ME00590A - N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof - Google Patents

N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof

Info

Publication number: ME00590A
Authority: ME; Montenegro
Prior art keywords: preparation; therapeutic application; aminoheteroaryl; indole; carboxamide derivatives
Prior art date: 2006-07-31

Application number

MEP-30/09A

Other languages

Bosnian (bs)

English (en)

Inventor

Laurent Dubois

Yannick Evanno

Andre Malanda

David Machnik

Catherine Gille

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-31

Filing date

2007-07-30

Publication date

2011-12-20

2007-07-30 Application filed filed Critical

2011-12-20 Publication of ME00590A publication Critical patent/ME00590A/xx

Links

230000001225 therapeutic effect Effects 0.000 title abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 cyclic amine Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Dermatology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Oncology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

MEP-30/09A 2006-07-31 2007-07-30 N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof ME00590A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0606988A FR2904316B1 (fr)	2006-07-31	2006-07-31	Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique.
PCT/FR2007/001316 WO2008015335A1 (fr)	2006-07-31	2007-07-30	Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
ME00590A true ME00590A (en)	2011-12-20

Family

ID=37806631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-30/09A ME00590A (en)	2006-07-31	2007-07-30	N-(aminoheteroaryl)-1h-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof

Country Status (36)

Country	Link
US (2)	US7786104B2 (pt)
EP (1)	EP2049525B1 (pt)
JP (1)	JP5306201B2 (pt)
KR (1)	KR20090033885A (pt)
CN (1)	CN101511819B (pt)
AR (1)	AR062143A1 (pt)
AT (1)	ATE453637T1 (pt)
AU (1)	AU2007280326B2 (pt)
BR (1)	BRPI0715199A2 (pt)
CA (1)	CA2658799C (pt)
CL (1)	CL2007002169A1 (pt)
CO (1)	CO6150179A2 (pt)
CY (1)	CY1109944T1 (pt)
DE (1)	DE602007004119D1 (pt)
DK (1)	DK2049525T3 (pt)
EA (1)	EA017375B1 (pt)
ES (1)	ES2338610T3 (pt)
FR (1)	FR2904316B1 (pt)
HR (1)	HRP20100121T1 (pt)
IL (1)	IL196571A0 (pt)
JO (1)	JO2644B1 (pt)
MA (1)	MA30695B1 (pt)
ME (1)	ME00590A (pt)
MX (1)	MX2009001222A (pt)
MY (1)	MY145031A (pt)
NO (1)	NO20090952L (pt)
NZ (1)	NZ574345A (pt)
PE (1)	PE20080688A1 (pt)
PL (1)	PL2049525T3 (pt)
PT (1)	PT2049525E (pt)
RS (1)	RS51235B (pt)
SI (1)	SI2049525T1 (pt)
TW (1)	TW200813023A (pt)
UY (1)	UY30518A1 (pt)
WO (1)	WO2008015335A1 (pt)
ZA (1)	ZA200900505B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2926554B1 (fr) *	2008-01-22	2010-03-12	Sanofi Aventis	Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
FR2926556B1 (fr) *	2008-01-22	2010-02-19	Sanofi Aventis	Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
FR2926553B1 (fr) *	2008-01-23	2010-02-19	Sanofi Aventis	Derives d'indole-2-carboxamides et d'azaindole-2- carboxamides substitues par un groupe silanyle, leur preparation et leur application en therapeutique
AU2010232729A1 (en)	2009-03-31	2011-10-20	Arqule, Inc.	Substituted indolo-pyridinone compounds
EP2794565B1 (en)	2011-12-21	2017-07-26	Novira Therapeutics Inc.	Hepatitis b antiviral agents
CA2881057C (en)	2012-08-28	2020-10-27	Janssen Sciences Ireland Uc	Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
JP6466348B2 (ja)	2013-02-28	2019-02-06	ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー	スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用
HUE033542T2 (en)	2013-04-03	2017-12-28	Janssen Sciences Ireland Uc	Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B
TW202126620A (zh)	2013-05-17	2021-07-16	愛爾蘭商健生科學愛爾蘭無限公司	胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途
HUE040446T2 (hu)	2013-05-17	2019-03-28	Janssen Sciences Ireland Uc	Szulfamoiltiofenamid-származékok és gyógyszerként történõ alkalmazásuk hepatitis B kezelésére
