MA55063A - Anticorps humanisés cd19 antihumains et procédés d'utilisation - Google Patents

Anticorps humanisés cd19 antihumains et procédés d'utilisation

Info

Publication number
MA55063A
MA55063A MA055063A MA55063A MA55063A MA 55063 A MA55063 A MA 55063A MA 055063 A MA055063 A MA 055063A MA 55063 A MA55063 A MA 55063A MA 55063 A MA55063 A MA 55063A
Authority
MA
Morocco
Prior art keywords
humanized
methods
antihuman antibodies
antihuman
antibodies
Prior art date
Application number
MA055063A
Other languages
English (en)
Inventor
Koller Claudia Ferrara
Guy Georges
Alexander Haas
Hubert Kettenberger
Laurent Lariviere
Ekkehard Moessner
Michael Molhoj
Tilman Schlothauer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA55063A publication Critical patent/MA55063A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA055063A 2015-10-01 2016-09-30 Anticorps humanisés cd19 antihumains et procédés d'utilisation MA55063A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15187820 2015-10-01

Publications (1)

Publication Number Publication Date
MA55063A true MA55063A (fr) 2022-01-05

Family

ID=54251433

Family Applications (2)

Application Number Title Priority Date Filing Date
MA055063A MA55063A (fr) 2015-10-01 2016-09-30 Anticorps humanisés cd19 antihumains et procédés d'utilisation
MA43024A MA43024B1 (fr) 2015-10-01 2016-09-30 Anticorps humanisés cd19 antihumains et procédés d'utilisation

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA43024A MA43024B1 (fr) 2015-10-01 2016-09-30 Anticorps humanisés cd19 antihumains et procédés d'utilisation

Country Status (31)

Country Link
US (3) US11286300B2 (fr)
EP (2) EP3356408B1 (fr)
JP (2) JP6629437B2 (fr)
KR (1) KR20180056768A (fr)
CN (2) CN114349862A (fr)
AR (1) AR106188A1 (fr)
AU (2) AU2016333511B2 (fr)
BR (1) BR112018006579A2 (fr)
CA (1) CA3000562A1 (fr)
CL (1) CL2018000728A1 (fr)
CO (1) CO2018002265A2 (fr)
CR (1) CR20180141A (fr)
DK (1) DK3356408T3 (fr)
ES (1) ES2791989T3 (fr)
HR (1) HRP20200767T1 (fr)
HU (1) HUE049083T2 (fr)
IL (2) IL257679B (fr)
LT (1) LT3356408T (fr)
MA (2) MA55063A (fr)
MX (2) MX387662B (fr)
MY (1) MY185171A (fr)
PE (1) PE20181054A1 (fr)
PH (1) PH12018500708A1 (fr)
PL (1) PL3356408T3 (fr)
PT (1) PT3356408T (fr)
RS (1) RS60250B1 (fr)
RU (2) RU2020124153A (fr)
SI (1) SI3356408T1 (fr)
TW (2) TWI747842B (fr)
UA (1) UA125285C2 (fr)
WO (1) WO2017055541A1 (fr)

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CR20170194A (es) 2014-11-14 2017-07-10 Hoffmann La Roche Moleculas de unión a antígeno que comprenden un trímero de ligando de la familia de tnf
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
WO2016156291A1 (fr) 2015-03-31 2016-10-06 F. Hoffmann-La Roche Ag Molécules de liaison à l'antigène comprenant un ligand trimérique des membres de la famille du tnf
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
PE20240096A1 (es) 2015-10-02 2024-01-18 Hoffmann La Roche Anticuerpos biespecificos especificos para un receptor de tnf coestimulador
EP3356407B1 (fr) * 2015-10-02 2021-11-03 F. Hoffmann-La Roche AG Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t anti-cd19xcd3
JP6918789B2 (ja) 2015-10-02 2021-08-11 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 高親和性を有する抗ヒトｃｄｃ１９抗体
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WO2018114754A1 (fr) 2016-12-19 2018-06-28 F. Hoffmann-La Roche Ag Polythérapie avec des agonistes de 4-1bb (cd137) ciblés
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EP3601345A1 (fr) 2017-03-29 2020-02-05 H. Hoffnabb-La Roche Ag Molécule bispécifique de liaison à l'antigène pour un récepteur de co-stimulation du tnf
AU2018247796A1 (en) 2017-04-04 2019-08-29 F. Hoffmann-La Roche Ag Novel bispecific antigen binding molecules capable of specific binding to CD40 and to FAP
WO2019086499A1 (fr) 2017-11-01 2019-05-09 F. Hoffmann-La Roche Ag Nouvelles molécules de liaison à l'antigène contenant un trimère de ligands de la famille du tnf
NZ773887A (en) 2018-10-01 2024-11-29 Hoffmann La Roche Bispecific antigen binding molecules comprising anti-fap clone 212
TWI861039B (zh) 2018-12-21 2024-11-11 瑞士商赫孚孟拉羅股份公司 靶向腫瘤之促效cd28抗原結合分子
CN113272327A (zh) * 2018-12-30 2021-08-17 豪夫迈·罗氏有限公司 抗兔cd19抗体及其使用方法
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
BR112022025856A2 (pt) 2020-06-19 2023-01-10 Hoffmann La Roche Anticorpo que se liga a cd3 e cd19, polinucleotídeo isolado, célula hospedeira, método de produção de um anticorpo que se liga a cd3 e cd19, composição farmacêutica, uso do anticorpo, método para tratar uma doença em um indivíduo e invenção
RU2020122142A (ru) * 2020-07-03 2022-01-04 Петр Иванович Никитин Композиция и способ для улучшения эффективности и снижения побочных эффектов терапевтического агента, доставляемого к мишени с помощью магнитного поля
US20240025993A1 (en) * 2020-11-06 2024-01-25 Novartis Ag Cd19 binding molecules and uses thereof
WO2025172924A1 (fr) * 2024-02-15 2025-08-21 Janssen Biotech, Inc. Compositions de récepteur anti-transferrine et procédés associés

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