NO960365L - Perhydroisoindolderivater som substans-P-antagonister - Google Patents

Perhydroisoindolderivater som substans-P-antagonister

Info

Publication number: NO960365L
Authority: NO; Norway
Prior art keywords: alkyl; optionally substituted; hydroxyalkyl; substance; phenyl
Prior art date: 1993-07-30

Application number

NO960365A

Other languages

English (en)

Norwegian (no)

Other versions

NO960365D0 (no

Inventor

Daniel Achard

Serge Grisoni

Evelyne James-Surcouf

Jean-Luc Malleron

Anne Morgat

Jean-Francois Peyronel

Jean-Francois Sabuco

Michel Tabart

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-30

Filing date

1996-01-29

Publication date

1996-01-29

1993-07-30 Priority claimed from FR9309400A external-priority patent/FR2709752B1/fr

1993-10-07 Priority claimed from FR9311946A external-priority patent/FR2710913B1/fr

1996-01-29 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1996-01-29 Publication of NO960365D0 publication Critical patent/NO960365D0/no

1996-01-29 Publication of NO960365L publication Critical patent/NO960365L/no

Links

ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 title 1
239000003890 substance P antagonist Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 cyclohexadlenyl Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO960365A 1993-07-30 1996-01-29 Perhydroisoindolderivater som substans-P-antagonister NO960365L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9309400A FR2709752B1 (fr)	1993-07-30	1993-07-30	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR9311946A FR2710913B1 (fr)	1993-10-07	1993-10-07	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR1994/000952 WO1995004040A1 (fr)	1993-07-30	1994-07-28	Derives de perhydroisoindole comme antagonistes de la substance p

Publications (2)

Publication Number	Publication Date
NO960365D0 NO960365D0 (no)	1996-01-29
NO960365L true NO960365L (no)	1996-01-29

Family

ID=26230522

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO960365A NO960365L (no)	1993-07-30	1996-01-29	Perhydroisoindolderivater som substans-P-antagonister

Country Status (19)

Country	Link
US (1)	US5624950A (de)
EP (1)	EP0711280B1 (de)
JP (1)	JPH09500893A (de)
KR (1)	KR960703858A (de)
AT (1)	ATE171445T1 (de)
AU (1)	AU7386594A (de)
CA (1)	CA2168233A1 (de)
CZ (1)	CZ26396A3 (de)
DE (1)	DE69413542T2 (de)
DK (1)	DK0711280T3 (de)
ES (1)	ES2123149T3 (de)
FI (1)	FI960399A0 (de)
HU (1)	HUT75304A (de)
IL (1)	IL110494A0 (de)
NO (1)	NO960365L (de)
PL (1)	PL312739A1 (de)
SK (1)	SK13096A3 (de)
TW (1)	TW365603B (de)
WO (1)	WO1995004040A1 (de)

Families Citing this family (54)