WO2015011281A1 (en)	2013-07-25	2015-01-29	Janssen R&D Ireland	Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
MX368158B (es)	2013-10-23	2019-09-20	Janssen Sciences Ireland Uc	Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
US9169212B2 (en)	2014-01-16	2015-10-27	Novira Therapeutics, Inc.	Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en)	2014-01-16	2019-08-27	Novira Therapeutics, Inc.	Azepane derivatives and methods of treating hepatitis B infections
JP6553059B2 (ja)	2014-02-05	2019-07-31	ノヴィラ・セラピューティクス・インコーポレイテッド	Ｈｂｖ感染の治療のための併用療法
PL3102572T3 (pl)	2014-02-06	2019-04-30	Janssen Sciences Ireland Uc	Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B
EP3271019A1 (en)	2015-03-19	2018-01-24	Novira Therapeutics Inc.	Azocane and azonane derivatives and methods of treating hepatitis b infections
US10875876B2 (en)	2015-07-02	2020-12-29	Janssen Sciences Ireland Uc	Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
AR106192A1 (es)	2015-09-29	2017-12-20	Novira Therapeutics Inc	Formas cristalinas de un agente antiviral contra la hepatitis b
WO2017181141A2 (en)	2016-04-15	2017-10-19	Novira Therapeutics, Inc.	Combinations and methods comprising a capsid assembly inhibitor
WO2017210545A1 (en)	2016-06-02	2017-12-07	Cadent Therapeutics, Inc.	Potassium channel modulators
EP3571193B1 (en)	2017-01-23	2021-12-01	Cadent Therapeutics, Inc.	Potassium channel modulators
SG11202007097QA (en)	2018-03-14	2020-08-28	Janssen Sciences Ireland Unlimited Co	Capsid assembly modulator dosing regimen
MX2021004647A (es)	2018-10-22	2021-08-16	Novartis Ag	Formas cristalinas de moduladores de los canales de potasio.
AU2020223865A1 (en)	2019-02-22	2021-07-15	Janssen Sciences Ireland Unlimited Company	Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
BR112021021454A2 (pt)	2019-05-06	2021-12-21	Janssen Sciences Ireland Unlimited Co	Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL248308A (pt)	1958-09-30
US4104385A (en)	1976-08-19	1978-08-01	Sterling Drug Inc.	Cyclic alkylidenyl N-[6-(amino)-3-pyridazinyl]aminomethylenemalonates
JP2004520299A (ja)	2000-12-12	2004-07-08	ニューロジェン・コーポレーション	スピロ［イソベンゾフラン−１，４’−ピペリジン］−３−オン類及び３ｈ−スピロイソベンゾフラン−１，４’−ピペリジン類
FR2832148B1 (fr) *	2001-11-14	2004-05-21	Oreal	Nouvelles bases d'oxydation 2,5-diaminopyridine utiles pour la teinture des fibres keratiniques
MY141521A (en)	2002-12-12	2010-05-14	Hoffmann La Roche	5-substituted-six-membered heteroaromatic glucokinase activators
EP1583531B1 (en)	2003-01-16	2007-04-18	SB Pharmco Puerto Rico Inc	Heteroaryl-substituted pyrrolo[2, 3- b]pyridine derivatives as crf receptor antagonists
US7223788B2 (en) *	2003-02-14	2007-05-29	Sanofi-Aventis Deutschland Gmbh	Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
GB0314136D0 (en)	2003-06-18	2003-07-23	Astrazeneca Ab	Therapeutic agents
GB0322016D0 (en)	2003-09-19	2003-10-22	Merck Sharp & Dohme	New compounds
JP2007505888A (ja)	2003-09-22	2007-03-15	ファイザーインコーポレイテッド	オキシトシン拮抗薬としての置換トリアゾール誘導体
WO2005035526A1 (en)	2003-10-09	2005-04-21	Argenta Discovery Ltd.	Bicyclic compounds and their therapeutic use
GB0326633D0 (en) *	2003-11-14	2003-12-17	Merck Sharp & Dohme	Therapeutic agents
JP2008515960A (ja)	2004-10-12	2008-05-15	アストラゼネカアクチボラグ	キノリン誘導体
US7875627B2 (en) *	2004-12-07	2011-01-25	Abbott Laboratories	Thienopyridyl compounds that inhibit vanilloid receptor subtype 1 (VR1) and uses thereof
FR2880625B1 (fr) *	2005-01-07	2007-03-09	Sanofi Aventis Sa	Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
US20080221107A1 (en)	2005-07-15	2008-09-11	Astrazeneca Ab	Therapeutic Agents
BRPI0619052A2 (pt) *	2005-11-28	2011-09-20	Hoffmann La Roche	compostos, processo para a sua preparação, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de diacilglicerol aciltransferase, e seu uso

