NO20051040L - Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter - Google Patents

Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter

Info

Publication number
NO20051040L
NO20051040L NO20051040A NO20051040A NO20051040L NO 20051040 L NO20051040 L NO 20051040L NO 20051040 A NO20051040 A NO 20051040A NO 20051040 A NO20051040 A NO 20051040A NO 20051040 L NO20051040 L NO 20051040L
Authority
NO
Norway
Prior art keywords
alkylphosphocholines
combination
antitumor drugs
cytostatics
benign
Prior art date
Application number
NO20051040A
Other languages
English (en)
Other versions
NO335196B1 (no
Inventor
Juergen Engel
Eckhard Guenther
Herbert Sindermann
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of NO20051040L publication Critical patent/NO20051040L/no
Publication of NO335196B1 publication Critical patent/NO335196B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen angår alkylfosfokoliner i kombinasjon med antitumormedikamenter for behandling av benigne og maligne tumorsykdommer hos mennesker og pattedyr. Alkylfosfokoliner kan anvendes i en i kombinasjon ifølge oppfinnelsen med en eller en kombinasjon av ulike godkjente cytostatika. Foretrukne alkylfosfokoliner er representert ved formel II.
NO20051040A 2002-07-30 2005-02-25 Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter NO335196B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39961502P 2002-07-30 2002-07-30
PCT/EP2003/008346 WO2004012744A1 (de) 2002-07-30 2003-07-29 Anwendung von alkylphosphocholinen in kombination mit antitumormedikamenten

Publications (2)

Publication Number Publication Date
NO20051040L true NO20051040L (no) 2005-02-25
NO335196B1 NO335196B1 (no) 2014-10-20

Family

ID=31495746

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051040A NO335196B1 (no) 2002-07-30 2005-02-25 Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter

Country Status (26)

Country Link
US (3) US8389497B2 (no)
EP (2) EP2301551A1 (no)
JP (1) JP2005535688A (no)
KR (3) KR101066804B1 (no)
CN (1) CN1302780C (no)
AR (1) AR040717A1 (no)
AT (1) ATE516036T1 (no)
AU (2) AU2003253350B2 (no)
BR (1) BR0313048A (no)
CA (1) CA2493023C (no)
CY (1) CY1111902T1 (no)
DK (1) DK1545553T3 (no)
ES (1) ES2369535T3 (no)
HR (1) HRP20050184B1 (no)
IL (1) IL166329A (no)
MX (1) MXPA05001203A (no)
NO (1) NO335196B1 (no)
NZ (1) NZ538428A (no)
PL (1) PL375493A1 (no)
PT (1) PT1545553E (no)
RU (1) RU2005105693A (no)
SI (1) SI1545553T1 (no)
TW (1) TWI332007B (no)
UA (1) UA82322C2 (no)
WO (1) WO2004012744A1 (no)
ZA (1) ZA200500453B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383605B2 (en) 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
JP2005535688A (ja) 2002-07-30 2005-11-24 ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗腫瘍医薬との組合せにおけるアルキルホスホコリンの使用
DE10324911B4 (de) 2003-05-30 2005-08-18 Siemens Ag Röntgenvorrichtung mit partiellem digitalem Detektor und Verfahren zum Betrieb einer solchen
WO2006081452A2 (en) * 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
UA99434C2 (ru) * 2005-12-19 2012-08-27 Аетерна Центаріс Гмбх Применение производных алкилфосфолипидов со сниженной цитотоксичностью
EP1962862B1 (en) * 2005-12-19 2013-09-04 Æterna Zentaris GmbH Alkyl phospholipid derivatives with reduced cytotoxicity and uses therof
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
US8703179B2 (en) 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
EA032294B1 (ru) * 2007-07-30 2019-05-31 Арди Байосайенсиз, Инк. Способ получения полиморфной формы производного n-(ариламино)сульфонамида, фармацевтическая композиция, содержащая указанное производное, и способ лечения с помощью указанного производного
CA2746129A1 (en) * 2008-12-11 2010-06-17 Abraxis Bioscience, Llc Combination chemotherapy of nanoparticulate taxanes and inhibitors of pro-survival and/or inflammatory signals
WO2011123691A1 (en) 2010-03-31 2011-10-06 Keryx Biopharmaceuticals, Inc. Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE136783T1 (de) * 1991-07-04 1996-05-15 Asta Medica Ag Arzneimittel mit antineoplastischer wirkung enthaltend als wirkstoff octadecyl-(2-(n- methylpiperidino)-ethyl>-phosphat und verfahren zu dessen herstellung
US5942639A (en) * 1991-07-04 1999-08-24 Asta Medica Aktiengesellschaft Process for the preparation of alkylphosphocholines and the production thereof in pure form
US6172050B1 (en) * 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
JP3079993B2 (ja) * 1996-03-27 2000-08-21 日本電気株式会社 真空マイクロデバイスおよびその製造方法
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
DK1051159T3 (da) * 1998-01-22 2002-08-05 Zentaris Ag Faste farmaceutiske præparater indeholdende miltefosin til oral administration ved behandling af leishmaniasis
DE19959689A1 (de) * 1998-12-04 2000-06-08 Max Delbrueck Centrum Mittel zur Tumortherapie
JP2002532553A (ja) * 1998-12-21 2002-10-02 インケイサ．ソシエダ アノニマ 有害な胃腸副作用を引き起こさない有力な抗炎症剤としてのエーテルリゾリン脂質の使用
MX368013B (es) * 2001-02-19 2019-09-13 Novartis Ag Tratamiento de cáncer.
ATE450265T1 (de) * 2001-03-23 2009-12-15 Shire Canada Inc Pharmazeutische mischung zur behandlung von krebs,die dioxolan nukleosidanalogen enthält
WO2003005522A1 (es) 2001-07-04 2003-01-16 Acuna Arturo Tapones para sellado de ductos para redes electricas, telefonicas y de fibra optica.
ES2263835T3 (es) * 2002-01-02 2006-12-16 Nerviano Medical Sciences S.R.L. Terapia combinada contra tumores que comprende derivados de distamicina acriloil sustituidos e inhibidores proteina quinasa (serina/treonina quinasa).
JP2005535688A (ja) 2002-07-30 2005-11-24 ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗腫瘍医薬との組合せにおけるアルキルホスホコリンの使用
WO2005000318A2 (en) * 2003-06-23 2005-01-06 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
WO2006081452A2 (en) 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
UA99434C2 (ru) * 2005-12-19 2012-08-27 Аетерна Центаріс Гмбх Применение производных алкилфосфолипидов со сниженной цитотоксичностью
WO2011123691A1 (en) 2010-03-31 2011-10-06 Keryx Biopharmaceuticals, Inc. Perifosine and capecitabine as a combined treatment for cancer

