NO332678B1 - Selektive dipeptidinhibitorer av kallikrein - Google Patents

Selektive dipeptidinhibitorer av kallikrein Download PDF

Info

Publication number: NO332678B1
Authority: NO; Norway
Prior art keywords: amino; propanoyl; phenyl; piperidine; carboxamidine
Prior art date: 2002-03-08

Application number

NO20043695A

Other languages

English (en)

Norwegian (no)

Other versions

NO20043695L (no

Inventor

David Michael Evans

Original Assignee

Kalvista Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-08

Filing date

2004-09-03

Publication date

2012-12-03

2004-09-03 Application filed by Kalvista Pharmaceuticals Ltd filed Critical Kalvista Pharmaceuticals Ltd

2004-10-07 Publication of NO20043695L publication Critical patent/NO20043695L/no

2012-12-03 Publication of NO332678B1 publication Critical patent/NO332678B1/no

Links

239000003112 inhibitor Substances 0.000 title abstract description 6
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150000001875 compounds Chemical class 0.000 claims abstract description 30
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
QUUYRYYUKNNNNS-UHFFFAOYSA-N piperidine-1-carboximidamide Chemical compound NC(=N)N1CCCCC1 QUUYRYYUKNNNNS-UHFFFAOYSA-N 0.000 claims description 57
125000000217 alkyl group Chemical group 0.000 claims description 56
-1 o-xylylene group Chemical group 0.000 claims description 19
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125000003118 aryl group Chemical group 0.000 claims description 8
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125000003545 alkoxy group Chemical group 0.000 claims description 5
125000003710 aryl alkyl group Chemical group 0.000 claims description 5
125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 4
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235000011090 malic acid Nutrition 0.000 description 1
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CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
YDCHPLOFQATIDS-UHFFFAOYSA-N methyl 2-bromoacetate Chemical compound COC(=O)CBr YDCHPLOFQATIDS-UHFFFAOYSA-N 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229960002748 norepinephrine Drugs 0.000 description 1
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
229940094443 oxytocics prostaglandins Drugs 0.000 description 1
150000003053 piperidines Chemical class 0.000 description 1
229940012957 plasmin Drugs 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
229910000343 potassium bisulfate Inorganic materials 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
150000003180 prostaglandins Chemical class 0.000 description 1
230000006337 proteolytic cleavage Effects 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
108010073863 saruplase Proteins 0.000 description 1
229910001923 silver oxide Inorganic materials 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011343 solid material Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000012622 synthetic inhibitor Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
IZIRSMBXMWPIBN-UHFFFAOYSA-N tert-butyl n-(1-benzylpiperidin-4-yl)carbamate;tert-butyl n-piperidin-4-ylcarbamate Chemical compound CC(C)(C)OC(=O)NC1CCNCC1.C1CC(NC(=O)OC(C)(C)C)CCN1CC1=CC=CC=C1 IZIRSMBXMWPIBN-UHFFFAOYSA-N 0.000 description 1
FSPABGHBPWUAST-UHFFFAOYSA-N tert-butyl n-[1-[(z)-n,n'-bis(phenylmethoxycarbonyl)carbamimidoyl]piperidin-4-yl]carbamate Chemical compound C1CC(NC(=O)OC(C)(C)C)CCN1C(NC(=O)OCC=1C=CC=CC=1)=NC(=O)OCC1=CC=CC=C1 FSPABGHBPWUAST-UHFFFAOYSA-N 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229960001322 trypsin Drugs 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
125000006839 xylylene group Chemical group 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20043695A 2002-03-08 2004-09-03 Selektive dipeptidinhibitorer av kallikrein NO332678B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0205527.5A GB0205527D0 (en)	2002-03-08	2002-03-08	Inhibitors
PCT/GB2003/000908 WO2003076458A2 (fr)	2002-03-08	2003-03-04	Inhibiteurs

Publications (2)

Publication Number	Publication Date
NO20043695L NO20043695L (no)	2004-10-07
NO332678B1 true NO332678B1 (no)	2012-12-03

Family

ID=9932619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20043695A NO332678B1 (no)	2002-03-08	2004-09-03	Selektive dipeptidinhibitorer av kallikrein

Country Status (26)

