NO20073099L - Amino-imidazoloner for inhibering av beta-sekretase - Google Patents
Amino-imidazoloner for inhibering av beta-sekretaseInfo
- Publication number
- NO20073099L NO20073099L NO20073099A NO20073099A NO20073099L NO 20073099 L NO20073099 L NO 20073099L NO 20073099 A NO20073099 A NO 20073099A NO 20073099 A NO20073099 A NO 20073099A NO 20073099 L NO20073099 L NO 20073099L
- Authority
- NO
- Norway
- Prior art keywords
- secretase
- imidazolones
- inhibition
- beta
- amino
- Prior art date
Links
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract 2
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract 2
- ZMLJHXQHPNGPJP-UHFFFAOYSA-N 4-aminoimidazol-2-one Chemical class NC1=NC(=O)N=C1 ZMLJHXQHPNGPJP-UHFFFAOYSA-N 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 102100021257 Beta-secretase 1 Human genes 0.000 abstract 1
- 206010019909 Hernia Diseases 0.000 abstract 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 abstract 1
- -1 aminoimidazolone compound Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64380505P | 2005-01-14 | 2005-01-14 | |
| PCT/US2006/000656 WO2006076284A2 (en) | 2005-01-14 | 2006-01-09 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20073099L true NO20073099L (no) | 2007-07-31 |
Family
ID=36581776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073099A NO20073099L (no) | 2005-01-14 | 2007-06-18 | Amino-imidazoloner for inhibering av beta-sekretase |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7563796B2 (pt) |
| EP (2) | EP2264036A1 (pt) |
| JP (1) | JP2008526966A (pt) |
| KR (1) | KR20070095948A (pt) |
| CN (1) | CN101103034A (pt) |
| AR (1) | AR052458A1 (pt) |
| AU (1) | AU2006205127A1 (pt) |
| BR (1) | BRPI0606690A2 (pt) |
| CA (1) | CA2593515A1 (pt) |
| CR (1) | CR9244A (pt) |
| GT (1) | GT200600009A (pt) |
| IL (1) | IL183938A0 (pt) |
| MX (1) | MX2007008555A (pt) |
| NO (1) | NO20073099L (pt) |
| PA (1) | PA8660001A1 (pt) |
| PE (1) | PE20060842A1 (pt) |
| RU (1) | RU2007126570A (pt) |
| TW (1) | TW200637866A (pt) |
| WO (1) | WO2006076284A2 (pt) |
| ZA (1) | ZA200705783B (pt) |
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| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| ATE444962T1 (de) * | 2004-06-16 | 2009-10-15 | Wyeth Corp | Amino-5,5-diphenylimidazolon-derivate zur beta- sekretase-hemmung |
| JP2008503460A (ja) * | 2004-06-16 | 2008-02-07 | ワイス | β−セクレターゼのインヒビターとしてのジフェニルイミダゾピリミジンおよびイミダゾールアミン |
| BRPI0607094A2 (pt) * | 2005-02-01 | 2009-08-04 | Wyeth Corp | composto da fórmula i; uso do composto para o tratamento de uma doença ou distúrbio associado à atividade excessiva de bace em um paciente que dele necessita; uso do composto para modular a atividade de bace; e composição farmacêutica |
| CN101146769A (zh) | 2005-02-14 | 2008-03-19 | 惠氏公司 | 作为β-分泌酶抑制剂的唑基酰基胍 |
| SG162790A1 (en) | 2005-06-14 | 2010-07-29 | Schering Corp | Aspartyl protease inhibitors |
| EP1896032B1 (en) | 2005-06-14 | 2012-10-31 | Merck Sharp & Dohme Corp. | The preparation and use of compounds as protease inhibitors |
| TW200738683A (en) * | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| JP2009500329A (ja) * | 2005-06-30 | 2009-01-08 | ワイス | アミノ−５−（６員）ヘテロアリールイミダゾロン化合物およびβ−セレクターゼ調節のためのその使用 |
| TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| AU2006294620A1 (en) * | 2005-09-26 | 2007-04-05 | Wyeth | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace) |
| CN101346357B (zh) | 2005-10-25 | 2014-04-02 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
| JP2009520027A (ja) * | 2005-12-19 | 2009-05-21 | ワイス | ２−アミノ−５−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用 |
| WO2007100536A1 (en) * | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
| US8168641B2 (en) | 2006-06-12 | 2012-05-01 | Schering Corporation | Aspartyl protease inhibitors |
| TW200815449A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds II |
| TW200815443A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds I |
| TW200808796A (en) * | 2006-06-14 | 2008-02-16 | Astrazeneca Ab | New compounds III |
| TW200815447A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
| TW200815349A (en) | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
| US7700606B2 (en) * | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
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| MX2009003102A (es) * | 2006-09-21 | 2009-04-01 | Wyeth Corp | INDOLILALQUILPIRIDIN-2-AMINAS PARA LA INHIBICION DE ß-SECRETASA. |
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| MX2009006228A (es) | 2006-12-12 | 2009-06-22 | Schering Corp | Inhibidores de aspartil proteasa. |
