NO20051040L - Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter - Google Patents

Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter

Info

Publication number
NO20051040L
NO20051040L NO20051040A NO20051040A NO20051040L NO 20051040 L NO20051040 L NO 20051040L NO 20051040 A NO20051040 A NO 20051040A NO 20051040 A NO20051040 A NO 20051040A NO 20051040 L NO20051040 L NO 20051040L
Authority
NO
Norway
Prior art keywords
alkylphosphocholines
combination
antitumor drugs
cytostatics
benign
Prior art date
Application number
NO20051040A
Other languages
English (en)
Other versions
NO335196B1 (no
Inventor
Juergen Engel
Eckhard Guenther
Herbert Sindermann
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of NO20051040L publication Critical patent/NO20051040L/no
Publication of NO335196B1 publication Critical patent/NO335196B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen angår alkylfosfokoliner i kombinasjon med antitumormedikamenter for behandling av benigne og maligne tumorsykdommer hos mennesker og pattedyr. Alkylfosfokoliner kan anvendes i en i kombinasjon ifølge oppfinnelsen med en eller en kombinasjon av ulike godkjente cytostatika. Foretrukne alkylfosfokoliner er representert ved formel II.
NO20051040A 2002-07-30 2005-02-25 Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter NO335196B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39961502P 2002-07-30 2002-07-30
PCT/EP2003/008346 WO2004012744A1 (de) 2002-07-30 2003-07-29 Anwendung von alkylphosphocholinen in kombination mit antitumormedikamenten

Publications (2)

Publication Number Publication Date
NO20051040L true NO20051040L (no) 2005-02-25
NO335196B1 NO335196B1 (no) 2014-10-20

Family

ID=31495746

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051040A NO335196B1 (no) 2002-07-30 2005-02-25 Anvendelse av alkylfosfokoliner i kombinasjon med antitumormedikamenter

Country Status (26)

Country Link
US (3) US8389497B2 (no)
EP (2) EP1545553B1 (no)
JP (1) JP2005535688A (no)
KR (3) KR20130016413A (no)
CN (1) CN1302780C (no)
AR (1) AR040717A1 (no)
AT (1) ATE516036T1 (no)
AU (2) AU2003253350B2 (no)
BR (1) BR0313048A (no)
CA (1) CA2493023C (no)
CY (1) CY1111902T1 (no)
DK (1) DK1545553T3 (no)
ES (1) ES2369535T3 (no)
HR (1) HRP20050184B1 (no)
IL (1) IL166329A (no)
MX (1) MXPA05001203A (no)
NO (1) NO335196B1 (no)
NZ (1) NZ538428A (no)
PL (1) PL375493A1 (no)
PT (1) PT1545553E (no)
RU (1) RU2005105693A (no)
SI (1) SI1545553T1 (no)
TW (1) TWI332007B (no)
UA (1) UA82322C2 (no)
WO (1) WO2004012744A1 (no)
ZA (1) ZA200500453B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383605B2 (en) 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
MXPA05001203A (es) 2002-07-30 2005-06-08 Zentaris Gmbh Uso de alquilfosfocolinas en combinacion con medicamentos antitumorales.
DE10324911B4 (de) 2003-05-30 2005-08-18 Siemens Ag Röntgenvorrichtung mit partiellem digitalem Detektor und Verfahren zum Betrieb einer solchen
WO2006081452A2 (en) * 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
CA2632449A1 (en) 2005-12-19 2007-06-28 Aeterna Zentaris Gmbh Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
UA99434C2 (ru) * 2005-12-19 2012-08-27 Аетерна Центаріс Гмбх Применение производных алкилфосфолипидов со сниженной цитотоксичностью
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
US8703179B2 (en) 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
KR20150091434A (ko) * 2007-07-30 2015-08-10 아디아 바이오사이언스즈 인크. 다형체를 포함하는, ｍｅｋ의 억제제로서의 ｎ-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법
US20120128732A1 (en) * 2008-12-11 2012-05-24 Vuong Trieu Combinations and modes of administration of therapeutic agents and combination therapy
CA2794513A1 (en) 2010-03-31 2011-10-06 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0521353T3 (da) * 1991-07-04 1996-05-13 Asta Medica Ag Lægemiddel med antineoplastisk virkning, der som virksomt stof indeholder octadecyl-(2-(N-metylpiperidino)-ethyl)-phosphat og fremgangsmåde til fremstilling deraf
US5942639A (en) * 1991-07-04 1999-08-24 Asta Medica Aktiengesellschaft Process for the preparation of alkylphosphocholines and the production thereof in pure form
US6172050B1 (en) * 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
JP3079993B2 (ja) * 1996-03-27 2000-08-21 日本電気株式会社 真空マイクロデバイスおよびその製造方法
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
PL189654B1 (pl) * 1998-01-22 2005-09-30 Zentaris Gmbh Zastosowanie miltefosyny do wytwarzania leków
PT1135193E (pt) * 1998-12-04 2003-01-31 Max Delbrueck Centrum Agentes para o tratamento de tumores a base de lipossomas e compreendendo tamoxifeno
DE69924146D1 (de) 1998-12-21 2005-04-14 Inkeysa Sa Etherlysophospholipide zur behandlung von chronischen entzündlichen erkrankungen
DK3351246T3 (da) * 2001-02-19 2019-06-03 Novartis Pharma Ag Rapamycinderivat til behandling af en solid tumor, som er associeret med dereguleret angionese
US6800639B2 (en) * 2001-03-23 2004-10-05 Shire Biochem Inc. Pharmaceutical combination for the treatment of cancer
WO2003005522A1 (es) 2001-07-04 2003-01-16 Acuna Arturo Tapones para sellado de ductos para redes electricas, telefonicas y de fibra optica.
HUP0402639A3 (en) * 2002-01-02 2012-02-28 Nerviano Medical Sciences Srl Antitumor combination comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors and its use
MXPA05001203A (es) 2002-07-30 2005-06-08 Zentaris Gmbh Uso de alquilfosfocolinas en combinacion con medicamentos antitumorales.
WO2005000318A2 (en) * 2003-06-23 2005-01-06 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
WO2006081452A2 (en) 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
UA99434C2 (ru) 2005-12-19 2012-08-27 Аетерна Центаріс Гмбх Применение производных алкилфосфолипидов со сниженной цитотоксичностью
CA2794513A1 (en) 2010-03-31 2011-10-06 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Also Published As