Country	Link
US (1)	US7649000B2 (fr)
EP (1)	EP1483284B1 (fr)
JP (1)	JP4330450B2 (fr)
KR (1)	KR100974633B1 (fr)
CN (1)	CN1274713C (fr)
AR (1)	AR039868A1 (fr)
AT (1)	ATE333463T1 (fr)
AU (1)	AU2003208471B2 (fr)
CA (1)	CA2478099C (fr)
DE (1)	DE60306904T2 (fr)
DK (1)	DK1483284T3 (fr)
EG (1)	EG25482A (fr)
ES (1)	ES2264523T3 (fr)
GB (1)	GB0205527D0 (fr)
IL (2)	IL163710A0 (fr)
MX (1)	MXPA04008523A (fr)
MY (1)	MY130830A (fr)
NO (1)	NO332678B1 (fr)
NZ (1)	NZ534891A (fr)
PL (1)	PL209670B1 (fr)
PT (1)	PT1483284E (fr)
RU (1)	RU2301225C2 (fr)
TW (1)	TWI283685B (fr)
UY (1)	UY27699A1 (fr)
WO (1)	WO2003076458A2 (fr)
ZA (1)	ZA200406856B (fr)

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JP4775259B2 (ja)	2004-03-31	2011-09-21	味の素株式会社	アニリン誘導体
CA2696208A1 (fr) *	2007-08-21	2009-02-26	Genzyme Corporation	Traitement par des inhibiteurs de la kallikreine
GB0918924D0 (en) *	2009-10-28	2009-12-16	Vantia Ltd	Azaindole derivatives
US9290485B2 (en)	2010-08-04	2016-03-22	Novartis Ag	N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB2494851A (en)	2011-07-07	2013-03-27	Kalvista Pharmaceuticals Ltd	Plasma kallikrein inhibitors
US20140378474A1 (en)	2012-01-27	2014-12-25	Novartis Ag	5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
EP2807156A1 (fr)	2012-01-27	2014-12-03	Novartis AG	Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la kallicréine plasmatique
GB201212081D0 (en)	2012-07-06	2012-08-22	Kalvista Pharmaceuticals Ltd	New polymorph
IL239682B (en)	2013-01-08	2018-10-31	Kalvista Pharmaceuticals Ltd	History of benzylamine and 2-(aminomethyl)pyridine
GB201300304D0 (en)	2013-01-08	2013-02-20	Kalvista Pharmaceuticals Ltd	Benzylamine derivatives
GB2510407A (en)	2013-02-04	2014-08-06	Kalvista Pharmaceuticals Ltd	Aqueous suspensions of kallikrein inhibitors for parenteral administration
MY174018A (en)	2013-05-23	2020-03-04	Kalvista Pharmaceuticals Ltd	Heterocyclic derivates
CA2920815C (fr)	2013-08-14	2021-09-21	Kalvista Pharmaceuticals Limited	Inhibiteurs de la kallicreine plasmatique
GB2517908A (en)	2013-08-14	2015-03-11	Kalvista Pharmaceuticals Ltd	Bicyclic inhibitors
TWI636047B (zh)	2013-08-14	2018-09-21	英商卡爾維斯塔製藥有限公司	雜環衍生物
CN105683211B (zh) *	2013-10-28	2020-10-20	拜斯科阿迪有限公司	新型多肽
RU2733405C2 (ru)	2014-02-07	2020-10-01	Экзитера Фармасьютикалз Инк.	Терапевтические соединения и композиции
GB201421088D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
GB201421085D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
GB201421083D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	Enzyme inhibitors
