MEP76708A - (imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker - Google Patents

(imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker

Info

Publication number: MEP76708A
Authority: ME; Montenegro
Prior art keywords: disease; compounds; pyridazine; imidazol; methyl
Prior art date: 2002-05-16

Application number

MEP-767/08A

Other languages

Bosnian (bs)

English (en)

Croatian (hr)

Inventor

Bernd Buettelmann

Neidhart Marie-Paule Heitz

Georg Jaeschke

Emmanuel Pinard

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-16

Filing date

2003-05-16

Publication date

2011-12-20

2003-05-16 Application filed filed Critical

2011-12-20 Publication of MEP76708A publication Critical patent/MEP76708A/xx

Links

GFSWLEBKUPUQNQ-UHFFFAOYSA-N 3-(imidazol-1-ylmethyl)pyridazine Chemical compound C1=CN=CN1CC1=CC=CN=N1 GFSWLEBKUPUQNQ-UHFFFAOYSA-N 0.000 title 1
239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
230000004770 neurodegeneration Effects 0.000 abstract 3
208000002193 Pain Diseases 0.000 abstract 2
206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
230000001684 chronic effect Effects 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000035143 Bacterial infection Diseases 0.000 abstract 1
208000000094 Chronic Pain Diseases 0.000 abstract 1
208000023105 Huntington disease Diseases 0.000 abstract 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000001154 acute effect Effects 0.000 abstract 1
208000005298 acute pain Diseases 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

MEP-767/08A 2002-05-16 2003-05-16 (imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker MEP76708A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02010217		2002-05-16
PCT/EP2003/005151 WO2003097637A1 (en)	2002-05-16	2003-05-16	(imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker

Publications (1)

Publication Number	Publication Date
MEP76708A true MEP76708A (en)	2011-12-20

Family

ID=29433072

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-767/08A MEP76708A (en)	2002-05-16	2003-05-16	(imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker

Country Status (30)

