PL3606504T3 - Stabilna postać użytkowa przeciwciała - Google Patents
Stabilna postać użytkowa przeciwciałaInfo
- Publication number
- PL3606504T3 PL3606504T3 PL18719338.8T PL18719338T PL3606504T3 PL 3606504 T3 PL3606504 T3 PL 3606504T3 PL 18719338 T PL18719338 T PL 18719338T PL 3606504 T3 PL3606504 T3 PL 3606504T3
- Authority
- PL
- Poland
- Prior art keywords
- antibody formulation
- stable antibody
- stable
- formulation
- antibody
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762482270P | 2017-04-06 | 2017-04-06 | |
| PCT/US2018/024032 WO2018187057A1 (en) | 2017-04-06 | 2018-03-23 | Stable antibody formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3606504T3 true PL3606504T3 (pl) | 2024-01-08 |
Family
ID=62028099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL23177973.7T PL4249512T3 (pl) | 2017-04-06 | 2018-03-23 | Stabilna postać użytkowa przeciwciała |
| PL18719338.8T PL3606504T3 (pl) | 2017-04-06 | 2018-03-23 | Stabilna postać użytkowa przeciwciała |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL23177973.7T PL4249512T3 (pl) | 2017-04-06 | 2018-03-23 | Stabilna postać użytkowa przeciwciała |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US11603407B2 (pl) |
| EP (3) | EP4628509A3 (pl) |
| JP (1) | JP7229171B2 (pl) |
| KR (1) | KR102667484B1 (pl) |
| CN (1) | CN110709062B (pl) |
| AR (1) | AR111455A1 (pl) |
| AU (1) | AU2018247501B2 (pl) |
| BR (1) | BR112019020246A2 (pl) |
| CA (1) | CA3059087A1 (pl) |
| CL (1) | CL2019002828A1 (pl) |
| CO (1) | CO2019011021A2 (pl) |
| DK (2) | DK3606504T5 (pl) |
| EA (1) | EA201992377A1 (pl) |
| ES (2) | ES3038266T3 (pl) |
| FI (2) | FI3606504T3 (pl) |
| HR (2) | HRP20231282T1 (pl) |
| HU (2) | HUE063509T2 (pl) |
| IL (1) | IL269499B2 (pl) |
| LT (2) | LT3606504T (pl) |
| MA (2) | MA49043B1 (pl) |
| MX (1) | MX2019011207A (pl) |
| MY (1) | MY198318A (pl) |
| PH (1) | PH12019502123A1 (pl) |
| PL (2) | PL4249512T3 (pl) |
| PT (2) | PT4249512T (pl) |
| RS (2) | RS67103B1 (pl) |
| SG (2) | SG11201908540PA (pl) |
| SI (2) | SI3606504T1 (pl) |
| SM (2) | SMT202500308T1 (pl) |
| TW (1) | TWI795396B (pl) |
| WO (1) | WO2018187057A1 (pl) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| JP7126941B2 (ja) | 2015-12-22 | 2022-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | がんを治療するための抗ｐｄ－１抗体と二重特異性抗ｃｄ２０／抗ｃｄ３抗体の組合せ |
| JP7541810B2 (ja) | 2016-03-03 | 2024-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ａｎｇｐｔｌ３阻害剤と組み合わせてｐｃｓｋ９阻害剤を投与することにより高脂血症を有する患者を処置するための方法 |
| KR20240011262A (ko) | 2017-02-21 | 2024-01-25 | 리제너론 파아마슈티컬스, 인크. | 폐암의 치료를 위한 항-pd-1 항체 |
| US11603407B2 (en) * | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| AU2018263868A1 (en) | 2017-05-02 | 2019-12-12 | Merck Sharp & Dohme Llc | Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| KR102885113B1 (ko) | 2018-10-18 | 2025-11-13 | 머크 샤프 앤드 돔 엘엘씨 | 항-rsv 항체의 제제 및 그의 사용 방법 |
| CN120842406A (zh) | 2018-10-31 | 2025-10-28 | 默沙东有限责任公司 | 抗人pd-1抗体晶体及其使用方法 |
| WO2020097141A1 (en) | 2018-11-07 | 2020-05-14 | Merck Sharp & Dohme Corp. | Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| CN113316458B (zh) | 2018-11-07 | 2024-08-02 | 默沙东有限责任公司 | 抗lag3抗体和抗pd-1抗体的共制剂 |
| HUE067601T2 (hu) | 2018-11-14 | 2024-10-28 | Regeneron Pharma | PD-1 inhibitorok intraléziós beadása a bõrrák kezelésére |
| CN113194925B (zh) * | 2018-12-14 | 2025-03-07 | 莫佛塞斯公司 | 抗体制剂 |
| KR102735988B1 (ko) | 2019-02-18 | 2024-12-03 | 일라이 릴리 앤드 캄파니 | 치료 항체 제제 |
| MA55084A (fr) | 2019-02-28 | 2022-01-05 | Regeneron Pharma | Administration d'inhibiteurs de pd-1 pour le traitement du cancer de la peau |
| MA55204A (fr) | 2019-03-06 | 2022-01-12 | Regeneron Pharma | Inhibiteurs de la voie il-4/il-13 pour une efficacité améliorée dans le traitement du cancer |
