PH27530A - Proteinase inhibitors and medicaments containing these - Google Patents

Proteinase inhibitors and medicaments containing these

Info

Publication number: PH27530A
Authority: PH; Philippines
Prior art keywords: peptide variants; trypsin inhibitor; inhibitory activity; proteinase inhibitors; medicaments containing
Prior art date: 1989-05-13

Application number

PH40464A

Other languages

English (en)

Inventor

Hans Fritz

Wolfgang Gebhard

Rathindra Das

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-13

Filing date

1990-05-02

Publication date

1993-08-18

1990-05-02 Application filed by Bayer Ag filed Critical Bayer Ag

1993-08-18 Publication of PH27530A publication Critical patent/PH27530A/en

Links

229940019748 antifibrinolytic proteinase inhibitors Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
230000002401 inhibitory effect Effects 0.000 abstract 2
LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 abstract 1
241000894006 Bacteria Species 0.000 abstract 1
102000004173 Cathepsin G Human genes 0.000 abstract 1
108090000617 Cathepsin G Proteins 0.000 abstract 1
241000206602 Eukaryota Species 0.000 abstract 1
102000016387 Pancreatic elastase Human genes 0.000 abstract 1
108010067372 Pancreatic elastase Proteins 0.000 abstract 1
108090000113 Plasma Kallikrein Proteins 0.000 abstract 1
102100034869 Plasma kallikrein Human genes 0.000 abstract 1
102000012479 Serine Proteases Human genes 0.000 abstract 1
108010022999 Serine Proteases Proteins 0.000 abstract 1
229940122618 Trypsin inhibitor Drugs 0.000 abstract 1
101710162629 Trypsin inhibitor Proteins 0.000 abstract 1
238000010353 genetic engineering Methods 0.000 abstract 1
108010093564 inter-alpha-inhibitor Proteins 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
239000002753 trypsin inhibitor Substances 0.000 abstract 1
108010088854 urinastatin Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Physics & Mathematics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)

PH40464A 1989-05-13 1990-05-02 Proteinase inhibitors and medicaments containing these PH27530A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3915689		1989-05-13
DE4001244		1990-01-18

Publications (1)

Publication Number	Publication Date
PH27530A true PH27530A (en)	1993-08-18

Family

ID=25880860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH40464A PH27530A (en)	1989-05-13	1990-05-02	Proteinase inhibitors and medicaments containing these

Country Status (17)

