NO305902B1 - Hydroksysubstituerte azetidinonforbindelser som kan anvendes som hypokolesterolemiske midler, farmasoytiske preparater som omfatter slike forbindelser, provesett som omfatter slike preparater, samt anvendelse av forbindelsene til fremstilling av medikamen - Google Patents

Hydroksysubstituerte azetidinonforbindelser som kan anvendes som hypokolesterolemiske midler, farmasoytiske preparater som omfatter slike forbindelser, provesett som omfatter slike preparater, samt anvendelse av forbindelsene til fremstilling av medikamen

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Publication number
NO305902B1
NO305902B1 NO19961133A NO961133A NO305902B1 NO 305902 B1 NO305902 B1 NO 305902B1 NO 19961133 A NO19961133 A NO 19961133A NO 961133 A NO961133 A NO 961133A NO 305902 B1 NO305902 B1 NO 305902B1
Authority
NO
Norway
Prior art keywords
compounds
aryl
hydroxy
alkyl
preparations
Prior art date
Application number
NO19961133A
Other languages
English (en)
Norwegian (no)
Other versions
NO961133L (no
NO961133D0 (no
Inventor
Brian A Mckittrick
Duane A Burnett
John W Clader
Sundeep Dugar
Stuart B Rosenblum
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26799377&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO305902(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO961133L publication Critical patent/NO961133L/no
Publication of NO961133D0 publication Critical patent/NO961133D0/no
Publication of NO305902B1 publication Critical patent/NO305902B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Dental Preparations (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19961133A 1993-09-21 1996-03-20 Hydroksysubstituerte azetidinonforbindelser som kan anvendes som hypokolesterolemiske midler, farmasoytiske preparater som omfatter slike forbindelser, provesett som omfatter slike preparater, samt anvendelse av forbindelsene til fremstilling av medikamen NO305902B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10244093A 1993-09-21 1993-09-21
US08/257,593 US5631365A (en) 1993-09-21 1994-06-09 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
PCT/US1994/010099 WO1995008532A1 (en) 1993-09-21 1994-09-14 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

Publications (3)

Publication Number Publication Date
NO961133L NO961133L (no) 1996-03-20
NO961133D0 NO961133D0 (no) 1996-03-20
NO305902B1 true NO305902B1 (no) 1999-08-16

Family

ID=26799377

Family Applications (6)

Application Number Title Priority Date Filing Date
NO19961133A NO305902B1 (no) 1993-09-21 1996-03-20 Hydroksysubstituerte azetidinonforbindelser som kan anvendes som hypokolesterolemiske midler, farmasoytiske preparater som omfatter slike forbindelser, provesett som omfatter slike preparater, samt anvendelse av forbindelsene til fremstilling av medikamen
NO2003007C NO2003007I2 (no) 1993-09-21 2003-08-21 Ezetimib
NO2005003C NO2005003I2 (no) 1993-09-21 2005-02-01 Hydroksysubstituerte azetidinonforbindelser som kan anvendes som hypokolesterolemiske midler, farmasoytiske preparater som omfatter slike forbindelser, provesett som omfatter slike preparater, samt anvendelse av forbindelsene til fremstilling av medikamentet
NO2014022C NO2014022I1 (no) 1993-09-21 2014-09-10 Rosuvastatin (som sink) og ezetimib
NO2014023C NO2014023I1 (no) 1993-09-21 2014-09-12 Ezetimib og atorvastatin
NO2017042C NO2017042I1 (no) 1993-09-21 2017-08-02 Ezetimib, eventuelt i form av et farmasøytisk akseptabelt salt

Family Applications After (5)

Application Number Title Priority Date Filing Date
NO2003007C NO2003007I2 (no) 1993-09-21 2003-08-21 Ezetimib
NO2005003C NO2005003I2 (no) 1993-09-21 2005-02-01 Hydroksysubstituerte azetidinonforbindelser som kan anvendes som hypokolesterolemiske midler, farmasoytiske preparater som omfatter slike forbindelser, provesett som omfatter slike preparater, samt anvendelse av forbindelsene til fremstilling av medikamentet
NO2014022C NO2014022I1 (no) 1993-09-21 2014-09-10 Rosuvastatin (som sink) og ezetimib
NO2014023C NO2014023I1 (no) 1993-09-21 2014-09-12 Ezetimib og atorvastatin
NO2017042C NO2017042I1 (no) 1993-09-21 2017-08-02 Ezetimib, eventuelt i form av et farmasøytisk akseptabelt salt

Country Status (35)

Country Link
US (5) US5631365A (de)
EP (1) EP0720599B1 (de)
JP (1) JP2803908B2 (de)
KR (1) KR100186853B1 (de)
CN (1) CN1050830C (de)
AT (1) ATE180249T1 (de)
AU (1) AU681445C (de)
BE (1) BE2014C056I2 (de)
BR (1) BR1100159A (de)
CA (1) CA2172149C (de)
CZ (2) CZ288861B6 (de)
DE (3) DE10399001I2 (de)
DK (1) DK0720599T3 (de)
ES (1) ES2132432T3 (de)
FI (1) FI110321B (de)
FR (2) FR05C0040I2 (de)
GE (1) GEP20043149B (de)
GR (1) GR3030312T3 (de)
HU (1) HU221185B1 (de)
IL (1) IL110956A (de)
LU (4) LU91050I2 (de)
MA (1) MA23332A1 (de)
MY (1) MY111314A (de)
NL (2) NL300132I2 (de)
NO (6) NO305902B1 (de)
NZ (1) NZ274041A (de)
PL (1) PL182617B1 (de)
RU (1) RU2138480C1 (de)
SG (1) SG46208A1 (de)
SK (1) SK281067B6 (de)
TN (1) TNSN94094A1 (de)
TW (1) TW427974B (de)
UA (1) UA41948C2 (de)
WO (1) WO1995008532A1 (de)
ZA (1) ZA947086B (de)

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