ATE557020T1 - Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen - Google Patents

Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen

Info

Publication number: ATE557020T1
Authority: AT; Austria
Prior art keywords: production; ethoxyü; benzoäbuthiophen; propanoate; azetidine
Prior art date: 2005-03-28

Application number

AT10007872T

Other languages

English (en)

Inventor

Akihito Saitoh

Yoshiaki Suzuki

Kenji Yonezawa

Mitsuhide Kawamura

Takahiko Kusanagi

Takashi Nakai

Original Assignee

Toyama Chemical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-28

Filing date

2006-03-27

Publication date

2012-05-15

2006-03-27 Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd

2012-05-15 Application granted granted Critical

2012-05-15 Publication of ATE557020T1 publication Critical patent/ATE557020T1/de

Links

GMWFCJXSQQHBPI-UHFFFAOYSA-N azetidin-3-ol Chemical class OC1CNC1 GMWFCJXSQQHBPI-UHFFFAOYSA-N 0.000 title 1
HQNACSFBDBYLJP-UHFFFAOYSA-N 1-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl]azetidin-3-ol Chemical compound C1C(O)CN1CCCOCCC1=CC=C(SC=C2)C2=C1 HQNACSFBDBYLJP-UHFFFAOYSA-N 0.000 abstract 1
GEZDICNOLPTCMD-UHFFFAOYSA-N 3-[2-(1-benzothiophen-5-yl)ethoxy]-1-(3-hydroxyazetidin-1-yl)propan-1-one Chemical compound C1C(O)CN1C(=O)CCOCCC1=CC=C(SC=C2)C2=C1 GEZDICNOLPTCMD-UHFFFAOYSA-N 0.000 abstract 1
239000012190 activator Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT10007872T 2005-03-28 2006-03-27 Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen ATE557020T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2005090831		2005-03-28
JP2005174738		2005-06-15
JP2005206808		2005-07-15
JP2005230666		2005-08-09

Publications (1)

Publication Number	Publication Date
ATE557020T1 true ATE557020T1 (de)	2012-05-15

Family

ID=37053344

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT10002020T ATE546443T1 (de)	2005-03-28	2006-03-27	Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze
AT10007872T ATE557020T1 (de)	2005-03-28	2006-03-27	Alkyl-3-ä2-(benzoäbüthiophen-5-yl)-ethoxyü- propanoate als intermediate in der herstellung von azetidin-3-ol derivativen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT10002020T ATE546443T1 (de)	2005-03-28	2006-03-27	Prozess zur herstellung von 1-(3-(2-(1- benzothiophen-5-yl)-ethoxy)propionsäure sowie deren salze

Country Status (22)

Country	Link
US (2)	US7951963B2 (de)
EP (4)	EP2210884B1 (de)
JP (1)	JP5031554B2 (de)
KR (2)	KR101337382B1 (de)
CN (1)	CN101151257B (de)
AT (2)	ATE546443T1 (de)
AU (1)	AU2006229271B2 (de)
BR (1)	BRPI0609496C8 (de)
CA (2)	CA2600381C (de)
CY (3)	CY1112956T1 (de)
DK (2)	DK2210884T3 (de)
ES (3)	ES2398934T3 (de)
IL (2)	IL186044A (de)
MX (1)	MX2007011938A (de)
NO (3)	NO340071B1 (de)
NZ (2)	NZ583580A (de)
PL (3)	PL2210884T3 (de)
PT (3)	PT2210884E (de)
SG (1)	SG155251A1 (de)
SI (3)	SI2348022T1 (de)
WO (1)	WO2006104088A1 (de)
ZA (1)	ZA200708262B (de)

