PL2248809T3 - 3-[2-(Benzo[b]tiofen-5-ylo)-etoksy]-propaniany alkilu jako związki pośrednie w wytwarzaniu pochodnych azetydyn-3-olu - Google Patents

3-[2-(Benzo[b]tiofen-5-ylo)-etoksy]-propaniany alkilu jako związki pośrednie w wytwarzaniu pochodnych azetydyn-3-olu

Info

Publication number: PL2248809T3
Authority: PL; Poland
Prior art keywords: azetidin; ethoxy; production; propanoates; thiophen
Prior art date: 2005-03-28

Application number

PL10007872T

Other languages

English (en)

Inventor

Akihito Saitoh

Yoshiaki Suzuki

Kenji Yonezawa

Mitsuhide Kawamura

Takahiko Kusanagi

Takashi Nakai

Original Assignee

Toyama Chemical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-28

Filing date

2006-03-27

Publication date

2012-10-31

2006-03-27 Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd

2012-10-31 Publication of PL2248809T3 publication Critical patent/PL2248809T3/pl

Links

GMWFCJXSQQHBPI-UHFFFAOYSA-N azetidin-3-ol Chemical class OC1CNC1 GMWFCJXSQQHBPI-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
HQNACSFBDBYLJP-UHFFFAOYSA-N 1-[3-[2-(1-benzothiophen-5-yl)ethoxy]propyl]azetidin-3-ol Chemical compound C1C(O)CN1CCCOCCC1=CC=C(SC=C2)C2=C1 HQNACSFBDBYLJP-UHFFFAOYSA-N 0.000 abstract 1
GEZDICNOLPTCMD-UHFFFAOYSA-N 3-[2-(1-benzothiophen-5-yl)ethoxy]-1-(3-hydroxyazetidin-1-yl)propan-1-one Chemical compound C1C(O)CN1C(=O)CCOCCC1=CC=C(SC=C2)C2=C1 GEZDICNOLPTCMD-UHFFFAOYSA-N 0.000 abstract 1
239000012190 activator Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL10007872T 2005-03-28 2006-03-27 3-[2-(Benzo[b]tiofen-5-ylo)-etoksy]-propaniany alkilu jako związki pośrednie w wytwarzaniu pochodnych azetydyn-3-olu PL2248809T3 (pl)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP2005090831		2005-03-28
JP2005174738		2005-06-15
JP2005206808		2005-07-15
JP2005230666		2005-08-09
EP10007872A EP2248809B1 (en)	2005-03-28	2006-03-27	Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoates as intermediates in the production of Azetidin-3-ol derivatives
EP06730075A EP1864978A4 (en)	2005-03-28	2006-03-27	PROCESS FOR PREPARING 1- (3- (2- (1-BENZOTHIOPHEN-5-YL) ETHOXY) PROPYL) AZETIDIN-3-OL OR SALTS THEREOF

Publications (1)

Publication Number	Publication Date
PL2248809T3 true PL2248809T3 (pl)	2012-10-31

Family

ID=37053344

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL10002020T PL2210884T3 (pl)	2005-03-28	2006-03-27	Proces wytwarzania kwasu 3-(2-(1-benzotiofen-5-ylo)etoksy)propionowego lub jego soli
PL10007872T PL2248809T3 (pl)	2005-03-28	2006-03-27	3-[2-(Benzo[b]tiofen-5-ylo)-etoksy]-propaniany alkilu jako związki pośrednie w wytwarzaniu pochodnych azetydyn-3-olu
PL11002265T PL2348022T3 (pl)	2005-03-28	2006-03-27	Proces produkcji 1-(3-(2-(1-benzotiofen-5-ylo)etoksy)propylo)azetydyn-3-olu lub jego soli

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL10002020T PL2210884T3 (pl)	2005-03-28	2006-03-27	Proces wytwarzania kwasu 3-(2-(1-benzotiofen-5-ylo)etoksy)propionowego lub jego soli

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL11002265T PL2348022T3 (pl)	2005-03-28	2006-03-27	Proces produkcji 1-(3-(2-(1-benzotiofen-5-ylo)etoksy)propylo)azetydyn-3-olu lub jego soli

Country Status (22)

Country	Link
US (2)	US7951963B2 (pl)
EP (4)	EP2210884B1 (pl)
JP (1)	JP5031554B2 (pl)
KR (2)	KR101337382B1 (pl)
CN (1)	CN101151257B (pl)
AT (2)	ATE557020T1 (pl)
AU (1)	AU2006229271B2 (pl)
BR (1)	BRPI0609496C8 (pl)
CA (2)	CA2799659C (pl)
CY (3)	CY1112956T1 (pl)
DK (2)	DK2210884T3 (pl)
ES (3)	ES2398934T3 (pl)
IL (2)	IL186044A (pl)
MX (1)	MX2007011938A (pl)
NO (3)	NO340071B1 (pl)
NZ (2)	NZ583580A (pl)
PL (3)	PL2210884T3 (pl)
PT (3)	PT2248809E (pl)
SG (1)	SG155251A1 (pl)
SI (3)	SI2248809T1 (pl)
WO (1)	WO2006104088A1 (pl)
ZA (1)	ZA200708262B (pl)

