NO20064895L - 6,6-Bisykliske ring-substituerte heterobisykliske protein-kinase inhibitorer - Google Patents
6,6-Bisykliske ring-substituerte heterobisykliske protein-kinase inhibitorerInfo
- Publication number
- NO20064895L NO20064895L NO20064895A NO20064895A NO20064895L NO 20064895 L NO20064895 L NO 20064895L NO 20064895 A NO20064895 A NO 20064895A NO 20064895 A NO20064895 A NO 20064895A NO 20064895 L NO20064895 L NO 20064895L
- Authority
- NO
- Norway
- Prior art keywords
- bisyclic
- ring
- protein kinase
- kinase inhibitors
- substituted heterobicyclic
- Prior art date
Links
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 125000002618 bicyclic heterocycle group Chemical class 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55925004P | 2004-04-02 | 2004-04-02 | |
| PCT/US2005/010606 WO2005097800A1 (fr) | 2004-04-02 | 2005-03-31 | Inhibiteurs de la proteine kinase heterobicycliques a substitution de noyau bicyclique 6,6 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20064895L true NO20064895L (no) | 2006-12-19 |
Family
ID=34967819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20064895A NO20064895L (no) | 2004-04-02 | 2006-10-26 | 6,6-Bisykliske ring-substituerte heterobisykliske protein-kinase inhibitorer |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US7534797B2 (fr) |
| EP (4) | EP2168968B1 (fr) |
| JP (2) | JP4832426B2 (fr) |
| KR (1) | KR101079272B1 (fr) |
| CN (2) | CN102924458B (fr) |
| AP (1) | AP2139A (fr) |
| AR (1) | AR048518A1 (fr) |
| AT (1) | ATE433979T1 (fr) |
| AU (1) | AU2005230818B2 (fr) |
| BR (1) | BRPI0509576A (fr) |
| CA (1) | CA2561950C (fr) |
| CY (1) | CY1109372T1 (fr) |
| DE (1) | DE602005014964D1 (fr) |
| DK (1) | DK1740591T3 (fr) |
| EA (1) | EA012873B1 (fr) |
| ES (2) | ES2652440T3 (fr) |
| HR (1) | HRP20090495T1 (fr) |
| IL (1) | IL178419A0 (fr) |
| MX (1) | MXPA06011423A (fr) |
| MY (1) | MY143225A (fr) |
| NO (1) | NO20064895L (fr) |
| PL (2) | PL1740591T3 (fr) |
| PT (2) | PT2168968T (fr) |
| RU (1) | RU2379308C2 (fr) |
| SG (1) | SG163576A1 (fr) |
| SI (1) | SI1740591T1 (fr) |
| TW (2) | TWI378934B (fr) |
| UA (1) | UA89493C2 (fr) |
| WO (1) | WO2005097800A1 (fr) |
Families Citing this family (168)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7429596B2 (en) * | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
| UA83509C2 (en) * | 2003-10-15 | 2008-07-25 | Оси Фармасьютикалз, Инк. | Imidazopyrazines as tyrosine kinase inhibitors |
| EP2168968B1 (fr) | 2004-04-02 | 2017-08-23 | OSI Pharmaceuticals, LLC | Inhibiteurs hétérobicycliques de la protéine kinase à anneau bicyclique substitué en 6,6 |
| TW200613306A (en) | 2004-07-20 | 2006-05-01 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
| EP1831225A2 (fr) * | 2004-11-19 | 2007-09-12 | The Regents of the University of California | Pyrazolopyrimidines anti-inflammatoires |
| ES2365869T3 (es) * | 2005-11-17 | 2011-10-11 | OSI Pharmaceuticals, LLC | COMPUESTOS BICÍCLICOS FUSIONADOS INHIBIDORES DE LA mTOR. |
| AR057960A1 (es) * | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
| TW200730529A (en) * | 2005-12-07 | 2007-08-16 | Osi Pharm Inc | Process to prepare substituted imidazopyrazine compounds |
| US8575164B2 (en) * | 2005-12-19 | 2013-11-05 | OSI Pharmaceuticals, LLC | Combination cancer therapy |
| JP2009520028A (ja) * | 2005-12-19 | 2009-05-21 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | Ｉｇｆｒ抑制剤および抗癌剤の併用 |
| ES2545907T3 (es) * | 2005-12-29 | 2015-09-16 | Abbvie Inc. | Inhibidores de proteína quinasa |
| CN101003537A (zh) * | 2006-01-17 | 2007-07-25 | 上海恒瑞医药有限公司 | 吡咯并哒嗪类衍生物及其制备方法和用途 |
| TW200738725A (en) * | 2006-01-25 | 2007-10-16 | Osi Pharm Inc | Unsaturated mTOR inhibitors |
| WO2007114926A2 (fr) | 2006-04-04 | 2007-10-11 | The Regents Of The University Of California | Antagonistes de la kinase |
| DE102006016426A1 (de) * | 2006-04-07 | 2007-10-11 | Merck Patent Gmbh | Neuartige Cyclobutyl-Verbindungen als Kinase-Inhibitoren |
| EP2258700A1 (fr) | 2006-05-09 | 2010-12-08 | Pfizer Products Inc. | Dérivés d'acides aminés cycloalkyles et compositions pharmaceutiques les contenant |
| EP2057164A1 (fr) | 2006-08-07 | 2009-05-13 | Incyte Corporation | Utilisation de triazolotriazines en tant qu'inhibiteurs des kinases |
| DE102006043443A1 (de) * | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| RS54510B1 (sr) | 2006-11-22 | 2016-06-30 | Incyte Holdings Corporation | Imidazotriazini i imidazopirimidini kao inhibitori kinaze |
| WO2008076143A1 (fr) * | 2006-12-18 | 2008-06-26 | Osi Pharmaceuticals, Inc. | Combinaison d'un inhibiteur de l'igfr et d'un agent anticancéreux |
| TW200900070A (en) * | 2007-02-27 | 2009-01-01 | Osi Pharm Inc | Combination cancer therapy |
| CN101730700A (zh) * | 2007-05-09 | 2010-06-09 | 雅培制药有限公司 | 用作蛋白激酶抑制剂的稠合杂环化合物 |
| WO2008141140A1 (fr) * | 2007-05-09 | 2008-11-20 | Abbott Laboratories | Composés hétérocycliques condensés utilisés en tant qu'inhibiteurs de protéines kinases |
| US8124759B2 (en) | 2007-05-09 | 2012-02-28 | Abbott Laboratories | Inhibitors of protein kinases |
| US20090274698A1 (en) * | 2007-07-06 | 2009-11-05 | Shripad Bhagwat | Combination anti-cancer therapy |
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