NO20071794L - Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer - Google Patents

Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer

Info

Publication number: NO20071794L
Authority: NO; Norway
Prior art keywords: treatment; cdk2; breast; angiogenesis; lung
Prior art date: 2004-10-13

Application number

NO20071794A

Other languages

English (en)

Norwegian (no)

Inventor

Peter Michael Wovkulich

Jin-Jun Liu

Kin-Chun Luk

Giacomo Pizzolato

Yi Ren

Kshitij Chhabilbhai Thakkar

Zhuming Zhang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-13

Filing date

2007-04-03

Publication date

2007-07-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20071794(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-04-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2007-07-10 Publication of NO20071794L publication Critical patent/NO20071794L/no

Links

206010006187 Breast cancer Diseases 0.000 title abstract 2
208000026310 Breast neoplasm Diseases 0.000 title abstract 2
102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 title abstract 2
108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 title abstract 2
208000000236 Prostatic Neoplasms Diseases 0.000 title abstract 2
230000033115 angiogenesis Effects 0.000 title abstract 2
210000000481 breast Anatomy 0.000 title abstract 2
208000020816 lung neoplasm Diseases 0.000 title abstract 2
201000003741 Gastrointestinal carcinoma Diseases 0.000 title 1
206010058467 Lung neoplasm malignant Diseases 0.000 title 1
206010060862 Prostate cancer Diseases 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
201000002313 intestinal cancer Diseases 0.000 title 1
210000004072 lung Anatomy 0.000 title 1
201000005202 lung cancer Diseases 0.000 title 1
QBCJSMSLBBCZGU-UHFFFAOYSA-N pyrazolo[3,4-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=NN=C3C=CC2=C1 QBCJSMSLBBCZGU-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
102000001253 Protein Kinase Human genes 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
210000001072 colon Anatomy 0.000 abstract 1
208000029742 colonic neoplasm Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000002307 prostate Anatomy 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20071794A 2004-10-13 2007-04-03 Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer NO20071794L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61817404P	2004-10-13	2004-10-13
PCT/EP2005/010653 WO2006040036A1 (en)	2004-10-13	2005-10-04	Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer

Publications (1)

Publication Number	Publication Date
NO20071794L true NO20071794L (no)	2007-07-10

Family

ID=35311946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20071794A NO20071794L (no)	2004-10-13	2007-04-03	Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer

Country Status (25)

Country	Link
US (1)	US7524840B2 (de)
EP (1)	EP1802625B1 (de)
JP (1)	JP2008515939A (de)
KR (1)	KR100858262B1 (de)
CN (2)	CN101039946B (de)
AR (1)	AR051326A1 (de)
AT (1)	ATE398619T1 (de)
AU (1)	AU2005293818A1 (de)
BR (1)	BRPI0518152A (de)
CA (1)	CA2582985A1 (de)
DE (1)	DE602005007623D1 (de)
DK (1)	DK1802625T3 (de)
ES (1)	ES2308551T3 (de)
HR (1)	HRP20080429T3 (de)
IL (1)	IL182423A0 (de)
MX (1)	MX2007004464A (de)
NO (1)	NO20071794L (de)
NZ (1)	NZ554353A (de)
PL (1)	PL1802625T3 (de)
PT (1)	PT1802625E (de)
RU (1)	RU2394826C2 (de)
SI (1)	SI1802625T1 (de)
TW (1)	TWI309652B (de)
WO (1)	WO2006040036A1 (de)
ZA (1)	ZA200702973B (de)

