NO20074618L - Metode for fremstilling av 1-(3-(2-(1-benzotiofen-5-yl)-etoksy)propyl)azetidin-3-ol eller salter derav - Google Patents

Metode for fremstilling av 1-(3-(2-(1-benzotiofen-5-yl)-etoksy)propyl)azetidin-3-ol eller salter derav

Info

Publication number
NO20074618L
NO20074618L NO20074618A NO20074618A NO20074618L NO 20074618 L NO20074618 L NO 20074618L NO 20074618 A NO20074618 A NO 20074618A NO 20074618 A NO20074618 A NO 20074618A NO 20074618 L NO20074618 L NO 20074618L
Authority
NO
Norway
Prior art keywords
benzothiophen
azetidin
ethoxy
propyl
salts
Prior art date
Application number
NO20074618A
Other languages
English (en)
Other versions
NO340071B1 (no
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of NO20074618L publication Critical patent/NO20074618L/no
Publication of NO340071B1 publication Critical patent/NO340071B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Fremgangsmåte for fremstilling av 1-(3-(2-(1-benzotiofen-5-yl)etoksy)propyl)azetidin-3-ol, eller salter derav, som omfatter anvendelse av en utgangsforbindelse som er et (fenyltio)eddiksyre-derivat, eller salter derav, representert ved den generelle formel: hvor X1 representerer et halogenatom, er anvendelig som en sikker fremgangsmåte for storskala-produksjon av 1-(3-(2-(1-benzotiofen-5-yl)etoksy)propyl)azetidin-3-ol, eller salter derav, som er anvendelige som et legemiddel mot sykdommer i det sentrale og perifere nervesystem.
NO20074618A 2005-03-28 2007-09-12 Propionsyreester-derivat NO340071B1 (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09
PCT/JP2006/306127 WO2006104088A1 (ja) 2005-03-28 2006-03-27 １－（３－（２－（１－ベンゾチオフェン－５－イル）エトキシ）プロピル）アゼチジン－３－オールまたはその塩の製造法

Publications (2)

Publication Number Publication Date
NO20074618L true NO20074618L (no) 2007-10-25
NO340071B1 NO340071B1 (no) 2017-03-06

Family

ID=37053344

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20074618A NO340071B1 (no) 2005-03-28 2007-09-12 Propionsyreester-derivat
NO20161419A NO340420B1 (no) 2005-03-28 2016-09-07 Metode for fremstilling av 1-(3-(2-(1-benzotiofen-5-yl)-etoksy)propyl)azetidin-3-ol eller salter derav
NO20161418A NO340366B1 (no) 2005-03-28 2016-09-07 Metode for fremstilling av 3-(2-(1-benzotiofen-5-yl)etoksy)propionsyre eller salter derav

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO20161419A NO340420B1 (no) 2005-03-28 2016-09-07 Metode for fremstilling av 1-(3-(2-(1-benzotiofen-5-yl)-etoksy)propyl)azetidin-3-ol eller salter derav
NO20161418A NO340366B1 (no) 2005-03-28 2016-09-07 Metode for fremstilling av 3-(2-(1-benzotiofen-5-yl)etoksy)propionsyre eller salter derav

Country Status (22)

Country Link
US (2) US7951963B2 (no)
EP (4) EP2210884B1 (no)
JP (1) JP5031554B2 (no)
KR (2) KR101337382B1 (no)
CN (1) CN101151257B (no)
AT (2) ATE557020T1 (no)
AU (1) AU2006229271B2 (no)
BR (1) BRPI0609496C8 (no)
CA (2) CA2799659C (no)
CY (3) CY1112956T1 (no)
DK (2) DK2210884T3 (no)
ES (3) ES2398934T3 (no)
IL (2) IL186044A (no)
MX (1) MX2007011938A (no)
NO (3) NO340071B1 (no)
NZ (2) NZ583580A (no)
PL (3) PL2210884T3 (no)
PT (3) PT2248809E (no)
SG (1) SG155251A1 (no)
SI (3) SI2248809T1 (no)
WO (1) WO2006104088A1 (no)
ZA (1) ZA200708262B (no)