Country	Link
US (1)	US7005432B2 (es)
EP (1)	EP1506190B1 (es)
JP (1)	JP4267569B2 (es)
KR (1)	KR100632868B1 (es)
CN (1)	CN1312151C (es)
AR (1)	AR040010A1 (es)
AT (1)	ATE329912T1 (es)
AU (1)	AU2003242542B2 (es)
BR (1)	BR0311177A (es)
CA (1)	CA2485926C (es)
CL (1)	CL2004001251A1 (es)
CY (1)	CY1105159T1 (es)
DE (1)	DE60306152T2 (es)
DK (1)	DK1506190T3 (es)
ES (1)	ES2265581T3 (es)
HR (1)	HRP20041060B1 (es)
IL (1)	IL164922A (es)
MA (1)	MA27117A1 (es)
ME (1)	MEP76708A (es)
MX (1)	MXPA04011253A (es)
NO (1)	NO329605B1 (es)
NZ (1)	NZ536310A (es)
PL (1)	PL211340B1 (es)
PT (1)	PT1506190E (es)
RS (1)	RS51200B (es)
RU (1)	RU2317294C2 (es)
SI (1)	SI1506190T1 (es)
TN (1)	TNSN04224A1 (es)
WO (1)	WO2003097637A1 (es)
ZA (1)	ZA200408789B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives
GB0218876D0 (en) *	2002-08-13	2002-09-25	Merck Sharp & Dohme	Therapeutic agents
CN100579579C (zh) *	2002-10-01	2010-01-13	诺华疫苗和诊断公司	抗癌及抗感染性疾病组合物及其使用方法
EP1888706B1 (de) *	2005-05-03	2017-03-01	Merck Patent GmbH	Organische elektrolumineszenzvorrichtung und in deren herstellung verwendete boronsäure- und borinsäure-derivate
US20090054392A1 (en) *	2007-08-20	2009-02-26	Wyeth	Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
JP5315710B2 (ja) *	2008-02-07	2013-10-16	セントラル硝子株式会社	１−ブロモ−３−フルオロ−５−ジフルオロメチルベンゼンの製造方法
DE102008015033A1 (de)	2008-03-17	2009-09-24	Aicuris Gmbh & Co. Kg	Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
MX2010009649A (es) *	2008-03-27	2010-12-17	Evotecv Neurosciences Gmbh	Metodos para tratar trastornos utilizando un antagonista selectivo del subtipo nr2b de nmda.
AU2010211050B2 (en)	2009-02-05	2016-05-12	Takeda Pharmaceutical Company Limited	Pyridazinone compounds
EP2602255B1 (en) *	2010-08-04	2017-04-26	Takeda Pharmaceutical Company Limited	Fused heterocyclic ring compound
WO2012019106A2 (en) *	2010-08-06	2012-02-09	Board Of Regents Of The University Of Nebraska	Positive and negative modulators of nmda receptors
WO2013160728A1 (en)	2012-04-26	2013-10-31	Alma Mater Studiorum - Universita' Di Bologna	Dual targeting compounds for the treatment of alzheimer's disease
WO2016025917A1 (en) *	2014-08-15	2016-02-18	Janssen Pharmaceuticals, Inc.	Triazoles as nr2b receptor inhibitors
DE102015011861B4 (de)	2015-09-10	2018-03-01	Rudolf Schindler	Neue cyclische Carboxamide als NMDA NR2B Rezeptor Inhibitoren
JP7071917B2 (ja)	2015-12-09	2022-05-19	カデントセラピューティクス，インコーポレーテッド	ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用
US10071988B2 (en)	2016-02-10	2018-09-11	Janssen Pharmaceutica Nv	Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
CN108713016B (zh)	2016-02-18	2021-10-08	先正达参股股份有限公司	杀有害生物活性吡唑衍生物
WO2017158151A1 (en)	2016-03-18	2017-09-21	Savira Pharmaceuticals Gmbh	Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017158147A1 (en)	2016-03-18	2017-09-21	Savira Pharmaceuticals Gmbh	Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
TW201819376A (zh)	2016-10-06	2018-06-01	比利時商健生藥品公司	經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
US11274107B2 (en)	2016-12-22	2022-03-15	Cadent Therapeutics, Inc.	NMDA receptor modulators and uses thereof
WO2019193516A2 (en)	2018-04-04	2019-10-10	Janssen Pharmaceutica Nv	Substituted pyridine and pyrimidines and their use as glun2b receptor modulators
AR115905A1 (es)	2018-08-03	2021-03-10	Cadent Therapeutics Inc	5-(3-cloro-4-fluorofenil)-7-ciclopropil-3-(2-(3-fluoro-3-metilazetidin-1-il)-2-oxoetil)-3,7-dihidro-4h-pirrolo[2,3-d]pirimidin-4-ona como modulador de los receptores de nmda
CA3143103A1 (en)	2019-06-14	2020-12-17	Janssen Pharmaceutica Nv	Pyridine carbamates and their use as glun2b receptor modulators
BR112021025141A2 (pt)	2019-06-14	2022-01-25	Janssen Pharmaceutica Nv	Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b
CN114008052A (zh)	2019-06-14	2022-02-01	詹森药业有限公司	取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途
JP7667097B2 (ja)	2019-06-14	2025-04-22	ヤンセンファーマシューティカエヌ．ベー．	置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
MX2021015511A (es)	2019-06-14	2022-01-31	Janssen Pharmaceutica Nv	Carbamatos de pirazina y sus usos como moduladores del receptor glun2b.
AU2020293642A1 (en)	2019-06-14	2022-01-20	Janssen Pharmaceutica Nv	Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
TW202112774A (zh)	2019-06-14	2021-04-01	比利時商健生藥品公司	經取代之吡唑并－吡啶醯胺及其作為ｇｌｕｎ２ｂ受體調節劑之用途
CN114478210A (zh) *	2022-02-26	2022-05-13	江苏壹药新材料有限公司	一种7-氯萘-2-甲醛的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4010797A1 (de) *	1990-04-04	1991-10-10	Hoechst Ag	Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
CN1131031C (zh)	1996-03-08	2003-12-17	弗·哈夫曼-拉罗切有限公司	作为nmda受体亚型阻断剂的4－苯基3，6－二氢－2h－吡啶基衍生物的应用
CA2220649C (en)	1996-12-03	2007-02-13	F. Hoffmann-La Roche Ag	4-hydroxy-piperidine derivatives
US6015824A (en)	1998-02-10	2000-01-18	Hoffmann-La Roche Ag	Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders
TWI254043B (en)	1999-06-08	2006-05-01	Hoffmann La Roche	Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
ATE257827T1 (de) *	1999-07-21	2004-01-15	Hoffmann La Roche	Triazolderivate
US6339093B1 (en)	1999-10-08	2002-01-15	Hoffmann-La Roche Inc.	Isoquinoline derivatives
ATE274494T1 (de)	2000-04-20	2004-09-15	Hoffmann La Roche	Pyrrolidin und piperidin derivate für die behandlung von neurodegenerativen erkrankungen
US6432985B2 (en)	2000-04-25	2002-08-13	Hoffmann-La Roche Inc.	Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
US7022882B2 (en)	2000-10-06	2006-04-04	The Regents Of The University Of California	NMDA receptor channel blocker with neuroprotective activity
CA2381630A1 (en)	2001-04-23	2002-10-23	Leonard Theodore Meltzer	Method for preventing dyskinesias
DE10120159A1 (de)	2001-04-25	2002-10-31	Merck Patent Gmbh	NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives

