NO953878L - Umettede fosfonatderivater av puriner og pyrimidiner - Google Patents

Umettede fosfonatderivater av puriner og pyrimidiner

Info

Publication number
NO953878L
NO953878L NO953878A NO953878A NO953878L NO 953878 L NO953878 L NO 953878L NO 953878 A NO953878 A NO 953878A NO 953878 A NO953878 A NO 953878A NO 953878 L NO953878 L NO 953878L
Authority
NO
Norway
Prior art keywords
pyrimidines
purines
phosphonate derivatives
unsaturated phosphonate
antivirals
Prior art date
Application number
NO953878A
Other languages
English (en)
Norwegian (no)
Other versions
NO953878D0 (no
Inventor
Patrick Casara
Jean-Francoise Nave
Serge Halazy
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO953878D0 publication Critical patent/NO953878D0/no
Publication of NO953878L publication Critical patent/NO953878L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Saccharide Compounds (AREA)
NO953878A 1993-04-01 1995-09-29 Umettede fosfonatderivater av puriner og pyrimidiner NO953878L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93400842A EP0618214A1 (de) 1993-04-01 1993-04-01 Ungesättigte Phosphonatderivate Purinen und Pyrimidinen
PCT/US1994/001837 WO1994022882A1 (en) 1993-04-01 1994-02-25 Unsaturated phosphonates derivatives of purines and pyrimidines

Publications (2)

Publication Number Publication Date
NO953878D0 NO953878D0 (no) 1995-09-29
NO953878L true NO953878L (no) 1995-12-01

Family

ID=8214695

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953878A NO953878L (no) 1993-04-01 1995-09-29 Umettede fosfonatderivater av puriner og pyrimidiner

Country Status (17)

Country Link
EP (2) EP0618214A1 (de)
JP (1) JPH08508481A (de)
CN (2) CN1046288C (de)
AT (1) ATE154605T1 (de)
AU (1) AU681395B2 (de)
CA (1) CA2159451C (de)
DE (1) DE69403910T2 (de)
DK (1) DK0701562T3 (de)
ES (1) ES2105684T3 (de)
FI (1) FI113539B (de)
GR (1) GR3024788T3 (de)
HU (1) HUT72459A (de)
IL (1) IL109152A0 (de)
NO (1) NO953878L (de)
NZ (1) NZ263904A (de)
WO (1) WO1994022882A1 (de)
ZA (1) ZA942092B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
CA2195262C (en) * 1996-01-18 2005-08-09 Masaru Ubasawa Phosphonate nucleotide compounds
FR2781229B1 (fr) * 1998-07-17 2001-11-30 Univ Nice Sophia Antipolis Nouveaux composes analogues des nucleotides, leurs procedes de preparation et leurs applications
GB9821058D0 (en) 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
EP1406911B1 (de) 2001-06-29 2016-01-06 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic 6-[2-(phosphonomethoxy)alkoxy ]pyrimidinederivate mit antiviraler wirksamkeit
WO2003028737A1 (en) * 2001-08-30 2003-04-10 Mitsubishi Pharma Corporation Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20060252729A1 (en) * 2003-07-30 2006-11-09 Krawczyk Steven H Nucleobase phosphonate analogs for antiviral treatment
ATE534652T1 (de) * 2005-04-01 2011-12-15 Univ California Phosphono-pent-2-en-1-yl-nukleoside und analoga
WO2006114065A2 (en) * 2005-04-25 2006-11-02 Institute Of Organic Chemistry And Biochemistry A Cademy Of Sciences Of The Czech Republic Use of compounds to inhibit neoplasia
CN100352823C (zh) * 2005-08-19 2007-12-05 浙江车头制药有限公司 一种腺嘌呤衍生物的制备方法
WO2008100447A2 (en) 2007-02-09 2008-08-21 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
EP3578563B1 (de) 2011-12-22 2021-04-14 Geron Corporation Guanin-analoga als telomerasesubstrate und telomerlängenaffektoren
KR102622656B1 (ko) 2016-02-18 2024-01-10 인버사, 인크. 5'-아데노신 디포스페이트 리보오스 (adpr)의 사용 방법
US10946034B2 (en) 2018-03-27 2021-03-16 Invirsa, Inc. Methods for the use of 5′-adenosine diphosphate ribose (ADPR)
CN108383872B (zh) * 2018-04-18 2019-07-12 南京师范大学 一种-1,1-二氟-3-磺酰基-2,4-戊二烯膦酸酯类化合物及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2017054C (en) * 1990-05-16 1999-08-10 Jack S. Wilson Automatic storage and retrieval system
JPH05509307A (ja) * 1990-07-19 1993-12-22 ビーチャム・グループ・パブリック・リミテッド・カンパニー プリンの抗ウイルス性ホスホノ―アルケン誘導体
EP0531597A1 (de) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Ungesättigte azyklische Phosphonsäure Purinderivats und Pyrimidinderivate
HU225970B1 (en) * 1991-10-11 2008-01-28 Acad Of Science Czech Republic Antiviral acyclic phosphonomethoxyalkyl-substituted alkenyl purine and pyrimidine derivatives, and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
GR3024788T3 (en) 1998-01-30
EP0701562A1 (de) 1996-03-20
FI113539B (fi) 2004-05-14
FI954615L (fi) 1995-09-28
CN1229084A (zh) 1999-09-22
EP0701562B1 (de) 1997-06-18
DE69403910T2 (de) 1998-01-29
DK0701562T3 (da) 1997-07-07
CN1120338A (zh) 1996-04-10
FI954615A0 (fi) 1995-09-28
WO1994022882A1 (en) 1994-10-13
ATE154605T1 (de) 1997-07-15
JPH08508481A (ja) 1996-09-10
HUT72459A (en) 1996-04-29
HU9502854D0 (en) 1995-11-28
ZA942092B (en) 1994-10-24
CN1046288C (zh) 1999-11-10
EP0618214A1 (de) 1994-10-05
CA2159451C (en) 1999-04-13
ES2105684T3 (es) 1997-10-16
NZ263904A (en) 1996-11-26
AU6516294A (en) 1994-10-24
CA2159451A1 (en) 1994-10-13
DE69403910D1 (de) 1997-07-24
NO953878D0 (no) 1995-09-29
IL109152A0 (en) 1994-06-24
AU681395B2 (en) 1997-08-28

