NO951684L - Pyrrolopyrimidinderivater med farmakologisk aktivitet - Google Patents

Pyrrolopyrimidinderivater med farmakologisk aktivitet

Info

Publication number
NO951684L
NO951684L NO951684A NO951684A NO951684L NO 951684 L NO951684 L NO 951684L NO 951684 A NO951684 A NO 951684A NO 951684 A NO951684 A NO 951684A NO 951684 L NO951684 L NO 951684L
Authority
NO
Norway
Prior art keywords
compounds
alkyl
trifluoromethyl
unsubstituted
alkoxy
Prior art date
Application number
NO951684A
Other languages
English (en)
Other versions
NO951684D0 (no
Inventor
Peter Traxler
Pascal Furet
Wolfgang K-D Brill
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO951684D0 publication Critical patent/NO951684D0/no
Publication of NO951684L publication Critical patent/NO951684L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Det blir beskrevet anvendelsen av forbindelser nevnt nedenfor i den terapeutiske behandling av tumorsyk- dommer og andre prollferative sykdommer, slik som psoriasis, og nye forbindelser av denne typen. Forbindelsene er forbindelser med formel I hvor n er fra O til 5, og når n Ikke er O, er R en eller flere substltuenter valgt fra halogen, alkyl, trlfluormetyl og alkoksy; og . _ R! og R£ er hver uavhengig av den andre alkyl, eller fenyl som er Ikke-substltuert eller substituert med halogen, trlfluormetyl, alkyl eller med alkoksy, er det også mulig for en av de to radlkalene Rj og R2 å være hydrogen, eller RI og R£ sammen danner en alkylénkjede som har fra 2 til 5 karbonatomer som er Ikke-substltuert eller substituert med alkyl; eller salter derav. Forbindelser med formel I hemmer protelnklnaser, for eksempel tyroslnprotelnklnase til reseptoren for den eplderoale vekstfaktoren EGF.
NO951684A 1994-05-03 1995-05-02 Pyrrolopyrimidinderivater med farmakologisk aktivitet NO951684L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH138594 1994-05-03
CH24595 1995-01-30

Publications (2)

Publication Number Publication Date
NO951684D0 NO951684D0 (no) 1995-05-02
NO951684L true NO951684L (no) 1995-11-06

Family

ID=25684008

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951684A NO951684L (no) 1994-05-03 1995-05-02 Pyrrolopyrimidinderivater med farmakologisk aktivitet

Country Status (20)

Country Link
US (2) US5686457A (no)
EP (1) EP0682027B1 (no)
JP (1) JP3042760B2 (no)
KR (1) KR950031113A (no)
CN (1) CN1128263A (no)
AT (1) ATE159257T1 (no)
AU (1) AU695244B2 (no)
CA (1) CA2148324A1 (no)
CZ (1) CZ113195A3 (no)
DE (1) DE59500788D1 (no)
DK (1) DK0682027T3 (no)
ES (1) ES2109796T3 (no)
FI (1) FI952033A7 (no)
GR (1) GR3025158T3 (no)
HU (1) HUT71818A (no)
IL (1) IL113531A0 (no)
NO (1) NO951684L (no)
NZ (1) NZ272031A (no)
PL (1) PL308426A1 (no)
SK (1) SK56195A3 (no)

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