ATE546443T1 - Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze - Google Patents

Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze

Info

Publication number: ATE546443T1
Authority: AT; Austria
Prior art keywords: benzothiophen; ethoxy; salts; producing; propionic acid
Prior art date: 2005-03-28

Application number

AT10002020T

Other languages

English (en)

Inventor

Akihito Saitoh

Yoshiaki Suzuki

Kenji Yonezawa

Mitsuhide Kawamura

Takahiko Kusanagi

Takashi Nakai

Original Assignee

Toyama Chemical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-28

Filing date

2006-03-27

Publication date

2012-03-15

2006-03-27 Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE546443T1 publication Critical patent/ATE546443T1/de

Links

238000000034 method Methods 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title abstract 2
HQNACSFBDBYLJP-UHFFFAOYSA-N 1-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl]azetidin-3-ol Chemical compound C1C(O)CN1CCCOCCC1=CC=C(SC=C2)C2=C1 HQNACSFBDBYLJP-UHFFFAOYSA-N 0.000 abstract 1
GEZDICNOLPTCMD-UHFFFAOYSA-N 3-[2-(1-benzothiophen-5-yl)ethoxy]-1-(3-hydroxyazetidin-1-yl)propan-1-one Chemical compound C1C(O)CN1C(=O)CCOCCC1=CC=C(SC=C2)C2=C1 GEZDICNOLPTCMD-UHFFFAOYSA-N 0.000 abstract 1
239000012190 activator Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT10002020T 2005-03-28 2006-03-27 Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze ATE546443T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2005090831		2005-03-28
JP2005174738		2005-06-15
JP2005206808		2005-07-15
JP2005230666		2005-08-09

Publications (1)

Publication Number	Publication Date
ATE546443T1 true ATE546443T1 (de)	2012-03-15

Family

ID=37053344

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT10007872T ATE557020T1 (de)	2005-03-28	2006-03-27	Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen
AT10002020T ATE546443T1 (de)	2005-03-28	2006-03-27	Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT10007872T ATE557020T1 (de)	2005-03-28	2006-03-27	Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen

Country Status (22)

Country	Link
US (2)	US7951963B2 (de)
EP (4)	EP2210884B1 (de)
JP (1)	JP5031554B2 (de)
KR (2)	KR101283930B1 (de)
CN (1)	CN101151257B (de)
AT (2)	ATE557020T1 (de)
AU (1)	AU2006229271B2 (de)
BR (1)	BRPI0609496C8 (de)
CA (2)	CA2600381C (de)
CY (3)	CY1112956T1 (de)
DK (2)	DK2210884T3 (de)
ES (3)	ES2398934T3 (de)
IL (2)	IL186044A (de)
MX (1)	MX2007011938A (de)
NO (3)	NO340071B1 (de)
NZ (2)	NZ583580A (de)
PL (3)	PL2248809T3 (de)
PT (3)	PT2348022E (de)
SG (1)	SG155251A1 (de)
SI (3)	SI2348022T1 (de)
WO (1)	WO2006104088A1 (de)
ZA (1)	ZA200708262B (de)

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JP4902247B2 (ja) *	2005-04-08	2012-03-21	富山化学工業株式会社	２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US7776905B2 (en)	2006-04-07	2010-08-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
ZA200900743B (en) *	2006-08-04	2010-05-26	Toyama Chemical Co Ltd	Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) *	2009-09-03	2014-09-17	富山化学工業株式会社	（１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) *	2009-09-03	2015-08-12	富山化学工業株式会社	２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
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JP6004307B2 (ja) *	2010-07-26	2016-10-05	富山化学工業株式会社	３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
EP2681185B8 (de) *	2011-03-02	2018-08-29	Bayer CropScience AG	Verfahren zur herstellung von aryl- und heteroarylessigsäure-derivaten
WO2013047786A1 (ja)	2011-09-30	2013-04-04	日本化成株式会社	重合性無機粒子分散剤、該重合性無機粒子分散剤を含む無機有機複合粒子、および無機有機樹脂複合材
CN104159583B (zh) *	2012-02-22	2018-04-13	富山化学工业株式会社	含有1‑(3‑(2‑(1‑苯并噻吩‑5‑基)乙氧基)丙基)氮杂环丁烷‑3‑醇或其盐的固体药物组合物
CA2878057A1 (en)	2012-07-16	2014-01-23	Rossitza Gueorguieva Alargova	Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
CN106061478B (zh)	2014-01-31	2019-04-30	富士胶片富山化学株式会社	含有烷基醚衍生物或其盐的神经损伤后的康复效果促进剂
JP6543268B2 (ja)	2014-04-15	2019-07-10	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物
BR112018069438B1 (pt)	2016-03-31	2022-07-05	Fujifilm Corporation	Método para produzir 5- (bromometil) -1-benzotiofeno

