MA53742A - Molécules de liaison à l'antigène capables de se lier à cd3 et cd137 mais pas simultanément - Google Patents

Molécules de liaison à l'antigène capables de se lier à cd3 et cd137 mais pas simultanément

Info

Publication number: MA53742A
Authority: MA; Morocco
Prior art keywords: antigen; bind; binding molecules; molecules; binding
Prior art date: 2018-09-28

Application number

MA053742A

Other languages

English (en)

Inventor

Shu Feng

Shu Wen Samantha Ho

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-09-28

Filing date

2019-09-27

Publication date

2022-01-05

2019-09-27 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

2022-01-05 Publication of MA53742A publication Critical patent/MA53742A/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Cell Biology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Pathology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

MA053742A 2018-09-28 2019-09-27 Molécules de liaison à l'antigène capables de se lier à cd3 et cd137 mais pas simultanément MA53742A (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2018185120		2018-09-28
JP2019104308		2019-06-04

Publications (1)

Publication Number	Publication Date
MA53742A true MA53742A (fr)	2022-01-05

Family

ID=69950671

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA053742A MA53742A (fr)	2018-09-28	2019-09-27	Molécules de liaison à l'antigène capables de se lier à cd3 et cd137 mais pas simultanément

Country Status (19)

Country	Link
US (1)	US20210388087A1 (fr)
EP (1)	EP3856785A4 (fr)
JP (3)	JP7519990B2 (fr)
KR (1)	KR20210068079A (fr)
CN (1)	CN113166247A (fr)
AU (1)	AU2019347412A1 (fr)
BR (1)	BR112021005722A2 (fr)
CA (1)	CA3114154A1 (fr)
CL (1)	CL2021000739A1 (fr)
CO (1)	CO2021005528A2 (fr)
CR (1)	CR20210199A (fr)
IL (1)	IL281787A (fr)
MA (1)	MA53742A (fr)
MX (1)	MX2021003608A (fr)
PE (1)	PE20211072A1 (fr)
PH (1)	PH12021550662A1 (fr)
SG (1)	SG11202101912UA (fr)
TW (1)	TW202028238A (fr)
WO (1)	WO2020067419A1 (fr)

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EP4310191A3 (fr)	2012-06-14	2024-05-15	Chugai Seiyaku Kabushiki Kaisha	Molécule de liaison à l'antigène contenant une région fc modifiée
CA2929044A1 (fr)	2013-11-11	2015-05-14	Chugai Seiyaku Kabushiki Kaisha	Molecule se liant a l'antigene contenant une region variable d'anticorps modifiee
US11154615B2 (en)	2014-11-11	2021-10-26	Chugai Seiyaku Kabushiki Kaisha	Library of antigen-binding molecules including modified antibody variable region
JP7357616B2 (ja)	2017-12-05	2023-10-06	中外製薬株式会社	Ｃｄ３およびｃｄ１３７に結合する改変された抗体可変領域を含む抗原結合分子
JP7314146B2 (ja)	2017-12-28	2023-07-25	中外製薬株式会社	細胞傷害誘導治療剤
US12435137B2 (en)	2018-08-03	2025-10-07	Chugai Seiyaku Kabushiki Kaisha	Antigen-binding molecule containing two antigen-binding domains that are linked to each other
JP2022501325A (ja)	2018-09-28	2022-01-06	中外製薬株式会社	改変された抗体可変領域を含む抗原結合分子
JP7359864B2 (ja)	2019-07-10	2023-10-11	中外製薬株式会社	クローディン６結合分子およびその使用
JP7736688B2 (ja) *	2020-03-31	2025-09-09	中外製薬株式会社	多重特異性抗原結合分子を製造するための方法
AR121692A1 (es) *	2020-03-31	2022-06-29	Chugai Pharmaceutical Co Ltd	Moléculas de unión a antígeno multiespecíficas activadoras de la inmunidad y usos de estas
CA3173587A1 (fr)	2020-03-31	2021-10-07	Chugai Seiyaku Kabushiki-Kaisha	Molecules multispecifiques de liaison a l'antigene ciblant dll3 et leurs utilisations
WO2023036043A1 (fr) *	2021-09-09	2023-03-16	广东东阳光药业有限公司	Molécule de liaison anti-cancéreuse et son utilisation
JP7470760B2 (ja) *	2021-09-29	2024-04-18	中外製薬株式会社	がんの治療に用いるための細胞傷害誘導治療剤
JP7557922B2 (ja)	2021-09-29	2024-09-30	中外製薬株式会社	Ｄｌｌ３標的多重特異性抗原結合分子の使用
JPWO2023053282A1 (fr) *	2021-09-29	2023-04-06
WO2023053272A1 (fr) *	2021-09-29	2023-04-06	Chugai Seiyaku Kabushiki Kaisha	Utilisations de molécules de liaison à un antigène multispécifiques ciblant dll3
EP4524248A4 (fr) *	2022-05-12	2026-07-01	Astellas Pharma Inc	Anticorps multispécifique anti-taa et anti-cd3
WO2024114676A1 (fr) *	2022-11-29	2024-06-06	江苏恒瑞医药股份有限公司	Protéine de liaison à cldn18.2/4-1bb et son utilisation médicale

