PT101875A - Derivados de benzeno e processo para a sua preparacao - Google Patents

Derivados de benzeno e processo para a sua preparacao Download PDF

Info

Publication number: PT101875A
Authority: PT; Portugal
Prior art keywords: group; preparation; benzene derivatives; angiotensin; therapeutics
Prior art date: 1989-10-24

Application number

PT101875A

Other languages

English (en)

Other versions

PT101875B (pt

Inventor

Takehiko Naka

Kohei Nishikawa

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-24

Filing date

1996-05-24

Publication date

1997-12-31

1996-05-24 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1997-12-31 Publication of PT101875A publication Critical patent/PT101875A/pt

1999-04-30 Publication of PT101875B publication Critical patent/PT101875B/pt

Links

UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
102000005862 Angiotensin II Human genes 0.000 abstract 1
101800000733 Angiotensin-2 Proteins 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 1
229950006323 angiotensin ii Drugs 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002460 imidazoles Chemical class 0.000 abstract 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyesters Or Polycarbonates (AREA)
Steroid Compounds (AREA)

PT101875A 1989-10-24 1996-05-24 Derivados de benzeno e processo para a sua preparacao PT101875B (pt)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
JP27738589		1989-10-24
JP32897489		1989-12-18
JP514790		1990-01-11
JP9167590		1990-04-05
JP9732490		1990-04-11
JP11314590		1990-04-27

Publications (2)

Publication Number	Publication Date
PT101875A true PT101875A (pt)	1997-12-31
PT101875B PT101875B (pt)	1999-04-30

Family

ID=27547894

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT95655A PT95655B (pt)	1989-10-24	1990-10-23	Processo para a preparacao de derivados de benzimidazol
PT101875A PT101875B (pt)	1989-10-24	1996-05-24	Derivados de benzeno e processo para a sua preparacao

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT95655A PT95655B (pt)	1989-10-24	1990-10-23	Processo para a preparacao de derivados de benzimidazol

Country Status (14)

Country	Link
US (1)	US5128356A (pt)
EP (1)	EP0425921B1 (pt)
JP (1)	JP3099241B2 (pt)
AT (1)	ATE126219T1 (pt)
AU (1)	AU649418B2 (pt)
CA (1)	CA2028302C (pt)
DE (1)	DE69021502T2 (pt)
FI (1)	FI102068B1 (pt)
HU (1)	HUT55384A (pt)
IE (1)	IE67956B1 (pt)
IL (1)	IL95975A (pt)
NO (1)	NO177304C (pt)
NZ (1)	NZ235762A (pt)
PT (2)	PT95655B (pt)

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CA2016710A1 (en) *	1989-05-15	1990-11-15	Prasun K. Chakravarty	Substituted benzimidazoles as angiotensin ii antagonists
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1990
- 1990-10-12 IL IL95975A patent/IL95975A/xx not_active IP Right Cessation
- 1990-10-15 AU AU64612/90A patent/AU649418B2/en not_active Ceased
- 1990-10-19 DE DE69021502T patent/DE69021502T2/de not_active Expired - Fee Related
- 1990-10-19 US US07/599,894 patent/US5128356A/en not_active Expired - Fee Related
- 1990-10-19 NZ NZ235762A patent/NZ235762A/en unknown
- 1990-10-19 AT AT90120054T patent/ATE126219T1/de not_active IP Right Cessation
- 1990-10-19 EP EP90120054A patent/EP0425921B1/en not_active Expired - Lifetime
- 1990-10-23 FI FI905215A patent/FI102068B1/fi not_active IP Right Cessation
- 1990-10-23 PT PT95655A patent/PT95655B/pt not_active IP Right Cessation
- 1990-10-23 CA CA002028302A patent/CA2028302C/en not_active Expired - Fee Related
- 1990-10-23 NO NO904569A patent/NO177304C/no not_active IP Right Cessation
- 1990-10-23 IE IE380390A patent/IE67956B1/en not_active IP Right Cessation
- 1990-10-23 JP JP02286299A patent/JP3099241B2/ja not_active Expired - Fee Related
- 1990-10-24 HU HU906539A patent/HUT55384A/hu unknown
1996
- 1996-05-24 PT PT101875A patent/PT101875B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL95975A0 (en)	1991-07-18
ATE126219T1 (de)	1995-08-15
IL95975A (en)	1997-06-10
CA2028302C (en)	2002-01-15
AU6461290A (en)	1991-05-02
PT95655B (pt)	1996-09-30
CA2028302A1 (en)	1991-04-25
IE903803A1 (en)	1991-04-24
NO904569L (no)	1991-04-25
NO904569D0 (no)	1990-10-23
HU906539D0 (en)	1991-04-29
JP3099241B2 (ja)	2000-10-16
US5128356A (en)	1992-07-07
FI905215A0 (fi)	1990-10-23
AU649418B2 (en)	1994-05-26
FI102068B (fi)	1998-10-15
IE67956B1 (en)	1996-05-15
PT101875B (pt)	1999-04-30
EP0425921A1 (en)	1991-05-08
DE69021502D1 (de)	1995-09-14
HUT55384A (en)	1991-05-28
NO177304B (no)	1995-05-15
NO177304C (no)	1995-08-23
NZ235762A (en)	1992-04-28
DE69021502T2 (de)	1996-01-11
FI102068B1 (fi)	1998-10-15
EP0425921B1 (en)	1995-08-09
JPH049373A (ja)	1992-01-14
PT95655A (pt)	1991-09-13