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2006
- 2006-03-27 ZA ZA200708262A patent/ZA200708262B/xx unknown
- 2006-03-27 SI SI200631556T patent/SI2348022T1/sl unknown
- 2006-03-27 SI SI200631383T patent/SI2248809T1/sl unknown
- 2006-03-27 MX MX2007011938A patent/MX2007011938A/es active IP Right Grant
- 2006-03-27 CN CN2006800102653A patent/CN101151257B/zh not_active Expired - Lifetime
- 2006-03-27 NZ NZ583580A patent/NZ583580A/en not_active IP Right Cessation
- 2006-03-27 EP EP10002020A patent/EP2210884B1/de not_active Expired - Lifetime
- 2006-03-27 CA CA2600381A patent/CA2600381C/en not_active Expired - Lifetime
- 2006-03-27 PL PL10007872T patent/PL2248809T3/pl unknown
- 2006-03-27 ES ES11002265T patent/ES2398934T3/es not_active Expired - Lifetime
- 2006-03-27 PL PL10002020T patent/PL2210884T3/pl unknown
- 2006-03-27 AU AU2006229271A patent/AU2006229271B2/en not_active Expired
- 2006-03-27 PL PL11002265T patent/PL2348022T3/pl unknown
- 2006-03-27 DK DK10002020.5T patent/DK2210884T3/da active
- 2006-03-27 CA CA2799659A patent/CA2799659C/en not_active Expired - Lifetime
- 2006-03-27 AT AT10007872T patent/ATE557020T1/de active
- 2006-03-27 AT AT10002020T patent/ATE546443T1/de active
- 2006-03-27 DK DK10007872.4T patent/DK2248809T3/da active
- 2006-03-27 BR BRPI0609496A patent/BRPI0609496C8/pt active IP Right Grant
- 2006-03-27 SI SI200631324T patent/SI2210884T1/sl unknown
- 2006-03-27 WO PCT/JP2006/306127 patent/WO2006104088A1/ja not_active Ceased
- 2006-03-27 ES ES10002020T patent/ES2380443T3/es not_active Expired - Lifetime
- 2006-03-27 PT PT110022654T patent/PT2348022E/pt unknown
- 2006-03-27 ES ES10007872T patent/ES2384312T3/es not_active Expired - Lifetime
- 2006-03-27 JP JP2007510482A patent/JP5031554B2/ja not_active Expired - Lifetime
- 2006-03-27 EP EP11002265A patent/EP2348022B1/de not_active Expired - Lifetime
- 2006-03-27 US US11/909,809 patent/US7951963B2/en active Active
- 2006-03-27 NZ NZ561672A patent/NZ561672A/en not_active IP Right Cessation
- 2006-03-27 PT PT10007872T patent/PT2248809E/pt unknown
- 2006-03-27 EP EP10007872A patent/EP2248809B1/de not_active Expired - Lifetime
- 2006-03-27 KR KR1020077024039A patent/KR101283930B1/ko not_active Expired - Lifetime
- 2006-03-27 PT PT10002020T patent/PT2210884E/pt unknown
- 2006-03-27 KR KR1020127032936A patent/KR101337382B1/ko not_active Expired - Lifetime
- 2006-03-27 EP EP06730075A patent/EP1864978A4/de not_active Withdrawn
- 2006-03-27 SG SG200905724-1A patent/SG155251A1/en unknown
2007
- 2007-09-12 NO NO20074618A patent/NO340071B1/no unknown
- 2007-09-18 IL IL186044A patent/IL186044A/en active IP Right Grant
2011
- 2011-01-06 US US12/985,616 patent/US8273902B2/en not_active Expired - Lifetime
- 2011-07-21 IL IL214245A patent/IL214245A/en active IP Right Grant
2012
- 2012-05-08 CY CY20121100434T patent/CY1112956T1/el unknown
- 2012-06-27 CY CY20121100566T patent/CY1112885T1/el unknown
2013
- 2013-01-25 CY CY20131100075T patent/CY1113571T1/el unknown
2016
- 2016-09-07 NO NO20161419A patent/NO340420B1/no unknown
- 2016-09-07 NO NO20161418A patent/NO340366B1/no unknown