| US12559551B2 (en) * | 2019-05-24 | 2026-02-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ANGPTL3 antibodies |
| BR112022001775A2 (pt) * | 2019-08-07 | 2022-06-07 | Beijing Hanmi Pharmaceutical Co Ltd | Formulação compreendendo o anticorpo biespecífico anti-pd-1/her2, método para preparo e uso do mesmo |
| KR20220113355A (ko) * | 2019-10-02 | 2022-08-12 | 알라맵 테라퓨틱스, 인크. | 항-코넥신 항체 제제 |
| CN114901677A (zh) * | 2019-11-04 | 2022-08-12 | 艾诺奥医药品有限公司 | 治疗脑癌的联合疗法 |
| KR20210059646A (ko) * | 2019-11-15 | 2021-05-25 | 삼성바이오에피스 주식회사 | 항체 의약품용 액상 조성물 |
| ES3063234T3 (en) | 2019-12-20 | 2026-04-15 | Formycon Ag | Formulations of anti-pd1 antibodies |
| BR112022013554A2 (pt) | 2020-01-08 | 2022-09-06 | argenx BV | Métodos para tratar distúrbios do pênfigo |
| KR20210097882A (ko) * | 2020-01-30 | 2021-08-10 | 삼성바이오에피스 주식회사 | 안정한 항-pd-1 항체 약제학적 제제 |
| ES3040184T3 (en) * | 2020-03-18 | 2025-10-29 | Gi Innovation Inc | Fusion protein preparation comprising il-2 and cd80 proteins |
| MX2022014734A (es) | 2020-05-26 | 2023-03-15 | Regeneron Pharma | Metodos de tratamiento del cancer de cuello uterino mediante la administracion del anticuerpo inhibidor de pd-1 cemiplimab. |
| BR112022023989A2 (pt) | 2020-05-26 | 2023-02-07 | Boehringer Ingelheim Int | Anticorpos anti-pd-1 |
| US20230272106A1 (en) * | 2020-06-19 | 2023-08-31 | Sinocelltech Ltd | Stable formulation for recombinant anti-pd-1 monoclonal antibody |
| JP2023531315A (ja) * | 2020-07-03 | 2023-07-21 | シーエスエル・イノベーション・プロプライエタリー・リミテッド | 第ｘｉｉ因子抗原結合タンパク質の高濃度製剤 |
| WO2022026914A1 (en) * | 2020-07-31 | 2022-02-03 | Alamab Therapeutics, Inc. | Anti-connexin antibody formulations |
| US12129290B2 (en) * | 2020-08-18 | 2024-10-29 | Omeros Corporation | Monoclonal antibodies, compositions and methods for detecting complement factor D |
| JP2023540217A (ja) | 2020-08-26 | 2023-09-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｐｄ－１阻害剤を投与することによりがんを処置する方法 |
| JP2023542490A (ja) | 2020-09-03 | 2023-10-10 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｐｄ－１阻害剤を投与することによりがん疼痛を処置する方法 |
| IL301533A (en) | 2020-09-24 | 2023-05-01 | Merck Sharp ַ& Dohme Llc | Stable compositions of programmed death receptor 1 (PD-1) antibodies and hyaluronidase variants and parts thereof and methods of using them |
| KR20230079096A (ko) * | 2020-09-30 | 2023-06-05 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항체-약물 접합체를 포함하는 약제학적 조성물 및 약제학적 조성물의 용도 |
| KR20230141869A (ko) | 2021-02-11 | 2023-10-10 | 리제너론 파마슈티칼스 인코포레이티드 | 신보조 요법으로서 pd-1 저해제의 투여에 의한 암 치료 방법 |
| MX2023009774A (es) | 2021-02-23 | 2023-10-30 | Regeneron Pharma | Metodos para tratar cancer de pulmon administrando un inhibidor de pd-1. |
| EP4313123A1 (en) | 2021-03-23 | 2024-02-07 | Regeneron Pharmaceuticals, Inc. | Methods of treating cancer in immunosuppressed or immunocompromised patients by administering a pd-1 inhibitor |
| JP2024527517A (ja) | 2021-06-23 | 2024-07-25 | フォーマイコン アーゲー | 抗ｐｄ１抗体製剤 |
| IL310808A (en) | 2021-08-13 | 2024-04-01 | Inovio Pharmaceuticals Inc | Combination therapy to treat brain cancer |
| WO2023198116A1 (en) * | 2022-04-14 | 2023-10-19 | Beigene Switzerland Gmbh | Stable high concentration arginine formulations containing pd-1 antibody and methods of use thereof |
| EP4507725A4 (en) * | 2022-04-14 | 2026-04-22 | Beone Medicines I Gmbh | Stable high-concentration sodium chloride formulations containing a PD-1 antibody and their methods of use |
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| AU2023413756A1 (en) | 2022-12-21 | 2025-07-10 | Formycon Ag | Formulations of anti-pd1 antibodies |
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