2003
- 2003-05-09 US US10/434,955 patent/US7005432B2/en not_active Expired - Fee Related
- 2003-05-15 AR ARP030101685A patent/AR040010A1/es active IP Right Grant
- 2003-05-16 PL PL374224A patent/PL211340B1/pl unknown
- 2003-05-16 MX MXPA04011253A patent/MXPA04011253A/es active IP Right Grant
- 2003-05-16 RU RU2004136979/04A patent/RU2317294C2/ru not_active IP Right Cessation
- 2003-05-16 NZ NZ536310A patent/NZ536310A/en not_active IP Right Cessation
- 2003-05-16 JP JP2004505370A patent/JP4267569B2/ja not_active Expired - Fee Related
- 2003-05-16 AT AT03752750T patent/ATE329912T1/de active
- 2003-05-16 BR BR0311177-6A patent/BR0311177A/pt not_active IP Right Cessation
- 2003-05-16 CA CA002485926A patent/CA2485926C/en not_active Expired - Fee Related
- 2003-05-16 KR KR1020047018485A patent/KR100632868B1/ko not_active Expired - Fee Related
- 2003-05-16 CN CNB038111926A patent/CN1312151C/zh not_active Expired - Fee Related
- 2003-05-16 DK DK03752750T patent/DK1506190T3/da active
- 2003-05-16 PT PT03752750T patent/PT1506190E/pt unknown
- 2003-05-16 SI SI200330332T patent/SI1506190T1/sl unknown
- 2003-05-16 ES ES03752750T patent/ES2265581T3/es not_active Expired - Lifetime
- 2003-05-16 RS YUP-985/04A patent/RS51200B/sr unknown
- 2003-05-16 HR HR20041060 patent/HRP20041060B1/xx not_active IP Right Cessation
- 2003-05-16 DE DE60306152T patent/DE60306152T2/de not_active Expired - Lifetime
- 2003-05-16 EP EP03752750A patent/EP1506190B1/en not_active Expired - Lifetime
- 2003-05-16 WO PCT/EP2003/005151 patent/WO2003097637A1/en not_active Ceased
- 2003-05-16 ME MEP-767/08A patent/MEP76708A/xx unknown
- 2003-05-16 AU AU2003242542A patent/AU2003242542B2/en not_active Ceased
2004
- 2004-05-24 CL CL200401251A patent/CL2004001251A1/es unknown
- 2004-10-28 NO NO20044666A patent/NO329605B1/no not_active IP Right Cessation
- 2004-10-28 IL IL164922A patent/IL164922A/en not_active IP Right Cessation
- 2004-10-29 ZA ZA2004/08789A patent/ZA200408789B/en unknown
- 2004-11-11 TN TNP2004000224A patent/TNSN04224A1/fr unknown
- 2004-11-12 MA MA27943A patent/MA27117A1/fr unknown
2006
- 2006-08-22 CY CY20061101161T patent/CY1105159T1/el unknown

