公司 |
Dll3及cd3抗體構築體
|
|
TWI829617B
(zh)
|
2015-07-31 |
2024-01-21 |
德商安美基研究（慕尼黑）公司 |
Ｆｌｔ３及ｃｄ３抗體構築體
|
|
EA039859B1
(ru)
|
2015-07-31 |
2022-03-21 |
Эмджен Рисерч (Мюник) Гмбх |
Биспецифические конструкты антител, связывающие egfrviii и cd3
|
|
US10975071B2
(en)
|
2015-09-28 |
2021-04-13 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
US10647703B2
(en)
|
2015-09-28 |
2020-05-12 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3356353A1
(fr)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibiteurs de protéines kras portant la mutation g12c
|
|
US10730867B2
(en)
|
2015-09-28 |
2020-08-04 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
US10689356B2
(en)
|
2015-09-28 |
2020-06-23 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
|
EP3356347A1
(fr)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibiteurs de protéines kras portant la mutation g12c
|
|
WO2017058792A1
(fr)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibiteurs de protéines kras portant la mutation g12c
|
|
US10414757B2
(en)
*
|
2015-11-16 |
2019-09-17 |
Araxes Pharma Llc |
2-substituted quinazoline compounds comprising a substituted heterocyclic group and methods of use thereof
|
|
US9988357B2
(en)
|
2015-12-09 |
2018-06-05 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
|
MA44146B1
(fr)
|
2015-12-22 |
2023-10-31 |
Regeneron Pharma |
Combinaison d'anticorps anti-pd-1 et d'anticorps bispécifiques anti-cd20/anti-cd3 pour traiter le cancer
|
|
KR102762431B1
(ko)
|
2016-01-08 |
2025-02-03 |
레플리뮨 리미티드 |
변형된 항종양 바이러스
|
|
IL313507A
(en)
|
2016-02-03 |
2024-08-01 |
Amgen Res Munich Gmbh |
Constructs of bispecific antibodies to BCMA and CD3 that bind to T cells, preparations containing the same and uses thereof
|
|
TN2018000266A1
(en)
|
2016-02-03 |
2020-01-16 |
Amgen Res Munich Gmbh |
Psma and cd3 bispecific t cell engaging antibody constructs.
|
|
WO2017172979A1
(fr)
|
2016-03-30 |
2017-10-05 |
Araxes Pharma Llc |
Composés quinazoline substitués et procédés d'utilisation
|
|
KR102694879B1
(ko)
|
2016-04-01 |
2024-08-16 |
암젠 인크 |
Flt3에 대한 키메라 수용체 및 이의 사용 방법
|
|
US10821140B2
(en)
|
2016-04-22 |
2020-11-03 |
Immvira Co., Limited |
Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy
|
|
SG11201810171SA
(en)
|
2016-05-18 |
2018-12-28 |
Mirati Therapeutics Inc |
Kras g12c inhibitors
|
|
BR112019000015A2
(pt)
|
2016-06-30 |
2019-04-24 |
Oncorus, Inc. |
distribuição por vírus oncolítico pseudotipado de polipeptídeos terapêuticos
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
JP7200104B2
(ja)
|
2016-08-01 |
2023-01-06 |
ヴァイロジン バイオテック カナダ リミテッド |
免疫系刺激分子を発現する腫瘍溶解性単純ヘルペスウイルスベクター
|
|
WO2018064510A1
(fr)
|
2016-09-29 |
2018-04-05 |
Araxes Pharma Llc |
Inhibiteurs de protéines mutantes kras g12c
|
|
US10377743B2
(en)
|
2016-10-07 |
2019-08-13 |
Araxes Pharma Llc |
Inhibitors of RAS and methods of use thereof
|
|
NZ754994A
(en)
|
2016-12-22 |
2022-12-23 |
Amgen Inc |
Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
|
|
GB201700350D0
(en)
|
2017-01-09 |
2017-02-22 |
Replimune Ltd |
Altered virus
|
|
JP2020505395A
(ja)
|
2017-01-26 |
2020-02-20 |
アラクセス ファーマ エルエルシー |
縮合ｎ−複素環式化合物およびその使用方法
|
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
|
WO2018218069A1
(fr)
|
2017-05-25 |
2018-11-29 |
Araxes Pharma Llc |
Dérivés de quinazoline utilisés en tant que modulateurs de kras, hras ou nras mutants
|
|
ES2928576T3
(es)
*
|
2017-09-08 |
2022-11-21 |
Amgen Inc |
Inhibidores de KRAS G12C y métodos de uso de los mismos
|
|
CA3099118A1
(fr)
|
2018-05-04 |
2019-11-07 |
Amgen Inc. |
Inhibiteurs de kras g12c et leurs procedes d'utilisation
|
|
MA52501A
(fr)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
|
EP3790886B1
(fr)
|
2018-05-10 |
2024-06-26 |
Amgen Inc. |
Inhibiteurs du kras g12c pour le traitement du cancer
|
|
EP3802535B1
(fr)
|
2018-06-01 |
2022-12-14 |
Amgen, Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
|
CA3099799A1
(fr)
|
2018-06-11 |
2019-12-19 |
Amgen Inc. |
Inhibiteurs de kras g12c pour le traitement du cancer
|
|
MA51848A
(fr)
|
2018-06-12 |
2021-04-21 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
|
CA3103049A1
(fr)
|
2018-06-21 |
2019-12-26 |
Janssen Pharmaceutica Nv |
Composes inhibiteurs d'oga
|
|
CN112313231B
(zh)
|
2018-06-21 |
2023-05-09 |
詹森药业有限公司 |
Oga抑制剂化合物
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
US11053226B2
(en)
|
2018-11-19 |
2021-07-06 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
US20220064141A1
(en)
|
2019-01-29 |
2022-03-03 |
Brightgene Bio-Medical Technology Co., Ltd. |
Benzopyridone heterocyclic compound and use thereof
|
|
EP3738593A1
(fr)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosage d'inhibiteur de kras pour le traitement de cancers
|
|
WO2020236948A1
(fr)
|
2019-05-21 |
2020-11-26 |
Amgen Inc. |
Formes à l'état solide
|
|
EP3972973A1
(fr)
|
2019-05-21 |
2022-03-30 |
Amgen Inc. |
Formes à l'état solide
|
|
EP4048671B1
(fr)
|
2019-10-24 |
2026-03-18 |
Amgen Inc. |
Dérivés de pyridopyrimidine utiles en tant qu'inhibiteurs de kras g12c et de kras g12d dans le traitement du cancer
|
|
US20230028414A1
(en)
|
2019-12-16 |
2023-01-26 |
Amgen Inc. |
Dosing regimen of kras g12c inhibitor
|