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SG10202003901UA (en)	2005-12-13	2020-05-28	Incyte Holdings Corp	Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
KR20150036210A (ko)	2007-06-13	2015-04-07	인사이트 코포레이션	야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염
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KR20100073454A (ko) *	2008-12-23	2010-07-01	국립암센터	트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물
AR076794A1 (es)	2009-05-22	2011-07-06	Incyte Corp	Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
SI2432472T1 (sl) *	2009-05-22	2019-11-29	Incyte Holdings Corp	3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
TW201113285A (en) *	2009-09-01	2011-04-16	Incyte Corp	Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
EP3354652B1 (de)	2010-03-10	2020-05-06	Incyte Holdings Corporation	Piperidin-4-yl azetidin-derivate als jak1-inhibitoren
JP2011201794A (ja) *	2010-03-24	2011-10-13	Fujifilm Corp	５−アミノピラゾール誘導体及びその塩の製造方法
PE20130216A1 (es)	2010-05-21	2013-02-27	Incyte Corp	Formulacion topica para un inhibidor de jak
PE20140146A1 (es)	2010-11-19	2014-02-06	Incyte Corp	Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
US9034884B2 (en)	2010-11-19	2015-05-19	Incyte Corporation	Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
CN103797010B (zh)	2011-06-20	2016-02-24	因塞特控股公司	作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
TW201313721A (zh)	2011-08-18	2013-04-01	Incyte Corp	作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk)	2011-09-07	2016-06-24	Інсайт Холдінгс Корпорейшн	Способи і проміжні сполуки для отримання інгібіторів jak
CN102603743B (zh) *	2012-02-24	2014-05-28	南京天易生物科技有限公司	抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
TW201406761A (zh)	2012-05-18	2014-02-16	Incyte Corp	做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
CN103626761B (zh) *	2012-08-24	2015-07-29	上海医药工业研究院	苯并吡啶氮杂卓类化合物及其作为抗肿瘤药物的应用
PH12020551186B1 (en)	2012-11-15	2024-03-20	Incyte Holdings Corp	Sustained-release dosage forms of ruxolitinib
RS62867B1 (sr)	2013-03-06	2022-02-28	Incyte Holdings Corp	Postupci i intermedijeri za dobijanje inhibitora jak
SMT202000315T1 (it)	2013-08-07	2020-07-08	Incyte Corp	Forme di dosaggio a rilascio prolungato per un inibitore di jak1
US9498467B2 (en)	2014-05-30	2016-11-22	Incyte Corporation	Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
US11155555B2 (en)	2015-09-23	2021-10-26	Janssen Pharmaceutica Nv	Compounds
EP3353164B1 (de)	2015-09-23	2021-11-03	Janssen Pharmaceutica, N.V.	Bi-heteroaryl-substituierte 1,4-benzodiazepine und ihre anwendung in der krebsbehandlung
CN106928040A (zh) *	2015-12-31	2017-07-07	上海医药工业研究院	Sglt2抑制剂中间体的制备方法
CA3046809A1 (en) *	2016-12-12	2018-06-21	The University Of Sydney	Non-peptide oxytocin receptor agonists
RS66947B1 (sr) *	2016-12-13	2025-07-31	Transthera Sciences Nanjing Inc	Jedinjenje inhibitora više kinaza, i njegova kristalna forma i upotreba
CN109020980B (zh) *	2017-06-09	2020-11-20	华东师范大学	一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物
WO2019113487A1 (en)	2017-12-08	2019-06-13	Incyte Corporation	Low dose combination therapy for treatment of myeloproliferative neoplasms
SG11202007164UA (en)	2018-01-30	2020-08-28	Incyte Corp	Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
SMT202400306T1 (it)	2018-03-30	2024-09-16	Incyte Corp	Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
US11833155B2 (en)	2020-06-03	2023-12-05	Incyte Corporation	Combination therapy for treatment of myeloproliferative neoplasms
WO2022113003A1 (en)	2020-11-27	2022-06-02	Rhizen Pharmaceuticals Ag	Cdk inhibitors
WO2022149057A1 (en)	2021-01-05	2022-07-14	Rhizen Pharmaceuticals Ag	Cdk inhibitors
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2005
- 2005-10-04 KR KR1020077008406A patent/KR100858262B1/ko not_active Expired - Fee Related
- 2005-10-04 AU AU2005293818A patent/AU2005293818A1/en not_active Abandoned
- 2005-10-04 HR HR20080429T patent/HRP20080429T3/xx unknown
- 2005-10-04 CN CN2005800351219A patent/CN101039946B/zh not_active Expired - Fee Related
- 2005-10-04 PL PL05792946T patent/PL1802625T3/pl unknown
- 2005-10-04 DE DE602005007623T patent/DE602005007623D1/de not_active Expired - Lifetime
- 2005-10-04 CA CA002582985A patent/CA2582985A1/en not_active Abandoned
- 2005-10-04 BR BRPI0518152-6A patent/BRPI0518152A/pt not_active IP Right Cessation
- 2005-10-04 CN CN2010101585349A patent/CN101899049A/zh active Pending
- 2005-10-04 SI SI200530331T patent/SI1802625T1/sl unknown
- 2005-10-04 ES ES05792946T patent/ES2308551T3/es not_active Expired - Lifetime
- 2005-10-04 NZ NZ554353A patent/NZ554353A/en not_active IP Right Cessation
- 2005-10-04 AT AT05792946T patent/ATE398619T1/de active
- 2005-10-04 DK DK05792946T patent/DK1802625T3/da active
- 2005-10-04 WO PCT/EP2005/010653 patent/WO2006040036A1/en not_active Ceased
- 2005-10-04 JP JP2007536037A patent/JP2008515939A/ja active Pending
- 2005-10-04 PT PT05792946T patent/PT1802625E/pt unknown
- 2005-10-04 RU RU2007117770/04A patent/RU2394826C2/ru not_active IP Right Cessation
- 2005-10-04 MX MX2007004464A patent/MX2007004464A/es active IP Right Grant
- 2005-10-04 EP EP05792946A patent/EP1802625B1/de not_active Expired - Lifetime
- 2005-10-05 US US11/244,251 patent/US7524840B2/en not_active Expired - Fee Related
- 2005-10-11 AR ARP050104254A patent/AR051326A1/es not_active Application Discontinuation
- 2005-10-12 TW TW094135532A patent/TWI309652B/zh not_active IP Right Cessation
2007
- 2007-04-03 NO NO20071794A patent/NO20071794L/no not_active Application Discontinuation
- 2007-04-10 IL IL182423A patent/IL182423A0/en unknown
- 2007-04-11 ZA ZA200702973A patent/ZA200702973B/xx unknown