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PL2210884T3 (pl) *	2005-03-28	2012-07-31	Toyama Chemical Co Ltd	Proces wytwarzania kwasu 3-(2-(1-benzotiofen-5-ylo)etoksy)propionowego lub jego soli
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NZ596889A (en)	2006-04-07	2013-06-28	Vertex Pharma	Use of amide indole derivatives as modulators of ATP-binding cassette transporters
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
KR20090038471A (ko) *	2006-08-04	2009-04-20	토야마 케미칼 컴퍼니 리미티드	알킬에테르 유도체 또는 그 염을 함유하는 프로테인키나제 ｃ 활성촉진제
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
JP5592205B2 (ja) *	2009-09-03	2014-09-17	富山化学工業株式会社	（１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
JP5763313B2 (ja) *	2009-09-03	2015-08-12	富山化学工業株式会社	２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
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RU2745977C2 (ru) *	2010-04-22	2021-04-05	Вертекс Фармасьютикалз Инкорпорейтед	Способ получения циклоалкилкарбоксамидо-индольных соединений
JP6004307B2 (ja) *	2010-07-26	2016-10-05	富山化学工業株式会社	３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
US9096568B2 (en) *	2011-03-02	2015-08-04	Bayer Intellectual Property Gmbh	Process for preparing aryl- and heteroarylacetic acid derivatives
CN103842066B (zh)	2011-09-30	2016-08-24	日本化成株式会社	聚合性无机颗粒分散剂、含有该聚合性无机颗粒分散剂的无机有机复合颗粒以及无机有机树脂复合材料
JP6054940B2 (ja)	2012-02-22	2016-12-27	富山化学工業株式会社	１−（３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピル）アゼチジン−３−オールまたはその塩を含有する固形医薬組成物
AU2013290444B2 (en)	2012-07-16	2018-04-26	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
ES2792950T3 (es)	2014-01-31	2020-11-12	Fujifilm Toyama Chemical Co Ltd	Agente potenciador del efecto de rehabilitación después de una lesión nerviosa que comprende un derivado alquil éter o una sal del mismo
SG10201913575VA (en)	2014-04-15	2020-02-27	Vertex Pharma	Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases
JP6804520B2 (ja) *	2016-03-31	2020-12-23	富士フイルム富山化学株式会社	５−ブロモメチル−１−ベンゾチオフェンの製造方法

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2006
- 2006-03-27 PL PL10002020T patent/PL2210884T3/pl unknown
- 2006-03-27 AU AU2006229271A patent/AU2006229271B2/en active Active
- 2006-03-27 CA CA2600381A patent/CA2600381C/en not_active Expired - Lifetime
- 2006-03-27 BR BRPI0609496A patent/BRPI0609496C8/pt active IP Right Grant
- 2006-03-27 KR KR1020127032936A patent/KR101337382B1/ko not_active Expired - Lifetime
- 2006-03-27 EP EP10002020A patent/EP2210884B1/de not_active Expired - Lifetime
- 2006-03-27 NZ NZ583580A patent/NZ583580A/en unknown
- 2006-03-27 SI SI200631556T patent/SI2348022T1/sl unknown
- 2006-03-27 SI SI200631383T patent/SI2248809T1/sl unknown
- 2006-03-27 EP EP06730075A patent/EP1864978A4/de not_active Withdrawn
- 2006-03-27 AT AT10002020T patent/ATE546443T1/de active
- 2006-03-27 EP EP10007872A patent/EP2248809B1/de not_active Expired - Lifetime
- 2006-03-27 PL PL10007872T patent/PL2248809T3/pl unknown
- 2006-03-27 MX MX2007011938A patent/MX2007011938A/es active IP Right Grant
- 2006-03-27 NZ NZ561672A patent/NZ561672A/en unknown
- 2006-03-27 DK DK10002020.5T patent/DK2210884T3/da active
- 2006-03-27 ZA ZA200708262A patent/ZA200708262B/xx unknown
- 2006-03-27 SG SG200905724-1A patent/SG155251A1/en unknown
- 2006-03-27 AT AT10007872T patent/ATE557020T1/de active
- 2006-03-27 WO PCT/JP2006/306127 patent/WO2006104088A1/ja not_active Ceased
- 2006-03-27 DK DK10007872.4T patent/DK2248809T3/da active
- 2006-03-27 CA CA2799659A patent/CA2799659C/en not_active Expired - Lifetime
- 2006-03-27 EP EP11002265A patent/EP2348022B1/de not_active Expired - Lifetime
- 2006-03-27 ES ES11002265T patent/ES2398934T3/es not_active Expired - Lifetime
- 2006-03-27 SI SI200631324T patent/SI2210884T1/sl unknown
- 2006-03-27 PT PT10002020T patent/PT2210884E/pt unknown
- 2006-03-27 ES ES10002020T patent/ES2380443T3/es not_active Expired - Lifetime
- 2006-03-27 US US11/909,809 patent/US7951963B2/en active Active
- 2006-03-27 PT PT110022654T patent/PT2348022E/pt unknown
- 2006-03-27 PL PL11002265T patent/PL2348022T3/pl unknown
- 2006-03-27 KR KR1020077024039A patent/KR101283930B1/ko not_active Expired - Lifetime
- 2006-03-27 ES ES10007872T patent/ES2384312T3/es not_active Expired - Lifetime
- 2006-03-27 CN CN2006800102653A patent/CN101151257B/zh not_active Expired - Lifetime
- 2006-03-27 PT PT10007872T patent/PT2248809E/pt unknown
- 2006-03-27 JP JP2007510482A patent/JP5031554B2/ja not_active Expired - Lifetime
2007
- 2007-09-12 NO NO20074618A patent/NO340071B1/no unknown
- 2007-09-18 IL IL186044A patent/IL186044A/en active IP Right Grant
2011
- 2011-01-06 US US12/985,616 patent/US8273902B2/en not_active Expired - Lifetime
- 2011-07-21 IL IL214245A patent/IL214245A/en active IP Right Grant
2012
- 2012-05-08 CY CY20121100434T patent/CY1112956T1/el unknown
- 2012-06-27 CY CY20121100566T patent/CY1112885T1/el unknown
2013
- 2013-01-25 CY CY20131100075T patent/CY1113571T1/el unknown
2016
- 2016-09-07 NO NO20161418A patent/NO340366B1/no unknown
- 2016-09-07 NO NO20161419A patent/NO340420B1/no unknown

