NO330569B1 - Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk bruk derav samt intermediater til fremstilling derav - Google Patents

Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk bruk derav samt intermediater til fremstilling derav Download PDF

Info

Publication number: NO330569B1
Authority: NO; Norway
Prior art keywords: group; alkyl; inhibitor; hydroxy; pharmaceutically acceptable
Prior art date: 2002-08-23

Application number

NO20051411A

Other languages

English (en)

Norwegian (no)

Other versions

NO20051411L (no

Inventor

Nobuhiko Fushimi

Kazuo Shimizu

Shigeru Yonekubo

Hirotaka Teranishi

Masaki Tomae

Masayuki Isaji

Original Assignee

Kissei Pharmaceutical Company Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-23

Filing date

2005-03-17

Publication date

2011-05-16

2005-03-17 Application filed by Kissei Pharmaceutical Company Ltd filed Critical Kissei Pharmaceutical Company Ltd

2005-04-26 Publication of NO20051411L publication Critical patent/NO20051411L/no

2011-05-16 Publication of NO330569B1 publication Critical patent/NO330569B1/no

Links

150000003217 pyrazoles Chemical class 0.000 title claims abstract description 107
238000002360 preparation method Methods 0.000 title claims description 20
239000000203 mixture Substances 0.000 title description 74
239000000543 intermediate Substances 0.000 title description 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 202
125000003161 (C1-C6) alkylene group Chemical group 0.000 claims abstract description 11
150000001875 compounds Chemical class 0.000 claims description 208
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 187
125000001424 substituent group Chemical group 0.000 claims description 177
125000000217 alkyl group Chemical group 0.000 claims description 160
125000003277 amino group Chemical group 0.000 claims description 138
-1 benzoyloxycarbonyl group Chemical group 0.000 claims description 132
125000006239 protecting group Chemical group 0.000 claims description 111
150000003839 salts Chemical class 0.000 claims description 103
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 91
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 78
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 51
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239000003112 inhibitor Substances 0.000 claims description 47
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 46
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125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
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238000000746 purification Methods 0.000 description 2
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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Life Sciences & Earth Sciences (AREA)
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Veterinary Medicine (AREA)
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Animal Behavior & Ethology (AREA)
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Epidemiology (AREA)
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Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
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Immunology (AREA)
Endocrinology (AREA)
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Cardiology (AREA)
Obesity (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
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Heart & Thoracic Surgery (AREA)
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Biomedical Technology (AREA)
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NO20051411A 2002-08-23 2005-03-17 Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk bruk derav samt intermediater til fremstilling derav NO330569B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2002244381		2002-08-23
JP2002324076A JP2004137245A (ja)	2002-08-23	2002-11-07	ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体
PCT/JP2003/010551 WO2004018491A1 (ja)	2002-08-23	2003-08-21	ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体

Publications (2)

Publication Number	Publication Date
NO20051411L NO20051411L (no)	2005-04-26
NO330569B1 true NO330569B1 (no)	2011-05-16

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NO20051411A NO330569B1 (no)	2002-08-23	2005-03-17	Pyrazolderivater, medisinske sammensetninger inneholdende slike, medisinsk bruk derav samt intermediater til fremstilling derav

Country Status (16)

Country	Link
US (2)	US7635684B2 (de)
EP (1)	EP1548024B1 (de)
JP (2)	JP2004137245A (de)
KR (1)	KR100985504B1 (de)
AU (1)	AU2003262263B8 (de)
BR (1)	BRPI0313694B8 (de)
CA (1)	CA2496329C (de)
ES (1)	ES2386140T3 (de)
IL (1)	IL167038A (de)
MX (1)	MXPA05002129A (de)
NO (1)	NO330569B1 (de)
NZ (1)	NZ538423A (de)
PL (1)	PL213094B1 (de)
RU (1)	RU2369613C2 (de)
TW (1)	TW200410980A (de)
WO (1)	WO2004018491A1 (de)