Also Published As

Publication number Publication date
CN1302780C (zh) 2007-03-07
UA82322C2 (uk) 2008-04-10
NZ538428A (en) 2006-09-29
CA2493023A1 (en) 2004-02-12
EP2301551A1 (de) 2011-03-30
KR20130016413A (ko) 2013-02-14
US20040097470A1 (en) 2004-05-20
WO2004012744A1 (de) 2004-02-12
KR20050026028A (ko) 2005-03-14
US8551977B2 (en) 2013-10-08
RU2005105693A (ru) 2005-07-10
ATE516036T1 (de) 2011-07-15
AU2003253350B2 (en) 2008-06-26
US8389497B2 (en) 2013-03-05
CA2493023C (en) 2012-01-31
ES2369535T3 (es) 2011-12-01
US8507710B2 (en) 2013-08-13
PL375493A1 (en) 2005-11-28
TW200404073A (en) 2004-03-16
NO335196B1 (no) 2014-10-20
KR101066804B1 (ko) 2011-09-22
SI1545553T1 (sl) 2011-09-30
JP2005535688A (ja) 2005-11-24
EP1545553A1 (de) 2005-06-29
AU2003253350A1 (en) 2004-02-23
ZA200500453B (en) 2005-08-31
MXPA05001203A (es) 2005-06-08
BR0313048A (pt) 2005-06-14
AU2008203060A1 (en) 2008-07-31
IL166329A0 (en) 2006-01-15
EP1545553B1 (de) 2011-07-13
CY1111902T1 (el) 2015-11-04
IL166329A (en) 2012-08-30
AU2008203060B2 (en) 2011-04-21
HRP20050184A2 (en) 2005-04-30
AR040717A1 (es) 2005-04-20
US20100189784A1 (en) 2010-07-29
TWI332007B (en) 2010-10-21
HK1080751A1 (en) 2006-05-04
HRP20050184B1 (hr) 2014-04-11
KR20110102485A (ko) 2011-09-16
PT1545553E (pt) 2011-09-12
US20100190738A1 (en) 2010-07-29
DK1545553T3 (da) 2011-09-12
CN1671397A (zh) 2005-09-21

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