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FR2727411B1 (fr) *	1994-11-30	1997-01-03	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent
DE19738339C2 (de) *	1997-09-02	2000-08-31	Siemens Ag	Verfahren zum benutzergesteuerten Abbauen von drahtlosen Telekommunikationsverbindungen in drahtlosen Telekommunikationssystemen, insbesondere DECT-Systemen
US6061833A (en) *	1998-12-17	2000-05-16	Wdc Holdings, Inc.	Protective glove with improved wrist strap
US6586446B1 (en)	1999-10-15	2003-07-01	Bristol-Myers Squibb Company	Bicyclic and tricyclic amines as modulators of chemokine receptor activity
US6784200B2 (en)	2000-10-13	2004-08-31	Bristol-Myers Squibb Pharma Company	Bicyclic and tricyclic amines as modulators of chemokine receptor activity
DK1246806T3 (da)	1999-11-03	2008-06-16	Amr Technology Inc	Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
MXPA03000275A (es)	2000-07-11	2004-12-13	Albany Molecular Res Inc	Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
UA91341C2 (ru)	2004-07-15	2010-07-26	Амр Текнолоджи, Інк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
US7956050B2 (en)	2005-07-15	2011-06-07	Albany Molecular Research, Inc.	Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
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AU2007300627B2 (en)	2006-09-22	2012-02-16	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt)	2007-01-10	2022-01-25	Msd Italia S.R.L.	Compostos de fórmula i e seus usos
US8399720B2 (en)	2007-03-23	2013-03-19	Ube Industries, Ltd.	Methods for producing fluorinated phenylsulfur pentafluorides
CA2857831C (en)	2007-03-23	2017-01-03	Ube Industries, Ltd.	Process for producing arylsulfur pentafluorides
AU2008233662B2 (en)	2007-04-02	2012-08-23	Msd K.K.	Indoledione derivative
WO2009002495A1 (en)	2007-06-27	2008-12-31	Merck & Co., Inc.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8030516B2 (en)	2007-10-19	2011-10-04	Ube Industries, Ltd.	Methods for producing perfluoroalkanedi(sulfonyl chloride)
US8598184B2 (en)	2008-03-03	2013-12-03	Tiger Pharmatech	Protein kinase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2334661B1 (de)	2008-09-22	2017-08-30	Ube Industries, Ltd.	Verfahren zur herstellung aromatischer poly(pentafluorsulfanyl)-verbindungen
WO2010081014A1 (en)	2009-01-09	2010-07-15	Im&T Research, Inc.	Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods
EP2413932A4 (de)	2009-04-01	2012-09-19	Merck Sharp & Dohme	Hemmer der akt-aktivität
ES2446971T3 (es)	2009-05-12	2014-03-11	Albany Molecular Research, Inc.	Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
JP5739415B2 (ja)	2009-05-12	2015-06-24	ブリストル−マイヤーズスクウィブカンパニー	（Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
CN102595902B (zh)	2009-05-12	2015-04-29	阿尔巴尼分子研究公司	7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
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WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
WO2012143879A1 (en)	2011-04-21	2012-10-26	Piramal Healthcare Limited	A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (de)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Neue verbindungen als erk-hemmer
EP3919620A1 (de)	2012-05-02	2021-12-08	Sirna Therapeutics, Inc.	Zusammensetzungen mit kurzer interferierender nukleinsäure (sina)
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WO2014100065A1 (en)	2012-12-20	2014-06-26	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3706742B1 (de)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
CA3108388A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
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Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2654726B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone et leur preparation.
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676442B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole et leur preparation.
FR2689889B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, et leur preparation.
FR2689888B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.

1994
- 1994-07-21 TW TW083106682A patent/TW365603B/zh active
- 1994-07-28 KR KR1019960700531A patent/KR960703858A/ko not_active Withdrawn
- 1994-07-28 JP JP7505618A patent/JPH09500893A/ja active Pending
- 1994-07-28 EP EP94923755A patent/EP0711280B1/de not_active Expired - Lifetime
- 1994-07-28 PL PL94312739A patent/PL312739A1/xx unknown
- 1994-07-28 HU HU9503986A patent/HUT75304A/hu unknown
- 1994-07-28 AU AU73865/94A patent/AU7386594A/en not_active Abandoned
- 1994-07-28 DK DK94923755T patent/DK0711280T3/da active
- 1994-07-28 AT AT94923755T patent/ATE171445T1/de not_active IP Right Cessation
- 1994-07-28 DE DE69413542T patent/DE69413542T2/de not_active Expired - Fee Related
- 1994-07-28 US US08/586,708 patent/US5624950A/en not_active Expired - Fee Related
- 1994-07-28 SK SK130-96A patent/SK13096A3/sk unknown
- 1994-07-28 IL IL11049494A patent/IL110494A0/xx unknown
- 1994-07-28 WO PCT/FR1994/000952 patent/WO1995004040A1/fr not_active Ceased
- 1994-07-28 CA CA002168233A patent/CA2168233A1/fr not_active Abandoned
- 1994-07-28 CZ CZ96263A patent/CZ26396A3/cs unknown
- 1994-07-28 ES ES94923755T patent/ES2123149T3/es not_active Expired - Lifetime
1996
- 1996-01-29 NO NO960365A patent/NO960365L/no unknown
- 1996-01-29 FI FI960399A patent/FI960399A0/fi unknown