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US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
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US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
ES2608474T3 (es) * 2010-04-22 2017-04-11 Vertex Pharmaceuticals Incorporated Proceso de producción de compuestos indol cycloalkylcarboxamido
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
WO2012116942A1 (de) 2011-03-02 2012-09-07 Bayer Cropscience Ag Verfahren zur herstellung von aryl- und heteroarylessigsäure-derivaten
WO2013047786A1 (ja) 2011-09-30 2013-04-04 日本化成株式会社 重合性無機粒子分散剤、該重合性無機粒子分散剤を含む無機有機複合粒子、および無機有機樹脂複合材
BR112014020434B1 (pt) * 2012-02-22 2021-10-13 Fujifilm Toyama Chemical Co., Ltd. Composição farmacêutica sólida
WO2014014841A1 (en) 2012-07-16 2014-01-23 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
BR112016017747A2 (pt) 2014-01-31 2017-08-08 Toyama Chemical Co Ltd Agente de intensificação de efeito de reabilitação pós lesão de nervo compreendendo derivados de éter de alquila ou sal do mesmo
ES2885181T3 (es) 2014-04-15 2021-12-13 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
RU2733381C2 (ru) 2016-03-31 2020-10-01 Тояма Кемикал Ко., Лтд. Способ получения 5-(бромметил)-1-бензотиофена

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Also Published As

Publication number Publication date
CY1112885T1 (el) 2016-04-13
NZ583580A (en) 2010-10-29
CN101151257A (zh) 2008-03-26
CA2600381A1 (en) 2006-10-05
CA2799659A1 (en) 2006-10-05
JP5031554B2 (ja) 2012-09-19
PT2210884E (pt) 2012-04-10
EP2248809A1 (en) 2010-11-10
US20090069576A1 (en) 2009-03-12
WO2006104088A1 (ja) 2006-10-05
NO340071B1 (no) 2017-03-06
CY1112956T1 (el) 2016-04-13
EP1864978A4 (en) 2009-07-01
EP2348022A1 (en) 2011-07-27
ES2384312T3 (es) 2012-07-03
EP1864978A1 (en) 2007-12-12
SI2248809T1 (sl) 2012-09-28
KR20130010090A (ko) 2013-01-25
NO340366B1 (no) 2017-04-10
PL2348022T3 (pl) 2013-06-28
NZ561672A (en) 2010-04-30
IL186044A (en) 2013-12-31
EP2248809B1 (en) 2012-05-09
KR101337382B1 (ko) 2013-12-06
BRPI0609496C1 (pt) 2021-05-11
PL2248809T3 (pl) 2012-10-31
JPWO2006104088A1 (ja) 2008-09-04
MX2007011938A (es) 2008-03-14
ATE557020T1 (de) 2012-05-15
NO340420B1 (no) 2017-04-18
US7951963B2 (en) 2011-05-31
IL186044A0 (en) 2008-02-09
EP2210884A3 (en) 2010-09-22
KR101283930B1 (ko) 2013-07-16
DK2210884T3 (da) 2012-03-26
ATE546443T1 (de) 2012-03-15
EP2348022B1 (en) 2013-01-09
NO20161419A1 (no) 2016-06-07
SI2210884T1 (sl) 2012-06-29
EP2210884A2 (en) 2010-07-28
CA2600381C (en) 2013-11-12
CY1113571T1 (el) 2016-06-22
BRPI0609496C8 (pt) 2021-05-25
US20110098484A1 (en) 2011-04-28
CA2799659C (en) 2014-12-02
DK2248809T3 (da) 2012-06-18
BRPI0609496A2 (pt) 2011-10-18
ES2380443T3 (es) 2012-05-11
EP2210884B1 (en) 2012-02-22
ZA200708262B (en) 2009-01-28
AU2006229271A1 (en) 2006-10-05
PL2210884T3 (pl) 2012-07-31
KR20080008334A (ko) 2008-01-23
PT2348022E (pt) 2013-02-13
SI2348022T1 (sl) 2013-05-31
IL214245A (en) 2014-12-31
PT2248809E (pt) 2012-07-02
NO20161418A1 (no) 2007-10-25
IL214245A0 (en) 2011-08-31
ES2398934T3 (es) 2013-03-22
BRPI0609496B1 (pt) 2020-11-24
SG155251A1 (en) 2009-09-30
CN101151257B (zh) 2012-07-18
AU2006229271B2 (en) 2012-02-09
US8273902B2 (en) 2012-09-25

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