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2019
- 2019-09-27 KR KR1020217012569A patent/KR20210068079A/ko not_active Withdrawn
- 2019-09-27 WO PCT/JP2019/038138 patent/WO2020067419A1/fr not_active Ceased
- 2019-09-27 SG SG11202101912UA patent/SG11202101912UA/en unknown
- 2019-09-27 CA CA3114154A patent/CA3114154A1/fr active Pending
- 2019-09-27 US US17/272,972 patent/US20210388087A1/en active Pending
- 2019-09-27 MA MA053742A patent/MA53742A/fr unknown
- 2019-09-27 BR BR112021005722A patent/BR112021005722A2/pt not_active Application Discontinuation
- 2019-09-27 TW TW108135110A patent/TW202028238A/zh unknown
- 2019-09-27 PE PE2021000378A patent/PE20211072A1/es unknown
- 2019-09-27 JP JP2021512587A patent/JP7519990B2/ja active Active
- 2019-09-27 EP EP19866533.3A patent/EP3856785A4/fr active Pending
- 2019-09-27 CN CN201980076578.6A patent/CN113166247A/zh active Pending
- 2019-09-27 MX MX2021003608A patent/MX2021003608A/es unknown
- 2019-09-27 CR CR20210199A patent/CR20210199A/es unknown
- 2019-09-27 AU AU2019347412A patent/AU2019347412A1/en not_active Withdrawn
2021
- 2021-03-24 IL IL281787A patent/IL281787A/en unknown
- 2021-03-24 PH PH12021550662A patent/PH12021550662A1/en unknown
- 2021-03-25 CL CL2021000739A patent/CL2021000739A1/es unknown
- 2021-04-28 CO CONC2021/0005528A patent/CO2021005528A2/es unknown
2024
- 2024-05-23 JP JP2024083730A patent/JP7777183B2/ja active Active
2025
- 2025-11-14 JP JP2025194883A patent/JP2026021604A/ja active Pending

Also Published As

Publication number	Publication date
WO2020067419A1 (fr)	2020-04-02
CO2021005528A2 (es)	2021-07-30
JP7519990B2 (ja)	2024-07-22
AU2019347412A1 (en)	2021-05-27
CN113166247A (zh)	2021-07-23
EP3856785A4 (fr)	2022-07-06
JP2024109792A (ja)	2024-08-14
SG11202101912UA (en)	2021-04-29
TW202028238A (zh)	2020-08-01
PE20211072A1 (es)	2021-06-09
CL2021000739A1 (es)	2021-09-24
EP3856785A1 (fr)	2021-08-04
CR20210199A (es)	2021-06-11
BR112021005722A2 (pt)	2021-07-06
CA3114154A1 (fr)	2020-04-02
JP2026021604A (ja)	2026-02-10
JP2022502010A (ja)	2022-01-11
MX2021003608A (es)	2021-05-28
KR20210068079A (ko)	2021-06-08
IL281787A (en)	2021-05-31
JP7777183B2 (ja)	2025-11-27
PH12021550662A1 (en)	2021-12-13
US20210388087A1 (en)	2021-12-16

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