Similar Documents

Publication Publication Date Title
NO953878L (no) Umettede fosfonatderivater av puriner og pyrimidiner
NO883073D0 (no) 3-desmetyl-mevalonsyrederivater, fremgangsmaate til deres fremstilling samt deres anvendelse som mellomprodukter.
ATE210459T1 (de) Verwendung von protease-inhibitoren als antiviral agentien
NO951162L (no) 1-(2-okso-acetyl)-piperidin-2-karboksylsyrederivater som multi-medikamentresistente sensitivisatorer for kreftceller
DK0631575T3 (da) Substituerede pyrimidiner samt deres anvendelse som fungicider
DE68925505D1 (de) Zusammensetzungen zum Erreichen eines Lasereffektes und Methoden zu deren Gebrauch
ATE245641T1 (de) Antivirale pyrimidinderivate
AR020054A1 (es) COMPOSICIoN QUE COMPRENDE UN ADENOVIRUS
ATE231839T1 (de) Polyaromatische antivirale zusammensetzungen
ATE252830T1 (de) Neue psoralene zur inaktivierung von pathogenen
NO911600L (no) Fremgangsmaate for fremstilling av n-(3-fluor-2-fosfonyl-metoksypropyl)-derivater av heterocykliske purin- og pyrimidinbaser.
ATE376445T1 (de) Synergistische hemmung von viralreplikation durch langkettigen kohlenwasserstoffe und nucleosid- analoge
NO983090L (no) Terapeutiske forbindelser
DK270789A (da) Hirudin-derivater, deres fremstilling og anvendelse
DK23289D0 (da) Disubstituerede pyridinderivater, fremgangsmaade og mellemprodukter til deres fremstilling samt deres anvendelse
PT1140113E (pt) Utilizacao de bisfosfonatos para profilaxia e tratamento de processos infecciosos
DE68927651D1 (de) Derivate von Fluorphosphonat-Nukleotiden
CA2100066A1 (en) Michellamines useful as antiviral agents, composition and method of treatment
ES2134259T3 (es) Compuestos antiviricos calanolidas, composiciones y utilizacion de los mismos.
DK1015437T3 (da) Benzoxazin- og benzothiazin-derivater og deres anvendelse i lægemidler
DK318589D0 (da) 19-substituerede progesteron-derivater, anvendelige som 19-hydroxylase-inhibitorer
SE8700555D0 (sv) Purine derivatives, their production and medicaments containing them
NO991589L (no) Nye 3-,5- og/eller 6-substituerte analoger av swainsonin, fremgangsmÕter for deres fremstilling og deres anvendelse som terapeutiske midler
AU538612B2 (en) Salt of furosemide or piretanide as acid component and penbutolol or (-)-3-(4-3-(3,4-dimethoxyphenylethylamino)-2- hydroxypropoxy)-phenyl)-crotonitrile as base component
ES2169040T3 (es) Planta resistente a dos o mas virus y preparacion de la misma.