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1999-04-30

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Patent granted, date of granting

Effective date: 19990119

2003-02-28

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20021130

Publication	Publication Date	Title
PT101875A (pt)	1997-12-31	Derivados de benzeno e processo para a sua preparacao
BR9002311A (pt)	1991-08-06	Composto e processo para sua preparacao,composicao fungicida e processo para controlar fungos fitopatogenicos
ES2044836T3 (es)	1994-01-16	Derivado de la piperidina, su utilizacion y compuesto farmaceutico que lo contiene.
BR8704582A (pt)	1988-04-26	Processo para preparar derivados de piridinacarboxamida
FR2446289A1 (fr)	1980-08-08	Compose de 2-penem, procede de preparation et composition pharmaceutique obtenue
BR8600183A (pt)	1986-09-30	Derivado de pirazolsulfonamida,processos para sua producao e composicao herbicida contendo o mesmo
BR8905791A (pt)	1990-06-12	Compostos de nitrometileno,processo para a sua preparacao e composicao pesticida
PT733621E (pt)	2002-09-30	Novos derivados de imidazole e processo para a sua preparacao
CA2011087A1 (en)	1990-09-10	Use of trifluoromethylphenylazolylmethyloxiranes as crop protection agents
ES8609204A1 (es)	1986-09-01	Procedimiento de preparar derivados aminicos
BR8901097A (pt)	1989-10-31	Processo para a preparacao de uma composicao biocida
BR9001894A (pt)	1991-07-30	Processo para preparar um composto,compostos assim preparados e composicoes pesticidas
PT93967A (pt)	1991-01-08	Processo para a preparacao de novos 1-aril-imidazois e de composicoes pesticidas e farmaceuticas que os contem e metodo para a sua utilizacao para controlar artropodes, nematoides, helmintas ou protozoarios
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FI882873A0 (fi)	1988-06-16	Tiofenderivat och foerfarande foer dess framstaellning.
RU94036445A (ru)	1996-08-20	Производные оксадиазолкарбонамида, способ их получения, промежуточные соединения, способ их получения, гербицидная композиция, способ борьбы с сорняками
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
PT99043A (pt)	1992-08-31	Processo para a preparacao de composicoes biocidas contendo derivados de 4,5-polimetileno-4-isotiazolin-3-onas
ATE73795T1 (de)	1992-04-15	Thioformamid-derivate.
BR9003508A (pt)	1991-08-27	Composicao biocida,processo para inibir o desenvolvimento de microrganismos e processo para a preparacao de um composto biocida
DK0485204T3 (da)	1995-10-16	Fremgangsmåde til fremstilling af 3-alkoxymethyl-cephalosporin-derivater
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JPS5515408A (en)	1980-02-02	Novel mitomycin derivative and its preparation
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