| CL2008000784A1 (es) * | 2007-03-20 | 2008-05-30 | Wyeth Corp | Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co |
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| JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
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| KR101324426B1 (ko) | 2008-06-13 | 2013-10-31 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
| JP5417860B2 (ja) * | 2008-08-26 | 2014-02-19 | 住友化学株式会社 | α−ヒドロキシエステル類の製造方法 |
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| US8883782B2 (en) | 2010-03-15 | 2014-11-11 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use |
| JP5584352B2 (ja) | 2010-03-15 | 2014-09-03 | アムジエン・インコーポレーテツド | β−セクレターゼ調節剤としてのアミノ−ジヒドロオキサジン系およびアミノ−ジヒドロチアジン系スピロ化合物ならびにそれらの医学的用途 |
| KR101730937B1 (ko) | 2010-06-09 | 2017-04-27 | 얀센 파마슈티카 엔.브이. | 베타-세크레타아제(ｂａｃｅ) 저해제로 유용한 5,6-디하이드로-2ｈ-[1,4]옥사진-3-일-아민 유도체 |
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| EP2643299B1 (en) | 2010-11-22 | 2016-06-22 | Noscira, S.A. | Bipyridine sulfonamide derivatives for the treatment of neurodegenerative diseases or conditions |
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| BR112013015430A2 (pt) | 2010-12-22 | 2016-09-20 | Janssen Pharmaceutica Nv | derivados de 5,6-diidro-imidazo[1,2-a]pirazin-8-ilamina úteis como inibidores de beta-secretase (bace) |
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| CN103415519B (zh) * | 2011-03-01 | 2016-03-02 | 詹森药业有限公司 | 作为β-分泌酶(BACE)抑制剂有用的6，7-二氢-吡唑[1，5-a]吡嗪-4-基胺衍生物 |
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| CN105283457B (zh) * | 2013-06-12 | 2018-09-18 | 詹森药业有限公司 | 作为β-分泌酶(BACE)抑制剂的4-氨基-6-苯基-5,6-二氢咪唑并[1,5-A]吡嗪衍生物 |
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| TW200730523A (en) | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| AU2006294620A1 (en) | 2005-09-26 | 2007-04-05 | Wyeth | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace) |
| JP2009520027A (ja) | 2005-12-19 | 2009-05-21 | ワイス | ２−アミノ−５−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用 |
| WO2007100536A1 (en) | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
| US7700606B2 (en) | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
-
2006
- 2006-01-09 EP EP10173563A patent/EP2264036A1/en not_active Withdrawn
- 2006-01-09 CN CNA2006800021783A patent/CN101103034A/zh active Pending
- 2006-01-09 JP JP2007551307A patent/JP2008526966A/ja not_active Withdrawn
- 2006-01-09 MX MX2007008555A patent/MX2007008555A/es unknown
- 2006-01-09 BR BRPI0606690-9A patent/BRPI0606690A2/pt not_active IP Right Cessation
- 2006-01-09 AU AU2006205127A patent/AU2006205127A1/en not_active Abandoned
- 2006-01-09 WO PCT/US2006/000656 patent/WO2006076284A2/en not_active Ceased
- 2006-01-09 EP EP06717815A patent/EP1836208A2/en not_active Withdrawn
- 2006-01-09 RU RU2007126570/04A patent/RU2007126570A/ru unknown
- 2006-01-09 CA CA002593515A patent/CA2593515A1/en not_active Abandoned
- 2006-01-09 KR KR1020077016053A patent/KR20070095948A/ko not_active Withdrawn
- 2006-01-10 PE PE2006000052A patent/PE20060842A1/es not_active Application Discontinuation
- 2006-01-11 GT GT200600009A patent/GT200600009A/es unknown
- 2006-01-13 AR ARP060100150A patent/AR052458A1/es not_active Application Discontinuation
- 2006-01-13 PA PA20068660001A patent/PA8660001A1/es unknown
- 2006-01-13 US US11/332,732 patent/US7563796B2/en not_active Expired - Fee Related
- 2006-01-13 TW TW095101509A patent/TW200637866A/zh unknown
-
2007
- 2007-06-14 IL IL183938A patent/IL183938A0/en unknown
- 2007-06-18 NO NO20073099A patent/NO20073099L/no not_active Application Discontinuation
- 2007-07-12 CR CR9244A patent/CR9244A/es not_active Application Discontinuation
- 2007-07-13 ZA ZA200705783A patent/ZA200705783B/xx unknown
-
2009
- 2009-06-18 US US12/487,395 patent/US20090253716A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090253716A1 (en) | 2009-10-08 |
| WO2006076284A2 (en) | 2006-07-20 |
| CN101103034A (zh) | 2008-01-09 |
| IL183938A0 (en) | 2007-10-31 |
| CR9244A (es) | 2007-09-07 |
| WO2006076284A3 (en) | 2007-04-19 |
| TW200637866A (en) | 2006-11-01 |
| ZA200705783B (en) | 2008-09-25 |
| BRPI0606690A2 (pt) | 2009-07-14 |
| AU2006205127A1 (en) | 2006-07-20 |
| JP2008526966A (ja) | 2008-07-24 |
| RU2007126570A (ru) | 2009-02-20 |
| CA2593515A1 (en) | 2006-07-20 |
| PE20060842A1 (es) | 2006-10-12 |
| KR20070095948A (ko) | 2007-10-01 |
| US20060160828A1 (en) | 2006-07-20 |
| PA8660001A1 (es) | 2006-09-08 |
| US7563796B2 (en) | 2009-07-21 |
| GT200600009A (es) | 2006-08-17 |
| EP1836208A2 (en) | 2007-09-26 |
| EP2264036A1 (en) | 2010-12-22 |
| AR052458A1 (es) | 2007-03-21 |
| MX2007008555A (es) | 2007-11-21 |
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