IL263235B (en)	2016-05-31	2022-07-01	Kalvista Pharmaceuticals Ltd	History of pyrazoles as plasma kallikrein inhibitors
GB201609607D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201719881D0 (en)	2017-11-29	2018-01-10	Kalvista Pharmaceuticals Ltd	Solid forms of plasma kallikrein inhibitor and salts thereof
HUE057912T2 (hu)	2017-11-29	2022-06-28	Kalvista Pharmaceuticals Ltd	Plazma kallikrein inhibitort tartalmazó dózisformák
KR20210084581A (ko)	2018-10-30	2021-07-07	엑시테라 파마슈티컬스 인코퍼레이티드	치료 화합물 및 조성물
GB201910116D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of hereditary angioedema
GB201910125D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of angioedema
WO2021028645A1 (fr)	2019-08-09	2021-02-18	Kalvista Pharmaceuticals Limited	Inhibiteurs de la kallicréine plasmatique
GB2591730A (en)	2019-12-09	2021-08-11	Kalvista Pharmaceuticals Ltd	New polymorphs
GB201918994D0 (en)	2019-12-20	2020-02-05	Kalvista Pharmaceuticals Ltd	Treatments of diabetic macular edema and impaired visual acuity
WO2021198534A1 (fr)	2020-04-04	2021-10-07	Oxurion NV	Inhibiteurs de la kallicréine plasmique destinés à être utilisés dans le traitement d'une maladie à coronavirus
TW202228686A (zh)	2020-10-15	2022-08-01	英商卡爾維斯塔製藥有限公司	血管性水腫之治療
US20230381162A1 (en)	2020-10-23	2023-11-30	Kalvista Pharmaceuticals Limited	Treatments of angioedema
JP2024505596A (ja)	2021-02-09	2024-02-06	カルビスタ・ファーマシューティカルズ・リミテッド	遺伝性血管性浮腫の治療
WO2023002219A1 (fr)	2021-07-23	2023-01-26	Kalvista Pharmaceuticals Limited	Traitements de l'angio-oedème héréditaire
WO2023144030A1 (fr)	2022-01-31	2023-08-03	Oxurion NV	Thérapie par inhibiteur de la kallicréine plasmatique pour une sensibilisation aux anti-vegf
WO2023148016A1 (fr)	2022-02-04	2023-08-10	Oxurion NV	Biomarqueur pour la réponse à une thérapie par inhibiteur de la kallicréine plasmatique
US20250281397A1 (en)	2022-04-27	2025-09-11	Kalvista Pharmaceuticals Limited	Formulations of a plasma kallikrein inhibitor
WO2024180100A1 (fr)	2023-02-27	2024-09-06	Kalvista Pharmaceuticals Limited	Nouvelle forme solide d'un inhibiteur de la kallicréine plasmatique
WO2025153806A1 (fr)	2024-01-15	2025-07-24	Kalvista Pharmaceuticals Limited	Procédés de détermination de l'activité amidolytique
WO2025172692A1 (fr)	2024-02-13	2025-08-21	Kalvista Pharmaceuticals Limited	Sebetralstat à administrer par voie orale pour le traitement d'une attaque d'angioedème héréditaire
WO2025172693A1 (fr)	2024-02-13	2025-08-21	Kalvista Pharmaceuticals Limited	Sebetralstat oral pour le traitement d'un épisode d'angio-œdème héréditaire