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EP2228378B1 (de)	2007-12-27	2015-09-09	Kissei Pharmaceutical Co., Ltd.	Pyrazolderivat-monosebacat
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2002
- 2002-11-07 JP JP2002324076A patent/JP2004137245A/ja active Pending
2003
- 2003-08-21 AU AU2003262263A patent/AU2003262263B8/en not_active Expired
- 2003-08-21 ES ES03792760T patent/ES2386140T3/es not_active Expired - Lifetime
- 2003-08-21 EP EP03792760A patent/EP1548024B1/de not_active Expired - Lifetime
- 2003-08-21 BR BRPI0313694A patent/BRPI0313694B8/pt not_active IP Right Cessation
- 2003-08-21 NZ NZ538423A patent/NZ538423A/en not_active IP Right Cessation
- 2003-08-21 JP JP2005501231A patent/JP4597048B2/ja not_active Expired - Lifetime
- 2003-08-21 MX MXPA05002129A patent/MXPA05002129A/es active IP Right Grant
- 2003-08-21 US US10/525,197 patent/US7635684B2/en active Active
- 2003-08-21 WO PCT/JP2003/010551 patent/WO2004018491A1/ja not_active Ceased
- 2003-08-21 RU RU2005108055/04A patent/RU2369613C2/ru active
- 2003-08-21 CA CA2496329A patent/CA2496329C/en not_active Expired - Lifetime
- 2003-08-21 KR KR1020057003117A patent/KR100985504B1/ko not_active Expired - Lifetime
- 2003-08-21 PL PL375551A patent/PL213094B1/pl unknown
- 2003-08-22 TW TW092123126A patent/TW200410980A/zh not_active IP Right Cessation
2005
- 2005-02-22 IL IL167038A patent/IL167038A/en unknown
- 2005-03-17 NO NO20051411A patent/NO330569B1/no not_active IP Right Cessation
2009
- 2009-04-09 US US12/421,236 patent/US8324176B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HK1082744A1 (zh)	2006-06-16
US20050272669A1 (en)	2005-12-08
NO20051411L (no)	2005-04-26
RU2369613C2 (ru)	2009-10-10
US8324176B2 (en)	2012-12-04
AU2003262263B8 (en)	2009-08-06
KR20050038633A (ko)	2005-04-27
JP4597048B2 (ja)	2010-12-15
WO2004018491A1 (ja)	2004-03-04
EP1548024A4 (de)	2010-05-12
MXPA05002129A (es)	2005-06-03
BRPI0313694B1 (pt)	2017-12-19
CA2496329A1 (en)	2004-03-04
PL213094B1 (pl)	2013-01-31
AU2003262263A1 (en)	2004-03-11
JP2004137245A (ja)	2004-05-13
JPWO2004018491A1 (ja)	2005-12-08
KR100985504B1 (ko)	2010-10-05
BRPI0313694B8 (pt)	2021-05-25
TW200410980A (en)	2004-07-01
IL167038A (en)	2010-11-30
US20090203633A1 (en)	2009-08-13
CA2496329C (en)	2012-05-15
RU2005108055A (ru)	2006-02-10
BR0313694A (pt)	2005-07-05
EP1548024B1 (de)	2012-06-06
PL375551A1 (en)	2005-11-28
TWI298071B (de)	2008-06-21
AU2003262263B2 (en)	2009-06-25
US7635684B2 (en)	2009-12-22
EP1548024A1 (de)	2005-06-29
NZ538423A (en)	2007-02-23
ES2386140T3 (es)	2012-08-10

Legal Events

Date	Code	Title	Description
2023-09-18	MK1K	Patent expired

Publication	Publication Date	Title
CA2496329C (en)	2012-05-15	Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
US7375087B2 (en)	2008-05-20	Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
US7393838B2 (en)	2008-07-01	Glucopyranosyloxypyrazole derivatives and use thereof in medicines
US7998975B2 (en)	2011-08-16	Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs
US7655633B2 (en)	2010-02-02	Nitrogen-containing heterocyclic derivatives, medicinal compositions containing the same and medicinal use thereof
HK1082744B (en)	2009-05-08	Pyrazole derivatives, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof