MA54547A - Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a - Google Patents

Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Info

Publication number
MA54547A
MA54547A MA054547A MA54547A MA54547A MA 54547 A MA54547 A MA 54547A MA 054547 A MA054547 A MA 054547A MA 54547 A MA54547 A MA 54547A MA 54547 A MA54547 A MA 54547A
Authority
MA
Morocco
Prior art keywords
amides useful
heteroaryl amides
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054547A
Other languages
English (en)
Inventor
John Gordon Allen
Abhisek Banerjee
Matthew Paul Bourbeau
Jian Jeffrey Chen
Michael J Frohn
Lei Jia
Matthew Richard Kaller
Kexue Li
Thomas T Nguyen
Nobuko Nishimura
Nuria A Tamayo
Qiufen May Xue
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54547A publication Critical patent/MA54547A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA054547A 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a MA54547A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783053P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54547A true MA54547A (fr) 2022-03-30

Family

ID=69374368

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054547A MA54547A (fr) 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Country Status (9)

Country Link
US (1) US12441736B2 (fr)
EP (1) EP3898592B1 (fr)
JP (1) JP7676308B2 (fr)
AU (1) AU2019401495B2 (fr)
CA (1) CA3123044A1 (fr)
ES (1) ES2997190T3 (fr)
MA (1) MA54547A (fr)
MX (1) MX2021007157A (fr)
WO (1) WO2020132653A1 (fr)

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AU2019401495B2 (en) 2018-12-20 2025-06-26 Amgen Inc. Heteroaryl amides useful as KIF18A inhibitors
MA54546A (fr) 2018-12-20 2022-03-30 Amgen Inc Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
EA202191730A1 (ru) * 2018-12-20 2021-08-24 Эмджен Инк. Ингибиторы kif18a
JP7640521B2 (ja) * 2019-08-02 2025-03-05 アムジエン・インコーポレーテツド Ｋｉｆ１８ａ阻害剤として有用なヘテロアリールアミド
ES3051918T3 (en) * 2019-08-02 2025-12-30 Amgen Inc Kif18a inhibitors
WO2021026098A1 (fr) * 2019-08-02 2021-02-11 Amgen Inc. Inhibiteurs de kif18a
CN114391012B (zh) 2019-08-02 2025-10-31 美国安进公司 作为kif18a抑制剂的吡啶衍生物
UY39477A (es) 2020-10-20 2022-05-31 Amgen Inc Compuestos espiro heterocíclicos y métodos de uso
US20230406860A1 (en) 2020-10-27 2023-12-21 Amgen Inc. Heterocyclic spiro compounds and methods of use
JP2024517693A (ja) 2021-04-29 2024-04-23 アムジエン・インコーポレーテツド ２－アミノベンゾチアゾール化合物及びその使用方法
WO2022268230A1 (fr) 2021-06-25 2022-12-29 杭州英创医药科技有限公司 Composé destiné à être utilisé en tant qu'inhibiteur de kif18a
EP4392407A1 (fr) * 2021-08-26 2024-07-03 Volastra Therapeutics, Inc. Inhibiteurs spiro-indoliniques de la kif18a
CN118076586A (zh) * 2021-09-16 2024-05-24 微境生物医药科技(上海)有限公司 Kif18a抑制剂
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CA3251671A1 (fr) 2022-02-16 2023-08-24 Amgen Inc. Composés quinazoline et leur utilisation en tant qu'inhibiteurs de protéines kras mutantes
EP4479401A1 (fr) 2022-02-16 2024-12-25 Amgen Inc. Composés de quinazoline et leur utilisation en tant qu'inhibiteurs de protéines kras mutantes
EP4495113A4 (fr) * 2022-03-17 2026-02-18 Wigen Biomedicine Tech Shanghai Co Ltd Inhibiteur de kif18a
IL316450A (en) * 2022-04-28 2024-12-01 Volastra Therapeutics Inc Compounds for inhibiting KIF18A
WO2023217230A1 (fr) * 2022-05-13 2023-11-16 上海湃隆生物科技有限公司 Inhibiteur de kinésine kif18a et son utilisation
CN116554151B (zh) * 2022-05-13 2024-09-20 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
CA3260194A1 (fr) * 2022-06-30 2025-06-07 Suzhou Genhouse Bio Co., Ltd. Composé contenant de l’azote et son utilisation
WO2024022508A1 (fr) * 2022-07-29 2024-02-01 武汉人福创新药物研发中心有限公司 Inhibiteur de la kif18a et utilisation
WO2024035950A1 (fr) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
JP2025529821A (ja) 2022-08-18 2025-09-09 アクセント・セラピューティクス・インコーポレイテッド Ｋｉｆ１８ａ阻害剤及びその使用
WO2024083208A1 (fr) * 2022-10-21 2024-04-25 杭州邦顺制药有限公司 Inhibiteur de protéine kif18a
WO2024099398A1 (fr) * 2022-11-10 2024-05-16 南京明德新药研发有限公司 Classe de composés sulfonamide contenant un hétérocycle ortho-condensé et leur utilisation
JP2025539080A (ja) 2022-11-14 2025-12-03 アムジエン・インコーポレーテツド 大環状ｋｒａｓ阻害剤及び使用方法
KR20250118840A (ko) * 2022-12-02 2025-08-06 션전 종거 바이올로지컬 테크놀로지 컴퍼니 리미티드 아미드 또는 우레아계 화합물
WO2024125488A1 (fr) * 2022-12-14 2024-06-20 浙江海正药业股份有限公司 Dérivé d'amide aromatique, son procédé de préparation et son utilisation pharmaceutique
WO2024137984A1 (fr) * 2022-12-22 2024-06-27 Accent Therapeutics, Inc. Inhibiteurs de kif18a et utilisations associées
CN120569373A (zh) * 2023-01-05 2025-08-29 浙江海正药业股份有限公司 芳香酰胺类衍生物及其制备方法和医药上的用途
WO2024156288A1 (fr) * 2023-01-29 2024-08-02 Shanghai Kygent Pharmaceutical Co., Ltd Inhibiteurs de dnmt1, compositions pharmaceutiques et applications thérapeutiques
AU2024226158A1 (en) * 2023-02-23 2025-08-14 Volastra Therapeutics, Inc. Solid formulations and polymorphic forms of indoline inhibitors of kif18a
WO2024217348A1 (fr) * 2023-04-18 2024-10-24 南京同诺康医药科技有限公司 Inhibiteur de kif18a, son procédé de préparation et son utilisation
CN121693499A (zh) * 2023-08-16 2026-03-17 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2025194057A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025194054A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés spirocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025217247A1 (fr) 2024-04-10 2025-10-16 Amgen Inc. Inhibiteurs spiro-hétérocycliques ancrés de protéines mutantes kras g12c et leurs utilisations
WO2025230878A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025230862A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés aminés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025240582A1 (fr) 2024-05-14 2025-11-20 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2026055477A1 (fr) 2024-09-06 2026-03-12 Amgen Inc. Composés macrocycliques constituant des modulateurs de kras et leurs utilisations

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