2006
- 2006-07-31 FR FR0606988A patent/FR2904316B1/fr not_active Expired - Fee Related
2007
- 2007-07-20 TW TW096126658A patent/TW200813023A/zh unknown
- 2007-07-24 CL CL200702169A patent/CL2007002169A1/es unknown
- 2007-07-26 PE PE2007000976A patent/PE20080688A1/es not_active Application Discontinuation
- 2007-07-30 BR BRPI0715199-3A2A patent/BRPI0715199A2/pt not_active IP Right Cessation
- 2007-07-30 JP JP2009522302A patent/JP5306201B2/ja not_active Expired - Fee Related
- 2007-07-30 DK DK07823371.5T patent/DK2049525T3/da active
- 2007-07-30 AR ARP070103358A patent/AR062143A1/es not_active Application Discontinuation
- 2007-07-30 NZ NZ574345A patent/NZ574345A/en not_active IP Right Cessation
- 2007-07-30 ME MEP-30/09A patent/ME00590A/xx unknown
- 2007-07-30 KR KR1020097002074A patent/KR20090033885A/ko not_active Ceased
- 2007-07-30 ZA ZA200900505A patent/ZA200900505B/xx unknown
- 2007-07-30 HR HR20100121T patent/HRP20100121T1/hr unknown
- 2007-07-30 DE DE602007004119T patent/DE602007004119D1/de active Active
- 2007-07-30 AU AU2007280326A patent/AU2007280326B2/en not_active Ceased
- 2007-07-30 JO JO2007310A patent/JO2644B1/en active
- 2007-07-30 SI SI200730186T patent/SI2049525T1/sl unknown
- 2007-07-30 ES ES07823371T patent/ES2338610T3/es active Active
- 2007-07-30 RS RSP-2010/0139A patent/RS51235B/sr unknown
- 2007-07-30 PT PT07823371T patent/PT2049525E/pt unknown
- 2007-07-30 CA CA2658799A patent/CA2658799C/fr active Active
- 2007-07-30 AT AT07823371T patent/ATE453637T1/de active
- 2007-07-30 WO PCT/FR2007/001316 patent/WO2008015335A1/fr not_active Ceased
- 2007-07-30 CN CN200780032445.6A patent/CN101511819B/zh not_active Expired - Fee Related
- 2007-07-30 EP EP07823371A patent/EP2049525B1/fr active Active
- 2007-07-30 MX MX2009001222A patent/MX2009001222A/es active IP Right Grant
- 2007-07-30 MY MYPI20090381A patent/MY145031A/en unknown
- 2007-07-30 EA EA200970171A patent/EA017375B1/ru not_active IP Right Cessation
- 2007-07-30 PL PL07823371T patent/PL2049525T3/pl unknown
- 2007-07-31 UY UY30518A patent/UY30518A1/es not_active Application Discontinuation
2009
- 2009-01-18 IL IL196571A patent/IL196571A0/en unknown
- 2009-01-26 US US12/359,468 patent/US7786104B2/en not_active Expired - Fee Related
- 2009-01-29 CO CO09008274A patent/CO6150179A2/es unknown
- 2009-02-13 MA MA31642A patent/MA30695B1/fr unknown
- 2009-03-02 NO NO20090952A patent/NO20090952L/no not_active Application Discontinuation
2010
- 2010-03-22 CY CY20101100268T patent/CY1109944T1/el unknown
- 2010-07-19 US US12/838,771 patent/US8586573B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CL2007002169A1 (es)	2008-03-07
CO6150179A2 (es)	2010-04-20
AU2007280326A1 (en)	2008-02-07
DK2049525T3 (da)	2010-05-03
BRPI0715199A2 (pt)	2013-10-01
EA017375B1 (ru)	2012-12-28
JO2644B1 (en)	2012-06-17
CY1109944T1 (el)	2014-09-10
ES2338610T3 (es)	2010-05-10
PL2049525T3 (pl)	2010-07-30
JP5306201B2 (ja)	2013-10-02
EA200970171A1 (ru)	2009-06-30
ZA200900505B (en)	2010-04-28
MX2009001222A (es)	2009-02-13
PT2049525E (pt)	2010-03-23
KR20090033885A (ko)	2009-04-06
TW200813023A (en)	2008-03-16
CA2658799C (fr)	2014-10-07
AU2007280326B2 (en)	2012-11-29
MA30695B1 (fr)	2009-09-01
NZ574345A (en)	2011-11-25
JP2009545574A (ja)	2009-12-24
RS51235B (sr)	2010-12-31
WO2008015335A1 (fr)	2008-02-07
CA2658799A1 (fr)	2008-02-07
MY145031A (en)	2011-12-15
AR062143A1 (es)	2008-10-15
DE602007004119D1 (de)	2010-02-11
IL196571A0 (en)	2009-11-18
CN101511819A (zh)	2009-08-19
UY30518A1 (es)	2008-02-29
PE20080688A1 (es)	2008-07-24
NO20090952L (no)	2009-04-23
FR2904316B1 (fr)	2008-09-05
EP2049525A1 (fr)	2009-04-22
CN101511819B (zh)	2014-04-23
ATE453637T1 (de)	2010-01-15
US20100286119A1 (en)	2010-11-11
HRP20100121T1 (hr)	2010-04-30
US20090156573A1 (en)	2009-06-18
SI2049525T1 (sl)	2010-04-30
EP2049525B1 (fr)	2009-12-30
US8586573B2 (en)	2013-11-19
FR2904316A1 (fr)	2008-02-01
US7786104B2 (en)	2010-08-31

