MA66264B1 - Formulation stable d'anticorps - Google Patents

Formulation stable d'anticorps

Info

Publication number
MA66264B1
MA66264B1 MA66264A MA66264A MA66264B1 MA 66264 B1 MA66264 B1 MA 66264B1 MA 66264 A MA66264 A MA 66264A MA 66264 A MA66264 A MA 66264A MA 66264 B1 MA66264 B1 MA 66264B1
Authority
MA
Morocco
Prior art keywords
antibody
antibody formulation
stable antibody
present
pharmaceutical formulations
Prior art date
Application number
MA66264A
Other languages
English (en)
Inventor
Qingyan HU
Dingjiang Liu
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of MA66264B1 publication Critical patent/MA66264B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des formulations pharmaceutiques stables comprenant un anticorps humain qui se lie spécifiquement à la protéine de mort programmée humaine-1 (PD-1). Dans certains modes de réalisation, les formulations contiennent, en plus d'un anticorps anti-PD-1, un tampon, un acide aminé, un tensioactif non ionique et un sucre. Les formulations pharmaceutiques de la présente invention présentent un degré substantiel de stabilité des anticorps en cas de stress et de stockage.
MA66264A 2017-04-06 2018-03-23 Formulation stable d'anticorps MA66264B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762482270P 2017-04-06 2017-04-06
EP23177973.7A EP4249512B1 (fr) 2017-04-06 2018-03-23 Formulation stable d'anticorps

Publications (1)

Publication Number Publication Date
MA66264B1 true MA66264B1 (fr) 2025-10-31

Family

ID=62028099

Family Applications (2)

Application Number Title Priority Date Filing Date
MA66264A MA66264B1 (fr) 2017-04-06 2018-03-23 Formulation stable d'anticorps
MA49043A MA49043B1 (fr) 2017-04-06 2018-03-23 Formulation stable d'anticorps

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA49043A MA49043B1 (fr) 2017-04-06 2018-03-23 Formulation stable d'anticorps

Country Status (31)

Country Link
US (2) US11603407B2 (fr)
EP (3) EP4249512B1 (fr)
JP (1) JP7229171B2 (fr)
KR (1) KR102667484B1 (fr)
CN (1) CN110709062B (fr)
AR (1) AR111455A1 (fr)
AU (1) AU2018247501B2 (fr)
BR (1) BR112019020246A2 (fr)
CA (1) CA3059087A1 (fr)
CL (1) CL2019002828A1 (fr)
CO (1) CO2019011021A2 (fr)
DK (2) DK4249512T3 (fr)
EA (1) EA201992377A1 (fr)
ES (2) ES2955062T3 (fr)
FI (2) FI4249512T3 (fr)
HR (2) HRP20231282T1 (fr)
HU (2) HUE072642T2 (fr)
IL (1) IL269499B2 (fr)
LT (2) LT3606504T (fr)
MA (2) MA66264B1 (fr)
MX (1) MX2019011207A (fr)
MY (1) MY198318A (fr)
PH (1) PH12019502123A1 (fr)
PL (2) PL3606504T3 (fr)
PT (2) PT4249512T (fr)
RS (2) RS64680B1 (fr)
SG (2) SG10202111008QA (fr)
SI (2) SI4249512T1 (fr)
SM (2) SMT202500308T1 (fr)
TW (1) TWI795396B (fr)
WO (1) WO2018187057A1 (fr)

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