Also Published As

Publication number	Publication date
TNSN04224A1 (fr)	2007-03-12
CY1105159T1 (el)	2009-11-04
MXPA04011253A (es)	2005-01-25
IL164922A (en)	2012-01-31
HRP20041060B1 (en)	2012-11-30
RU2317294C2 (ru)	2008-02-20
CN1653062A (zh)	2005-08-10
DK1506190T3 (da)	2006-10-16
KR100632868B1 (ko)	2006-10-13
NZ536310A (en)	2007-08-31
CL2004001251A1 (es)	2005-04-22
NO329605B1 (no)	2010-11-22
IL164922A0 (en)	2005-12-18
AU2003242542B2 (en)	2008-10-16
RS98504A (sr)	2006-12-15
CA2485926A1 (en)	2003-11-27
EP1506190B1 (en)	2006-06-14
EP1506190A1 (en)	2005-02-16
HRP20041060A2 (en)	2005-06-30
PL374224A1 (en)	2005-10-03
US7005432B2 (en)	2006-02-28
MA27117A1 (fr)	2004-12-20
ES2265581T3 (es)	2007-02-16
ATE329912T1 (de)	2006-07-15
HK1080845A1 (en)	2006-05-04
KR20040106558A (ko)	2004-12-17
JP4267569B2 (ja)	2009-05-27
US20030229096A1 (en)	2003-12-11
RU2004136979A (ru)	2005-07-10
CA2485926C (en)	2009-11-24
JP2005532326A (ja)	2005-10-27
PT1506190E (pt)	2006-11-30
SI1506190T1 (sl)	2006-10-31
DE60306152T2 (de)	2007-04-26
AU2003242542A1 (en)	2003-12-02
ZA200408789B (en)	2005-12-28
DE60306152D1 (de)	2006-07-27
RS51200B (sr)	2010-12-31
NO20044666L (no)	2004-12-15
AR040010A1 (es)	2005-03-09
CN1312151C (zh)	2007-04-25
WO2003097637A1 (en)	2003-11-27
BR0311177A (pt)	2005-03-15
PL211340B1 (pl)	2012-05-31

Publication	Publication Date	Title
MEP76708A (en)	2011-12-20	(imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker
MA31593B1 (fr)	2010-08-02	Derives de 2-aza-bicyclo[3.3.0]octane
DE60336850D1 (en)	2011-06-01	Substituierte arylcyclopropylacetamide als glucokinaseaktivatoren
PH12014500937A1 (en)	2015-09-21	5-ht 1a receptor substype agonist
EP2039687A4 (en)	2010-09-08	THERAPEUTIC OR PROPHYLACTIC AGENT AGAINST MULTIPLE SCLEROSIS
MX2010002098A (es)	2010-03-30	Compuesto policiclico.
WO2002060879A3 (en)	2003-03-27	Bacterial gyrase inhibitors and uses thereof
SG11201407596TA (en)	2014-12-30	Conjugation reagents
NO20074311L (no)	2007-11-23	Kinazolinderivat med tyrosinkinase-inhiberendeaktivitet
MA30703B1 (fr)	2009-09-01	Dérivés de 5,6-bisaryl-2-pyridine-carboxamide, leur préparation et leur application en thérapeutique comme antagonistes des recepteurs a l'urotensine ii.
WO2001081309A3 (en)	2002-01-17	4-benzyl-1-[2-(4-hydroxy-phenoxy)-ethyl]-piperidine-3,4-diol
WO2006090273A3 (en)	2006-10-05	[1,8]naphthyridin-2-ones and related compounds with keto or hydroxyl linkers for the treatment of schizophrenia
WO2007096740A3 (en)	2007-10-18	Novel cephalosporins
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EA014959B3 (ru)	2014-10-30	Ингибиторы глицинового переносчика-1
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MX2009011449A (es)	2010-01-25	Agente terapeutico o profilactico para disquinesia.
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