Publication	Publication Date	Title
NO20090952L (no)	2009-04-23	N-(aminoheteroaryl) - lh - indol-2-karboksamidderivater og fremstilling og terapeutisk anvendelse derav
MX2010008101A (es)	2010-08-04	Derivados de indol 2-carboxamidas y de azaindol 2-carboxamidas sustituidos con un silanilo, su preparacion y su aplicacion en terapeutica.
ATE556058T1 (de)	2012-05-15	1-(2h)-isochinolonderivat
NO20072371L (no)	2007-07-12	Kinuklidinderivater og deres anvendelse som muskarine M3-reseptorantagonister
MEP36508A (en)	2011-02-10	Triazolopyrazine derivatives useful as anti-cancer agents
NO20075169L (no)	2007-12-12	Nye imidazo (1,5-A)pyndindenvater, fremgangsmate for fremstilling og farmasoytiske sammensetninger som inneholder samme.
SE0400284D0 (sv)	2004-02-10	Novel compounds
EA201171328A1 (ru)	2012-05-30	Производное замещенного изохинолина
MEP51408A (en)	2011-02-10	Selected cgrp antagonists, method for production and use thereof as medicament
NO20063748L (no)	2006-08-22	Kinolinderivater og anvendelse derav som mykobakterielle inhibitorer
CY1107974T1 (el)	2013-09-04	Παραγωγα κινολινης και κιναζολινης εχοντα συναφεια προς τους υποδοχεις τυπου 5ht1
NO20073357L (no)	2007-08-30	5-karboksamid substituerte tiazol derivater som reagerer med ionekanaler, i saerdeleshet med ionekanaler fra Kv familien
HRP20050710A2 (en)	2006-07-31	Substituted n-arylheterocycles, method for production and use thereof as medicaments
TW200517388A (en)	2005-06-01	Thiazole derivatives as cannabinoid receptor modulators
NO20073663L (no)	2007-09-03	Tiazol-4-karboksamid-derivater som mGluR5 antagonister
NO20072478L (no)	2007-06-25	Salter av isofosforamidsennep og analoger av disse som antitumor midler
ATE307810T1 (de)	2005-11-15	Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
MXPA02012034A (es)	2003-04-25	Derivados de tiofeno utiles como agentes anticancerosos.
HRP20050933A2 (en)	2006-12-31	Organic compounds
EA200701745A1 (ru)	2008-06-30	Циклопропанкарбоксамидные производные
WO2007044724A3 (en)	2007-06-28	Aminopyrimidine, aminopyridine and aniline derivatives inhibitors of pim-i and/or pim-3
DE602005016261D1 (de)	2009-10-08	Substituierte arylaminderivate und verwendungsverfahren
MX2010001005A (es)	2010-03-09	Derivados de (hetero)aril-metilen-n-cicloalquilcarboxamida condensados de 6 elementos con n como fungicidas.
PH12012500542A1 (en)	2012-11-12	Substituted amide compound
ATE372995T1 (de)	2007-09-15	Benzo(b)(1,4)dioxepinderivate