Country	Link
US (1)	US5407915A (fr)
EP (1)	EP0401508B1 (fr)
JP (2)	JP3126975B2 (fr)
KR (1)	KR0156246B1 (fr)
AT (1)	ATE114332T1 (fr)
AU (1)	AU623769B2 (fr)
CA (1)	CA2016627C (fr)
DE (1)	DE59007737D1 (fr)
DK (1)	DK0401508T3 (fr)
ES (1)	ES2066033T3 (fr)
GR (1)	GR3015124T3 (fr)
HU (1)	HU214985B (fr)
IE (1)	IE65710B1 (fr)
IL (1)	IL94349A (fr)
NZ (1)	NZ233635A (fr)
PH (1)	PH27530A (fr)
PT (1)	PT94016B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
US7078383B2 (en) *	1988-09-02	2006-07-18	Dyax Corp.	ITI-D1 Kunitz domain mutants as HNE inhibitors
US5663143A (en) *	1988-09-02	1997-09-02	Dyax Corp.	Engineered human-derived kunitz domains that inhibit human neutrophil elastase
CA2055425A1 (fr) *	1990-11-13	1992-05-14	Hideaki Morishita	Polypeptide, fragment d'adn l'encodant, methode pour le fabriquer, procede d'inhibition enzymatique, composition medicamenteuse et methodes de traitement faisant appel a ce
AU1581692A (en) *	1991-03-01	1992-10-06	Protein Engineering Corporation	Inhibitors of human neutrophil elastase and human cathepsin g
CA2082226A1 (fr) *	1991-11-08	1993-05-09	Hideaki Morishita	Polypeptide, fragment d'adn codant ledit polypeptide, composition medicamenteuse le contenant et mode de preparation
IL104327A0 (en) *	1992-01-07	1993-05-13	Novo Nordisk As	Variant of human kunitz-type protease inhibitor
JP2769083B2 (ja) *	1993-02-22	1998-06-25	日清食品株式会社	エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
JP3570558B2 (ja) *	1993-05-01	2004-09-29	持田製薬株式会社	Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法
US5650394A (en) *	1993-11-04	1997-07-22	Adeza Biomedical	Use of urinastatin-like compounds to prevent premature delivery
ATE277081T1 (de)	1994-01-11	2004-10-15	Dyax Corp	Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
WO1996026273A1 (fr) *	1995-02-23	1996-08-29	Adeza Biomedical Corporation	Polypeptides tires de l'urinastatine presentant une activite d'inhibition calcique et leur utilisation pour retarder les accouchements prematures
JP3469584B2 (ja) *	1996-03-11	2003-11-25	バイエルコーポレイション	ヒトビクニン
US20070140979A1 (en) *	1998-12-22	2007-06-21	Bayer Aktiengesellschaft	Method for accelerating the rate of mucociliary clearance
ES2209542T3 (es) *	1998-12-22	2004-06-16	Bayer Aktiengesellschaft	Metodo para acelerar la velocidad de eliminacion mucociliar usando un inhibidor de serinproteasa de tipo kunitz.
US6660482B1 (en) *	2000-02-28	2003-12-09	Rhode Island Hospital	Inter-alpha-trypsin inhibitor as a marker for sepsis
JP2004538676A (ja) *	2001-03-27	2004-12-24	アウェア，インコーポレイテッド	受信機トランスペアレントｑモード
ES2348230T3 (es)	2002-06-07	2010-12-01	Dyax Corp.	Prevención y reducción de la isquemia.
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
EP2386310B1 (fr)	2002-08-28	2018-11-07	Dyax Corp.	Procédés de conservation d'organes et de tissus
DK1587907T3 (da) *	2003-01-07	2011-04-04	Dyax Corp	Kunitz-domænebibliotek
US6989369B2 (en) *	2003-02-07	2006-01-24	Dyax Corp.	Kunitz domain peptides
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US8637454B2 (en) *	2009-01-06	2014-01-28	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
SMT201800552T1 (it)	2010-01-06	2018-11-09	Dyax Corp	Proteine che legano la callicreina plasmatica
KR102320178B1 (ko)	2011-01-06	2021-11-02	다케다 파머수티컬 컴패니 리미티드	혈장 칼리크레인 결합 단백질
PL3110434T3 (pl)	2014-02-24	2019-01-31	Takeda Gmbh	Białka fuzyjne uti
US10428158B2 (en)	2014-03-27	2019-10-01	Dyax Corp.	Compositions and methods for treatment of diabetic macular edema
EP3387018A1 (fr)	2015-12-11	2018-10-17	Dyax Corp.	Inhibiteurs de la kallicréine plasmatique et utilisations desdits inhibiteurs pour traiter une crise d'angio- dème héréditaire
EP4090427A1 (fr)	2020-01-13	2022-11-23	Takeda Pharmaceutical Company Limited	Inhibiteurs de la kallicréine plasmatique et leurs utilisations pour traiter une crise d'angio-oedème héréditaire pédiatrique
US11725043B2 (en)	2020-03-05	2023-08-15	DiaMedica USA Inc.	Ulinastatin polypeptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
FR2599752B1 (fr) *	1986-06-10	1989-11-03	Transgene Sa	Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
FR2601033B1 (fr) *	1986-07-02	1990-01-19	Transgene Sa	Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation
EP0255011A3 (fr) *	1986-07-29	1988-11-23	Miles Inc.	Gène humain pour l'inhibiteur d'inter-alpha-trypsine

1990
- 1990-05-01 DK DK90108284.2T patent/DK0401508T3/da active
- 1990-05-01 AT AT90108284T patent/ATE114332T1/de not_active IP Right Cessation
- 1990-05-01 ES ES90108284T patent/ES2066033T3/es not_active Expired - Lifetime
- 1990-05-01 EP EP90108284A patent/EP0401508B1/fr not_active Expired - Lifetime
- 1990-05-01 DE DE59007737T patent/DE59007737D1/de not_active Expired - Fee Related
- 1990-05-02 PH PH40464A patent/PH27530A/en unknown
- 1990-05-10 NZ NZ233635A patent/NZ233635A/en unknown
- 1990-05-10 IL IL94349A patent/IL94349A/en not_active IP Right Cessation
- 1990-05-11 IE IE171390A patent/IE65710B1/en not_active IP Right Cessation
- 1990-05-11 HU HU903010A patent/HU214985B/hu not_active IP Right Cessation
- 1990-05-11 AU AU54970/90A patent/AU623769B2/en not_active Ceased
- 1990-05-11 CA CA002016627A patent/CA2016627C/fr not_active Expired - Fee Related
- 1990-05-11 PT PT94016A patent/PT94016B/pt active IP Right Grant
- 1990-05-11 JP JP02120186A patent/JP3126975B2/ja not_active Expired - Fee Related
- 1990-05-12 KR KR1019900006865A patent/KR0156246B1/ko not_active Expired - Fee Related
1993
- 1993-03-05 US US08/027,602 patent/US5407915A/en not_active Expired - Fee Related
1995
- 1995-02-22 GR GR940403586T patent/GR3015124T3/el unknown
2000
- 2000-09-13 JP JP2000278172A patent/JP2001112492A/ja active Pending