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SI2248809T1 (sl) *	2005-03-28	2012-09-28	Toyama Chemical Co Ltd	Alkil-3-(2-(benzo(b)tiofen-5-il)-etoksi)-propanoati kot vmesniki v proizvodnji derivatov azetidin-3-ola
JP4902247B2 (ja) *	2005-04-08	2012-03-21	富山化学工業株式会社	２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
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USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
CA2659835A1 (en) *	2006-08-04	2008-02-07	Toyama Chemical Co., Ltd.	Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
JP5763313B2 (ja) *	2009-09-03	2015-08-12	富山化学工業株式会社	２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
JP5592205B2 (ja) *	2009-09-03	2014-09-17	富山化学工業株式会社	（１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
ES2608474T3 (es) *	2010-04-22	2017-04-11	Vertex Pharmaceuticals Incorporated	Proceso de producción de compuestos indol cycloalkylcarboxamido
JP6004307B2 (ja) *	2010-07-26	2016-10-05	富山化学工業株式会社	３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
WO2012116942A1 (de)	2011-03-02	2012-09-07	Bayer Cropscience Ag	Verfahren zur herstellung von aryl- und heteroarylessigsäure-derivaten
WO2013047786A1 (ja)	2011-09-30	2013-04-04	日本化成株式会社	重合性無機粒子分散剤、該重合性無機粒子分散剤を含む無機有機複合粒子、および無機有機樹脂複合材
BR112014020434B1 (pt) *	2012-02-22	2021-10-13	Fujifilm Toyama Chemical Co., Ltd.	Composição farmacêutica sólida
WO2014014841A1 (en)	2012-07-16	2014-01-23	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
BR112016017747A2 (pt)	2014-01-31	2017-08-08	Toyama Chemical Co Ltd	Agente de intensificação de efeito de reabilitação pós lesão de nervo compreendendo derivados de éter de alquila ou sal do mesmo
ES2885181T3 (es)	2014-04-15	2021-12-13	Vertex Pharma	Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
RU2733381C2 (ru)	2016-03-31	2020-10-01	Тояма Кемикал Ко., Лтд.	Способ получения 5-(бромметил)-1-бензотиофена

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2006
- 2006-03-27 SI SI200631383T patent/SI2248809T1/sl unknown
- 2006-03-27 EP EP10002020A patent/EP2210884B1/en not_active Expired - Lifetime
- 2006-03-27 SI SI200631324T patent/SI2210884T1/sl unknown
- 2006-03-27 PT PT10007872T patent/PT2248809E/pt unknown
- 2006-03-27 KR KR1020127032936A patent/KR101337382B1/ko not_active Expired - Lifetime
- 2006-03-27 ES ES11002265T patent/ES2398934T3/es not_active Expired - Lifetime
- 2006-03-27 ES ES10007872T patent/ES2384312T3/es not_active Expired - Lifetime
- 2006-03-27 DK DK10002020.5T patent/DK2210884T3/da active
- 2006-03-27 BR BRPI0609496A patent/BRPI0609496C8/pt active IP Right Grant
- 2006-03-27 AT AT10007872T patent/ATE557020T1/de active
- 2006-03-27 PT PT10002020T patent/PT2210884E/pt unknown
- 2006-03-27 ZA ZA200708262A patent/ZA200708262B/xx unknown
- 2006-03-27 US US11/909,809 patent/US7951963B2/en active Active
- 2006-03-27 CA CA2799659A patent/CA2799659C/en not_active Expired - Lifetime
- 2006-03-27 AU AU2006229271A patent/AU2006229271B2/en not_active Expired
- 2006-03-27 EP EP11002265A patent/EP2348022B1/en not_active Expired - Lifetime
- 2006-03-27 NZ NZ583580A patent/NZ583580A/en not_active IP Right Cessation
- 2006-03-27 AT AT10002020T patent/ATE546443T1/de active
- 2006-03-27 KR KR1020077024039A patent/KR101283930B1/ko not_active Expired - Lifetime
- 2006-03-27 JP JP2007510482A patent/JP5031554B2/ja not_active Expired - Lifetime
- 2006-03-27 ES ES10002020T patent/ES2380443T3/es not_active Expired - Lifetime
- 2006-03-27 SI SI200631556T patent/SI2348022T1/sl unknown
- 2006-03-27 EP EP10007872A patent/EP2248809B1/en not_active Expired - Lifetime
- 2006-03-27 DK DK10007872.4T patent/DK2248809T3/da active
- 2006-03-27 NZ NZ561672A patent/NZ561672A/en not_active IP Right Cessation
- 2006-03-27 PL PL10002020T patent/PL2210884T3/pl unknown
- 2006-03-27 PT PT110022654T patent/PT2348022E/pt unknown
- 2006-03-27 CA CA2600381A patent/CA2600381C/en not_active Expired - Lifetime
- 2006-03-27 MX MX2007011938A patent/MX2007011938A/es active IP Right Grant
- 2006-03-27 PL PL10007872T patent/PL2248809T3/pl unknown
- 2006-03-27 CN CN2006800102653A patent/CN101151257B/zh not_active Expired - Lifetime
- 2006-03-27 PL PL11002265T patent/PL2348022T3/pl unknown
- 2006-03-27 WO PCT/JP2006/306127 patent/WO2006104088A1/ja not_active Ceased
- 2006-03-27 SG SG200905724-1A patent/SG155251A1/en unknown
- 2006-03-27 EP EP06730075A patent/EP1864978A4/en not_active Withdrawn
2007
- 2007-09-12 NO NO20074618A patent/NO340071B1/no unknown
- 2007-09-18 IL IL186044A patent/IL186044A/en active IP Right Grant
2011
- 2011-01-06 US US12/985,616 patent/US8273902B2/en not_active Expired - Lifetime
- 2011-07-21 IL IL214245A patent/IL214245A/en active IP Right Grant
2012
- 2012-05-08 CY CY20121100434T patent/CY1112956T1/el unknown
- 2012-06-27 CY CY20121100566T patent/CY1112885T1/el unknown
2013
- 2013-01-25 CY CY20131100075T patent/CY1113571T1/el unknown
2016
- 2016-09-07 NO NO20161419A patent/NO340420B1/no unknown
- 2016-09-07 NO NO20161418A patent/NO340366B1/no unknown