Also Published As

Publication number	Publication date
RU2007117770A (ru)	2008-11-20
HRP20080429T3 (en)	2008-09-30
WO2006040036A1 (en)	2006-04-20
KR100858262B1 (ko)	2008-09-11
JP2008515939A (ja)	2008-05-15
CN101899049A (zh)	2010-12-01
PL1802625T3 (pl)	2008-12-31
NZ554353A (en)	2010-01-29
US20060079511A1 (en)	2006-04-13
US7524840B2 (en)	2009-04-28
PT1802625E (pt)	2008-08-06
EP1802625B1 (de)	2008-06-18
ATE398619T1 (de)	2008-07-15
BRPI0518152A (pt)	2008-11-04
RU2394826C2 (ru)	2010-07-20
AR051326A1 (es)	2007-01-03
EP1802625A1 (de)	2007-07-04
SI1802625T1 (sl)	2008-10-31
AU2005293818A1 (en)	2006-04-20
CN101039946A (zh)	2007-09-19
KR20070054243A (ko)	2007-05-28
CN101039946B (zh)	2010-12-08
CA2582985A1 (en)	2006-04-20
ES2308551T3 (es)	2008-12-01
IL182423A0 (en)	2007-07-24
TW200628469A (en)	2006-08-16
TWI309652B (en)	2009-05-11
DE602005007623D1 (de)	2008-07-31
ZA200702973B (en)	2009-09-30
DK1802625T3 (da)	2008-09-01
HK1108284A1 (en)	2008-05-02
MX2007004464A (es)	2007-05-07

Legal Events

Date	Code	Title	Description
2012-06-04	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20071794L (no)	2007-07-10	Disubstituerte pyrazolobenzodiazepiner nyttige som inhibitorer for CDK2 og angiogenese, og for behandling av bryst, tarm, lunge og prostata cancer
BRPI0511975A (pt)	2008-01-22	pirazolopirimidinas
IL260127B (en)	2022-04-01	mek inhibitors and methods of using them
MY149512A (en)	2013-09-13	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
WO2006123113A3 (en)	2007-01-04	Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors
NO20081952L (no)	2008-06-20	Substituerte pyrazolforbindelser
GEP20125368B (en)	2012-01-10	Kinase inhibitors
MX2008005398A (es)	2008-09-24	Derivados de 4-(3-amino-pirazol)-pirimidina para uso como inhibidores de tirosina cinasa en el tratamiento de cancer.
MX2009005011A (es)	2009-05-20	Imidazopirazinas como inhibidores de proteina quinasa.
MXPA05007352A (es)	2006-02-17	Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion.
PL1853602T3 (pl)	2010-11-30	Związki chemiczne
PL1853588T3 (pl)	2008-11-28	Związki chemiczne
TNSN08020A1 (en)	2009-07-14	1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them
MXPA05013076A (es)	2006-03-09	Compuestos de isoindolina-1-ona como inhibidores de cinasa.
NO20044526L (no)	2004-12-21	Hemisterlinderivater og anvendelser derav
MXPA05009151A (es)	2005-10-20	Inhibidores de cinasa heterociclica.
EA200701930A1 (ru)	2008-02-28	Производные пиримидина для лечения гиперпролиферативных нарушений
ATE419242T1 (de)	2009-01-15	Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
TW200716545A (en)	2007-05-01	Indole derivatives having anti-tumor activity
WO2005103034A8 (en)	2006-11-02	Novel piperidine substituted diaminothiazoles
UA101464C2 (en)	2013-04-10	Phosphatidylinositol 3-kinase inhibitors and methods of their use
TH82893A (th)	2007-02-08	ไดซับสทิทิวเต็ดไพราโซโลเบนโซไดอะเซพีน
UA96742C2 (en)	2011-12-12	Mek inhibitors and use thereof
ATE540951T1 (de)	2012-01-15	Substituierte 7,8-dihydro-1h-pyrimidoä4,5- büdiazepin-4-amine als kinase inhibitoren