Also Published As

Publication number	Publication date
AU623769B2 (en)	1992-05-21
JP3126975B2 (ja)	2001-01-22
ATE114332T1 (de)	1994-12-15
US5407915A (en)	1995-04-18
JP2001112492A (ja)	2001-04-24
ES2066033T3 (es)	1995-03-01
DE59007737D1 (de)	1995-01-05
NZ233635A (en)	1991-12-23
HU214985B (hu)	1998-08-28
EP0401508A2 (fr)	1990-12-12
KR0156246B1 (ko)	1998-11-16
PT94016A (pt)	1991-01-08
KR900017607A (ko)	1990-12-19
JPH03255099A (ja)	1991-11-13
EP0401508B1 (fr)	1994-11-23
GR3015124T3 (en)	1995-05-31
IE65710B1 (en)	1995-11-15
IL94349A0 (en)	1991-03-10
HU903010D0 (en)	1990-09-28
CA2016627C (fr)	2000-08-22
IL94349A (en)	1998-01-04
AU5497090A (en)	1990-11-15
PT94016B (pt)	1997-05-28
IE901713L (en)	1990-11-13
DK0401508T3 (da)	1995-05-15
CA2016627A1 (fr)	1990-11-13
EP0401508A3 (fr)	1991-03-27

Publication	Publication Date	Title
PH27530A (en)	1993-08-18	Proteinase inhibitors and medicaments containing these
Johnson et al.	1986	Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region.
Sherman et al.	1992	Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center.
MX9603775A (es)	1997-07-31	Proteinas inhibidoras del dominio de kunitz, derivadas del inhibidor del precursor de la beta-proteina amiloide de alzheimer.
ATE226636T1 (de)	2002-11-15	Serpin-resistenter t-pa; mutanten; gene
IL122116A0 (en)	1998-04-05	Polypeptide comprising kunitz-type serine protease inhibitor
WO1996035788A3 (fr)	1996-12-12	Peptides inhibiteurs de proteases de type kunitz
MY116539A (en)	2004-02-28	New amino acid derivatives
UA99895C2 (uk)	2012-10-25	Пептидоміметичний інгібітор протеаз
NO930517L (no)	1993-08-16	Benzimidazolylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
AU639257B2 (en)	1993-07-22	Proteins having anticoagulant properties
Rowan et al.	1990	Inhibition of cysteine proteinases by a protein inhibitor from potato
ATE92935T1 (de)	1993-08-15	Serinproteaseinhibitoren und isolierungsverfahren dazu.
NZ319474A (en)	2000-01-28	Guanidino protease inhibitors
WO1999063090A3 (fr)	2000-03-02	Peptides inhibiteurs de protease
AU4720093A (en)	1994-03-03	Inhibitor resistant serine proteases
Schoenberger et al.	1989	Limited proteolysis of Cl‐inhibitor by chymotrypsin‐like proteinases
Braud et al.	2002	The stratagem utilized by the plasminogen activator from the snake Trimeresurus stejnegeri to escape serpins
Knäuper et al.	1991	Inactivation of human plasma C1‐inhibitor by human PMN leucocyte matrix metalloproteinases
Takahara et al.	1982	Mouse plasma trypsin inhibitors: Inhibitory spectrum of contrapsin and alpha-1-antitrypsin
Sulikowski et al.	2002	α1‐Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1
PL307864A1 (en)	1995-06-26	Retroviral infection inhibition
Ecke et al.	1994	Alternative targeting of a serpin-type inhibitor by glycosaminoglycans (GAGs): Heparin binding of protein C inhibitor (pci) prevents its interaction with tissue kallikrein (tk)
Rarabas et al.	1994	Investigations of thrombin inhibitors in fibrinolytic systems
Hayashi et al.	1994	Fibrin (ogen) binding region in urinary protein c inhibitor