Also Published As

Publication number	Publication date
CY1112885T1 (el)	2016-04-13
NZ583580A (en)	2010-10-29
CN101151257A (zh)	2008-03-26
CA2600381A1 (en)	2006-10-05
CA2799659A1 (en)	2006-10-05
JP5031554B2 (ja)	2012-09-19
PT2210884E (pt)	2012-04-10
EP2248809A1 (en)	2010-11-10
US20090069576A1 (en)	2009-03-12
WO2006104088A1 (ja)	2006-10-05
NO340071B1 (no)	2017-03-06
CY1112956T1 (el)	2016-04-13
EP1864978A4 (en)	2009-07-01
EP2348022A1 (en)	2011-07-27
ES2384312T3 (es)	2012-07-03
EP1864978A1 (en)	2007-12-12
SI2248809T1 (sl)	2012-09-28
KR20130010090A (ko)	2013-01-25
NO340366B1 (no)	2017-04-10
PL2348022T3 (pl)	2013-06-28
NZ561672A (en)	2010-04-30
IL186044A (en)	2013-12-31
EP2248809B1 (en)	2012-05-09
KR101337382B1 (ko)	2013-12-06
BRPI0609496C1 (pt)	2021-05-11
JPWO2006104088A1 (ja)	2008-09-04
MX2007011938A (es)	2008-03-14
ATE557020T1 (de)	2012-05-15
NO340420B1 (no)	2017-04-18
US7951963B2 (en)	2011-05-31
IL186044A0 (en)	2008-02-09
EP2210884A3 (en)	2010-09-22
KR101283930B1 (ko)	2013-07-16
DK2210884T3 (da)	2012-03-26
ATE546443T1 (de)	2012-03-15
EP2348022B1 (en)	2013-01-09
NO20161419A1 (no)	2016-06-07
SI2210884T1 (sl)	2012-06-29
EP2210884A2 (en)	2010-07-28
CA2600381C (en)	2013-11-12
CY1113571T1 (el)	2016-06-22
BRPI0609496C8 (pt)	2021-05-25
US20110098484A1 (en)	2011-04-28
CA2799659C (en)	2014-12-02
DK2248809T3 (da)	2012-06-18
BRPI0609496A2 (pt)	2011-10-18
ES2380443T3 (es)	2012-05-11
EP2210884B1 (en)	2012-02-22
ZA200708262B (en)	2009-01-28
AU2006229271A1 (en)	2006-10-05
PL2210884T3 (pl)	2012-07-31
KR20080008334A (ko)	2008-01-23
PT2348022E (pt)	2013-02-13
SI2348022T1 (sl)	2013-05-31
NO20074618L (no)	2007-10-25
IL214245A (en)	2014-12-31
PT2248809E (pt)	2012-07-02
NO20161418A1 (no)	2007-10-25
IL214245A0 (en)	2011-08-31
ES2398934T3 (es)	2013-03-22
BRPI0609496B1 (pt)	2020-11-24
SG155251A1 (en)	2009-09-30
CN101151257B (zh)	2012-07-18
AU2006229271B2 (en)	2012-02-09
US8273902B2 (en)	2012-09-25

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