Also Published As

Publication number	Publication date
EP0711280B1 (de)	1998-09-23
US5624950A (en)	1997-04-29
DK0711280T3 (da)	1999-06-14
CZ26396A3 (en)	1996-05-15
NO960365D0 (no)	1996-01-29
KR960703858A (ko)	1996-08-31
HUT75304A (en)	1997-05-28
DE69413542T2 (de)	1999-03-25
WO1995004040A1 (fr)	1995-02-09
PL312739A1 (en)	1996-05-13
DE69413542D1 (de)	1998-10-29
ES2123149T3 (es)	1999-01-01
ATE171445T1 (de)	1998-10-15
FI960399A7 (fi)	1996-01-29
SK13096A3 (en)	1996-09-04
TW365603B (en)	1999-08-01
AU7386594A (en)	1995-02-28
FI960399A0 (fi)	1996-01-29
HU9503986D0 (en)	1996-03-28
CA2168233A1 (fr)	1995-02-09
IL110494A0 (en)	1994-10-21
EP0711280A1 (de)	1996-05-15
JPH09500893A (ja)	1997-01-28

Publication	Publication Date	Title
NO955047L (no)	1995-12-13	Sekundære aminer som antidiabetiske og antifedme-midler
NO20025821L (no)	2003-02-04	2-aminokarbonyl-9H-purinderivater
NO308248B1 (no)	2000-08-21	Forbindelser som er anvendbare som antiproliferative midler og GARFT-inhibitorer, samt farmasøytisk preparat
YU223490A (sh)	1993-05-28	Novi derivati izoindolana, njihovo dobijanje i farmaceutske smeše koje ih sadrže
MX9701305A (es)	1998-05-31	Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas.
TW365603B (en)	1999-08-01	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
NO986055D0 (no)	1998-12-22	Nye heterocykliske forbindelser, deres fremstilling, farmas÷ytiske preparat
NO20004121L (no)	2000-10-17	Nye forbindelser og deres anvendelse som positive AMPA- reseptormodulatorer
CA2318349A1 (en)	1999-07-08	Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
BR0111596A (pt)	2004-03-02	Composto e seu uso, processo para sua produção, composição farmacêutica e processo e método para prevenir ou tratar doenças
MX9202287A (es)	1993-02-01	Nuevos derivados de perhidroisoindol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
DK0889876T3 (da)	2001-09-24	Meta-substituerede phenylensulfonamidderivater
RU94045855A (ru)	1996-09-10	Производные пергидроизоиндола, способы их получения и содержащие их фармацевтические композиции
DE69120100D1 (de)	1996-07-18	Annelierte Thiophen-Derivate, ihre Herstellung und Verwendung
NO971625L (no)	1997-05-30	Nye peptider med immunomodulatoriske effekter
NO924598L (no)	1992-11-27	Fremstilling av substituerte piperidiner
DE69433984D1 (de)	2004-10-14	Arylpiperazinderivate von indol als liganden der rezeptoren 5 ht1-like, 5 ht1b und 5 ht1d
TR199802518T2 (xx)	1999-04-21	4-Diketon ikameli yeni tiazolidon-2 t�revleri.
SE9603283D0 (sv)	1996-09-10	New compounds
FR2674849B1 (fr)	1994-12-23	Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
NO20050664L (no)	2005-04-15	2,4 substituerte indoler og anvendelse derav som 5-HT6 modulatorer
DK0920425T3 (da)	2003-05-26	Substituerede 4-(1H-benzimidazol-2-yl-amino)piperidiner, der er nyttige til behandling af allergiske sygdomme
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