NO20090069L - Malrettede forbindelser rettet mot binding til PDGFR-alfa og deres anvendelse - Google Patents

Malrettede forbindelser rettet mot binding til PDGFR-alfa og deres anvendelse

Info

Publication number
NO20090069L
NO20090069L NO20090069A NO20090069A NO20090069L NO 20090069 L NO20090069 L NO 20090069L NO 20090069 A NO20090069 A NO 20090069A NO 20090069 A NO20090069 A NO 20090069A NO 20090069 L NO20090069 L NO 20090069L
Authority
NO
Norway
Prior art keywords
alpha
pdgfr
antibodies
targeted
compounds targeting
Prior art date
Application number
NO20090069A
Other languages
English (en)
Inventor
David C Blakey
Naomi Laing
Jaspal Singh Kang
Ian Foltz
Gadi Gazit-Bornstein
Xiaodang Yang
Susan Ann Cartlidge
Laura Taylor
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20090069L publication Critical patent/NO20090069L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Målrettede bindemidler mot antigenet PDGFR-alfa og bruk av slike midler er beskrevet her. Mer spesifikt angår oppfinnelsen hele humane monoklonale antistoffer målrettet mot antigenet PDGFR-alfa, og bruk av disse antistoffene. Aspekter ifølge oppfinnelsen angår også hybridomer eller andre cellelinjer som uttrykker slike antistoffer. De beskrevne målrettede bindemidlene og antistoffene er anvendelige som diagnostikk og til behandling av sykdommer forbundet med aktiviteten og/eller overekspresjon av PDGFR-alfa.
NO20090069A 2006-08-03 2009-01-06 Malrettede forbindelser rettet mot binding til PDGFR-alfa og deres anvendelse NO20090069L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83564706P 2006-08-03 2006-08-03
PCT/US2007/075117 WO2008112003A2 (en) 2006-08-03 2007-08-02 Targeted binding agents directed to pdgfr-alpha and uses thereof

Publications (1)

Publication Number Publication Date
NO20090069L true NO20090069L (no) 2009-02-25

Family

ID=39146823

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20090069A NO20090069L (no) 2006-08-03 2009-01-06 Malrettede forbindelser rettet mot binding til PDGFR-alfa og deres anvendelse

Country Status (23)

Country Link
US (3) US20090324601A1 (no)
EP (3) EP2420514A1 (no)
JP (1) JP5437804B2 (no)
KR (1) KR101531422B1 (no)
CN (2) CN101558082B (no)
AR (1) AR062268A1 (no)
AU (1) AU2007348940B2 (no)
BR (1) BRPI0715223A2 (no)
CA (1) CA2657898A1 (no)
CL (1) CL2007002225A1 (no)
DK (1) DK2049571T3 (no)
ES (1) ES2402380T3 (no)
IL (2) IL196209A (no)
MX (2) MX2009001021A (no)
NO (1) NO20090069L (no)
NZ (2) NZ596381A (no)
PL (1) PL2049571T3 (no)
PT (1) PT2049571E (no)
SI (1) SI2049571T1 (no)
TW (1) TWI503329B (no)
UY (1) UY30525A1 (no)
WO (1) WO2008112003A2 (no)
ZA (1) ZA200900461B (no)

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KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
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WO2024207070A1 (en) * 2023-04-04 2024-10-10 Telix Pharmaceuticals (Innovations) Pty Ltd Methods of treating cancers expressing pdgfralpha
WO2024207069A1 (en) * 2023-04-04 2024-10-10 Telix Pharmaceuticals (Innovations) Pty Ltd Reagents and methods for imaging cancers expressing pdgfralpha
CN121194990A (zh) * 2023-04-04 2025-12-23 泰利斯制药(创新)有限公司 用于对表达PDGFRα的癌症进行成像的试剂和方法
WO2025101767A1 (en) * 2023-11-08 2025-05-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Immuno-targeting the ectopic phosphorylation sites of pdgfra generated by man2a1-fer fusion in hepatocellular carcinoma

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KR101531422B1 (ko) 2015-06-26
MX2009001021A (es) 2009-02-05
EP2420513A1 (en) 2012-02-22
US20080089837A1 (en) 2008-04-17
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