Publication number Publication date
EP1545553B1 (de) 2011-07-13
PL375493A1 (en) 2005-11-28
HRP20050184B1 (hr) 2014-04-11
US8507710B2 (en) 2013-08-13
KR20110102485A (ko) 2011-09-16
IL166329A0 (en) 2006-01-15
NO335196B1 (no) 2014-10-20
US8389497B2 (en) 2013-03-05
BR0313048A (pt) 2005-06-14
SI1545553T1 (sl) 2011-09-30
ZA200500453B (en) 2005-08-31
US20100189784A1 (en) 2010-07-29
KR101066804B1 (ko) 2011-09-22
HK1080751A1 (en) 2006-05-04
HRP20050184A2 (en) 2005-04-30
CA2493023C (en) 2012-01-31
CA2493023A1 (en) 2004-02-12
TW200404073A (en) 2004-03-16
DK1545553T3 (da) 2011-09-12
IL166329A (en) 2012-08-30
PT1545553E (pt) 2011-09-12
ATE516036T1 (de) 2011-07-15
AU2008203060A1 (en) 2008-07-31
AU2003253350A1 (en) 2004-02-23
AU2003253350B2 (en) 2008-06-26
CN1671397A (zh) 2005-09-21
RU2005105693A (ru) 2005-07-10
KR20050026028A (ko) 2005-03-14
TWI332007B (en) 2010-10-21
MXPA05001203A (es) 2005-06-08
US20040097470A1 (en) 2004-05-20
EP1545553A1 (de) 2005-06-29
AU2008203060B2 (en) 2011-04-21
UA82322C2 (uk) 2008-04-10
WO2004012744A1 (de) 2004-02-12
KR20130016413A (ko) 2013-02-14
ES2369535T3 (es) 2011-12-01
US8551977B2 (en) 2013-10-08
CY1111902T1 (el) 2015-11-04
JP2005535688A (ja) 2005-11-24
US20100190738A1 (en) 2010-07-29
EP2301551A1 (de) 2011-03-30
NZ538428A (en) 2006-09-29
CN1302780C (zh) 2007-03-07
AR040717A1 (es) 2005-04-20

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