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GB9019558D0 (en) *	1990-09-07	1990-10-24	Szelke Michael	Enzyme inhibitors
AU2882792A (en) *	1991-10-23	1993-05-21	Procter & Gamble Company, The	Tripeptide derivative anti-inflammatory agents
SE9301911D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptide derivatives
GB9318637D0 (en) *	1993-09-08	1993-10-27	Ferring Res Ltd	Enzyme inhibitors

2002
- 2002-03-08 GB GBGB0205527.5A patent/GB0205527D0/en not_active Ceased
2003
- 2003-02-26 TW TW092104061A patent/TWI283685B/zh not_active IP Right Cessation
- 2003-03-03 EG EG2003030209A patent/EG25482A/xx active
- 2003-03-04 PL PL372977A patent/PL209670B1/pl unknown
- 2003-03-04 AT AT03706759T patent/ATE333463T1/de active
- 2003-03-04 WO PCT/GB2003/000908 patent/WO2003076458A2/fr not_active Ceased
- 2003-03-04 DE DE60306904T patent/DE60306904T2/de not_active Expired - Lifetime
- 2003-03-04 NZ NZ534891A patent/NZ534891A/xx not_active IP Right Cessation
- 2003-03-04 EP EP03706759A patent/EP1483284B1/fr not_active Expired - Lifetime
- 2003-03-04 ES ES03706759T patent/ES2264523T3/es not_active Expired - Lifetime
- 2003-03-04 JP JP2003574673A patent/JP4330450B2/ja not_active Expired - Fee Related
- 2003-03-04 CA CA2478099A patent/CA2478099C/fr not_active Expired - Lifetime
- 2003-03-04 KR KR1020047013816A patent/KR100974633B1/ko not_active Expired - Fee Related
- 2003-03-04 PT PT03706759T patent/PT1483284E/pt unknown
- 2003-03-04 MX MXPA04008523A patent/MXPA04008523A/es active IP Right Grant
- 2003-03-04 DK DK03706759T patent/DK1483284T3/da active
- 2003-03-04 CN CNB038054019A patent/CN1274713C/zh not_active Expired - Fee Related
- 2003-03-04 RU RU2004126610/04A patent/RU2301225C2/ru not_active IP Right Cessation
- 2003-03-04 US US10/506,535 patent/US7649000B2/en not_active Expired - Lifetime
- 2003-03-04 AU AU2003208471A patent/AU2003208471B2/en not_active Ceased
- 2003-03-04 IL IL16371003A patent/IL163710A0/xx unknown
- 2003-03-06 AR ARP030100772A patent/AR039868A1/es active IP Right Grant
- 2003-03-06 UY UY27699A patent/UY27699A1/es not_active Application Discontinuation
- 2003-03-07 MY MYPI20030803A patent/MY130830A/en unknown
2004
- 2004-08-24 IL IL163710A patent/IL163710A/en active IP Right Grant
- 2004-08-27 ZA ZA200406856A patent/ZA200406856B/en unknown
- 2004-09-03 NO NO20043695A patent/NO332678B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL163710A0 (en)	2005-12-18
ES2264523T3 (es)	2007-01-01
EP1483284A2 (fr)	2004-12-08
AU2003208471B2 (en)	2006-09-28
KR100974633B1 (ko)	2010-08-06
TW200403255A (en)	2004-03-01
KR20040089705A (ko)	2004-10-21
AU2003208471A1 (en)	2003-09-22
IL163710A (en)	2010-12-30
DE60306904D1 (de)	2006-08-31
PT1483284E (pt)	2006-11-30
US20060052313A1 (en)	2006-03-09
DK1483284T3 (da)	2006-10-16
EG25482A (en)	2012-01-15
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Publication	Publication Date	Title
NO332678B1 (no)	2012-12-03	Selektive dipeptidinhibitorer av kallikrein
JP3453357B2 (ja)	2003-10-06	トロンビンの阻害剤および基質
AU702360B2 (en)	1999-02-18	Ketoheterocyclic inhibitors of factor Xa
EP0815123B1 (fr)	2001-10-04	Imitateurs de feuillets beta et leur utilisation en tant qu'inhibiteurs de protease
CA2193844A1 (fr)	1996-02-08	Inhibiteurs de la thrombine
CA2217682A1 (fr)	1996-10-17	Inhibiteurs de la thrombine
CZ386997A3 (cs)	1998-07-15	Peptidylové heterocyklické sloučeniny vhodné pro léčení chorob týkajících se trombinu
JPH04330094A (ja)	1992-11-18	有機化学における改良
WO1996030396A1 (fr)	1996-10-03	IMITATEURS DE FEUILLETS β ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PROTEASE
WO2012140500A1 (fr)	2012-10-18	Inhibiteurs sélectifs de cystéine protéase et leurs utilisations
AU710408B2 (en)	1999-09-23	Inhibitors of factor Xa
CS106492A3 (en)	1992-10-14	Derivatives of amidinophenylalanine, process for preparing thereof, theiruse and compositions comprising said derivatives
US6586426B1 (en)	2003-07-01	β-sheet mimetics and use thereof as protease inhibitors
CA2342985C (fr)	2009-09-15	Inhibiteurs de la cysteine protease et de la serine protease contenant de l'hydroxamate
CA2256391C (fr)	2009-11-24	Derives de peptidyl-arginine aldehyde anticoagulants
US6417161B1 (en)	2002-07-09	Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
HK1072265B (en)	2006-09-15	Selective dipeptide inhibitors of kallikrein
CA2163011A1 (fr)	1994-12-22	Nouveaux derives de peptides