PL3606504T3 - Stabilna postać użytkowa przeciwciała - Google Patents
Stabilna postać użytkowa przeciwciałaInfo
- Publication number
- PL3606504T3 PL3606504T3 PL18719338.8T PL18719338T PL3606504T3 PL 3606504 T3 PL3606504 T3 PL 3606504T3 PL 18719338 T PL18719338 T PL 18719338T PL 3606504 T3 PL3606504 T3 PL 3606504T3
- Authority
- PL
- Poland
- Prior art keywords
- antibody formulation
- stable antibody
- stable
- formulation
- antibody
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762482270P | 2017-04-06 | 2017-04-06 | |
| PCT/US2018/024032 WO2018187057A1 (en) | 2017-04-06 | 2018-03-23 | Stable antibody formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3606504T3 true PL3606504T3 (pl) | 2024-01-08 |
Family
ID=62028099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18719338.8T PL3606504T3 (pl) | 2017-04-06 | 2018-03-23 | Stabilna postać użytkowa przeciwciała |
| PL23177973.7T PL4249512T3 (pl) | 2017-04-06 | 2018-03-23 | Stabilna postać użytkowa przeciwciała |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL23177973.7T PL4249512T3 (pl) | 2017-04-06 | 2018-03-23 | Stabilna postać użytkowa przeciwciała |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US11603407B2 (pl) |
| EP (3) | EP4249512B1 (pl) |
| JP (1) | JP7229171B2 (pl) |
| KR (1) | KR102667484B1 (pl) |
| CN (1) | CN110709062B (pl) |
| AR (1) | AR111455A1 (pl) |
| AU (1) | AU2018247501B2 (pl) |
| BR (1) | BR112019020246A2 (pl) |
| CA (1) | CA3059087A1 (pl) |
| CL (1) | CL2019002828A1 (pl) |
| CO (1) | CO2019011021A2 (pl) |
| DK (2) | DK4249512T3 (pl) |
| EA (1) | EA201992377A1 (pl) |
| ES (2) | ES2955062T3 (pl) |
| FI (2) | FI4249512T3 (pl) |
| HR (2) | HRP20231282T1 (pl) |
| HU (2) | HUE072642T2 (pl) |
| IL (1) | IL269499B2 (pl) |
| LT (2) | LT3606504T (pl) |
| MA (2) | MA66264B1 (pl) |
| MX (1) | MX2019011207A (pl) |
| MY (1) | MY198318A (pl) |
| PH (1) | PH12019502123A1 (pl) |
| PL (2) | PL3606504T3 (pl) |
| PT (2) | PT4249512T (pl) |
| RS (2) | RS64680B1 (pl) |
| SG (2) | SG10202111008QA (pl) |
| SI (2) | SI4249512T1 (pl) |
| SM (2) | SMT202500308T1 (pl) |
| TW (1) | TWI795396B (pl) |
| WO (1) | WO2018187057A1 (pl) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| LT3394103T (lt) | 2015-12-22 | 2023-09-11 | Regeneron Pharmaceuticals, Inc. | Antikūnų prieš pd-1 ir bispecifinių antikūnų prieš cd20/cd3 derinys, skirtas vėžiui gydyti |
| MA43734A (fr) | 2016-03-03 | 2018-11-28 | Regeneron Pharma | Procédés de traitement de patients atteints d'hyperlipidémie par administration d'un inhibiteur de pcsk9 en combinaison avec un inhibiteur d'angptl3 |
| MA47604A (fr) | 2017-02-21 | 2020-01-01 | Regeneron Pharma | Anticorps anti-pd-1 pour le traitement du cancer du poumon |
| US11603407B2 (en) * | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| JP7382232B2 (ja) | 2017-05-02 | 2023-11-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗ｌａｇ３抗体の製剤および抗ｌａｇ３抗体と抗ｐｄ－１抗体との共製剤 |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| WO2020081408A1 (en) | 2018-10-18 | 2020-04-23 | Merck Sharp & Dohme Corp. | Formulations of anti-rsv antibodies and methods of use thereof |
| MX2021004928A (es) | 2018-10-31 | 2021-06-08 | Merck Sharp & Dohme Llc | Cristales de anticuerpo anti-pd-1 humano y metodos de uso de los mismos. |
| EP3876978A4 (en) | 2018-11-07 | 2022-09-28 | Merck Sharp & Dohme Corp. | STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF |
| EP3876990A4 (en) | 2018-11-07 | 2023-09-06 | Merck Sharp & Dohme LLC | CO-FORMULATIONS OF ANTI-LAG3 ANTIBODIES AND ANTI-PD-1 ANTIBODIES |
| SI3880186T1 (sl) | 2018-11-14 | 2024-07-31 | Regeneron Pharmaceuticals, Inc., | Intralezijska uporaba zaviralcev PD-1 za zdravljenje kožnega raka |