Also Published As

Publication number	Publication date
PL2348022T3 (pl)	2013-06-28
NO340420B1 (no)	2017-04-18
WO2006104088A1 (ja)	2006-10-05
CY1112885T1 (el)	2016-04-13
EP2248809A1 (de)	2010-11-10
CA2600381C (en)	2013-11-12
IL214245A (en)	2014-12-31
PT2210884E (pt)	2012-04-10
BRPI0609496C8 (pt)	2021-05-25
CA2799659A1 (en)	2006-10-05
NO20161418A1 (no)	2007-10-25
SG155251A1 (en)	2009-09-30
EP1864978A4 (de)	2009-07-01
AU2006229271A1 (en)	2006-10-05
PT2348022E (pt)	2013-02-13
ATE546443T1 (de)	2012-03-15
CY1112956T1 (el)	2016-04-13
SI2210884T1 (sl)	2012-06-29
SI2348022T1 (sl)	2013-05-31
NZ561672A (en)	2010-04-30
BRPI0609496C1 (pt)	2021-05-11
US20090069576A1 (en)	2009-03-12
CY1113571T1 (el)	2016-06-22
CA2600381A1 (en)	2006-10-05
EP2210884A3 (de)	2010-09-22
US20110098484A1 (en)	2011-04-28
NO20074618L (no)	2007-10-25
PL2210884T3 (pl)	2012-07-31
BRPI0609496B1 (pt)	2020-11-24
IL186044A0 (en)	2008-02-09
EP2210884B1 (de)	2012-02-22
NZ583580A (en)	2010-10-29
EP2348022B1 (de)	2013-01-09
PL2248809T3 (pl)	2012-10-31
KR20130010090A (ko)	2013-01-25
CN101151257B (zh)	2012-07-18
AU2006229271B2 (en)	2012-02-09
ES2398934T3 (es)	2013-03-22
JPWO2006104088A1 (ja)	2008-09-04
KR101337382B1 (ko)	2013-12-06
EP1864978A1 (de)	2007-12-12
EP2210884A2 (de)	2010-07-28
EP2348022A1 (de)	2011-07-27
DK2210884T3 (da)	2012-03-26
PT2248809E (pt)	2012-07-02
CN101151257A (zh)	2008-03-26
MX2007011938A (es)	2008-03-14
ES2384312T3 (es)	2012-07-03
BRPI0609496A2 (pt)	2011-10-18
JP5031554B2 (ja)	2012-09-19
NO340071B1 (no)	2017-03-06
SI2248809T1 (sl)	2012-09-28
ZA200708262B (en)	2009-01-28
IL186044A (en)	2013-12-31
NO20161419A1 (no)	2016-06-07
NO340366B1 (no)	2017-04-10
EP2248809B1 (de)	2012-05-09
DK2248809T3 (da)	2012-06-18
US8273902B2 (en)	2012-09-25
ES2380443T3 (es)	2012-05-11
CA2799659C (en)	2014-12-02
KR101283930B1 (ko)	2013-07-16
IL214245A0 (en)	2011-08-31
US7951963B2 (en)	2011-05-31
KR20080008334A (ko)	2008-01-23

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