Also Published As

Publication number	Publication date
PT2210884E (pt)	2012-04-10
PL2210884T3 (pl)	2012-07-31
US7951963B2 (en)	2011-05-31
EP2348022B1 (de)	2013-01-09
BRPI0609496C8 (pt)	2021-05-25
SI2248809T1 (sl)	2012-09-28
EP2248809B1 (de)	2012-05-09
ES2384312T3 (es)	2012-07-03
EP2210884A3 (de)	2010-09-22
PT2248809E (pt)	2012-07-02
IL214245A0 (en)	2011-08-31
EP2248809A1 (de)	2010-11-10
IL214245A (en)	2014-12-31
EP2348022A1 (de)	2011-07-27
MX2007011938A (es)	2008-03-14
KR101283930B1 (ko)	2013-07-16
WO2006104088A1 (ja)	2006-10-05
NO340366B1 (no)	2017-04-10
CY1112885T1 (el)	2016-04-13
IL186044A (en)	2013-12-31
NZ561672A (en)	2010-04-30
DK2210884T3 (da)	2012-03-26
SI2210884T1 (sl)	2012-06-29
ZA200708262B (en)	2009-01-28
SI2348022T1 (sl)	2013-05-31
US8273902B2 (en)	2012-09-25
CN101151257A (zh)	2008-03-26
NO340071B1 (no)	2017-03-06
ES2398934T3 (es)	2013-03-22
DK2248809T3 (da)	2012-06-18
AU2006229271A1 (en)	2006-10-05
AU2006229271B2 (en)	2012-02-09
EP1864978A4 (de)	2009-07-01
CY1113571T1 (el)	2016-06-22
JPWO2006104088A1 (ja)	2008-09-04
KR101337382B1 (ko)	2013-12-06
NO20074618L (no)	2007-10-25
CY1112956T1 (el)	2016-04-13
JP5031554B2 (ja)	2012-09-19
ATE557020T1 (de)	2012-05-15
EP2210884B1 (de)	2012-02-22
CA2799659C (en)	2014-12-02
EP2210884A2 (de)	2010-07-28
NO340420B1 (no)	2017-04-18
CN101151257B (zh)	2012-07-18
NO20161418A1 (no)	2007-10-25
US20110098484A1 (en)	2011-04-28
BRPI0609496A2 (pt)	2011-10-18
BRPI0609496C1 (pt)	2021-05-11
NZ583580A (en)	2010-10-29
BRPI0609496B1 (pt)	2020-11-24
CA2600381C (en)	2013-11-12
KR20130010090A (ko)	2013-01-25
SG155251A1 (en)	2009-09-30
PL2248809T3 (pl)	2012-10-31
CA2600381A1 (en)	2006-10-05
PT2348022E (pt)	2013-02-13
CA2799659A1 (en)	2006-10-05
IL186044A0 (en)	2008-02-09
KR20080008334A (ko)	2008-01-23
US20090069576A1 (en)	2009-03-12
ES2380443T3 (es)	2012-05-11
EP1864978A1 (de)	2007-12-12
PL2348022T3 (pl)	2013-06-28
NO20161419A1 (no)	2016-06-07

Publication	Publication Date	Title
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