| KR20210104736A (ko) * | 2018-12-14 | 2021-08-25 | 모르포시스 아게 | 항체 제형 |
| CN120241997A (zh) | 2019-02-18 | 2025-07-04 | 伊莱利利公司 | 治疗性抗体制剂 |
| MA55084A (fr) | 2019-02-28 | 2022-01-05 | Regeneron Pharma | Administration d'inhibiteurs de pd-1 pour le traitement du cancer de la peau |
| MX2021010560A (es) | 2019-03-06 | 2021-11-12 | Regeneron Pharma | Inhibidores de la via il-4/il-13 para una eficacia aumentada en el tratamiento de cancer. |
| US12559551B2 (en) * | 2019-05-24 | 2026-02-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ANGPTL3 antibodies |
| WO2021023267A1 (zh) * | 2019-08-07 | 2021-02-11 | 信达生物制药(苏州)有限公司 | 包含抗pd-1/her2双特异性抗体的制剂及其制备方法和用途 |
| AU2020358101A1 (en) * | 2019-10-02 | 2022-04-28 | Alamab Therapeutics, Inc. | Anto-connexin antibody formulations |
| AU2020380288B2 (en) * | 2019-11-04 | 2024-02-01 | Inovio Pharmaceuticals, Inc. | Combination therapy to treat brain cancer |
| KR20210059646A (ko) * | 2019-11-15 | 2021-05-25 | 삼성바이오에피스 주식회사 | 항체 의약품용 액상 조성물 |
| SI4076385T1 (sl) | 2019-12-20 | 2026-04-30 | Formycon Ag | Formulacije protiteles anti-pd1 |
| JP2023509195A (ja) | 2020-01-08 | 2023-03-07 | アルジェニクス ビーブイ | 天疱瘡症を治療する方法 |
| KR20210097882A (ko) * | 2020-01-30 | 2021-08-10 | 삼성바이오에피스 주식회사 | 안정한 항-pd-1 항체 약제학적 제제 |
| JP7697959B2 (ja) * | 2020-03-18 | 2025-06-24 | ジーアイ イノベーション， インコーポレイテッド | Ｉｌ－２タンパク質とｃｄ８０タンパク質を含む融合タンパク質製剤 |
| MX2022014734A (es) | 2020-05-26 | 2023-03-15 | Regeneron Pharma | Metodos de tratamiento del cancer de cuello uterino mediante la administracion del anticuerpo inhibidor de pd-1 cemiplimab. |
| CR20220596A (es) | 2020-05-26 | 2023-01-23 | Boehringer Ingelheim Int | Anticuerpos anti-pd-1 |
| PH12022552898A1 (en) * | 2020-06-19 | 2023-12-04 | Sinocelltech Ltd | Stable formulation for recombinant anti-pd-1 monoclonal antibody |
| KR20230035355A (ko) * | 2020-07-03 | 2023-03-13 | 씨에스엘 이노베이션 피티와이 엘티디 | 인자 xii 항원 결합 단백질의 고농도 제형 |
| JP2023537316A (ja) * | 2020-07-31 | 2023-08-31 | アラマブ セラピューティクス， インコーポレイテッド | 抗コネキシン抗体製剤 |
| JP7634082B2 (ja) * | 2020-08-18 | 2025-02-20 | オメロス コーポレーション | 補体因子ｄを検出するためのモノクローナル抗体、組成物、および方法 |
| KR20230056761A (ko) | 2020-08-26 | 2023-04-27 | 리제너론 파마슈티칼스 인코포레이티드 | Pd-1 저해제의 투여에 의한 암 치료 방법 |
| CN116194142A (zh) | 2020-09-03 | 2023-05-30 | 瑞泽恩制药公司 | 通过施用pd-1抑制剂治疗癌症疼痛的方法 |
| JP2023545926A (ja) | 2020-09-24 | 2023-11-01 | メルク・シャープ・アンド・ドーム・エルエルシー | プログラム死受容体１（ｐｄ－１）抗体とヒアルロニダーゼ変異体とそれらのフラグメントとの安定製剤およびその使用方法 |
| AU2021354827A1 (en) * | 2020-09-30 | 2023-06-01 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising antibody-drug conjugate, and use of pharmaceutical composition |
| WO2022173931A1 (en) | 2021-02-11 | 2022-08-18 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer by administering a neoadjuvant pd-1 inhibitor |
| EP4297782A1 (en) | 2021-02-23 | 2024-01-03 | Regeneron Pharmaceuticals, Inc. | Methods of treating lung cancer by administering a pd-1 inhibitor |
| EP4313123A1 (en) | 2021-03-23 | 2024-02-07 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer in immunosuppressed or immunocompromised patients by administering a pd-1 inhibitor |
| JP2024527517A (ja) | 2021-06-23 | 2024-07-25 | フォーマイコン アーゲー | 抗ｐｄ１抗体製剤 |
| IL310808A (en) | 2021-08-13 | 2024-04-01 | Inovio Pharmaceuticals Inc | Combination therapy to treat brain cancer |
| WO2023198115A1 (en) * | 2022-04-14 | 2023-10-19 | Beigene Switzerland Gmbh | Stable high concentration sodium chloride formulations containing pd-1 antibody and methods of use thereof |
| CN119173272A (zh) * | 2022-04-14 | 2024-12-20 | 百济神州瑞士有限责任公司 | 含有pd-1抗体的稳定高浓度精氨酸配制品及其使用方法 |
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